begin name
wegner1
end name

begin reactions
103 {1.0}101 + {1.0}99 = {1.0}105
125 {1.0}99 = {1.0}129
132 {1.0}105 = {1.0}129 + {1.0}101
139 {1.0}129 = {1.0}19
149 {1.0}147 + {2.0}129 = {1.0}153
156 {1.0}147 = {1.0}5
164 {1.0}153 = {1.0}9
172 {1.0}25 = {1.0}174
178 {1.0}27 = {1.0}181
192 {1.0}181 + {1.0}96 = {1.0}$EXTERNAL
194 {1.0}174 + {1.0}96 = {1.0}198
29 {1.0}species27 = {1.0}5 + {2.0}species17
31 {1.0}9 = {1.0}species19
33 {1.0}9 + {2.0}11 = {1.0}13
35 {3.0}15 + {1.0}species13 = {3.0}19
37 {1.0}5 + {2.0}19 = {1.0}9
39 {1.0}19 = {1.0}21
41 {1.0}21 + {1.0}15 = {1.0}$EXTERNAL
43 {1.0}15 + {1.0}25 = {1.0}27
77 {2.0}75 = {1.0}79
86 {1.0}79 + {2.0}84 = {1.0}96
reaction1 {1.0}$EXTERNAL = {1.0}75
reaction10 {1.0}84 = {1.0}$EXTERNAL
reaction11 {1.0}75 = {1.0}$EXTERNAL
reaction12 {1.0}79 = {2.0}75
reaction13 {1.0}$EXTERNAL = {1.0}99
reaction14 {1.0}$EXTERNAL = {1.0}147
reaction15 {1.0}147 = {1.0}$EXTERNAL
reaction16 {1.0}101 = {1.0}$EXTERNAL
reaction17 {1.0}129 = {1.0}99
reaction18 {1.0}species2 = {1.0}$EXTERNAL
reaction19 {1.0}15 = {1.0}species1
reaction2 {1.0}$EXTERNAL = {1.0}101
reaction20 {1.0}99 = {1.0}$EXTERNAL
reaction21 {1.0}species2 = {1.0}11
reaction22 {1.0}$EXTERNAL = {1.0}species3
reaction23 {1.0}species3 = {1.0}$EXTERNAL
reaction24 {1.0}species4 = {1.0}species3
reaction25 {1.0}species18 = {1.0}species27
reaction26 {1.0}species20 = {1.0}species17
reaction27 {1.0}species3 = {1.0}species4
reaction28 {1.0}species5 = {1.0}species4 + {1.0}101
reaction29 {1.0}species17 = {1.0}$EXTERNAL
reaction3 {1.0}$EXTERNAL = {1.0}174
reaction30 {1.0}species3 = {1.0}species17
reaction31 {1.0}101 + {1.0}species3 = {1.0}species5
reaction32 {1.0}species19 = {1.0}5 + {2.0}21
reaction33 {1.0}species4 = {1.0}species20
reaction34 {1.0}147 + {2.0}species4 = {1.0}species6
reaction35 {1.0}5 + {2.0}species20 = {1.0}species18
reaction36 {1.0}species18 + {2.0}11 = {1.0}species21
reaction37 {1.0}species6 = {1.0}species18
reaction38 {1.0}species14 = {1.0}species20
reaction39 {1.0}174 = {1.0}$EXTERNAL
reaction4 {1.0}$EXTERNAL = {1.0}species1
reaction40 {1.0}species7 = {1.0}$EXTERNAL
reaction41 {1.0}species7 = {1.0}species22
reaction42 {1.0}$EXTERNAL = {1.0}species7
reaction43 {1.0}species1 = {1.0}$EXTERNAL
reaction44 {1.0}5 + {1.0}species22 = {1.0}species23
reaction45 {1.0}species3 + {1.0}species7 = {1.0}species8
reaction46 {1.0}species24 + {1.0}25 = {1.0}species25
reaction47 {1.0}$EXTERNAL = {1.0}species9
reaction48 {1.0}species18 + {2.0}species22 = {1.0}species26
reaction49 {1.0}species10 + {1.0}96 = {1.0}$EXTERNAL
reaction5 {1.0}$EXTERNAL = {1.0}species2
reaction50 {1.0}species25 = {1.0}species10
reaction51 {1.0}species9 = {1.0}$EXTERNAL
reaction52 {1.0}species24 = {1.0}species9
reaction53 {1.0}species18 + {1.0}species28 = {1.0}species30
reaction54 {1.0}9 + {1.0}species28 = {1.0}species30
reaction55 {1.0}species21 + {1.0}species28 = {1.0}species29
reaction56 {1.0}13 + {1.0}species28 = {1.0}species29
reaction57 {1.0}species26 + {1.0}species28 = {1.0}species29
reaction58 {1.0}9 + {2.0}species22 = {1.0}species11
reaction59 {1.0}species11 + {1.0}species28 = {1.0}species29
reaction6 {1.0}$EXTERNAL = {1.0}84
reaction60 {1.0}species23 + {1.0}species28 = {1.0}species29
reaction61 {1.0}99 + {1.0}species7 = {1.0}species12
reaction62 {3.0}19 + {3.0}11 = {1.0}species13
reaction63 {3.0}species20 + {3.0}11 = {1.0}species14
reaction64 {1.0}9 = {1.0}$EXTERNAL
reaction65 {1.0}species18 = {1.0}$EXTERNAL
reaction66 {1.0}$EXTERNAL = {1.0}species15
reaction67 {1.0}species15 = {1.0}$EXTERNAL
reaction68 {1.0}species13 + {3.0}species31 = {3.0}19
reaction69 {1.0}species14 + {3.0}species31 = {1.0}species20
reaction7 {1.0}5 + {1.0}11 = {1.0}species16
reaction70 {1.0}species15 = {1.0}species31
reaction8 {1.0}99 = {1.0}21
reaction9 {1.0}96 = {1.0}$EXTERNAL
end reactions

begin rate equations
103 = 1*(-(103k2*105[t]) + 103k1*101[t]*99[t])
125 = 1*function3[125k, 96[t], 99[t], 125km]
132 = 1*function3[132k, 96[t], 105[t], 132km]
139 = 139k1*129[t]
149 = 1*149k1*129[t]^2*147[t]
156 = 156k1*147[t] - 156k2*5[t]
164 = 164k1*153[t]
172 = -(172k2*174[t]) + 172k1*25[t]
178 = -(178k2*181[t]) + 178k1*27[t]
192 = 1*192k1*181[t]*96[t]
194 = 1*(-(194k2*198[t]) + 194k1*174[t]*96[t])
29 = 29k1*3*species27[t]
31 = 3*function1[9[t], 31Km, 31V]
33 = 3*(-(33k2*13[t]) + 33k1*11[t]^2*9[t])
35 = 35k1*species13[t]*15[t]^3
37 = 3*37k1*19[t]^2*5[t]
39 = 3*function1[19[t], 39Km, 39V]
41 = 3*41k1*15[t]*21[t]
43 = 3*(43k1*15[t]*25[t] - 43k2*27[t])
77 = 1*function2[parameter1, 77k, 75[t], 75[t]]
86 = 1*(86k1*79[t]*84[t]^2 - 86k2*96[t])
reaction1 = 1*function4[reaction1v]
reaction10 = reaction10k1*1*84[t]
reaction11 = reaction11k1*1*75[t]
reaction12 = reaction12k1*1*79[t]
reaction13 = 1*function4[reaction13v]
reaction14 = 1*function4[reaction14v]
reaction15 = reaction15k1*1*147[t]
reaction16 = reaction16k1*1*101[t]
reaction17 = 1*function1[129[t], reaction17Km, reaction17V]
reaction18 = reaction18k1*1*species2[t]
reaction19 = -(reaction19k2*species1[t]) + reaction19k1*15[t]
reaction2 = 1*function5[reaction2k, reaction2k1, species30[t]]
reaction20 = reaction20k1*1*99[t]
reaction21 = reaction21k1*species2[t] - reaction21k2*11[t]
reaction22 = 1*function4[reaction22v]
reaction23 = reaction23k1*1*species3[t]
reaction24 = 1*function1[species4[t], reaction24Km, reaction24V]
reaction25 = 3*function1[species18[t], reaction25Km, reaction25V]
reaction26 = 3*function1[species20[t], reaction26Km, reaction26V]
reaction27 = 1*function3[reaction27k, 96[t], species3[t], reaction27km]
reaction28 = 1*function3[reaction28k, 96[t], species5[t], reaction28km]
reaction29 = reaction29k1*3*species17[t]
reaction3 = 1*function6[reaction3k, reaction3k1, species30[t], species16[t], species23[t]]
reaction30 = -(reaction30k2*species17[t]) + reaction30k1*species3[t]
reaction31 = 1*(-(reaction31k2*species5[t]) + reaction31k1*species3[t]*101[t])
reaction32 = reaction32k1*3*species19[t]
reaction33 = reaction33k1*species4[t]
reaction34 = reaction34k1*1*species4[t]^2*147[t]
reaction35 = reaction35k1*3*species20[t]^2*5[t]
reaction36 = 3*(-(reaction36k2*species21[t]) + reaction36k1*species18[t]*11[t]^2)
reaction37 = reaction37k1*species6[t]
reaction38 = reaction38k1*species14[t]
reaction39 = 1*function7[reaction39k1, 174[t], species15[t]]
reaction4 = 1*function5[reaction4k, reaction4k1, species30[t]]
reaction40 = reaction40k1*1*species7[t]
reaction41 = -(reaction41k2*species22[t]) + reaction41k1*species7[t]
reaction42 = 1*function5[reaction42k, reaction42k1, species30[t]]
reaction43 = 1*function7[reaction43k1, species1[t], 174[t]]
reaction44 = 3*(-(reaction44k2*species23[t]) + reaction44k1*species22[t]*5[t])
reaction45 = 1*(reaction45k1*species3[t]*species7[t] - reaction45k2*species8[t])
reaction46 = 3*(-(reaction46k2*species25[t]) + reaction46k1*species24[t]*25[t])
reaction47 = 1*function5[reaction47k, reaction47k1, species30[t]]
reaction48 = 3*(reaction48k1*species18[t]*species22[t]^2 - reaction48k2*species26[t])
reaction49 = reaction49k1*1*species10[t]*96[t]
reaction5 = 1*function5[reaction5k, reaction5k1, species30[t]]
reaction50 = -(reaction50k2*species10[t]) + reaction50k1*species25[t]
reaction51 = 1*function7[reaction51k1, species9[t], 174[t]]
reaction52 = reaction52k1*species24[t] - reaction52k2*species9[t]
reaction53 = 3*(reaction53k1*species18[t]*species28[t] - reaction53k2*species30[t])
reaction54 = 3*(-(reaction54k2*species30[t]) + reaction54k1*species28[t]*9[t])
reaction55 = 3*(reaction55k1*species21[t]*species28[t] - reaction55k2*species29[t])
reaction56 = 3*(-(reaction56k2*species29[t]) + reaction56k1*species28[t]*13[t])
reaction57 = 3*(reaction57k1*species26[t]*species28[t] - reaction57k2*species29[t])
reaction58 = -(reaction58k2*species11[t]) + reaction58k1*species22[t]^2*9[t]
reaction59 = reaction59k1*species11[t]*species28[t] - reaction59k2*species29[t]
reaction6 = 1*function4[reaction6v]
reaction60 = 3*(reaction60k1*species23[t]*species28[t] - reaction60k2*species29[t])
reaction61 = 1*(-(reaction61k2*species12[t]) + reaction61k1*species7[t]*99[t])
reaction62 = -(reaction62k2*species13[t]) + reaction62k1*11[t]^3*19[t]^3
reaction63 = -(reaction63k2*species14[t]) + reaction63k1*species20[t]^3*11[t]^3
reaction64 = reaction64k1*3*9[t]
reaction65 = reaction65k1*3*species18[t]
reaction66 = 1*function4[reaction66v]
reaction67 = reaction67k1*1*species15[t]
reaction68 = reaction68k1*species13[t]*species31[t]^3
reaction69 = reaction69k1*species14[t]*species31[t]^3
reaction7 = 3*(-(reaction7k2*species16[t]) + reaction7k1*11[t]*5[t])
reaction70 = reaction70k1*species15[t] - reaction70k2*species31[t]
reaction8 = -(reaction8k2*21[t]) + reaction8k1*99[t]
reaction9 = reaction9k1*1*96[t]
end rate equations

begin parameters
parameter1 = 0.01
reaction31k1 = 1.0
reaction31k2 = 0.1
reaction32k1 = 0.0492
reaction33k1 = 16.6
reaction34k1 = 1000.0
reaction35k1 = 255.068
reaction36k1 = 1.6
reaction36k2 = 1.6
reaction37k1 = 0.16
reaction38k1 = 0.232
reaction39k1 = 0.1
reaction40k1 = 0.232
reaction41k1 = 0.1
reaction41k2 = 0.2
reaction42k = "2e-05"
reaction42k1 = 0.00055
reaction43k1 = 0.05
reaction44k1 = 1.0
reaction44k2 = 0.05288
reaction45k1 = 0.1
reaction45k2 = 0.1
reaction46k1 = 2.9
reaction46k2 = 0.2
reaction47k = 0.0001
reaction47k1 = 0.0022
reaction48k1 = 1.6
reaction48k2 = 1.6
reaction49k1 = 1900.0
reaction50k1 = 1.0
reaction50k2 = 0.01
reaction51k1 = 0.5
reaction52k1 = 0.05
reaction52k2 = 3.0
reaction53k1 = 0.463
reaction53k2 = 0.102
reaction54k1 = 0.463
reaction54k2 = 0.102
reaction55k1 = 0.2
reaction55k2 = 0.2
reaction56k1 = 0.2
reaction56k2 = 0.2
reaction57k1 = 0.2
reaction57k2 = 0.2
reaction58k1 = 1.6
reaction58k2 = 1.6
reaction59k1 = 0.2
reaction59k2 = 0.2
reaction60k1 = 0.1
reaction60k2 = 0.1
reaction61k1 = 0.1
reaction61k2 = 0.1
reaction62k1 = 1.0
reaction62k2 = 1.0
reaction63k1 = 1.0
reaction63k2 = 1.0
reaction64k1 = 0.005
reaction65k1 = 0.005
reaction66v = "2e-05"
reaction67k1 = 0.1
reaction68k1 = 0.1
reaction69k1 = 0.1
reaction70k1 = 0.1
reaction70k2 = 0.1
29k1 = 0.0492
31Km = 40.0
31V = 2.34
33k1 = 1.6
33k2 = 1.6
35k1 = 0.232
37k1 = 255.068
39Km = 0.53
39V = 3.51
41k1 = 0.2
43k1 = 2.9
43k2 = 0.2
77k = 9.45
86k1 = 0.03333
86k2 = 0.03333
103k1 = 1.0
103k2 = 0.1
125k = 1000.0
125km = 0.0318
132k = 3.51
132km = 0.53
139k1 = 16.6
149k1 = 1000.0
156k1 = 0.156
156k2 = 0.156
164k1 = 0.16
172k1 = 0.1
172k2 = 0.01
178k1 = 1.0
178k2 = 0.01
192k1 = 1900.0
194k1 = 8.69
194k2 = 0.01
reaction1v = 0.00146
reaction2k = 0.0001
reaction2k1 = 0.031
reaction3k = 0.0001
reaction3k1 = 0.1
reaction4k = 0.000228
reaction4k1 = 0.0285
reaction5k = "2e-05"
reaction5k1 = 0.00055
reaction6v = 0.0125
reaction7k1 = 1.0
reaction7k2 = 0.05288
reaction8k1 = 0.156
reaction8k2 = 0.336
reaction9k1 = 0.027778
reaction10k1 = 0.027778
reaction11k1 = 0.027778
reaction12k1 = 0.03333
reaction13v = 0.0156
reaction14v = 0.01183
reaction15k1 = 0.1266
reaction16k1 = 0.065
reaction17Km = 3.51
reaction17V = 0.53
reaction18k1 = 0.232
reaction19k1 = 0.2333
reaction19k2 = 1.8056
reaction20k1 = 0.2
reaction21k1 = 0.1
reaction21k2 = 0.2
reaction22v = 0.04528
reaction23k1 = 0.2
reaction24Km = 3.51
reaction24V = 0.53
reaction25Km = 40.0
reaction25V = 2.34
reaction26Km = 0.53
reaction26V = 3.51
reaction27k = 1000.0
reaction27km = 0.0318
reaction28k = 3.51
reaction28km = 0.53
reaction29k1 = 0.2
reaction30k1 = 0.156
reaction30k2 = 0.336
1 = 1.0
3 = 1.0
end parameters

begin initial conditions
101[0] = 101i
105[0] = 105i
11[0] = 11i
129[0] = 129i
13[0] = 13i
147[0] = 147i
15[0] = 15i
153[0] = 153i
174[0] = 174i
181[0] = 181i
19[0] = 19i
198[0] = 198i
21[0] = 21i
25[0] = 25i
27[0] = 27i
5[0] = 5i
75[0] = 75i
79[0] = 79i
84[0] = 84i
9[0] = 9i
96[0] = 96i
99[0] = 99i
species1[0] = species1i
species10[0] = species10i
species11[0] = species11i
species12[0] = species12i
species13[0] = species13i
species14[0] = species14i
species15[0] = species15i
species16[0] = species16i
species17[0] = species17i
species18[0] = species18i
species19[0] = species19i
species2[0] = species2i
species20[0] = species20i
species21[0] = species21i
species22[0] = species22i
species23[0] = species23i
species24[0] = species24i
species25[0] = species25i
species26[0] = species26i
species27[0] = species27i
species28[0] = species28i
species29[0] = species29i
species3[0] = species3i
species30[0] = species30i
species31[0] = species31i
species4[0] = species4i
species5[0] = species5i
species6[0] = species6i
species7[0] = species7i
species8[0] = species8i
species9[0] = species9i
end initial conditions

begin initial values
101i = 0.0
105i = 0.0
11i = 0.0
129i = 0.0
13i = 0.0
147i = 0.0
15i = 0.0
153i = 0.0
174i = 0.0
181i = 0.0
19i = 0.0
198i = 0.0
21i = 0.0
25i = 0.0
27i = 0.0
5i = 0.0
75i = 0.0
79i = 0.0
84i = 0.0
9i = 0.0
96i = 0.0
99i = 0.0
species1i = 0.0
species10i = 0.0
species11i = 0.0
species12i = 0.0
species13i = 0.0
species14i = 0.0
species15i = 0.0
species16i = 0.0
species17i = 0.0
species18i = 0.0
species19i = 0.0
species2i = 0.0
species20i = 0.0
species21i = 0.0
species22i = 0.0
species23i = 0.0
species24i = 0.0
species25i = 0.0
species26i = 0.0
species27i = 0.0
species28i = 0.0999999951844375
species29i = 0.0
species3i = 0.0
species30i = 0.0
species31i = 0.0
species4i = 0.0
species5i = 0.0
species6i = 0.0
species7i = 0.0
species8i = 0.0
species9i = 0.0
end initial values

begin assignment rules
parameter2 := 2*species16[t] + species2[t] + 11[t]
parameter4 := species1[t] + 15[t] + 181[t] + 27[t]
parameter5 := species19[t] + 105[t] + 129[t] + 13[t] + 153[t] + 19[t] + 21[t] + 9[t] + 99[t]
parameter6 := species16[t] + species18[t] + species19[t] + species21[t] + species23[t] + species26[t] + species27[t] + species6[t] + 13[t] + 147[t] + 153[t] + 5[t] + 9[t]
parameter9 := species6[t] + 147[t] + 153[t]
parameter10 := species11[t] + species16[t] + 2*species18[t] + species19[t] + species21[t] + species23[t] + 2*species26[t] + species27[t] + 13[t] + 5[t] + 9[t]
parameter8 := species17[t] + species18[t] + species20[t] + species21[t] + species26[t] + species27[t] + species3[t] + species4[t] + species5[t] + species6[t] + species8[t]
parameter7 := species18[t] + species20[t] + species21[t] + species26[t] + species4[t] + species6[t]
parameter3 := 174[t] + 181[t] + 198[t] + 25[t] + 27[t]
end assignment rules

begin function definitions
function2[TGFbeta_,k_,s_,s2_] := k*s*s2*TGFbeta
function6[k_,k1_,m_,m2_,m3_] := (k + k1*m)/(1 + m2 + m3)
function5[k_,k1_,m_] := k + k1*m
function7[k1_,substrate_,modifier_] := k1*(1 + modifier)*substrate
function3[k_,rec_,s_,km_] := (k*rec*s)/(km + s)
function1[substrate_,Km_,V_] := (substrate*V)/(Km + substrate)
function4[v_] := v
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units