begin name
shen2
end name

begin reactions
v1 {1.0}NAD + {1.0}XYL = {1.0}XLAC
v2 {1.0}XLAC = {1.0}XA
v3 {1.0}XLAC = {1.0}XA
v4 {1.0}XA = {1.0}KDX
v5 {1.0}KDX = {1.0}KGSA
v6 {1.0}KGSA + {1.0}NAD = {1.0}KG
v7 {1.0}PYR = {1.0}NAD + {1.0}LAC
end reactions

begin rate equations
v1 = (Eb*VmXDH*NAD[t]*XYL[t])/(1000*KmXDHNAD*KmXDHXYL*(1 + (Ntot - NAD[t])/KmXDHNADH + NAD[t]/KmXDHNAD)*(1 + XLAC[t]/KmXDHXLAC + XYL[t]/KmXDHXYL))
v2 = kXLA*XLAC[t]
v3 = (Ec*VmXLA*XLAC[t])/(1000*KmXLAXLAC*(1 + XA[t]/KmXLAXA + XLAC[t]/KmXLAXLAC))
v4 = (Ed*VmXAD*XA[t])/(1000*KmXADXA*(1 + (Ntot - NAD[t])/KiXADNADH)*(1 + KDX[t]/KmXADKDX + XA[t]/KmXADXA))
v5 = (Ex*fracX*VmKDXD*KDX[t])/(1000*KmKDXDKDX*(1 + KDX[t]/KmKDXDKDX + KGSA[t]/KmKDXDKGSA)*(1 + KG[t]/KiKDXDakg + LAC[t]/KiKDXDLAC + PYR[t]/KiKDXDPYR + XA[t]/KiKDXDxylonate))
v6 = (Ea*VmKGSADH*KGSA[t]*NAD[t])/(1000*KmKGSADHKGSA*KmKGSADHNAD*((1 + KG[t]/KmKGSADHKG + KGSA[t]/KmKGSADHKGSA)*(1 + (Ntot - NAD[t])/KmKGSADHNADH + NAD[t]/KmKGSADHNAD) + (KDX[t]*(1 + (Ntot - NAD[t])/KmKGSADHNADH2 + NAD[t]/KmKGSADHNAD))/KmKGSADHKDX))
v7 = kLDH*(Ntot - NAD[t])*PYR[t]
end rate equations

begin parameters
Ea = 10.0
Eb = 2.5
Ec = 0.8
Ed = 8.67
Ex = 0.5
KiKDXDLAC = 27.9762
KiKDXDPYR = 17.9168
KiKDXDakg = 14.7919
KiKDXDxylonate = 18.3001
KiXADNADH = 10.4629
KmKDXDKDX = 0.207656
KmKDXDKGSA = 0.288658
KmKGSADHKDX = 0.2136
KmKGSADHKG = 0.279059
KmKGSADHKGSA = 0.0217501
KmKGSADHNAD = 0.596286
KmKGSADHNADH = 0.2674
KmKGSADHNADH2 = 0.0241
KmXADKDX = 0.862428
KmXADXA = 0.793955
KmXDHNAD = 0.161239
KmXDHNADH = 0.0297091
KmXDHXLAC = 0.535734
KmXDHXYL = 0.19851
KmXLAXA = 0.0381004
KmXLAXLAC = 0.445269
Ntot = 8.0
VmKDXD = 107.075
VmKGSADH = 49.3374
VmXAD = 42.359
VmXDH = 119.743
VmXLA = 944.406
fracX = 0.251104
kLDH = 10.0
kXLA = 0.00718272
default = 1.0
end parameters

begin initial conditions
KDX[0] = KDXi
KG[0] = KGi
KGSA[0] = KGSAi
LAC[0] = LACi
NAD[0] = NADi
PYR[0] = PYRi
XA[0] = XAi
XLAC[0] = XLACi
XYL[0] = XYLi
end initial conditions

begin initial values
KDXi = 0.0
KGi = 0.0
KGSAi = 0.0
LACi = 0.0
NADi = 8.0
PYRi = 0.0
XAi = 0.0
XLACi = 0.0
XYLi = 5.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
KDX http://identifiers.org/obo.chebi/CHEBI%3A1060
KDX http://identifiers.org/kegg.compound/C03826
KG http://identifiers.org/kegg.compound/C00026
KG http://identifiers.org/obo.chebi/CHEBI%3A30915
KGSA http://identifiers.org/kegg.compound/C00433
KGSA http://identifiers.org/obo.chebi/CHEBI%3A17415
LAC http://identifiers.org/obo.chebi/CHEBI%3A28358
LAC http://identifiers.org/kegg.compound/C01432
NAD http://identifiers.org/kegg.compound/C00003
NAD http://identifiers.org/obo.chebi/CHEBI%3A15846
PYR http://identifiers.org/obo.chebi/CHEBI%3A32816
PYR http://identifiers.org/kegg.compound/C00022
XA http://identifiers.org/obo.chebi/CHEBI%3A48093
XA http://identifiers.org/kegg.compound/C00502
XLAC http://identifiers.org/obo.chebi/CHEBI%3A15867
XLAC http://identifiers.org/kegg.compound/C02266
XYL http://identifiers.org/obo.chebi/CHEBI%3A15936
XYL http://identifiers.org/kegg.compound/C00181
end species annotations

begin units
end units