#teusink2

FIX: Glc

#reactions
v_1:
 {1.0}ATP + {1.0}Glc = {1.0}HMP
  ((Glc*VHK*ATP)/(KATP*KGlc*(1 + ATP/KATP)*(1 + Glc/KGlc + (wildtype*HMP**2)/KiTre6P)))
v_2:
 {1.0}ATP + {1.0}HMP = {1.0}Fru16P2
  (gR*VPFK*ATP*HMP*(1 + ATP/KRATP + HMP/KRHMP + (gR*ATP*HMP)/(KRATP*KRHMP)))/(KRATP*KRHMP*((1 + ATP/KRATP + HMP/KRHMP + (gR*ATP*HMP)/(KRATP*KRHMP))**2 + (L0*(1 + (ci*ATP)/KiATP)**2*(1 + (c2*ATP)/KRATP + (c1*HMP)/KRHMP + (c1*c2*gT*ATP*HMP)/(KRATP*KRHMP))**2)/(1 + ATP/KiATP)**2))
v_3:
 {1.0}Fru16P2 = {4.0}ATP
  (Vlower*(5 - ATP)*Fru16P2)/(KADP*KFru16P2*(1 + (5 - ATP)/KADP)*(1 + Fru16P2/KFru16P2))
v_4:
 {1.0}ATP = $pool
  (VATPase*ATP)/(KATP3 + ATP)


#parameters
EXTERNAL = 0.0
KADP = 0.1
KATP = 0.15
KATP3 = 3.0
KFru16P2 = 1.0
KGlc = 1.0
KRATP = 0.06
KRHMP = 1.0
KiATP = 10.0
KiTre6P = 4.422
L0 = 1000.0
VATPase = 68.0
VHK = 68.0
VPFK = 30.0
Vlower = 20.0
c1 = 0.0005
c2 = 1.0
ci = 10.0
gR = 10.0
gT = 1.0
wildtype = 1.0
Glc = 10.0
default_compartment = 1.0


#initial values
ATP = 4.0
Fru16P2 = 1.0
HMP = 0.1


#assignment rules