begin name smallbone17 end name begin reactions ADHADH1 {1.0}AcAld + {1.0}NADH = {1.0}NAD + {1.0}$EtOH ADHADH5 {1.0}AcAld + {1.0}NADH = {1.0}NAD + {1.0}$EtOH AK {2.0}ADP = {1.0}AMP + {1.0}ATP ATPase {1.0}ATP = {1.0}ADP ENOENO1 {1.0}P2G = {1.0}PEP ENOENO2 {1.0}P2G = {1.0}PEP FBA {1.0}F16bP = {1.0}DHAP + {1.0}GAP GPD {1.0}DHAP + {1.0}NADH = {1.0}G3P + {1.0}NAD GPM {1.0}P3G = {1.0}P2G GPP {1.0}G3P = {1.0}$GLY HXKGLK1 {1.0}ATP + {1.0}GLC = {1.0}ADP + {1.0}G6P HXKHXK1 {1.0}ATP + {1.0}GLC = {1.0}ADP + {1.0}G6P HXKHXK2 {1.0}ATP + {1.0}GLC = {1.0}ADP + {1.0}G6P HXT {1.0}$GLCx = {1.0}GLC PDCPDC1 {1.0}PYR = {1.0}AcAld PDCPDC5 {1.0}PYR = {1.0}AcAld PDCPDC6 {1.0}PYR = {1.0}AcAld PFK {1.0}ATP + {1.0}F6P = {1.0}ADP + {1.0}F16bP PGI {1.0}G6P = {1.0}F6P PGK {1.0}ADP + {1.0}BPG = {1.0}ATP + {1.0}P3G PGM {1.0}G6P = {1.0}G1P PYKCDC19 {1.0}ADP + {1.0}PEP = {1.0}ATP + {1.0}PYR PYKPYK2 {1.0}ADP + {1.0}PEP = {1.0}ATP + {1.0}PYR TDHTDH1 {1.0}GAP + {1.0}NAD = {1.0}BPG + {1.0}NADH TDHTDH2 {1.0}GAP + {1.0}NAD = {1.0}BPG + {1.0}NADH TDHTDH3 {1.0}GAP + {1.0}NAD = {1.0}BPG + {1.0}NADH TPI {1.0}DHAP = {1.0}GAP TPP {1.0}T6P = {1.0}$TRH TPS {1.0}G6P + {1.0}UDG = {1.0}T6P + {1.0}UDP UGP {1.0}G1P + {1.0}UTP = {1.0}UDG acetatebranch {1.0}AcAld + {1.0}NAD = {1.0}NADH + {1.0}$ACE succinatebranch {1.0}PYR + {3.0}NAD = {0.75}$SUC + {3.0}NADH udptoutp {1.0}ATP + {1.0}UDP = {1.0}ADP + {1.0}UTP end reactions begin rate equations ADHADH1 = (ADH1*ADHADH1kcat*(-((EtOH*NAD[t])/(ADHADH1Kacald*ADHADH1Kinadh*KeqADH)) + (AcAld[t]*NADH[t])/(ADHADH1Kacald*ADHADH1Kinadh)))/(1 + (ADHADH1Knad*EtOH)/(ADHADH1Ketoh*ADHADH1Kinad) + (ADHADH1Knadh*AcAld[t])/(ADHADH1Kacald*ADHADH1Kinadh) + NAD[t]/ADHADH1Kinad + (EtOH*NAD[t])/(ADHADH1Ketoh*ADHADH1Kinad) + (ADHADH1Knadh*AcAld[t]*NAD[t])/(ADHADH1Kacald*ADHADH1Kinad*ADHADH1Kinadh) + (EtOH*AcAld[t]*NAD[t])/(ADHADH1Ketoh*ADHADH1Kiacald*ADHADH1Kinad) + NADH[t]/ADHADH1Kinadh + (ADHADH1Knad*EtOH*NADH[t])/(ADHADH1Ketoh*ADHADH1Kinad*ADHADH1Kinadh) + (AcAld[t]*NADH[t])/(ADHADH1Kacald*ADHADH1Kinadh) + (EtOH*AcAld[t]*NADH[t])/(ADHADH1Kacald*ADHADH1Kietoh*ADHADH1Kinadh)) ADHADH5 = (ADH5*ADHADH5kcat*(-((EtOH*NAD[t])/(ADHADH5Kacald*ADHADH5Kinadh*KeqADH)) + (AcAld[t]*NADH[t])/(ADHADH5Kacald*ADHADH5Kinadh)))/(1 + (ADHADH5Knad*EtOH)/(ADHADH5Ketoh*ADHADH5Kinad) + (ADHADH5Knadh*AcAld[t])/(ADHADH5Kacald*ADHADH5Kinadh) + NAD[t]/ADHADH5Kinad + (EtOH*NAD[t])/(ADHADH5Ketoh*ADHADH5Kinad) + (ADHADH5Knadh*AcAld[t]*NAD[t])/(ADHADH5Kacald*ADHADH5Kinad*ADHADH5Kinadh) + (EtOH*AcAld[t]*NAD[t])/(ADHADH5Ketoh*ADHADH5Kiacald*ADHADH5Kinad) + NADH[t]/ADHADH5Kinadh + (ADHADH5Knad*EtOH*NADH[t])/(ADHADH5Ketoh*ADHADH5Kinad*ADHADH5Kinadh) + (AcAld[t]*NADH[t])/(ADHADH5Kacald*ADHADH5Kinadh) + (EtOH*AcAld[t]*NADH[t])/(ADHADH5Kacald*ADHADH5Kietoh*ADHADH5Kinadh)) AK = AKk*(ADP[t]^2 - (AMP[t]*ATP[t])/AKKeq) ATPase = (ATPaseVmax*ATP[t])/(ATPaseKatp*(1 + ATP[t]/ATPaseKatp)) ENOENO1 = (ENO1*ENOENO1kcat*(P2G[t]/ENOENO1Kp2g - PEP[t]/(ENOENO1Kp2g*KeqENO)))/(1 + P2G[t]/ENOENO1Kp2g + PEP[t]/ENOENO1Kpep) ENOENO2 = (ENO2*ENOENO2kcat*(P2G[t]/ENOENO2Kp2g - PEP[t]/(ENOENO2Kp2g*KeqENO)))/(1 + P2G[t]/ENOENO2Kp2g + PEP[t]/ENOENO2Kpep) FBA = (FBA1*FBAkcat*(F16bP[t]/FBAKf16bp - (DHAP[t]*GAP[t])/(FBAKeq*FBAKf16bp)))/(1 + DHAP[t]/FBAKdhap + F16bP[t]/FBAKf16bp + GAP[t]/FBAKgap + (DHAP[t]*GAP[t])/(FBAKdhap*FBAKgap) + (F16bP[t]*GAP[t])/(FBAKf16bp*FBAKigap)) GPD = (GPDVmax*(-((G3P[t]*NAD[t])/GPDKeq) + DHAP[t]*NADH[t]))/(GPDKdhap*GPDKnadh*(1 + ADP[t]/GPDKadp + ATP[t]/GPDKatp + F16bP[t]/GPDKfbp)*(1 + DHAP[t]/GPDKdhap + G3P[t]/GPDKg3p)*(1 + NAD[t]/GPDKnad + NADH[t]/GPDKnadh)) GPM = (GPM1*GPMkcat*(-(P2G[t]/(GPMKeq*GPMKp3g)) + P3G[t]/GPMKp3g))/(1 + P2G[t]/GPMKp2g + P3G[t]/GPMKp3g) GPP = (GPPVmax*G3P[t])/(GPPKg3p*(1 + G3P[t]/GPPKg3p)) HXKGLK1 = (GLK1*HXKGLK1kcat*(-((ADP[t]*G6P[t])/(HXKGLK1Katp*HXKGLK1Kglc*KeqHXK)) + (ATP[t]*GLC[t])/(HXKGLK1Katp*HXKGLK1Kglc)))/((1 + ADP[t]/HXKGLK1Kadp + ATP[t]/HXKGLK1Katp)*(1 + G6P[t]/HXKGLK1Kg6p + GLC[t]/HXKGLK1Kglc)) HXKHXK1 = (HXK1*HXKHXK1kcat*(-((ADP[t]*G6P[t])/(HXKHXK1Katp*HXKHXK1Kglc*KeqHXK)) + (ATP[t]*GLC[t])/(HXKHXK1Katp*HXKHXK1Kglc)))/((1 + ADP[t]/HXKHXK1Kadp + ATP[t]/HXKHXK1Katp)*(1 + G6P[t]/HXKHXK1Kg6p + GLC[t]/HXKHXK1Kglc + T6P[t]/HXKHXK1Kit6p)) HXKHXK2 = (HXK2*HXKHXK2kcat*(-((ADP[t]*G6P[t])/(HXKHXK2Katp*HXKHXK2Kglc*KeqHXK)) + (ATP[t]*GLC[t])/(HXKHXK2Katp*HXKHXK2Kglc)))/((1 + ADP[t]/HXKHXK2Kadp + ATP[t]/HXKHXK2Katp)*(1 + G6P[t]/HXKHXK2Kg6p + GLC[t]/HXKHXK2Kglc + T6P[t]/HXKHXK2Kit6p)) HXT = (HXTVmax*(GLCx - GLC[t]))/(HXTKglc*(1 + GLCx/HXTKglc + GLC[t]/HXTKglc + (GLCx*HXTKi*GLC[t])/HXTKglc^2)) PDCPDC1 = (PDC1*PDCPDC1kcat*PYR[t])/(PDCPDC1Kpyr*(1 + PYR[t]/PDCPDC1Kpyr)) PDCPDC5 = (PDC5*PDCPDC5kcat*PYR[t])/(PDCPDC5Kpyr*(1 + PYR[t]/PDCPDC5Kpyr)) PDCPDC6 = (PDC6*PDCPDC6kcat*PYR[t])/(PDCPDC6Kpyr*(1 + PYR[t]/PDCPDC6Kpyr)) PFK = (PFKgR*PFKkcat*(PFK1 + PFK2 - Abs[PFK1 - PFK2])*ATP[t]*(1 - (ADP[t]*F16bP[t])/(PFKKeq*ATP[t]*F6P[t]))*F6P[t]*(1 + ADP[t]/PFKKadp + ATP[t]/PFKKatp + F16bP[t]/PFKKf16 + (PFKgR*ADP[t]*F16bP[t])/(PFKKadp*PFKKf16) + F6P[t]/PFKKf6p + (PFKgR*ATP[t]*F6P[t])/(PFKKatp*PFKKf6p)))/(2*PFKKatp*PFKKf6p*((PFKL0*(1 + (PFKCamp*AMP[t])/PFKKamp)^2*(1 + (PFKCatp*ATP[t])/PFKKatp)^2*(1 + (PFKCiatp*ATP[t])/PFKKiatp)^2*(1 + (F26bP*PFKCf26)/PFKKf26 + (PFKCf16*F16bP[t])/PFKKf16)^2)/((1 + AMP[t]/PFKKamp)^2*(1 + ATP[t]/PFKKiatp)^2*(1 + F26bP/PFKKf26 + F16bP[t]/PFKKf16)^2) + (1 + ADP[t]/PFKKadp + ATP[t]/PFKKatp + F16bP[t]/PFKKf16 + (PFKgR*ADP[t]*F16bP[t])/(PFKKadp*PFKKf16) + F6P[t]/PFKKf6p + (PFKgR*ATP[t]*F6P[t])/(PFKKatp*PFKKf6p))^2)) PGI = (PGI1*PGIkcat*(-(F6P[t]/(PGIKeq*PGIKg6p)) + G6P[t]/PGIKg6p))/(1 + F6P[t]/PGIKf6p + G6P[t]/PGIKg6p) PGK = (PGK1*PGKkcat*(ADP[t]/PGKKadp)^(-1 + PGKnHadp)*((ADP[t]*BPG[t])/(PGKKadp*PGKKbpg) - (ATP[t]*P3G[t])/(PGKKadp*PGKKbpg*PGKKeq)))/((1 + (ADP[t]/PGKKadp)^PGKnHadp + ATP[t]/PGKKatp)*(1 + BPG[t]/PGKKbpg + P3G[t]/PGKKp3g)) PGM = (PGMVmax*(-(G1P[t]/(PGMKeq*PGMKg6p)) + G6P[t]/PGMKg6p))/(1 + G1P[t]/PGMKg1p + G6P[t]/PGMKg6p) PYKCDC19 = (CDC19*PYKCDC19kcat*(ADP[t]*PEP[t] - (ATP[t]*PYR[t])/KeqPYK))/(PYKCDC19Kadp*PYKCDC19Kpep*(1 + ADP[t]/PYKCDC19Kadp + ATP[t]/PYKCDC19Katp)*(1 + (PYKCDC19L0*(1 + ATP[t]/PYKCDC19Kiatp))/(1 + F16bP[t]/PYKCDC19Kf16p) + PEP[t]/PYKCDC19Kpep + PYR[t]/PYKCDC19Kpyr)) PYKPYK2 = (PYK2*PYKPYK2kcat*(ADP[t]*PEP[t] - (ATP[t]*PYR[t])/KeqPYK))/(PYKPYK2Kadp*PYKPYK2Kpep*(1 + ADP[t]/PYKPYK2Kadp + ATP[t]/PYKPYK2Katp)*(1 + (PYKPYK2L0*(1 + ATP[t]/PYKPYK2Kiatp))/(1 + F16bP[t]/PYKPYK2Kf16p) + PEP[t]/PYKPYK2Kpep + PYR[t]/PYKPYK2Kpyr)) TDHTDH1 = (TDH1*TDHTDH1kcat*((GAP[t]*NAD[t])/(TDHTDH1Kgap*TDHTDH1Knad) - (BPG[t]*NADH[t])/(KeqTDH*TDHTDH1Kgap*TDHTDH1Knad)))/((1 + BPG[t]/TDHTDH1Kbpg + GAP[t]/TDHTDH1Kgap)*(1 + NAD[t]/TDHTDH1Knad + NADH[t]/TDHTDH1Knadh)) TDHTDH2 = (TDH2*TDHTDH2kcat*((GAP[t]*NAD[t])/(TDHTDH2Kgap*TDHTDH2Knad) - (BPG[t]*NADH[t])/(KeqTDH*TDHTDH2Kgap*TDHTDH2Knad)))/((1 + BPG[t]/TDHTDH2Kbpg + GAP[t]/TDHTDH2Kgap)*(1 + NAD[t]/TDHTDH2Knad + NADH[t]/TDHTDH2Knadh)) TDHTDH3 = (TDH3*TDHTDH3kcat*((GAP[t]*NAD[t])/(TDHTDH3Kgap*TDHTDH3Knad) - (BPG[t]*NADH[t])/(KeqTDH*TDHTDH3Kgap*TDHTDH3Knad)))/((1 + BPG[t]/TDHTDH3Kbpg + GAP[t]/TDHTDH3Kgap)*(1 + NAD[t]/TDHTDH3Knad + NADH[t]/TDHTDH3Knadh)) TPI = (TPI1*TPIkcat*(DHAP[t] - GAP[t]/TPIKeq))/(TPIKdhap*(1 + DHAP[t]/TPIKdhap + (GAP[t]*(1 + GAP[t]^4/TPIKigap^4))/TPIKgap)) TPP = (TPPVmax*T6P[t])/(TPPKt6p*(1 + T6P[t]/TPPKt6p)) TPS = (TPSVmax*G6P[t]*UDG[t])/(TPSKg6p*TPSKudg*(1 + G6P[t]/TPSKg6p)*(1 + UDG[t]/TPSKudg)) UGP = (UGPVmax*G1P[t]*UTP[t])/(UGPKg1p*UGPKutp*(UGPKiutp/UGPKutp + G1P[t]/UGPKg1p + (UGPKiutp*UDG[t])/(UGPKiudg*UGPKutp) + (G1P[t]*UDG[t])/(UGPKg1p*UGPKiudg) + UTP[t]/UGPKutp + (G1P[t]*UTP[t])/(UGPKg1p*UGPKutp))) acetatebranch = acetatebranchk*AcAld[t]*NAD[t] succinatebranch = succinatebranchk*NAD[t]*PYR[t] udptoutp = udptoutpk*ATP[t]*UDP[t] end rate equations begin parameters ADH1 = 0.0409771277320022 ADH5 = 0.00106249605621922 ADHADH1Kacald = 0.4622 ADHADH1Ketoh = 17.0 ADHADH1Kiacald = 1.1 ADHADH1Kietoh = 90.0 ADHADH1Kinad = 0.92 ADHADH1Kinadh = 0.031 ADHADH1Knad = 0.17 ADHADH1Knadh = 0.11 ADHADH1kcat = 176.0 ADHADH5Kacald = 1.11 ADHADH5Ketoh = 17.0 ADHADH5Kiacald = 1.1 ADHADH5Kietoh = 90.0 ADHADH5Kinad = 0.92 ADHADH5Kinadh = 0.031 ADHADH5Knad = 0.17 ADHADH5Knadh = 0.11 ADHADH5kcat = 0.0 AKKeq = 0.45 AKk = 0.75 ATPaseKatp = 3.0 ATPaseVmax = 1.13333333333333 CDC19 = 0.512097526792801 ENO1 = 0.171592988538958 ENO2 = 0.493611573294543 ENOENO1Kp2g = 0.043 ENOENO1Kpep = 0.5 ENOENO1kcat = 7.6 ENOENO2Kp2g = 0.104 ENOENO2Kpep = 0.5 ENOENO2kcat = 19.87 EXTERNAL = 0.0 F26bP = 0.003 FBA1 = 0.334598664262206 FBAKdhap = 2.0 FBAKeq = 0.069 FBAKf16bp = 0.4507 FBAKgap = 2.4 FBAKigap = 10.0 FBAkcat = 4.139 GLK1 = 0.0112717406104807 GPD1 = 0.00170877794272468 GPD2 = 0.000198351416606057 GPDKadp = 2.0 GPDKatp = 0.73 GPDKdhap = 0.54 GPDKeq = 10000.0 GPDKfbp = 4.8 GPDKg3p = 1.2 GPDKnad = 0.93 GPDKnadh = 0.023 GPDVmax = 0.783333333333333 GPM1 = 0.182500074724267 GPMKeq = 0.19 GPMKp2g = 1.41 GPMKp3g = 1.2 GPMkcat = 400.0 GPPKg3p = 3.5 GPPVmax = 0.883333333333333 HOR2 = 0.0013683673909939 HXK1 = 0.0041951864287446 HXK2 = 0.0153328384926289 HXKGLK1Kadp = 0.23 HXKGLK1Katp = 0.865 HXKGLK1Kg6p = 30.0 HXKGLK1Kglc = 0.0106 HXKGLK1kcat = 0.0721 HXKHXK1Kadp = 0.23 HXKHXK1Katp = 0.293 HXKHXK1Kg6p = 30.0 HXKHXK1Kglc = 0.15 HXKHXK1Kit6p = 0.2 HXKHXK1kcat = 10.2 HXKHXK2Kadp = 0.23 HXKHXK2Katp = 0.195 HXKHXK2Kg6p = 30.0 HXKHXK2Kglc = 0.2 HXKHXK2Kit6p = 0.04 HXKHXK2kcat = 63.1 HXTKglc = 0.9 HXTKi = 0.91 HXTVmax = 3.35 KeqADH = 14492.7536231884 KeqENO = 6.7 KeqHXK = 2000.0 KeqPYK = 6500.0 KeqTDH = 0.00533412710224736 NA = "6.02214e+20" PDC1 = 0.266952694557084 PDC5 = 0.00308868608169189 PDC6 = 0.0016352160527653 PDCPDC1Kpyr = 8.5 PDCPDC1kcat = 12.14 PDCPDC5Kpyr = 7.08 PDCPDC5kcat = 10.32 PDCPDC6Kpyr = 2.92 PDCPDC6kcat = 9.21 PFK1 = 0.0116962574765781 PFK2 = 0.00975915538330228 PFKCamp = 0.0845 PFKCatp = 3.0 PFKCf16 = 0.397 PFKCf26 = 0.0174 PFKCiatp = 100.0 PFKKadp = 1.0 PFKKamp = 0.0995 PFKKatp = 0.71 PFKKeq = 800.0 PFKKf16 = 0.111 PFKKf26 = 0.000682 PFKKf6p = 0.1 PFKKiatp = 0.65 PFKL0 = 0.66 PFKgR = 5.12 PFKkcat = 209.6 PGI1 = 0.0345726768225249 PGIKeq = 0.29 PGIKf6p = 0.307 PGIKg6p = 1.0257 PGIkcat = 487.36 PGK1 = 0.0644142281647388 PGKKadp = 0.2 PGKKatp = 1.99 PGKKbpg = 0.003 PGKKeq = 3200.0 PGKKp3g = 4.58 PGKkcat = 58.6 PGKnHadp = 2.0 PGM1 = 0.000815573865768647 PGM2 = 0.00031467219294138 PGMKeq = 0.1667 PGMKg1p = 0.023 PGMKg6p = 0.05 PGMVmax = 0.12762 PYK2 = 0.00151748381804475 PYKCDC19Kadp = 0.243 PYKCDC19Katp = 1.5 PYKCDC19Kf16p = 0.2 PYKCDC19Kiatp = 9.3 PYKCDC19Kpep = 0.281 PYKCDC19Kpyr = 21.0 PYKCDC19L0 = 100.0 PYKCDC19kcat = 20.146 PYKPYK2Kadp = 0.3 PYKPYK2Katp = 1.5 PYKPYK2Kf16p = 0.2 PYKPYK2Kiatp = 9.3 PYKPYK2Kpep = 0.19 PYKPYK2Kpyr = 21.0 PYKPYK2L0 = 100.0 PYKPYK2kcat = 0.0 RHR2 = 0.0127951193429578 TDH1 = 0.087716160700349 TDH2 = 0.0 TDH3 = 1.05110118662137 TDHTDH1Kbpg = 0.0098 TDHTDH1Kgap = 0.495 TDHTDH1Knad = 0.09 TDHTDH1Knadh = 0.06 TDHTDH1kcat = 19.12 TDHTDH2Kbpg = 0.0098 TDHTDH2Kgap = 0.77 TDHTDH2Knad = 0.09 TDHTDH2Knadh = 0.06 TDHTDH2kcat = 8.633 TDHTDH3Kbpg = 0.909 TDHTDH3Kgap = 0.423 TDHTDH3Knad = 0.09 TDHTDH3Knadh = 0.06 TDHTDH3kcat = 18.162 TPI1 = 0.073589454911377 TPIKdhap = 6.454 TPIKeq = 0.045 TPIKgap = 5.25 TPIKigap = 35.1 TPIkcat = 564.38 TPPKt6p = 0.5 TPPVmax = 2.33999999999999 TPS1 = 0.000848120435592663 TPS2 = 0.000664962953368736 TPSKg6p = 3.8 TPSKudg = 0.886 TPSVmax = 0.49356 UGP1 = 0.00155052854965178 UGPKg1p = 0.32 UGPKiudg = 0.0035 UGPKiutp = 0.11 UGPKutp = 0.11 UGPVmax = 13.2552 acetatebranchk = 0.00554339592436782 cell = 1.0 extracellular = 1.0 succinatebranchk = 0.00549663630823988 sumAXP = 6.02 sumNAD = 1.59 sumUXP = 1.39784619487425 udptoutpk = 0.0745258294103764 volume = "2e-14" ACE = 55.7500633495734 EtOH = 55.472577854384 GLCx = 74.0 GLY = 0.15 SUC = 0.0 TRH = 0.00384697134241316 defaultcompartment = 1.0 end parameters begin initial conditions ADP[0] = ADPi AMP[0] = AMPi ATP[0] = ATPi AcAld[0] = AcAldi BPG[0] = BPGi DHAP[0] = DHAPi F16bP[0] = F16bPi F6P[0] = F6Pi G1P[0] = G1Pi G3P[0] = G3Pi G6P[0] = G6Pi GAP[0] = GAPi GLC[0] = GLCi NAD[0] = NADi NADH[0] = NADHi P2G[0] = P2Gi P3G[0] = P3Gi PEP[0] = PEPi PYR[0] = PYRi T6P[0] = T6Pi UDG[0] = UDGi UDP[0] = UDPi UTP[0] = UTPi end initial conditions begin initial values ADPi = 1.29 AMPi = 0.44 ATPi = 4.29 AcAldi = 0.178140579850657 BPGi = 0.000736873499865602 DHAPi = 0.290344213186674 F16bPi = 1.14580464751733 F6Pi = 0.0588603054728053 G1Pi = 0.13481212658623 G3Pi = 0.068500732297821 G6Pi = 0.193120800911304 GAPi = 0.0789727571926259 GLCi = 1.5700004483456 NADi = 1.50329030201531 NADHi = 0.0867096979846952 P2Gi = 0.0169344770274836 P3Gi = 0.117456252783611 PEPi = 0.152501353339511 PYRi = 0.527117851793548 T6Pi = 0.02 UDGi = 0.467246194874247 UDPi = 0.2815 UTPi = 0.6491 end initial values begin assignment rules sumPXG := P2G[t] + P3G[t] energycharge := (ADP[t]/2 + ATP[t])/sumAXP fitconc := Sqrt[(1 - (NA*sumPXG*volume)/1618640)^2 + (1 - (NA*volume*DHAP[t])/3496987)^2 + (1 - (NA*volume*F16bP[t])/13800392)^2 + (1 - (NA*volume*F6P[t])/708930)^2 + (1 - (NA*volume*G6P[t])/2326001)^2 + (1 - (NA*volume*GAP[t])/951170)^2 + (1 - (NA*volume*GLC[t])/18909525)^2 + (1 - (NA*volume*PEP[t])/1836769)^2 + (1 - (NA*volume*PYR[t])/6348755)^2]/3 end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units