#yamada1

FIX: IFN

#reactions
v1:
 {1.0}JAK + {1.0}R = {1.0}RJ
  cytoplasm * (kf * R * JAK - kb * RJ)
v10:
 {1.0}IFNRJ2_star_SHP2 = {1.0}SHP2 + {1.0}IFNRJ2
  cytoplasm * kf * IFNRJ2_star_SHP2
v11:
 {1.0}STAT1c_star + {1.0}PPX = {1.0}STAT1c_star_PPX
  cytoplasm * (kf * PPX * STAT1c_star - kb * STAT1c_star_PPX)
v12:
 {1.0}STAT1c_star_PPX = {1.0}STAT1c + {1.0}PPX
  cytoplasm * kf * STAT1c_star_PPX
v13:
 {1.0}STAT1c_star_STAT1c_star + {1.0}PPX = {1.0}STAT1c_star_STAT1c_star_PPX
  cytoplasm * (kf * PPX * STAT1c_star_STAT1c_star - kb * STAT1c_star_STAT1c_star_PPX)
v14:
 {1.0}STAT1c_star_STAT1c_star_PPX = {1.0}STAT1c_STAT1c_star + {1.0}PPX
  cytoplasm * kf * STAT1c_star_STAT1c_star_PPX
v15:
 {1.0}STAT1c_star + {1.0}STAT1c = {1.0}STAT1c_STAT1c_star
  cytoplasm * (kf * STAT1c * STAT1c_star - kb * STAT1c_STAT1c_star)
v16:
 {1.0}STAT1c_star_STAT1c_star = {1.0}STAT1n_star_STAT1n_star
  cytoplasm * kf * STAT1c_star_STAT1c_star
v17:
 {2.0}STAT1n_star = {1.0}STAT1n_star_STAT1n_star
  nucleus * (kf * STAT1n_star * STAT1n_star - kb * STAT1n_star_STAT1n_star)
v18:
 {1.0}STAT1n_star + {1.0}PPN = {1.0}STAT1n_star_PPN
  nucleus * (kf * PPN * STAT1n_star - kb * STAT1n_star_PPN)
v19:
 {1.0}STAT1n_star_PPN = {1.0}STAT1n + {1.0}PPN
  nucleus * kf * STAT1n_star_PPN
v2:
 {1.0}RJ + {1.0}IFN = {1.0}IFNRJ
  cytoplasm * (kf * IFN * RJ - kb * IFNRJ)
v20:
 {1.0}STAT1n_star_STAT1n_star + {1.0}PPN = {1.0}STAT1n_star_STAT1n_star_PPN
  nucleus * (kf * PPN * STAT1n_star_STAT1n_star - kb * STAT1n_star_STAT1n_star_PPN)
v21:
 {1.0}STAT1n_star_STAT1n_star_PPN = {1.0}STAT1n_STAT1n_star + {1.0}PPN
  nucleus * kf * STAT1n_star_STAT1n_star_PPN
v22:
 {1.0}STAT1n_star + {1.0}STAT1n = {1.0}STAT1n_STAT1n_star
  nucleus * (kf * STAT1n * STAT1n_star - kb * STAT1n_STAT1n_star)
v23:
 {1.0}STAT1n = {1.0}STAT1c
  nucleus * kf * STAT1n
v24:
 $pool = {1.0}mRNAn
  nucleus * ka * STAT1n_star_STAT1n_star / (kb + STAT1n_star_STAT1n_star)
v25:
 {1.0}mRNAn = {1.0}mRNAc
  nucleus * kf * mRNAn
v26:
 $pool = {1.0}SOCS1
  cytoplasm * kf * mRNAc
v27:
 {1.0}mRNAc = $pool
  cytoplasm * kf * mRNAc
v28:
 {1.0}SOCS1 = $pool
  cytoplasm * kf * SOCS1
v29:
 {1.0}IFNRJ2_star + {1.0}SOCS1 = {1.0}IFNRJ2_star_SOCS1
  cytoplasm * (kf * SOCS1 * IFNRJ2_star - kb * IFNRJ2_star_SOCS1)
v3:
 {2.0}IFNRJ = {1.0}IFNRJ2
  cytoplasm * (kf * IFNRJ * IFNRJ - kb * IFNRJ2)
v30:
 {1.0}IFNRJ2_star_SOCS1 + {1.0}STAT1c = {1.0}IFNRJ2_star_SOCS1_STAT1c
  cytoplasm * (kf * STAT1c * IFNRJ2_star_SOCS1 - kb * IFNRJ2_star_SOCS1_STAT1c)
v31:
 {1.0}IFNRJ2_star_SOCS1_STAT1c + {1.0}SHP2 = {1.0}IFNRJ2_star_SHP2_SOCS1_STAT1c
  cytoplasm * (kf * SHP2 * IFNRJ2_star_SOCS1_STAT1c - kb * IFNRJ2_star_SHP2_SOCS1_STAT1c)
v32:
 {1.0}IFNRJ2_star_SHP2_SOCS1_STAT1c = {1.0}IFNRJ2 + {1.0}SOCS1 + {1.0}STAT1c + {1.0}SHP2
  cytoplasm * kf * IFNRJ2_star_SHP2_SOCS1_STAT1c
v33:
 {1.0}IFNRJ2_star_SHP2_SOCS1_STAT1c = {1.0}IFNRJ2_star_SHP2_STAT1c
  cytoplasm * kf * IFNRJ2_star_SHP2_SOCS1_STAT1c
v34:
 {1.0}IFNRJ2_star_SOCS1 + {1.0}SHP2 = {1.0}IFNRJ2_star_SHP2_SOCS1
  cytoplasm * (kf * SHP2 * IFNRJ2_star_SOCS1 - kb * IFNRJ2_star_SHP2_SOCS1)
v35:
 {1.0}IFNRJ2_star_SHP2_SOCS1 + {1.0}STAT1c = {1.0}IFNRJ2_star_SHP2_SOCS1_STAT1c
  cytoplasm * (kf * STAT1c * IFNRJ2_star_SHP2_SOCS1 - kb * IFNRJ2_star_SHP2_SOCS1_STAT1c)
v36:
 {1.0}IFNRJ2_star_STAT1c + {1.0}SHP2 = {1.0}IFNRJ2_star_SHP2_STAT1c
  cytoplasm * (kf * SHP2 * IFNRJ2_star_STAT1c - kb * IFNRJ2_star_SHP2_STAT1c)
v37:
 {1.0}IFNRJ2_star_SHP2_STAT1c = {1.0}STAT1c + {1.0}SHP2 + {1.0}IFNRJ2
  cytoplasm * kf * IFNRJ2_star_SHP2_STAT1c
v38:
 {1.0}IFNRJ2_star_SOCS1_STAT1c = {1.0}IFNRJ2_star_STAT1c
  cytoplasm * kf * IFNRJ2_star_SOCS1_STAT1c
v39:
 {1.0}IFNRJ2_star_SHP2_SOCS1 = {1.0}IFNRJ2_star_SHP2
  cytoplasm * kf * IFNRJ2_star_SHP2_SOCS1
v4:
 {1.0}IFNRJ2 = {1.0}IFNRJ2_star
  cytoplasm * kf * IFNRJ2
v40:
 {1.0}IFNRJ2_star_SHP2_SOCS1 = {1.0}SHP2 + {1.0}IFNRJ2 + {1.0}SOCS1
  cytoplasm * kf * IFNRJ2_star_SHP2_SOCS1
v41:
 {1.0}IFNRJ2_star_SOCS1 = {1.0}IFNRJ2_star
  cytoplasm * kf * IFNRJ2_star_SOCS1
v42:
 {1.0}IFNRJ2_star_STAT1c + {1.0}SOCS1 = {1.0}IFNRJ2_star_SOCS1_STAT1c
  cytoplasm * (kf * SOCS1 * IFNRJ2_star_STAT1c - kb * IFNRJ2_star_SOCS1_STAT1c)
v43:
 {1.0}IFNRJ2_star_SHP2 + {1.0}SOCS1 = {1.0}IFNRJ2_star_SHP2_SOCS1
  cytoplasm * (kf * SOCS1 * IFNRJ2_star_SHP2 - kb * IFNRJ2_star_SHP2_SOCS1)
v44:
 {1.0}IFNRJ2_star_SHP2_STAT1c + {1.0}SOCS1 = {1.0}IFNRJ2_star_SHP2_SOCS1_STAT1c
  cytoplasm * (kf * SOCS1 * IFNRJ2_star_SHP2_STAT1c - kb * IFNRJ2_star_SHP2_SOCS1_STAT1c)
v45:
 {1.0}R + {1.0}IFN = {1.0}IFNR
  cytoplasm * (kf * IFN * R - kb * IFNR)
v46:
 {1.0}JAK + {1.0}IFNR = {1.0}IFNRJ
  cytoplasm * (kf * IFNR * JAK - kb * IFNRJ)
v5:
 {1.0}IFNRJ2_star + {1.0}STAT1c = {1.0}IFNRJ2_star_STAT1c
  cytoplasm * (kf * STAT1c * IFNRJ2_star - kb * IFNRJ2_star_STAT1c)
v6:
 {1.0}IFNRJ2_star_STAT1c = {1.0}STAT1c_star + {1.0}IFNRJ2_star
  cytoplasm * kf * IFNRJ2_star_STAT1c
v7:
 {1.0}STAT1c_star + {1.0}IFNRJ2_star = {1.0}IFNRJ2_star_STAT1c_star
  cytoplasm * (kf * IFNRJ2_star * STAT1c_star - kb * IFNRJ2_star_STAT1c_star)
v8:
 {2.0}STAT1c_star = {1.0}STAT1c_star_STAT1c_star
  cytoplasm * (kf * STAT1c_star * STAT1c_star - kb * STAT1c_star_STAT1c_star)
v9:
 {1.0}SHP2 + {1.0}IFNRJ2_star = {1.0}IFNRJ2_star_SHP2
  cytoplasm * (kf * IFNRJ2_star * SHP2 - kb * IFNRJ2_star_SHP2)


#parameters
IFN = 10.0
v1_kf = 0.1
v1_kb = 0.05
v2_kf = 0.02
v2_kb = 0.02
v3_kf = 0.04
v3_kb = 0.2
v4_kf = 0.005
v5_kf = 0.008
v5_kb = 0.8
v6_kf = 0.4
v7_kf = 0.005
v7_kb = 0.5
v8_kf = 0.02
v8_kb = 0.1
v9_kf = 0.001
v9_kb = 0.2
v10_kf = 0.003
v11_kf = 0.001
v11_kb = 0.2
v12_kf = 0.003
v13_kf = 0.001
v13_kb = 0.2
v14_kf = 0.003
v15_kf = 2e-07
v15_kb = 0.2
v16_kf = 0.005
v17_kf = 0.02
v17_kb = 0.1
v18_kf = 0.001
v18_kb = 0.2
v19_kf = 0.005
v20_kf = 0.001
v20_kb = 0.2
v21_kf = 0.005
v22_kf = 2e-07
v22_kb = 0.2
v23_kf = 0.05
v24_ka = 0.01
v24_kb = 400.0
v25_kf = 0.001
v26_kf = 0.01
v27_kf = 0.0005
v28_kf = 0.0005
v29_kf = 0.02
v29_kb = 0.1
v30_kf = 0.008
v30_kb = 0.8
v31_kf = 0.001
v31_kb = 0.2
v32_kf = 0.003
v33_kf = 0.0005
v34_kf = 0.001
v34_kb = 0.2
v35_kf = 0.008
v35_kb = 0.8
v36_kf = 0.001
v36_kb = 0.2
v37_kf = 0.003
v38_kf = 0.0005
v39_kf = 0.0005
v40_kf = 0.003
v41_kf = 0.0005
v42_kf = 0.02
v42_kb = 0.1
v43_kf = 0.02
v43_kb = 0.1
v44_kf = 0.02
v44_kb = 0.1
v45_kf = 0.02
v45_kb = 0.02
v46_kf = 0.1
v46_kb = 0.05
cytoplasm = 1.0
nucleus = 1.0


#initial values
IFNR = 0.0
IFNRJ = 0.0
IFNRJ2 = 0.0
IFNRJ2_star = 0.0
IFNRJ2_star_SHP2 = 0.0
IFNRJ2_star_SHP2_SOCS1 = 0.0
IFNRJ2_star_SHP2_SOCS1_STAT1c = 0.0
IFNRJ2_star_SHP2_STAT1c = 0.0
IFNRJ2_star_SOCS1 = 0.0
IFNRJ2_star_SOCS1_STAT1c = 0.0
IFNRJ2_star_STAT1c = 0.0
IFNRJ2_star_STAT1c_star = 0.0
JAK = 10.0
PPN = 60.0
PPX = 50.0
R = 10.0
RJ = 0.0
SHP2 = 100.0
SOCS1 = 0.0
STAT1c = 1000.0
STAT1c_STAT1c_star = 0.0
STAT1c_star = 0.0
STAT1c_star_PPX = 0.0
STAT1c_star_STAT1c_star = 0.0
STAT1c_star_STAT1c_star_PPX = 0.0
STAT1n = 0.0
STAT1n_STAT1n_star = 0.0
STAT1n_star = 0.0
STAT1n_star_PPN = 0.0
STAT1n_star_STAT1n_star = 0.0
STAT1n_star_STAT1n_star_PPN = 0.0
mRNAc = 0.0
mRNAn = 0.0


#assignment rules