begin name
yang
end name

begin reactions
R1 {1.0}$EXTERNAL = {1.0}x1
R10 {1.0}x1 = {1.0}x10
R11 {1.0}x10 = {1.0}x11
R12 {1.0}x10 = {1.0}x12
R13 {1.0}x12 = {1.0}x13
R14 {1.0}x13 = {1.0}x14
R16 {1.0}$EXTERNAL = {1.0}x16
R17 {1.0}x17 = {1.0}$EXTERNAL
R18 {1.0}x9 = {1.0}$EXTERNAL
R19 {1.0}x20 = {1.0}$EXTERNAL
R2 {1.0}x1 = {1.0}x2
R20 {1.0}x20 = {1.0}$EXTERNAL
R21 {1.0}$EXTERNAL = {1.0}x21
R22 {1.0}x22 = {1.0}$EXTERNAL
R23 {1.0}x12 = {1.0}$EXTERNAL
R24 {1.0}x13 = {1.0}$EXTERNAL
R25 {1.0}x8 = {1.0}$EXTERNAL
R26 {1.0}x3 = {1.0}$EXTERNAL
R27 {1.0}x2 = {1.0}$EXTERNAL
R28 {1.0}x16 = {1.0}$EXTERNAL
R29 {1.0}x11 = {1.0}$EXTERNAL
R3 {1.0}x2 = {1.0}x3
R30 {1.0}x21 = {1.0}$EXTERNAL
R31 {1.0}x21 = {1.0}$EXTERNAL
R32 {1.0}x21 = {1.0}$EXTERNAL
R34 {1.0}x1 = {1.0}$EXTERNAL
R4 {1.0}x1 = {1.0}x4
R5 {1.0}x4 = {1.0}x5
R6 {1.0}x1 = {1.0}x6
R7 {1.0}x6 = {1.0}x7
R8 {1.0}x6 = {1.0}x8
R9 {1.0}$EXTERNAL = {1.0}x9
end reactions

begin rate equations
R1 = (cell*K15*lin*x15[t]*(1 + x11[t]/KI22 + x13[t]/KI21 + x2[t]/KI20 + x4[t]/KI19))/(lin + k15*(1 + x1[t]/ks))
R10 = (cell*K21*x1[t]*x21[t])/(x1[t] + k21*(1 + x10[t]/ks + x11[t]/ki12 + x3[t]/ki8 + x5[t]/ki7 + x7[t]/ki11))
R11 = (cell*K24*x10[t]*x24[t])/(x10[t] + k24*(1 + x11[t]/ks))
R12 = (cell*K21*x10[t]*x21[t])/(x10[t] + k21*(1 + x11[t]/ki12 + x12[t]/ks + x3[t]/ki8 + x5[t]/ki7 + x7[t]/ki11))
R13 = (cell*K22*x12[t]*x22[t])/(x12[t] + k22*(1 + x13[t]/ks))
R14 = (cell*K23*x13[t]*x23[t])/(x13[t] + k23*(1 + x11[t]/ki15 + x14[t]/ks + x5[t]/ki14))
R16 = (a24*cell*x7[t]^2)/(KI24^2 + x7[t]^2)
R17 = cell*ki17*x17[t]*x2[t]
R18 = cell*kd9*x9[t]
R19 = cell*ki5*x20[t]*x6[t]
R2 = (cell*K16*x1[t]*x16[t])/(x1[t] + k16*(1 + x2[t]/ks))
R20 = cell*ki4*x2[t]*x20[t]
R21 = cell*KI23*x13[t]*x21[t]
R22 = (cell*K22*x12[t]*x22[t])/(129*(k22 + x12[t]))
R23 = cell*kd12*x12[t]
R24 = cell*kd13*x13[t]
R25 = cell*kd8*x8[t]
R26 = cell*kd3*x3[t]
R27 = cell*kd2*x2[t]
R28 = cell*kd16*x16[t]
R29 = cell*kd11*x11[t]
R3 = (cell*K24*x2[t]*x24[t])/(x2[t] + k24*(1 + x3[t]/ks))
R30 = cell*ki9*x12[t]*x21[t]
R31 = cell*ki10*x10[t]*x21[t]
R32 = cell*ki6*x2[t]*x21[t]
R34 = 0.1*cell*x1[t]
R4 = (cell*K17*x1[t]*x17[t])/(x1[t] + k17*(1 + x3[t]/ki16 + x4[t]/ki18 + x4[t]/ks))
R5 = (cell*K24*x24[t]*x4[t])/(x4[t] + k24*(1 + x5[t]/ks))
R6 = (cell*K18*x1[t]*x18[t])/(x1[t] + k18*(1 + x6[t]/ks + x7[t]/ki3))
R7 = (cell*K19*x19[t]*x6[t])/(x6[t] + k19*(1 + x1[t]/ki1 + x3[t]/ki2 + x7[t]/ks))
R8 = (cell*K20*x20[t]*x6[t])/(x6[t] + k20*(1 + x8[t]/ks))
R9 = cell*kd8*x8[t]
end rate equations

begin parameters
K15 = 3600.0
K16 = 1000.0
K17 = 1000.0
K18 = 1000.0
K19 = 3000.0
K20 = 1599.0
K21 = 5000.0
K22 = 125.0
K23 = 150.0
K24 = 500.0
KI19 = 500.0
KI20 = 200.0
KI21 = 500.0
KI22 = 500.0
KI23 = 0.053
KI24 = "2.3e-05"
a24 = 0.15
k15 = 2600.0
k16 = 70.0
k17 = 50.0
k18 = 50.0
k19 = 160.0
k20 = 4.0
k21 = 5.0
k22 = 20.0
k23 = 3.9
k24 = 70.0
kd11 = 0.001
kd12 = 0.07
kd13 = 0.01
kd16 = 0.01
kd2 = 0.05
kd3 = 0.01
kd8 = 0.1
kd9 = 0.001
ki1 = 0.3
ki10 = 0.01
ki11 = 15.0
ki12 = 6.3
ki14 = 0.2
ki15 = 0.86
ki16 = 10.0
ki17 = 10.0
ki18 = 10.0
ki2 = 30.0
ki3 = 30.0
ki4 = 0.6
ki5 = 0.1
ki6 = 0.01
ki7 = 30.0
ki8 = 4.0
ki9 = 0.175
ks = 500.0
lin = 12.0
cell = 1.0
end parameters

begin initial conditions
x1[0] = x1i
x10[0] = x10i
x11[0] = x11i
x12[0] = x12i
x13[0] = x13i
x14[0] = x14i
x15[0] = x15i
x16[0] = x16i
x17[0] = x17i
x18[0] = x18i
x19[0] = x19i
x2[0] = x2i
x20[0] = x20i
x21[0] = x21i
x22[0] = x22i
x23[0] = x23i
x24[0] = x24i
x25[0] = x25i
x3[0] = x3i
x4[0] = x4i
x5[0] = x5i
x6[0] = x6i
x7[0] = x7i
x8[0] = x8i
x9[0] = x9i
end initial conditions

begin initial values
x1i = 0.001
x10i = 0.001
x11i = 0.001
x12i = 0.001
x13i = 0.001
x14i = 0.001
x15i = 1.5
x16i = 1.5
x17i = 0.5
x18i = 0.2
x19i = 0.5
x2i = 0.001
x20i = 0.5
x21i = 5.0
x22i = 0.76
x23i = 0.07
x24i = 0.8
x25i = 0.0
x3i = 0.001
x4i = 0.001
x5i = 0.001
x6i = 0.001
x7i = 0.001
x8i = 0.001
x9i = 0.001
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
x1 http://identifiers.org/obo.chebi/CHEBI:15843
x1 http://identifiers.org/kegg.compound/C00219
x10 http://identifiers.org/obo.chebi/CHEBI:15632
x10 http://identifiers.org/kegg.compound/C05356
x11 http://identifiers.org/obo.chebi/CHEBI:28209
x11 http://identifiers.org/kegg.compound/C04805
x12 http://identifiers.org/obo.chebi/CHEBI:15651
x13 http://identifiers.org/obo.chebi/CHEBI:15647
x14 http://identifiers.org/obo.chebi/CHEBI:15646
x15 http://identifiers.org/uniprot/P04054
x16 http://identifiers.org/uniprot/P16050
x17 http://identifiers.org/uniprot/P18054
x19 http://identifiers.org/uniprot/Q9H7Z7
x2 http://identifiers.org/obo.chebi/CHEBI:15628
x2 http://identifiers.org/kegg.compound/C05966
x20 http://identifiers.org/uniprot/P24557
x21 http://identifiers.org/uniprot/P09917
x22 http://identifiers.org/uniprot/P09960
x23 http://identifiers.org/uniprot/Q08477
x24 http://identifiers.org/uniprot/P36969
x3 http://identifiers.org/obo.chebi/CHEBI:15558
x3 http://identifiers.org/kegg.compound/C04742
x4 http://identifiers.org/obo.chebi/CHEBI:15626
x4 http://identifiers.org/kegg.compound/C05965
x5 http://identifiers.org/obo.chebi/CHEBI:34146
x5 http://identifiers.org/kegg.compound/C14777
x6 http://identifiers.org/obo.chebi/CHEBI:15554
x6 http://identifiers.org/kegg.compound/C00427
x7 http://identifiers.org/obo.chebi/CHEBI:15551
x7 http://identifiers.org/kegg.compound/C00584
x8 http://identifiers.org/obo.chebi/CHEBI:15627
x8 http://identifiers.org/kegg.compound/C02198
x9 http://identifiers.org/obo.chebi/CHEBI:28728
x9 http://identifiers.org/kegg.compound/C05963
end species annotations

begin units
end units