begin name smallbone23 end name begin reactions PDH {1.0}$p3g = {1.0}php PSA {1.0}php = {1.0}pser PSP {1.0}pser = {1.0}$ser end reactions begin rate equations PDH = (cell*p3g*PDHkcatA*serA)/(PDHKAp3g*(1 + ser/PDHKiAser)*(1 + p3g/PDHKAp3g + php[t]/PDHKAphp)) PSA = (cell*PSAkcatC*serC*php[t])/(PSAKCphp*(1 + php[t]/PSAKCphp + pser[t]/PSAKCpser)) PSP = (cell*PSPkcatB*serB*pser[t])/(PSPKBpser*(1 + ser/PSPKBser + pser[t]/PSPKBpser)) end rate equations begin parameters p3g = 2.36 ser = 4.9 serA = 1.15 serB = 0.25 serC = 0.1 PDHkcatA = 0.55 PDHKAp3g = 1.2 PDHKAphp = 0.0032 PDHKiAser = 0.0038 PSAkcatC = 1.75 PSAKCphp = 0.0015 PSAKCpser = 0.0017 PSPkcatB = 1.43 PSPKBpser = 0.0015 PSPKBser = 0.15 cell = 1.0 end parameters begin initial conditions php[0] = phpi pser[0] = pseri end initial conditions begin initial values phpi = 0.6 pseri = 0.09 end initial values begin assignment rules end assignment rules begin function definitions end function definitions begin events end events begin process annotations PDH http://identifiers.org/ec-code/1.1.1.95 PSA http://identifiers.org/ec-code/2.6.1.52 PSP http://identifiers.org/ec-code/3.1.3.3 end process annotations begin species annotations p3g http://identifiers.org/chebi/CHEBI:58272 php http://identifiers.org/chebi/CHEBI:18110 pser http://identifiers.org/chebi/CHEBI:57524 ser http://identifiers.org/chebi/CHEBI:17115 serA http://identifiers.org/uniprot/P0A9T0 serB http://identifiers.org/uniprot/P0AGB0 serC http://identifiers.org/uniprot/P23721 end species annotations begin units end units