begin name
schoeberl1
end name

begin reactions
v1 {1.0}x2 + {1.0}$x1 = {1.0}x3
v10 {1.0}x6 + {1.0}x16 = {1.0}x10
v100 {1.0}x60 + {1.0}x81 = {1.0}x85
v101 {1.0}x85 = {1.0}x55 + {1.0}x60
v102 {1.0}x15 = {1.0}x17
v103 {1.0}x32 = {1.0}x63
v104 {1.0}x33 = {1.0}x64
v105 {1.0}x25 = {1.0}x19
v106 {1.0}x25 + {1.0}x12 = {1.0}x88
v107 {1.0}x88 = {1.0}x9 + {1.0}x19
v108 {1.0}x27 = {1.0}x20
v109 {1.0}x27 + {1.0}x12 = {1.0}x89
v11 {2.0}x10 = {1.0}x11
v110 {1.0}x89 = {1.0}x9 + {1.0}x20
v111 {1.0}x29 = {1.0}x21
v112 {1.0}x29 + {1.0}x12 = {1.0}x90
v113 {1.0}x90 = {1.0}x9 + {1.0}x21
v114 {1.0}x34 = {1.0}x65
v115 {1.0}x34 + {1.0}x12 = {1.0}x91
v116 {1.0}x91 = {1.0}x9 + {1.0}x65
v117 {1.0}x35 = {1.0}x66
v118 {1.0}x35 + {1.0}x12 = {1.0}x92
v119 {1.0}x92 = {1.0}x9 + {1.0}x66
v12 {1.0}x11 = {1.0}x8
v120 {1.0}x36 = {1.0}x67
v121 {1.0}x36 + {1.0}x12 = {1.0}x93
v122 {1.0}x93 = {1.0}x9 + {1.0}x67
v123 {1.0}x37 = {1.0}x68
v124 {1.0}x37 + {1.0}x12 = {1.0}x94
v125 {1.0}x94 = {1.0}x68 + {1.0}x9
v13 {1.0}$EXTERNAL = {1.0}x2
v14 {1.0}x8 + {1.0}x14 = {1.0}x17
v15 {1.0}x9 = {1.0}x12
v16 {1.0}x22 + {1.0}x15 = {1.0}x23
v17 {1.0}x24 + {1.0}x23 = {1.0}x25
v18 {1.0}x26 + {1.0}x25 = {1.0}x27
v19 {1.0}x27 = {1.0}x28 + {1.0}x25
v2 {2.0}x3 = {1.0}x4
v20 {1.0}x25 + {1.0}x43 = {1.0}x29
v21 {1.0}x29 = {1.0}x25 + {1.0}x26
v22 {1.0}x31 + {1.0}x15 = {1.0}x32
v23 {1.0}x32 = {1.0}x33
v24 {1.0}x22 + {1.0}x33 = {1.0}x34
v25 {1.0}x24 + {1.0}x34 = {1.0}x35
v26 {1.0}x26 + {1.0}x35 = {1.0}x36
v27 {1.0}x36 = {1.0}x35 + {1.0}x28
v28 {1.0}x28 + {1.0}x41 = {1.0}x42
v29 {1.0}x42 = {1.0}x43 + {1.0}x45
v3 {1.0}x4 = {1.0}x5
v30 {1.0}x35 + {1.0}x43 = {1.0}x37
v31 {1.0}x37 = {1.0}x35 + {1.0}x26
v32 {1.0}x35 = {1.0}x15 + {1.0}x38
v33 {1.0}x38 = {1.0}x40 + {1.0}x30
v34 {1.0}x25 = {1.0}x15 + {1.0}x30
v35 {1.0}x30 = {1.0}x24 + {1.0}x22
v36 {1.0}x40 = {1.0}x31
v37 {1.0}x33 = {1.0}x15 + {1.0}x40
v38 {1.0}x22 + {1.0}x40 = {1.0}x39
v39 {1.0}x34 = {1.0}x15 + {1.0}x39
v4 {1.0}x23 + {1.0}x12 = {1.0}x7
v40 {1.0}x24 + {1.0}x39 = {1.0}x38
v41 {1.0}x30 + {1.0}x33 = {1.0}x35
v42 {1.0}x44 + {1.0}x45 = {1.0}x46
v43 {1.0}x46 = {1.0}x41 + {1.0}x44
v44 {1.0}x47 + {1.0}x45 = {1.0}x48
v45 {1.0}x48 = {1.0}x49 + {1.0}x45
v46 {1.0}x49 + {1.0}x45 = {1.0}x50
v47 {1.0}x50 = {1.0}x51 + {1.0}x45
v48 {1.0}x51 + {1.0}x53 = {1.0}x52
v49 {1.0}x52 = {1.0}x49 + {1.0}x53
v5 {1.0}x7 = {1.0}x18 + {1.0}x9
v50 {1.0}x53 + {1.0}x49 = {1.0}x54
v51 {1.0}x54 = {1.0}x47 + {1.0}x53
v52 {1.0}x55 + {1.0}x51 = {1.0}x56
v53 {1.0}x56 = {1.0}x51 + {1.0}x57
v54 {1.0}x51 + {1.0}x57 = {1.0}x58
v55 {1.0}x58 = {1.0}x59 + {1.0}x51
v56 {1.0}x59 + {1.0}x60 = {1.0}x61
v57 {1.0}x61 = {1.0}x57 + {1.0}x60
v58 {1.0}x60 + {1.0}x57 = {1.0}x62
v59 {1.0}x62 = {1.0}x55 + {1.0}x60
v6 {1.0}x2 = {1.0}x6
v60 {1.0}x6 = {1.0}x86
v61 {1.0}x16 = {1.0}x13
v62 {1.0}x8 = {1.0}x87
v63 {1.0}x17 + {1.0}x22 = {1.0}x18
v64 {1.0}x24 + {1.0}x18 = {1.0}x19
v65 {1.0}x26 + {1.0}x19 = {1.0}x20
v66 {1.0}x20 = {1.0}x69 + {1.0}x19
v67 {1.0}x71 + {1.0}x19 = {1.0}x21
v68 {1.0}x21 = {1.0}x19 + {1.0}x26
v69 {1.0}x31 + {1.0}x17 = {1.0}x63
v7 {1.0}x5 = {1.0}x8
v70 {1.0}x63 = {1.0}x64
v71 {1.0}x22 + {1.0}x64 = {1.0}x65
v72 {1.0}x24 + {1.0}x65 = {1.0}x66
v73 {1.0}x26 + {1.0}x66 = {1.0}x67
v74 {1.0}x67 = {1.0}x66 + {1.0}x69
v75 {1.0}x69 + {1.0}x41 = {1.0}x70
v76 {1.0}x70 = {1.0}x71 + {1.0}x72
v77 {1.0}x71 + {1.0}x66 = {1.0}x68
v78 {1.0}x68 = {1.0}x66 + {1.0}x26
v79 {1.0}x66 = {1.0}x17 + {1.0}x38
v8 {1.0}x5 + {1.0}x14 = {1.0}x15
v80 {1.0}x19 = {1.0}x17 + {1.0}x30
v81 {1.0}x64 = {1.0}x17 + {1.0}x40
v82 {1.0}x65 = {1.0}x17 + {1.0}x39
v83 {1.0}x30 + {1.0}x64 = {1.0}x66
v84 {1.0}x44 + {1.0}x72 = {1.0}x73
v85 {1.0}x73 = {1.0}x41 + {1.0}x44
v86 {1.0}x47 + {1.0}x72 = {1.0}x74
v87 {1.0}x74 = {1.0}x75 + {1.0}x72
v88 {1.0}x72 + {1.0}x75 = {1.0}x76
v89 {1.0}x76 = {1.0}x72 + {1.0}x77
v9 {1.0}x23 = {1.0}x18
v90 {1.0}x77 + {1.0}x53 = {1.0}x78
v91 {1.0}x78 = {1.0}x75 + {1.0}x53
v92 {1.0}x53 + {1.0}x75 = {1.0}x79
v93 {1.0}x79 = {1.0}x47 + {1.0}x53
v94 {1.0}x55 + {1.0}x77 = {1.0}x80
v95 {1.0}x80 = {1.0}x81 + {1.0}x77
v96 {1.0}x77 + {1.0}x81 = {1.0}x82
v97 {1.0}x82 = {1.0}x83 + {1.0}x77
v98 {1.0}x83 + {1.0}x60 = {1.0}x84
v99 {1.0}x84 = {1.0}x81 + {1.0}x60
end reactions

begin rate equations
v1 = k1*x1*x1mult*x2[t] - kr1*x3[t]
v10 = -(kr10*x10[t]) + k10*x16[t]*x6[t]
v100 = k58*x60[t]*x81[t] - kr58*x85[t]
v101 = k59*x85[t]
v102 = k6*x15[t] - kr6*x17[t]
v103 = k6*x32[t] - kr6*x63[t]
v104 = k6*x33[t] - kr6*x64[t]
v105 = -(kr6*x19[t]) + k6*x25[t]
v106 = k4*x12[t]*x25[t] - kr4*x88[t]
v107 = k5*x88[t]
v108 = -(kr6*x20[t]) + k6*x27[t]
v109 = k4*x12[t]*x27[t] - kr4*x89[t]
v11 = k2*x10[t]^2 - kr2*x11[t]
v110 = k5*x89[t]
v111 = -(kr6*x21[t]) + k6*x29[t]
v112 = k4*x12[t]*x29[t] - kr4*x90[t]
v113 = k5*x90[t]
v114 = k6*x34[t] - kr6*x65[t]
v115 = k4*x12[t]*x34[t] - kr4*x91[t]
v116 = k5*x91[t]
v117 = k6*x35[t] - kr6*x66[t]
v118 = k4*x12[t]*x35[t] - kr4*x92[t]
v119 = k5*x92[t]
v12 = k3*x11[t] - kr3*x8[t]
v120 = k6*x36[t] - kr6*x67[t]
v121 = k4*x12[t]*x36[t] - kr4*x93[t]
v122 = k5*x93[t]
v123 = k6*x37[t] - kr6*x68[t]
v124 = k4*x12[t]*x37[t] - kr4*x94[t]
v125 = k5*x94[t]
v13 = k13
v14 = -(kr14*x17[t]) + k14*x14[t]*x8[t]
v15 = k15*x9[t]
v16 = k16*x15[t]*x22[t] - kr16*x23[t]
v17 = k17*x23[t]*x24[t] - kr17*x25[t]
v18 = k18*x25[t]*x26[t] - kr18*x27[t]
v19 = k19*x27[t] - kr19*x25[t]*x28[t]
v2 = k2*x3[t]^2 - kr2*x4[t]
v20 = -(kr20*x29[t]) + k20*x25[t]*x43[t]
v21 = -(kr21*x25[t]*x26[t]) + k21*x29[t]
v22 = k22*x15[t]*x31[t] - kr22*x32[t]
v23 = k23*x32[t] - kr23*x33[t]
v24 = k24*x22[t]*x33[t] - kr24*x34[t]
v25 = k25*x24[t]*x34[t] - kr25*x35[t]
v26 = k18*x26[t]*x35[t] - kr18*x36[t]
v27 = -(kr19*x28[t]*x35[t]) + k19*x36[t]
v28 = k28*x28[t]*x41[t] - kr28*x42[t]
v29 = k29*x42[t] - kr29*x43[t]*x45[t]
v3 = k3*x4[t] - kr3*x5[t]
v30 = -(kr20*x37[t]) + k20*x35[t]*x43[t]
v31 = -(kr21*x26[t]*x35[t]) + k21*x37[t]
v32 = k32*x35[t] - kr32*x15[t]*x38[t]
v33 = k33*x38[t] - kr33*x30[t]*x40[t]
v34 = k34*x25[t] - kr34*x15[t]*x30[t]
v35 = -(kr35*x22[t]*x24[t]) + k35*x30[t]
v36 = (Vm36*x40[t])/(Km36 + x40[t])
v37 = k37*x33[t] - kr37*x15[t]*x40[t]
v38 = -(kr24*x39[t]) + k24*x22[t]*x40[t]
v39 = k37*x34[t] - kr37*x15[t]*x39[t]
v4 = k4*x12[t]*x23[t] - kr4*x7[t]
v40 = -(kr40*x38[t]) + k40*x24[t]*x39[t]
v41 = k41*x30[t]*x33[t] - kr41*x35[t]
v42 = k42*x44[t]*x45[t] - kr42*x46[t]
v43 = k43*x46[t]
v44 = k44*x45[t]*x47[t] - kr44*x48[t]
v45 = k45*x48[t]
v46 = k44*x45[t]*x49[t] - kr44*x50[t]
v47 = k47*x50[t]
v48 = -(kr48*x52[t]) + k48*x51[t]*x53[t]
v49 = k49*x52[t]
v5 = k5*x7[t]
v50 = k50*x49[t]*x53[t] - kr50*x54[t]
v51 = k49*x54[t]
v52 = k52*x51[t]*x55[t] - kr52*x56[t]
v53 = k53*x56[t]
v54 = k52*x51[t]*x57[t] - kr52*x58[t]
v55 = k55*x58[t]
v56 = k56*x59[t]*x60[t] - kr56*x61[t]
v57 = k57*x61[t]
v58 = k58*x57[t]*x60[t] - kr58*x62[t]
v59 = k59*x62[t]
v6 = k6*x2[t] - kr6*x6[t]
v60 = k60*x6[t]
v61 = k61*x16[t]
v62 = k60*x8[t]
v63 = -(kr16*x18[t]) + k16*x17[t]*x22[t]
v64 = -(kr17*x19[t]) + k17*x18[t]*x24[t]
v65 = -(kr18*x20[t]) + k18*x19[t]*x26[t]
v66 = k19*x20[t] - kr19*x19[t]*x69[t]
v67 = -(kr20*x21[t]) + k20*x19[t]*x71[t]
v68 = k21*x21[t] - kr21*x19[t]*x26[t]
v69 = k22*x17[t]*x31[t] - kr22*x63[t]
v7 = k7*x5[t]
v70 = k23*x63[t] - kr23*x64[t]
v71 = k24*x22[t]*x64[t] - kr24*x65[t]
v72 = k25*x24[t]*x65[t] - kr25*x66[t]
v73 = k18*x26[t]*x66[t] - kr18*x67[t]
v74 = k19*x67[t] - kr19*x66[t]*x69[t]
v75 = k28*x41[t]*x69[t] - kr28*x70[t]
v76 = k29*x70[t] - kr29*x71[t]*x72[t]
v77 = -(kr20*x68[t]) + k20*x66[t]*x71[t]
v78 = -(kr21*x26[t]*x66[t]) + k21*x68[t]
v79 = -(kr32*x17[t]*x38[t]) + k32*x66[t]
v8 = -(kr8*x15[t]) + k8*x14[t]*x5[t]
v80 = k34*x19[t] - kr34*x17[t]*x30[t]
v81 = -(kr37*x17[t]*x40[t]) + k37*x64[t]
v82 = -(kr37*x17[t]*x39[t]) + k37*x65[t]
v83 = k41*x30[t]*x64[t] - kr41*x66[t]
v84 = k42*x44[t]*x72[t] - kr42*x73[t]
v85 = k43*x73[t]
v86 = k44*x47[t]*x72[t] - kr44*x74[t]
v87 = k45*x74[t]
v88 = k44*x72[t]*x75[t] - kr44*x76[t]
v89 = k47*x76[t]
v9 = k7*x23[t]
v90 = k48*x53[t]*x77[t] - kr48*x78[t]
v91 = k49*x78[t]
v92 = k50*x53[t]*x75[t] - kr50*x79[t]
v93 = k49*x79[t]
v94 = k52*x55[t]*x77[t] - kr52*x80[t]
v95 = k53*x80[t]
v96 = k52*x77[t]*x81[t] - kr52*x82[t]
v97 = k55*x82[t]
v98 = k56*x60[t]*x83[t] - kr56*x84[t]
v99 = k57*x84[t]
end rate equations

begin parameters
Km36 = 200000000000000.0
RT = 50000.0
Vm36 = 61200.0
k1 = 0.003
k10 = 3.25581
k11 = 0.001
k12 = 60.0
k13 = 130.2
k14 = 0.0001
k15 = 600000.0
k16 = 0.001
k17 = 0.001
k18 = 0.0015
k19 = 30.0
k2 = 0.001
k20 = 0.00021
k21 = 1.38
k22 = 0.0021
k23 = 360.0
k24 = 0.001
k25 = 0.001
k28 = 0.0001
k29 = 60.0
k3 = 60.0
k32 = 6.0
k33 = 12.0
k34 = 1.8
k35 = 0.09
k37 = 18.0
k4 = "1.038e-05"
k40 = 0.003
k41 = 0.003
k42 = 0.0071
k43 = 60.0
k44 = 0.00111
k45 = 210.0
k47 = 174.0
k48 = 0.00143
k49 = 3.48
k50 = "2.5e-05"
k52 = 0.00534
k53 = 960.0
k55 = 342.0
k56 = 0.00145
k57 = 16.2
k58 = 0.0005
k59 = 18.0
k6 = 0.003
k60 = 0.04002
k61 = 0.01002
k7 = 0.003
k8 = 0.0001
kr1 = 0.228
kr10 = 0.66
kr11 = 6.0
kr12 = 0.6
kr14 = 12.0
kr16 = 16.5
kr17 = 3.6
kr18 = 78.0
kr19 = "1e-05"
kr2 = 6.0
kr20 = 24.0
kr21 = "2.2e-05"
kr22 = 6.0
kr23 = 36.0
kr24 = 33.0
kr25 = 1.284
kr28 = 0.318
kr29 = "7e-05"
kr3 = 0.6
kr32 = "2.4e-05"
kr33 = 0.0021
kr34 = 0.00045
kr35 = 0.00045
kr37 = "9e-05"
kr4 = 0.0996
kr40 = 3.84
kr41 = 2.574
kr42 = 12.0
kr44 = 1.0998
kr48 = 48.0
kr50 = 30.0
kr52 = 1.98
kr56 = 36.0
kr58 = 30.0
kr6 = 0.3
kr8 = 12.0
x1mult = 1.0
x1 = 4962.0
c1 = 1.0
c2 = 1.0
c3 = "4.3e-06"
end parameters

begin initial conditions
x10[0] = x10i
x11[0] = x11i
x12[0] = x12i
x13[0] = x13i
x14[0] = x14i
x15[0] = x15i
x16[0] = x16i
x17[0] = x17i
x18[0] = x18i
x19[0] = x19i
x2[0] = x2i
x20[0] = x20i
x21[0] = x21i
x22[0] = x22i
x23[0] = x23i
x24[0] = x24i
x25[0] = x25i
x26[0] = x26i
x27[0] = x27i
x28[0] = x28i
x29[0] = x29i
x3[0] = x3i
x30[0] = x30i
x31[0] = x31i
x32[0] = x32i
x33[0] = x33i
x34[0] = x34i
x35[0] = x35i
x36[0] = x36i
x37[0] = x37i
x38[0] = x38i
x39[0] = x39i
x4[0] = x4i
x40[0] = x40i
x41[0] = x41i
x42[0] = x42i
x43[0] = x43i
x44[0] = x44i
x45[0] = x45i
x46[0] = x46i
x47[0] = x47i
x48[0] = x48i
x49[0] = x49i
x5[0] = x5i
x50[0] = x50i
x51[0] = x51i
x52[0] = x52i
x53[0] = x53i
x54[0] = x54i
x55[0] = x55i
x56[0] = x56i
x57[0] = x57i
x58[0] = x58i
x59[0] = x59i
x6[0] = x6i
x60[0] = x60i
x61[0] = x61i
x62[0] = x62i
x63[0] = x63i
x64[0] = x64i
x65[0] = x65i
x66[0] = x66i
x67[0] = x67i
x68[0] = x68i
x69[0] = x69i
x7[0] = x7i
x70[0] = x70i
x71[0] = x71i
x72[0] = x72i
x73[0] = x73i
x74[0] = x74i
x75[0] = x75i
x76[0] = x76i
x77[0] = x77i
x78[0] = x78i
x79[0] = x79i
x8[0] = x8i
x80[0] = x80i
x81[0] = x81i
x82[0] = x82i
x83[0] = x83i
x84[0] = x84i
x85[0] = x85i
x86[0] = x86i
x87[0] = x87i
x88[0] = x88i
x89[0] = x89i
x9[0] = x9i
x90[0] = x90i
x91[0] = x91i
x92[0] = x92i
x93[0] = x93i
x94[0] = x94i
end initial conditions

begin initial values
x10i = 0.0
x11i = 0.0
x12i = 81000.0
x13i = 0.0
x14i = 12000.0
x15i = 0.0
x16i = 0.0
x17i = 0.0
x18i = 0.0
x19i = 0.0
x2i = 50000.0
x20i = 0.0
x21i = 0.0
x22i = 11000.0
x23i = 0.0
x24i = 26300.0
x25i = 0.0
x26i = 72000.0
x27i = 0.0
x28i = 0.0
x29i = 0.0
x3i = 0.0
x30i = 40000.0
x31i = 101000.0
x32i = 0.0
x33i = 0.0
x34i = 0.0
x35i = 0.0
x36i = 0.0
x37i = 0.0
x38i = 0.0
x39i = 0.0
x4i = 0.0
x40i = 0.0
x41i = 40000.0
x42i = 0.0
x43i = 0.0
x44i = 40000.0
x45i = 0.0
x46i = 0.0
x47i = 22000000.0
x48i = 0.0
x49i = 0.0
x5i = 0.0
x50i = 0.0
x51i = 0.0
x52i = 0.0
x53i = 40000.0
x54i = 0.0
x55i = 21000000.0
x56i = 0.0
x57i = 0.0
x58i = 0.0
x59i = 0.0
x6i = 0.0
x60i = 10000000.0
x61i = 0.0
x62i = 0.0
x63i = 0.0
x64i = 0.0
x65i = 0.0
x66i = 0.0
x67i = 0.0
x68i = 0.0
x69i = 0.0
x7i = 0.0
x70i = 0.0
x71i = 0.0
x72i = 0.0
x73i = 0.0
x74i = 0.0
x75i = 0.0
x76i = 0.0
x77i = 0.0
x78i = 0.0
x79i = 0.0
x8i = 0.0
x80i = 0.0
x81i = 0.0
x82i = 0.0
x83i = 0.0
x84i = 0.0
x85i = 0.0
x86i = 0.0
x87i = 0.0
x88i = 0.0
x89i = 0.0
x9i = 0.0
x90i = 0.0
x91i = 0.0
x92i = 0.0
x93i = 0.0
x94i = 0.0
end initial values

begin assignment rules
k5 := Piecewise[{{1.55, C < 3100}, {0.2, C > 100000}}, 1.55 - 0.000013500000000000001*C]
C := RT/(1 + kr1/(k1*x1))
EGFEGFRact := x11[t] + x15[t] + x17[t] + x18[t] + x19[t] + x20[t] + x21[t] + x23[t] + x25[t] + x27[t] + x29[t] + x32[t] + x33[t] + x34[t] + x35[t] + x36[t] + x37[t] + x5[t] + x63[t] + x64[t] + x65[t] + x66[t] + x67[t] + x68[t] + x7[t] + x8[t] + x88[t] + x89[t] + x90[t] + x91[t] + x92[t] + x93[t] + x94[t]
SHCPt := x33[t] + x34[t] + x35[t] + x36[t] + x37[t] + x38[t] + x39[t] + x40[t] + x64[t] + x65[t] + x66[t] + x67[t] + x68[t] + x91[t] + x92[t] + x93[t] + x94[t]
Rafact := x45[t] + x46[t] + x48[t] + x50[t] + x72[t] + x73[t] + x74[t] + x76[t]
ERKPP := x59[t] + x83[t]
MEKPP := x51[t] + x77[t]
RasGTP := x28[t] + x42[t] + x69[t] + x70[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units