begin name
sharp1
end name

begin reactions
reaction1 {1.0}$species4 + {1.0}$species3 + {1.0}$species1 + {1.0}$species8 + {1.0}$species6 + {1.0}$species2 + {1.0}$species7 = {1.0}species5
reaction10 {2.0}species21 = {1.0}species24 + {2.0}species21
reaction11 {1.0}$species22 = {1.0}species24
reaction12 {1.0}species24 = {1.0}$species23
reaction13 {1.0}species24 + {1.0}$species25 + {1.0}$species27 + {1.0}$species26 + {1.0}$species16 = {1.0}species28
reaction14 {1.0}species14 = {1.0}species15
reaction15 {1.0}species29 + {1.0}species31 = {1.0}species30
reaction16 {1.0}species15 + {1.0}species30 = {1.0}species32
reaction17 {1.0}species33 + {1.0}species31 = {1.0}species34
reaction18 {1.0}species15 + {1.0}species34 = {1.0}species35
reaction19 {1.0}species36 + {1.0}species31 = {1.0}species37
reaction2 {1.0}species9 + {1.0}$species10 = {1.0}species11
reaction20 {1.0}species15 + {1.0}species37 = {1.0}species38
reaction21 {1.0}species32 = {1.0}species15 + {1.0}species31
reaction22 {1.0}species35 = {1.0}species15 + {1.0}species31
reaction23 {1.0}species38 = {1.0}species15 + {1.0}species31
reaction24 {1.0}species30 = {1.0}species31
reaction25 {1.0}species34 = {1.0}species31
reaction26 {1.0}species37 = {1.0}species31
reaction27 {1.0}species31 = {1.0}species39
reaction28 {1.0}species40 + {1.0}species39 = {1.0}species41
reaction29 {1.0}species42 + {1.0}species39 = {1.0}species43
reaction3 {1.0}species11 + {1.0}$species12 = {1.0}species13
reaction30 {1.0}species44 + {1.0}species39 = {1.0}species45
reaction31 {1.0}$species22 = {1.0}species46
reaction32 {2.0}species39 = {1.0}species46 + {2.0}species39
reaction33 {1.0}species46 = {1.0}$species23
reaction34 {1.0}$species22 = {1.0}species47
reaction35 {1.0}species47 = {1.0}$species23
reaction36 {1.0}$species22 = {1.0}species48
reaction37 {1.0}species48 = {1.0}$species23
reaction38 {1.0}species15 + {1.0}species29 = {1.0}species49
reaction39 {1.0}species46 = {1.0}species29 + {1.0}species46
reaction4 {1.0}species14 = {1.0}species15
reaction40 {1.0}species29 = {1.0}$species23
reaction41 {1.0}species29 = {1.0}species40
reaction42 {1.0}species15 + {1.0}species33 = {1.0}species50
reaction43 {1.0}species47 = {1.0}species33 + {1.0}species47
reaction44 {1.0}species33 = {1.0}$species23
reaction45 {1.0}species33 = {1.0}species42
reaction46 {1.0}species15 + {1.0}species36 = {1.0}species51
reaction47 {1.0}species48 = {1.0}species36 + {1.0}species48
reaction48 {1.0}species36 = {1.0}$species23
reaction49 {1.0}species36 = {1.0}species44
reaction5 {1.0}species15 = {1.0}species14
reaction50 {1.0}species49 + {1.0}species31 = {1.0}species32
reaction51 {1.0}species41 = {1.0}species30
reaction52 {1.0}species50 + {1.0}species31 = {1.0}species35
reaction53 {1.0}species43 = {1.0}species34
reaction54 {1.0}species51 + {1.0}species31 = {1.0}species38
reaction55 {1.0}species45 = {1.0}species37
reaction56 {1.0}species49 = {1.0}species15
reaction57 {1.0}species50 = {1.0}species15
reaction58 {1.0}species51 = {1.0}species15
reaction59 {2.0}species39 = {1.0}species24 + {2.0}species39
reaction6 {1.0}$species4 + {1.0}$species3 + {1.0}$species1 + {1.0}$species8 + {1.0}$species18 + {1.0}$species17 + {1.0}$species16 + {1.0}$species53 = {1.0}species52
reaction7 {1.0}species19 = {1.0}species20
reaction8 {1.0}species20 = {1.0}species19
reaction9 {1.0}species20 = {1.0}species21
end reactions

begin rate equations
reaction1 = compartment1*(reaction1k1*species1*species2*species3*species4*species6*species7*species8 - reaction1k2*species5[t])
reaction10 = compartment1*reaction10k1*species21[t]^2
reaction11 = compartment1*reaction11k1*species22
reaction12 = compartment1*reaction12k1*species24[t]
reaction13 = compartment1*(reaction13k1*species16*species25*species26*species27*species24[t] - reaction13k2*species28[t])
reaction14 = compartment1*function2[reaction14k, species28[t], species14[t], reaction14Km]
reaction15 = compartment1*(-(reaction15k2*species30[t]) + reaction15k1*species29[t]*species31[t])
reaction16 = compartment1*(reaction16k1*species15[t]*species30[t] - reaction16k2*species32[t])
reaction17 = compartment1*(reaction17k1*species31[t]*species33[t] - reaction17k2*species34[t])
reaction18 = compartment1*(reaction18k1*species15[t]*species34[t] - reaction18k2*species35[t])
reaction19 = compartment1*(reaction19k1*species31[t]*species36[t] - reaction19k2*species37[t])
reaction2 = compartment1*function1[reaction2k1, species5[t], species9[t], species10, reaction2k2, species11[t]]
reaction20 = compartment1*(reaction20k1*species15[t]*species37[t] - reaction20k2*species38[t])
reaction21 = compartment1*reaction21k1*species32[t]
reaction22 = compartment1*reaction22k1*species35[t]
reaction23 = compartment1*reaction23k1*species38[t]
reaction24 = compartment1*reaction24k1*species30[t]
reaction25 = compartment1*reaction25k1*species34[t]
reaction26 = compartment1*reaction26k1*species37[t]
reaction27 = compartment1*(reaction27k1*species31[t] - reaction27k2*species39[t])
reaction28 = compartment1*(reaction28k1*species39[t]*species40[t] - reaction28k2*species41[t])
reaction29 = compartment1*(reaction29k1*species39[t]*species42[t] - reaction29k2*species43[t])
reaction3 = compartment1*(reaction3k1*species12*species11[t] - reaction3k2*species13[t])
reaction30 = compartment1*(reaction30k1*species39[t]*species44[t] - reaction30k2*species45[t])
reaction31 = compartment1*reaction31k1*species22
reaction32 = compartment1*reaction32k1*species39[t]^2
reaction33 = compartment1*reaction33k1*species46[t]
reaction34 = compartment1*reaction34k1*species22
reaction35 = compartment1*reaction35k1*species47[t]
reaction36 = compartment1*reaction36k1*species22
reaction37 = compartment1*reaction37k1*species48[t]
reaction38 = compartment1*(reaction38k1*species15[t]*species29[t] - reaction38k2*species49[t])
reaction39 = compartment1*reaction39k1*species46[t]
reaction4 = compartment1*function2[reaction4k, species13[t], species14[t], reaction4Km]
reaction40 = compartment1*reaction40k1*species29[t]
reaction41 = compartment1*(reaction41k1*species29[t] - reaction41k2*species40[t])
reaction42 = compartment1*(reaction42k1*species15[t]*species33[t] - reaction42k2*species50[t])
reaction43 = compartment1*reaction43k1*species47[t]
reaction44 = compartment1*reaction44k1*species33[t]
reaction45 = compartment1*(reaction45k1*species33[t] - reaction45k2*species42[t])
reaction46 = compartment1*(reaction46k1*species15[t]*species36[t] - reaction46k2*species51[t])
reaction47 = compartment1*reaction47k1*species48[t]
reaction48 = compartment1*reaction48k1*species36[t]
reaction49 = compartment1*(reaction49k1*species36[t] - reaction49k2*species44[t])
reaction5 = compartment1*reaction5k1*species15[t]
reaction50 = compartment1*(-(reaction50k2*species32[t]) + reaction50k1*species31[t]*species49[t])
reaction51 = compartment1*reaction51k1*species41[t]
reaction52 = compartment1*(-(reaction52k2*species35[t]) + reaction52k1*species31[t]*species50[t])
reaction53 = compartment1*reaction53k1*species43[t]
reaction54 = compartment1*(-(reaction54k2*species38[t]) + reaction54k1*species31[t]*species51[t])
reaction55 = compartment1*reaction55k1*species45[t]
reaction56 = compartment1*reaction56k1*species49[t]
reaction57 = compartment1*reaction57k1*species50[t]
reaction58 = compartment1*reaction58k1*species51[t]
reaction59 = compartment1*reaction59k1*species39[t]^2
reaction6 = compartment1*(reaction6k1*species1*species16*species17*species18*species3*species4*species53*species8 - reaction6k2*species52[t])
reaction7 = compartment1*function2[reaction7k, species52[t], species19[t], reaction7Km]
reaction8 = compartment1*reaction8k1*species20[t]
reaction9 = compartment1*(reaction9k1*species20[t] - reaction9k2*species21[t])
end rate equations

begin parameters
species1 = 1.0
species10 = 1.0
species12 = 1.0
species16 = 1.0
species17 = 1.0
species18 = 1.0
species2 = 1.0
species22 = 1.0
species23 = 0.0
species25 = 1.0
species26 = 1.0
species27 = 1.0
species3 = 1.0
species4 = 1.0
species53 = 1.0
species6 = 1.0
species7 = 1.0
species8 = 1.0
reaction27k2 = "8e-05"
reaction28k1 = 0.5
reaction28k2 = 0.0005
reaction29k1 = 0.5
reaction29k2 = 0.0005
reaction30k1 = 0.5
reaction30k2 = 0.0005
reaction31k1 = "1.54e-06"
reaction32k1 = 0.0165
reaction33k1 = 0.00028
reaction34k1 = "1.78e-07"
reaction35k1 = 0.00028
reaction36k1 = "1.27e-07"
reaction37k1 = 0.00028
reaction38k1 = 0.0225
reaction38k2 = 0.00125
reaction39k1 = 0.00408
reaction40k1 = 0.000113
reaction41k1 = 0.0003
reaction41k2 = 0.0002
reaction42k1 = 0.006
reaction42k2 = 0.00175
reaction43k1 = 0.00408
reaction44k1 = 0.000113
reaction45k1 = 0.00015
reaction45k2 = 0.0001
reaction46k1 = 0.009
reaction46k2 = 0.00175
reaction47k1 = 0.00408
reaction48k1 = 0.000113
reaction49k1 = 0.00015
reaction49k2 = 0.0001
reaction50k1 = 0.5
reaction50k2 = 0.0005
reaction51k1 = 0.0138
reaction52k1 = 0.5
reaction52k2 = 0.0005
reaction53k1 = 0.0052
reaction54k1 = 0.5
reaction54k2 = 0.0005
reaction55k1 = 0.0052
reaction56k1 = 0.00407
reaction57k1 = 0.0015
reaction58k1 = 0.0022
reaction59k1 = 0.001
reaction20k1 = 0.07
reaction20k2 = 0.00175
reaction21k1 = 0.0204
reaction22k1 = 0.0075
reaction23k1 = 0.011
reaction24k1 = "2.25e-05"
reaction25k1 = "2.25e-05"
reaction26k1 = "2.25e-05"
reaction27k1 = 0.09
reaction1k1 = 0.0001
reaction1k2 = 0.0001
reaction2k1 = 0.001
reaction2k2 = 0.001
reaction3k1 = 0.003
reaction3k2 = 0.01
reaction4k = 0.1
reaction4Km = 0.1
reaction5k1 = 0.1
reaction6k1 = 0.0001
reaction6k2 = 0.0001
reaction7k = 0.1
reaction7Km = 0.1
reaction8k1 = 0.1
reaction9k1 = 0.1
reaction9k2 = 0.1
reaction10k1 = 0.02
reaction11k1 = 0.001
reaction12k1 = 0.1
reaction13k1 = 0.1
reaction13k2 = 0.1
reaction14k = 0.1
reaction14Km = 0.1
reaction15k1 = 0.5
reaction15k2 = 0.0005
reaction16k1 = 0.185
reaction16k2 = 0.0125
reaction17k1 = 0.5
reaction17k2 = 0.0005
reaction18k1 = 0.048
reaction18k2 = 0.00175
reaction19k1 = 0.5
reaction19k2 = 0.0005
compartment1 = 1.0
end parameters

begin initial conditions
species11[0] = species11i
species13[0] = species13i
species14[0] = species14i
species15[0] = species15i
species19[0] = species19i
species20[0] = species20i
species21[0] = species21i
species24[0] = species24i
species28[0] = species28i
species29[0] = species29i
species30[0] = species30i
species31[0] = species31i
species32[0] = species32i
species33[0] = species33i
species34[0] = species34i
species35[0] = species35i
species36[0] = species36i
species37[0] = species37i
species38[0] = species38i
species39[0] = species39i
species40[0] = species40i
species41[0] = species41i
species42[0] = species42i
species43[0] = species43i
species44[0] = species44i
species45[0] = species45i
species46[0] = species46i
species47[0] = species47i
species48[0] = species48i
species49[0] = species49i
species5[0] = species5i
species50[0] = species50i
species51[0] = species51i
species52[0] = species52i
species9[0] = species9i
end initial conditions

begin initial values
species11i = 0.0
species13i = 0.0
species14i = 0.1
species15i = 0.0
species19i = 1.0
species20i = 0.0
species21i = 0.0
species24i = 0.0
species28i = 0.0
species29i = 0.0
species30i = 0.0
species31i = 0.1
species32i = 0.0
species33i = 0.0
species34i = 0.0
species35i = 0.0
species36i = 0.0
species37i = 0.0
species38i = 0.0
species39i = 0.0
species40i = 0.0
species41i = 0.0
species42i = 0.0
species43i = 0.0
species44i = 0.0
species45i = 0.0
species46i = 0.0
species47i = 0.0
species48i = 0.0
species49i = 0.0
species5i = 0.0
species50i = 0.0
species51i = 0.0
species52i = 0.0
species9i = 1.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
function2[k_,Enzyme_,Substrate_,Km_] := (Enzyme*k*Substrate)/(Km + Substrate)
function1[k1_,Enzyme_,Substrate1_,Substrate2_,k2_,Product_] := -(k2*Product) + Enzyme*k1*Substrate1*Substrate2
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units