#schoeberl1

FIX: x1

#reactions
v1:
 {1.0}x2 + {1.0}x1 = {1.0}x3
  k1 * x1 * x1mult * x2 - kr1 * x3
v10:
 {1.0}x6 + {1.0}x16 = {1.0}x10
  k10 * x6 * x16 - kr10 * x10
v100:
 {1.0}x60 + {1.0}x81 = {1.0}x85
  k58 * x60 * x81 - kr58 * x85
v101:
 {1.0}x85 = {1.0}x55 + {1.0}x60
  k59 * x85
v102:
 {1.0}x15 = {1.0}x17
  k6 * x15 - kr6 * x17
v103:
 {1.0}x32 = {1.0}x63
  k6 * x32 - kr6 * x63
v104:
 {1.0}x33 = {1.0}x64
  k6 * x33 - kr6 * x64
v105:
 {1.0}x25 = {1.0}x19
  k6 * x25 - kr6 * x19
v106:
 {1.0}x25 + {1.0}x12 = {1.0}x88
  k4 * x25 * x12 - kr4 * x88
v107:
 {1.0}x88 = {1.0}x9 + {1.0}x19
  k5 * x88
v108:
 {1.0}x27 = {1.0}x20
  k6 * x27 - kr6 * x20
v109:
 {1.0}x27 + {1.0}x12 = {1.0}x89
  k4 * x27 * x12 - kr4 * x89
v11:
 {2.0}x10 = {1.0}x11
  k2 * x10 * x10 - kr2 * x11
v110:
 {1.0}x89 = {1.0}x9 + {1.0}x20
  k5 * x89
v111:
 {1.0}x29 = {1.0}x21
  k6 * x29 - kr6 * x21
v112:
 {1.0}x29 + {1.0}x12 = {1.0}x90
  k4 * x29 * x12 - kr4 * x90
v113:
 {1.0}x90 = {1.0}x9 + {1.0}x21
  k5 * x90
v114:
 {1.0}x34 = {1.0}x65
  k6 * x34 - kr6 * x65
v115:
 {1.0}x34 + {1.0}x12 = {1.0}x91
  k4 * x34 * x12 - kr4 * x91
v116:
 {1.0}x91 = {1.0}x9 + {1.0}x65
  k5 * x91
v117:
 {1.0}x35 = {1.0}x66
  k6 * x35 - kr6 * x66
v118:
 {1.0}x35 + {1.0}x12 = {1.0}x92
  k4 * x35 * x12 - kr4 * x92
v119:
 {1.0}x92 = {1.0}x9 + {1.0}x66
  k5 * x92
v12:
 {1.0}x11 = {1.0}x8
  k3 * x11 - kr3 * x8
v120:
 {1.0}x36 = {1.0}x67
  k6 * x36 - kr6 * x67
v121:
 {1.0}x36 + {1.0}x12 = {1.0}x93
  k4 * x36 * x12 - kr4 * x93
v122:
 {1.0}x93 = {1.0}x9 + {1.0}x67
  k5 * x93
v123:
 {1.0}x37 = {1.0}x68
  k6 * x37 - kr6 * x68
v124:
 {1.0}x37 + {1.0}x12 = {1.0}x94
  k4 * x37 * x12 - kr4 * x94
v125:
 {1.0}x94 = {1.0}x68 + {1.0}x9
  k5 * x94
v13:
 $pool = {1.0}x2
  k13
v14:
 {1.0}x8 + {1.0}x14 = {1.0}x17
  k14 * x8 * x14 - kr14 * x17
v15:
 {1.0}x9 = {1.0}x12
  k15 * x9
v16:
 {1.0}x22 + {1.0}x15 = {1.0}x23
  k16 * x22 * x15 - kr16 * x23
v17:
 {1.0}x24 + {1.0}x23 = {1.0}x25
  k17 * x24 * x23 - kr17 * x25
v18:
 {1.0}x26 + {1.0}x25 = {1.0}x27
  k18 * x26 * x25 - kr18 * x27
v19:
 {1.0}x27 = {1.0}x28 + {1.0}x25
  k19 * x27 - kr19 * x28 * x25
v2:
 {2.0}x3 = {1.0}x4
  k2 * x3 * x3 - kr2 * x4
v20:
 {1.0}x25 + {1.0}x43 = {1.0}x29
  k20 * x25 * x43 - kr20 * x29
v21:
 {1.0}x29 = {1.0}x25 + {1.0}x26
  k21 * x29 - kr21 * x25 * x26
v22:
 {1.0}x31 + {1.0}x15 = {1.0}x32
  k22 * x31 * x15 - kr22 * x32
v23:
 {1.0}x32 = {1.0}x33
  k23 * x32 - kr23 * x33
v24:
 {1.0}x22 + {1.0}x33 = {1.0}x34
  k24 * x22 * x33 - kr24 * x34
v25:
 {1.0}x24 + {1.0}x34 = {1.0}x35
  k25 * x24 * x34 - kr25 * x35
v26:
 {1.0}x26 + {1.0}x35 = {1.0}x36
  k18 * x26 * x35 - kr18 * x36
v27:
 {1.0}x36 = {1.0}x35 + {1.0}x28
  k19 * x36 - kr19 * x35 * x28
v28:
 {1.0}x28 + {1.0}x41 = {1.0}x42
  k28 * x28 * x41 - kr28 * x42
v29:
 {1.0}x42 = {1.0}x43 + {1.0}x45
  k29 * x42 - kr29 * x43 * x45
v3:
 {1.0}x4 = {1.0}x5
  k3 * x4 - kr3 * x5
v30:
 {1.0}x35 + {1.0}x43 = {1.0}x37
  k20 * x35 * x43 - kr20 * x37
v31:
 {1.0}x37 = {1.0}x35 + {1.0}x26
  k21 * x37 - kr21 * x35 * x26
v32:
 {1.0}x35 = {1.0}x15 + {1.0}x38
  k32 * x35 - kr32 * x15 * x38
v33:
 {1.0}x38 = {1.0}x40 + {1.0}x30
  k33 * x38 - kr33 * x40 * x30
v34:
 {1.0}x25 = {1.0}x15 + {1.0}x30
  k34 * x25 - kr34 * x15 * x30
v35:
 {1.0}x30 = {1.0}x24 + {1.0}x22
  k35 * x30 - kr35 * x24 * x22
v36:
 {1.0}x40 = {1.0}x31
  Vm36 * x40 / (Km36 + x40)
v37:
 {1.0}x33 = {1.0}x15 + {1.0}x40
  k37 * x33 - kr37 * x15 * x40
v38:
 {1.0}x22 + {1.0}x40 = {1.0}x39
  k24 * x22 * x40 - kr24 * x39
v39:
 {1.0}x34 = {1.0}x15 + {1.0}x39
  k37 * x34 - kr37 * x15 * x39
v4:
 {1.0}x23 + {1.0}x12 = {1.0}x7
  k4 * x23 * x12 - kr4 * x7
v40:
 {1.0}x24 + {1.0}x39 = {1.0}x38
  k40 * x24 * x39 - kr40 * x38
v41:
 {1.0}x30 + {1.0}x33 = {1.0}x35
  k41 * x30 * x33 - kr41 * x35
v42:
 {1.0}x44 + {1.0}x45 = {1.0}x46
  k42 * x44 * x45 - kr42 * x46
v43:
 {1.0}x46 = {1.0}x41 + {1.0}x44
  k43 * x46
v44:
 {1.0}x47 + {1.0}x45 = {1.0}x48
  k44 * x47 * x45 - kr44 * x48
v45:
 {1.0}x48 = {1.0}x49 + {1.0}x45
  k45 * x48
v46:
 {1.0}x49 + {1.0}x45 = {1.0}x50
  k44 * x49 * x45 - kr44 * x50
v47:
 {1.0}x50 = {1.0}x51 + {1.0}x45
  k47 * x50
v48:
 {1.0}x51 + {1.0}x53 = {1.0}x52
  k48 * x51 * x53 - kr48 * x52
v49:
 {1.0}x52 = {1.0}x49 + {1.0}x53
  k49 * x52
v5:
 {1.0}x7 = {1.0}x18 + {1.0}x9
  k5 * x7
v50:
 {1.0}x53 + {1.0}x49 = {1.0}x54
  k50 * x53 * x49 - kr50 * x54
v51:
 {1.0}x54 = {1.0}x47 + {1.0}x53
  k49 * x54
v52:
 {1.0}x55 + {1.0}x51 = {1.0}x56
  k52 * x55 * x51 - kr52 * x56
v53:
 {1.0}x56 = {1.0}x51 + {1.0}x57
  k53 * x56
v54:
 {1.0}x51 + {1.0}x57 = {1.0}x58
  k52 * x51 * x57 - kr52 * x58
v55:
 {1.0}x58 = {1.0}x59 + {1.0}x51
  k55 * x58
v56:
 {1.0}x59 + {1.0}x60 = {1.0}x61
  k56 * x59 * x60 - kr56 * x61
v57:
 {1.0}x61 = {1.0}x57 + {1.0}x60
  k57 * x61
v58:
 {1.0}x60 + {1.0}x57 = {1.0}x62
  k58 * x60 * x57 - kr58 * x62
v59:
 {1.0}x62 = {1.0}x55 + {1.0}x60
  k59 * x62
v6:
 {1.0}x2 = {1.0}x6
  k6 * x2 - kr6 * x6
v60:
 {1.0}x6 = {1.0}x86
  k60 * x6
v61:
 {1.0}x16 = {1.0}x13
  k61 * x16
v62:
 {1.0}x8 = {1.0}x87
  k60 * x8
v63:
 {1.0}x17 + {1.0}x22 = {1.0}x18
  k16 * x17 * x22 - kr16 * x18
v64:
 {1.0}x24 + {1.0}x18 = {1.0}x19
  k17 * x24 * x18 - kr17 * x19
v65:
 {1.0}x26 + {1.0}x19 = {1.0}x20
  k18 * x26 * x19 - kr18 * x20
v66:
 {1.0}x20 = {1.0}x69 + {1.0}x19
  k19 * x20 - kr19 * x69 * x19
v67:
 {1.0}x71 + {1.0}x19 = {1.0}x21
  k20 * x71 * x19 - kr20 * x21
v68:
 {1.0}x21 = {1.0}x19 + {1.0}x26
  k21 * x21 - kr21 * x19 * x26
v69:
 {1.0}x31 + {1.0}x17 = {1.0}x63
  k22 * x31 * x17 - kr22 * x63
v7:
 {1.0}x5 = {1.0}x8
  k7 * x5
v70:
 {1.0}x63 = {1.0}x64
  k23 * x63 - kr23 * x64
v71:
 {1.0}x22 + {1.0}x64 = {1.0}x65
  k24 * x22 * x64 - kr24 * x65
v72:
 {1.0}x24 + {1.0}x65 = {1.0}x66
  k25 * x24 * x65 - kr25 * x66
v73:
 {1.0}x26 + {1.0}x66 = {1.0}x67
  k18 * x26 * x66 - kr18 * x67
v74:
 {1.0}x67 = {1.0}x66 + {1.0}x69
  k19 * x67 - kr19 * x66 * x69
v75:
 {1.0}x69 + {1.0}x41 = {1.0}x70
  k28 * x69 * x41 - kr28 * x70
v76:
 {1.0}x70 = {1.0}x71 + {1.0}x72
  k29 * x70 - kr29 * x71 * x72
v77:
 {1.0}x71 + {1.0}x66 = {1.0}x68
  k20 * x71 * x66 - kr20 * x68
v78:
 {1.0}x68 = {1.0}x66 + {1.0}x26
  k21 * x68 - kr21 * x66 * x26
v79:
 {1.0}x66 = {1.0}x17 + {1.0}x38
  k32 * x66 - kr32 * x17 * x38
v8:
 {1.0}x5 + {1.0}x14 = {1.0}x15
  k8 * x5 * x14 - kr8 * x15
v80:
 {1.0}x19 = {1.0}x17 + {1.0}x30
  k34 * x19 - kr34 * x17 * x30
v81:
 {1.0}x64 = {1.0}x17 + {1.0}x40
  k37 * x64 - kr37 * x17 * x40
v82:
 {1.0}x65 = {1.0}x17 + {1.0}x39
  k37 * x65 - kr37 * x17 * x39
v83:
 {1.0}x30 + {1.0}x64 = {1.0}x66
  k41 * x30 * x64 - kr41 * x66
v84:
 {1.0}x44 + {1.0}x72 = {1.0}x73
  k42 * x44 * x72 - kr42 * x73
v85:
 {1.0}x73 = {1.0}x41 + {1.0}x44
  k43 * x73
v86:
 {1.0}x47 + {1.0}x72 = {1.0}x74
  k44 * x47 * x72 - kr44 * x74
v87:
 {1.0}x74 = {1.0}x75 + {1.0}x72
  k45 * x74
v88:
 {1.0}x72 + {1.0}x75 = {1.0}x76
  k44 * x72 * x75 - kr44 * x76
v89:
 {1.0}x76 = {1.0}x72 + {1.0}x77
  k47 * x76
v9:
 {1.0}x23 = {1.0}x18
  k7 * x23
v90:
 {1.0}x77 + {1.0}x53 = {1.0}x78
  k48 * x77 * x53 - kr48 * x78
v91:
 {1.0}x78 = {1.0}x75 + {1.0}x53
  k49 * x78
v92:
 {1.0}x53 + {1.0}x75 = {1.0}x79
  k50 * x53 * x75 - kr50 * x79
v93:
 {1.0}x79 = {1.0}x47 + {1.0}x53
  k49 * x79
v94:
 {1.0}x55 + {1.0}x77 = {1.0}x80
  k52 * x55 * x77 - kr52 * x80
v95:
 {1.0}x80 = {1.0}x81 + {1.0}x77
  k53 * x80
v96:
 {1.0}x77 + {1.0}x81 = {1.0}x82
  k52 * x77 * x81 - kr52 * x82
v97:
 {1.0}x82 = {1.0}x83 + {1.0}x77
  k55 * x82
v98:
 {1.0}x83 + {1.0}x60 = {1.0}x84
  k56 * x83 * x60 - kr56 * x84
v99:
 {1.0}x84 = {1.0}x81 + {1.0}x60
  k57 * x84


#parameters
Km36 = 200000000000000.0
RT = 50000.0
Vm36 = 61200.0
k1 = 0.003
k10 = 3.25581
k11 = 0.001
k12 = 60.0
k13 = 130.2
k14 = 0.0001
k15 = 600000.0
k16 = 0.001
k17 = 0.001
k18 = 0.0015
k19 = 30.0
k2 = 0.001
k20 = 0.00021
k21 = 1.38
k22 = 0.0021
k23 = 360.0
k24 = 0.001
k25 = 0.001
k28 = 0.0001
k29 = 60.0
k3 = 60.0
k32 = 6.0
k33 = 12.0
k34 = 1.8
k35 = 0.09
k37 = 18.0
k4 = 1.038e-05
k40 = 0.003
k41 = 0.003
k42 = 0.0071
k43 = 60.0
k44 = 0.00111
k45 = 210.0
k47 = 174.0
k48 = 0.00143
k49 = 3.48
k50 = 2.5e-05
k52 = 0.00534
k53 = 960.0
k55 = 342.0
k56 = 0.00145
k57 = 16.2
k58 = 0.0005
k59 = 18.0
k6 = 0.003
k60 = 0.04002
k61 = 0.01002
k7 = 0.003
k8 = 0.0001
kr1 = 0.228
kr10 = 0.66
kr11 = 6.0
kr12 = 0.6
kr14 = 12.0
kr16 = 16.5
kr17 = 3.6
kr18 = 78.0
kr19 = 1e-05
kr2 = 6.0
kr20 = 24.0
kr21 = 2.2e-05
kr22 = 6.0
kr23 = 36.0
kr24 = 33.0
kr25 = 1.284
kr28 = 0.318
kr29 = 7e-05
kr3 = 0.6
kr32 = 2.4e-05
kr33 = 0.0021
kr34 = 0.00045
kr35 = 0.00045
kr37 = 9e-05
kr4 = 0.0996
kr40 = 3.84
kr41 = 2.574
kr42 = 12.0
kr44 = 1.0998
kr48 = 48.0
kr50 = 30.0
kr52 = 1.98
kr56 = 36.0
kr58 = 30.0
kr6 = 0.3
kr8 = 12.0
x1mult = 1.0
x1 = 4962.0
c1 = 1.0
c2 = 1.0
c3 = 4.3e-06


#initial values
x10 = 0.0
x11 = 0.0
x12 = 81000.0
x13 = 0.0
x14 = 12000.0
x15 = 0.0
x16 = 0.0
x17 = 0.0
x18 = 0.0
x19 = 0.0
x2 = 50000.0
x20 = 0.0
x21 = 0.0
x22 = 11000.0
x23 = 0.0
x24 = 26300.0
x25 = 0.0
x26 = 72000.0
x27 = 0.0
x28 = 0.0
x29 = 0.0
x3 = 0.0
x30 = 40000.0
x31 = 101000.0
x32 = 0.0
x33 = 0.0
x34 = 0.0
x35 = 0.0
x36 = 0.0
x37 = 0.0
x38 = 0.0
x39 = 0.0
x4 = 0.0
x40 = 0.0
x41 = 40000.0
x42 = 0.0
x43 = 0.0
x44 = 40000.0
x45 = 0.0
x46 = 0.0
x47 = 22000000.0
x48 = 0.0
x49 = 0.0
x5 = 0.0
x50 = 0.0
x51 = 0.0
x52 = 0.0
x53 = 40000.0
x54 = 0.0
x55 = 21000000.0
x56 = 0.0
x57 = 0.0
x58 = 0.0
x59 = 0.0
x6 = 0.0
x60 = 10000000.0
x61 = 0.0
x62 = 0.0
x63 = 0.0
x64 = 0.0
x65 = 0.0
x66 = 0.0
x67 = 0.0
x68 = 0.0
x69 = 0.0
x7 = 0.0
x70 = 0.0
x71 = 0.0
x72 = 0.0
x73 = 0.0
x74 = 0.0
x75 = 0.0
x76 = 0.0
x77 = 0.0
x78 = 0.0
x79 = 0.0
x8 = 0.0
x80 = 0.0
x81 = 0.0
x82 = 0.0
x83 = 0.0
x84 = 0.0
x85 = 0.0
x86 = 0.0
x87 = 0.0
x88 = 0.0
x89 = 0.0
x9 = 0.0
x90 = 0.0
x91 = 0.0
x92 = 0.0
x93 = 0.0
x94 = 0.0


#assignment rules
!F k5 = piecewise(1.55, lt(C, 3100.0), 0.2, gt(C, 100000.0), C * -1.350000e-05 + 1.55)
!F C = RT / (kr1 / (k1 * x1) + 1.0)
!F EGF_EGFR_act = x5 + x7 + x15 + x23 + x25 + x27 + x29 + x32 + x33 + x34 + x35 + x36 + x37 + x88 + x89 + x90 + x91 + x92 + x93 + x94 + x8 + x11 + x17 + x18 + x19 + x20 + x21 + x63 + x64 + x65 + x66 + x67 + x68
!F SHC_P_t = x33 + x34 + x35 + x36 + x37 + x38 + x39 + x40 + x91 + x92 + x93 + x94 + x64 + x65 + x66 + x67 + x68
!F Raf_act = x45 + x46 + x48 + x50 + x72 + x73 + x74 + x76
!F ERK_PP = x59 + x83
!F MEK_PP = x51 + x77
!F Ras_GTP = x42 + x28 + x70 + x69