#schilling1 #reactions reaction_1: {1.0}JAK2 = {1.0}pJAK2 JAK2_phosphorylation_by_Epo * JAK2 * Epo * cell reaction_10: {1.0}Delay06_mSHP1 = {1.0}Delay07_mSHP1 SHP1_delay * Delay06_mSHP1 * cell reaction_11: {1.0}Delay07_mSHP1 = {1.0}Delay08_mSHP1 SHP1_delay * Delay07_mSHP1 * cell reaction_12: {1.0}Delay08_mSHP1 = {1.0}actSHP1 SHP1_delay * Delay08_mSHP1 * cell reaction_13: {1.0}actSHP1 = {1.0}SHP1 actSHP1_deactivation * actSHP1 * cell reaction_14: {1.0}pEpoR = {1.0}EpoR pEpoR_dephosphorylation_by_actSHP1 * pEpoR * actSHP1 * cell reaction_15: {1.0}pJAK2 = {1.0}JAK2 pJAK2_dephosphorylation_by_actSHP1 * pJAK2 * actSHP1 * cell reaction_16: {1.0}SOS = {1.0}mSOS SOS_recruitment_by_pEpoR * SOS * pEpoR * cell reaction_17: {1.0}mSOS = {1.0}SOS mSOS_release_from_membrane * mSOS * cell reaction_18: {1.0}Raf = {1.0}pRaf mSOS_induced_Raf_phosphorylation * Raf * mSOS * cell reaction_19: {1.0}pRaf = {1.0}Raf pRaf_dephosphorylation * pRaf * cell reaction_2: {1.0}EpoR = {1.0}pEpoR EpoR_phosphorylation_by_pJAK2 * EpoR * pJAK2 * cell reaction_20: {1.0}MEK2 = {1.0}pMEK2 First_MEK2_phosphorylation_by_pRaf * MEK2 * pRaf * cell reaction_21: {1.0}MEK1 = {1.0}pMEK1 First_MEK1_phosphorylation_by_pRaf * MEK1 * pRaf * cell reaction_22: {1.0}pMEK2 = {1.0}ppMEK2 Second_MEK2_phosphorylation_by_pRaf * pMEK2 * pRaf * cell reaction_23: {1.0}pMEK1 = {1.0}ppMEK1 Second_MEK1_phosphorylation_by_pRaf * pMEK1 * pRaf * cell reaction_24: {1.0}ppMEK2 = {1.0}pMEK2 First_MEK_dephosphorylation * ppMEK2 * cell reaction_25: {1.0}ppMEK1 = {1.0}pMEK1 First_MEK_dephosphorylation * ppMEK1 * cell reaction_26: {1.0}pMEK2 = {1.0}MEK2 Second_MEK_dephosphorylation * pMEK2 * cell reaction_27: {1.0}pMEK1 = {1.0}MEK1 Second_MEK_dephosphorylation * pMEK1 * cell reaction_28: {1.0}ERK1 = {1.0}pERK1 First_ERK1_phosphorylation_by_ppMEK * ERK1 * ppMEK2 * cell reaction_29: {1.0}ERK2 = {1.0}pERK2 First_ERK2_phosphorylation_by_ppMEK * ERK2 * ppMEK2 * cell reaction_3: {1.0}SHP1 = {1.0}mSHP1 SHP1_activation_by_pEpoR * SHP1 * pEpoR * cell reaction_30: {1.0}ERK1 = {1.0}pERK1 First_ERK1_phosphorylation_by_ppMEK * ERK1 * ppMEK1 * cell reaction_31: {1.0}ERK2 = {1.0}pERK2 First_ERK2_phosphorylation_by_ppMEK * ERK2 * ppMEK1 * cell reaction_32: {1.0}pERK1 = {1.0}ppERK1 Second_ERK1_phosphorylation_by_ppMEK * pERK1 * ppMEK2 * cell reaction_33: {1.0}pERK2 = {1.0}ppERK2 Second_ERK2_phosphorylation_by_ppMEK * pERK2 * ppMEK2 * cell reaction_34: {1.0}pERK1 = {1.0}ppERK1 Second_ERK1_phosphorylation_by_ppMEK * pERK1 * ppMEK1 * cell reaction_35: {1.0}pERK2 = {1.0}ppERK2 Second_ERK2_phosphorylation_by_ppMEK * pERK2 * ppMEK1 * cell reaction_36: {1.0}ppERK1 = {1.0}pERK1 First_ERK_dephosphorylation * ppERK1 * cell reaction_37: {1.0}ppERK2 = {1.0}pERK2 First_ERK_dephosphorylation * ppERK2 * cell reaction_38: {1.0}pERK1 = {1.0}ERK1 Second_ERK_dephosphorylation * pERK1 * cell reaction_39: {1.0}pERK2 = {1.0}ERK2 Second_ERK_dephosphorylation * pERK2 * cell reaction_4: {1.0}mSHP1 = {1.0}Delay01_mSHP1 SHP1_delay * mSHP1 * cell reaction_40: {1.0}mSOS = {1.0}pSOS ppERK_neg_feedback_on_mSOS * mSOS * ppERK1 * cell reaction_41: {1.0}mSOS = {1.0}pSOS ppERK_neg_feedback_on_mSOS * mSOS * ppERK2 * cell reaction_42: {1.0}pSOS = {1.0}SOS pSOS_dephosphorylation * pSOS * cell reaction_5: {1.0}Delay01_mSHP1 = {1.0}Delay02_mSHP1 SHP1_delay * Delay01_mSHP1 * cell reaction_6: {1.0}Delay02_mSHP1 = {1.0}Delay03_mSHP1 SHP1_delay * Delay02_mSHP1 * cell reaction_7: {1.0}Delay03_mSHP1 = {1.0}Delay04_mSHP1 SHP1_delay * Delay03_mSHP1 * cell reaction_8: {1.0}Delay04_mSHP1 = {1.0}Delay05_mSHP1 SHP1_delay * Delay04_mSHP1 * cell reaction_9: {1.0}Delay05_mSHP1 = {1.0}Delay06_mSHP1 SHP1_delay * Delay05_mSHP1 * cell #parameters EpoR_phosphorylation_by_pJAK2 = 3.15714 First_ERK1_phosphorylation_by_ppMEK = 2.4927 First_ERK2_phosphorylation_by_ppMEK = 2.44361 First_ERK_dephosphorylation = 39.0886 First_MEK1_phosphorylation_by_pRaf = 0.687193 First_MEK2_phosphorylation_by_pRaf = 3.11919 First_MEK_dephosphorylation = 0.130937 JAK2_phosphorylation_by_Epo = 0.0122149 SHP1_activation_by_pEpoR = 0.408408 SHP1_delay = 0.408408 SOS_recruitment_by_pEpoR = 0.10271 Second_ERK1_phosphorylation_by_ppMEK = 59.5251 Second_ERK2_phosphorylation_by_ppMEK = 53.0816 Second_ERK_dephosphorylation = 3.00453 Second_MEK1_phosphorylation_by_pRaf = 667.957 Second_MEK2_phosphorylation_by_pRaf = 215.158 Second_MEK_dephosphorylation = 0.0732724 actSHP1_deactivation = 0.0248773 mSOS_induced_Raf_phosphorylation = 0.144515 mSOS_release_from_membrane = 15.5956 pEpoR_dephosphorylation_by_actSHP1 = 1.19995 pJAK2_dephosphorylation_by_actSHP1 = 0.368384 pRaf_dephosphorylation = 0.374228 pSOS_dephosphorylation = 0.124944 ppERK_neg_feedback_on_mSOS = 5122.68 scale_SOS = 1.10228 scale_pEpoR = 0.493312 scale_pJAK2 = 0.21008 scale_ppERK = 13.5981 scale_ppMEK = 40.5364 cell = 1.0 #initial values Delay01_mSHP1 = 0.0 Delay02_mSHP1 = 0.0 Delay03_mSHP1 = 0.0 Delay04_mSHP1 = 0.0 Delay05_mSHP1 = 0.0 Delay06_mSHP1 = 0.0 Delay07_mSHP1 = 0.0 Delay08_mSHP1 = 0.0 ERK1 = 7.0 ERK2 = 21.0 Epo = 50.0 EpoR = 1.0 JAK2 = 2.0 MEK1 = 24.0 MEK2 = 11.0 Raf = 3.7719 SHP1 = 10.7991 SOS = 2.5101 actSHP1 = 0.0 mSHP1 = 0.0 mSOS = 0.0 pERK1 = 0.0 pERK2 = 0.0 pEpoR = 0.0 pJAK2 = 0.0 pMEK1 = 0.0 pMEK2 = 0.0 pRaf = 0.0 pSOS = 0.0 ppERK1 = 0.0 ppERK2 = 0.0 ppMEK1 = 0.0 ppMEK2 = 0.0 #assignment rules !F rescaled_SOS = scale_SOS * SOS !F rescaled_pSOS = scale_SOS * pSOS !F rescaled_mSOS = scale_SOS * mSOS !F rescaled_ppMEK2 = scale_ppMEK * ppMEK2 !F rescaled_ppMEK1 = scale_ppMEK * ppMEK1 !F rescaled_ppERK2 = scale_ppERK * ppERK2 !F rescaled_ppERK1 = scale_ppERK * ppERK1 !F rescaled_pJAK2 = scale_pJAK2 * pJAK2 !F rescaled_pEpoR = scale_pEpoR * pEpoR