begin name
yugi2
end name

begin reactions
re30 {1.0}$EXTERNAL = {1.0}s4
re31 {1.0}s4 = {1.0}$EXTERNAL
re32 {1.0}s4 = {1.0}s11
re33 {1.0}s8 = {1.0}s14
re34 {1.0}s7 = {1.0}s15
re35 {1.0}s5 = {1.0}s16
re36 {1.0}s6 = {1.0}s17
re37 {1.0}s9 = {1.0}s18
re38 {1.0}s10 = {1.0}s19
re39 {1.0}s3 = {1.0}s21
re40 {1.0}$s24 = {1.0}s23
re41 {1.0}s23 = {1.0}s25
re42 {1.0}s23 = {1.0}s26
re43 {1.0}s26 = {1.0}s27
re44 {1.0}s25 = {1.0}s27
re45 {1.0}s27 = {1.0}s25
re46 {1.0}s26 = {1.0}s23
re47 {1.0}s27 = {1.0}s36
re48 {1.0}$s28 = {1.0}s29
re49 {1.0}s29 = {1.0}$s28
re50 {1.0}s26 = {1.0}s37
re51 {1.0}s25 = {1.0}s38
re52 {1.0}$s30 = {1.0}s31
re53 {1.0}s31 = {1.0}$s30
re54 {1.0}$s32 = {1.0}s33
re55 {1.0}s33 = {1.0}$s32
re56 {1.0}$s34 = {1.0}s35
re57 {1.0}s35 = {1.0}$s34
re58 {1.0}$s1 = {1.0}s13
re59 {1.0}s13 = {1.0}$s1
end reactions

begin rate equations
re30 = (KPFKLakg*KPFKLcit*KPFKLicit*KPFKLmal*KPFKLpep*s22*VfPFKL*s13[t]*s9[t])/((KPFKLf6p + s22)*(KPFKLcit + s10[t])*(KPFKLPHOSS775 + s13[t])*(KPFKLpep + s5[t])*(KPFKLicit + s6[t])*(KPFKLakg + s7[t])*(KPFKLmal + s8[t])*(KPFKLf26bp + s9[t]))
re31 = (KFBPasef26bp*VfFBPase*s10[t]*s4[t])/((KFBPasecit + s10[t])*(KFBPasef16bp + s4[t])*(KFBPasef26bp + s9[t]))
re32 = kALDO*s4[t]
re33 = -kmal
re34 = -kakg
re35 = -kpep
re36 = -kicit
re37 = -kf26bp
re38 = -kcit
re39 = -kf6p
re40 = re40k1*(s24 - s23[t])
re41 = insulin*re41k1*s23[t] - re41k2*s25[t]
re42 = re42k1*s23[t]*s31[t]
re43 = insulin*re43k1*s26[t] - re43k2*s27[t]
re44 = re44k1*s25[t]*s31[t]
re45 = re45k1*s27[t]
re46 = re46k1*s26[t]
re47 = re47k1*s27[t]
re48 = re48k1*s25[t]*(s28 - s29[t])
re49 = re49k1*s29[t]
re50 = re50k1*s26[t]
re51 = re51k1*s25[t]
re52 = re52k1*s29[t]*(s30 - s31[t])
re53 = re53k1*s31[t]
re54 = re54k1*s31[t]*(s32 - s33[t])
re55 = re55k1*s33[t]*s35[t]
re56 = re56k1*s31[t]*(s34 - s35[t])
re57 = re57k1*s35[t]
re58 = re58k1*(s1 - s13[t])*s33[t]
re59 = re59k1*s13[t]
end rate equations

begin parameters
KFBPasecit = 0.0211646
KFBPasef16bp = 0.104089638
KFBPasef26bp = 17.51744342
KPFKLPHOSS775 = 6.283705757
KPFKLakg = 24661.01154
KPFKLcit = 41.30426029
KPFKLf26bp = 1.282443082
KPFKLf6p = 0.014114844
KPFKLicit = 1784.508205
KPFKLmal = 9.544729149
KPFKLpep = 0.633518366
VfFBPase = 9.932861302
VfPFKL = 695063.7194
insulin = 1.0
kALDO = 0.008187906
kakg = -3.544494721
kcit = -0.351935646
kf26bp = -0.083430336
kf6p = -0.930115636
kicit = -0.038210156
kmal = 1.005530417
kpep = 43.99195576
s1 = 1.235570941
s24 = 46.2222520609226
s28 = 4.33812187331668
s30 = 0.0959163701057347
s32 = 2.7769943784158
s34 = 14.9913345914433
re40k1 = 0.0477985900779305
re41k1 = 7.78160761103111
re41k2 = 1.61147523779118
re42k1 = 9.93311225447353
re43k1 = 0.363030286526969
re43k2 = 0.408127912886804
re44k1 = "3.88248960751442e-05"
re45k1 = 0.28442597446931
re46k1 = "1.00000000282413e-05"
re47k1 = 0.0948960328385619
re48k1 = 0.00919578911309774
re49k1 = 7.70618517548016
re50k1 = "1.00277786609339e-05"
re51k1 = 0.00792717614041237
re52k1 = 0.419682384304397
re53k1 = 0.124330492920416
re54k1 = 0.00752464611370891
re55k1 = 1.95497593092361
re56k1 = 0.00105342379833469
re57k1 = 0.00145811601430322
re58k1 = 26.8316707654711
re59k1 = 0.0166525139097609
default = 1.0
end parameters

begin initial conditions
s10[0] = s10i
s11[0] = s11i
s12[0] = s12i
s13[0] = s13i
s14[0] = s14i
s15[0] = s15i
s16[0] = s16i
s17[0] = s17i
s18[0] = s18i
s19[0] = s19i
s2[0] = s2i
s21[0] = s21i
s23[0] = s23i
s25[0] = s25i
s26[0] = s26i
s27[0] = s27i
s29[0] = s29i
s3[0] = s3i
s31[0] = s31i
s33[0] = s33i
s35[0] = s35i
s36[0] = s36i
s37[0] = s37i
s38[0] = s38i
s4[0] = s4i
s5[0] = s5i
s6[0] = s6i
s7[0] = s7i
s8[0] = s8i
s9[0] = s9i
end initial conditions

begin initial values
s10i = 17.7476118652
s11i = 0.0
s12i = 1.0
s13i = 0.759332005
s14i = 0.0
s15i = 0.0
s16i = 0.0
s17i = 0.0
s18i = 0.0
s19i = 0.0
s2i = 1.0
s21i = 0.0
s23i = 37.81914621
s25i = 2.507671281
s26i = 852.608418
s27i = 3.930695895
s29i = 0.012942682
s3i = 14.0774258421
s31i = 0.004015031
s33i = 0.000988831
s35i = 0.043352951
s36i = 0.0
s37i = 0.0
s38i = 0.0
s4i = 104.07239819
s5i = 108.094519859
s6i = 1.79487179487
s7i = 25.1885369533
s8i = 68.8788335846
s9i = 1.0
end initial values

begin assignment rules
s22 := s3[t]
end assignment rules

begin function definitions
end function definitions

begin events
ev10min = (t > 10, {kakg -> 0.36199095, kcit -> 1.085972851, kicit -> -0.038210156, kf26bp -> -0.050207413, kmal -> 3.921568627, kpep -> 9.049773756, kf6p -> -1.055806938}, 0)
ev5min = (t > 5, {kakg -> 0, kcit -> -0.211161388, kf6p -> 0.271493213, kicit -> -0.038210156, kf26bp -> 0.119075279, kmal -> -0.904977376, kpep -> -6.334841629}, 0)
ev2min = (t > 2, {kakg -> -1.357466063, kcit -> 0.351935646, kf6p -> 1.357466063, kicit -> -0.038210156, kf26bp -> 0.028924455, kmal -> -1.508295626, kpep -> 7.54147813}, 0)
ev30min = (t > 30, {kpep -> -0.301659125, kmal -> 0.502765209, kf26bp -> -0.003055632, kicit -> 0.031674208, kakg -> 0.369532428, kf6p -> 0.070387129, kcit -> 0.306686777}, 0)
ev45min = (t > 45, {kf6p -> 0.070387129, kcit -> 0.306686777, kakg -> 0.369532428, kicit -> 0.031674208, kf26bp -> -0.003055632, kmal -> 0.502765209, kpep -> -0.301659125}, 0)
ev20min = (t > 20, {kakg -> 0.226244344, kcit -> 0.377073906, kf6p -> -0.165912519, kicit -> 0.031674208, kf26bp -> -0.032601514, kmal -> 1.206636501, kpep -> -3.619909502}, 0)
ev15min = (t > 15, {kakg -> 1.085972851, kcit -> 0.452488688, kf6p -> -0.12066365, kicit -> -0.018099548, kf26bp -> 0.100115778, kpep -> -4.826546003, kmal -> 1.809954751}, 0)
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units