begin name schilling1 end name begin reactions reaction1 {1.0}JAK2 = {1.0}pJAK2 reaction10 {1.0}Delay06mSHP1 = {1.0}Delay07mSHP1 reaction11 {1.0}Delay07mSHP1 = {1.0}Delay08mSHP1 reaction12 {1.0}Delay08mSHP1 = {1.0}actSHP1 reaction13 {1.0}actSHP1 = {1.0}SHP1 reaction14 {1.0}pEpoR = {1.0}EpoR reaction15 {1.0}pJAK2 = {1.0}JAK2 reaction16 {1.0}SOS = {1.0}mSOS reaction17 {1.0}mSOS = {1.0}SOS reaction18 {1.0}Raf = {1.0}pRaf reaction19 {1.0}pRaf = {1.0}Raf reaction2 {1.0}EpoR = {1.0}pEpoR reaction20 {1.0}MEK2 = {1.0}pMEK2 reaction21 {1.0}MEK1 = {1.0}pMEK1 reaction22 {1.0}pMEK2 = {1.0}ppMEK2 reaction23 {1.0}pMEK1 = {1.0}ppMEK1 reaction24 {1.0}ppMEK2 = {1.0}pMEK2 reaction25 {1.0}ppMEK1 = {1.0}pMEK1 reaction26 {1.0}pMEK2 = {1.0}MEK2 reaction27 {1.0}pMEK1 = {1.0}MEK1 reaction28 {1.0}ERK1 = {1.0}pERK1 reaction29 {1.0}ERK2 = {1.0}pERK2 reaction3 {1.0}SHP1 = {1.0}mSHP1 reaction30 {1.0}ERK1 = {1.0}pERK1 reaction31 {1.0}ERK2 = {1.0}pERK2 reaction32 {1.0}pERK1 = {1.0}ppERK1 reaction33 {1.0}pERK2 = {1.0}ppERK2 reaction34 {1.0}pERK1 = {1.0}ppERK1 reaction35 {1.0}pERK2 = {1.0}ppERK2 reaction36 {1.0}ppERK1 = {1.0}pERK1 reaction37 {1.0}ppERK2 = {1.0}pERK2 reaction38 {1.0}pERK1 = {1.0}ERK1 reaction39 {1.0}pERK2 = {1.0}ERK2 reaction4 {1.0}mSHP1 = {1.0}Delay01mSHP1 reaction40 {1.0}mSOS = {1.0}pSOS reaction41 {1.0}mSOS = {1.0}pSOS reaction42 {1.0}pSOS = {1.0}SOS reaction5 {1.0}Delay01mSHP1 = {1.0}Delay02mSHP1 reaction6 {1.0}Delay02mSHP1 = {1.0}Delay03mSHP1 reaction7 {1.0}Delay03mSHP1 = {1.0}Delay04mSHP1 reaction8 {1.0}Delay04mSHP1 = {1.0}Delay05mSHP1 reaction9 {1.0}Delay05mSHP1 = {1.0}Delay06mSHP1 end reactions begin rate equations reaction1 = cell*JAK2phosphorylationbyEpo*Epo[t]*JAK2[t] reaction10 = cell*SHP1delay*Delay06mSHP1[t] reaction11 = cell*SHP1delay*Delay07mSHP1[t] reaction12 = cell*SHP1delay*Delay08mSHP1[t] reaction13 = actSHP1deactivation*cell*actSHP1[t] reaction14 = cell*pEpoRdephosphorylationbyactSHP1*actSHP1[t]*pEpoR[t] reaction15 = cell*pJAK2dephosphorylationbyactSHP1*actSHP1[t]*pJAK2[t] reaction16 = cell*SOSrecruitmentbypEpoR*pEpoR[t]*SOS[t] reaction17 = cell*mSOSreleasefrommembrane*mSOS[t] reaction18 = cell*mSOSinducedRafphosphorylation*mSOS[t]*Raf[t] reaction19 = cell*pRafdephosphorylation*pRaf[t] reaction2 = cell*EpoRphosphorylationbypJAK2*EpoR[t]*pJAK2[t] reaction20 = cell*FirstMEK2phosphorylationbypRaf*MEK2[t]*pRaf[t] reaction21 = cell*FirstMEK1phosphorylationbypRaf*MEK1[t]*pRaf[t] reaction22 = cell*SecondMEK2phosphorylationbypRaf*pMEK2[t]*pRaf[t] reaction23 = cell*SecondMEK1phosphorylationbypRaf*pMEK1[t]*pRaf[t] reaction24 = cell*FirstMEKdephosphorylation*ppMEK2[t] reaction25 = cell*FirstMEKdephosphorylation*ppMEK1[t] reaction26 = cell*SecondMEKdephosphorylation*pMEK2[t] reaction27 = cell*SecondMEKdephosphorylation*pMEK1[t] reaction28 = cell*FirstERK1phosphorylationbyppMEK*ERK1[t]*ppMEK2[t] reaction29 = cell*FirstERK2phosphorylationbyppMEK*ERK2[t]*ppMEK2[t] reaction3 = cell*SHP1activationbypEpoR*pEpoR[t]*SHP1[t] reaction30 = cell*FirstERK1phosphorylationbyppMEK*ERK1[t]*ppMEK1[t] reaction31 = cell*FirstERK2phosphorylationbyppMEK*ERK2[t]*ppMEK1[t] reaction32 = cell*SecondERK1phosphorylationbyppMEK*pERK1[t]*ppMEK2[t] reaction33 = cell*SecondERK2phosphorylationbyppMEK*pERK2[t]*ppMEK2[t] reaction34 = cell*SecondERK1phosphorylationbyppMEK*pERK1[t]*ppMEK1[t] reaction35 = cell*SecondERK2phosphorylationbyppMEK*pERK2[t]*ppMEK1[t] reaction36 = cell*FirstERKdephosphorylation*ppERK1[t] reaction37 = cell*FirstERKdephosphorylation*ppERK2[t] reaction38 = cell*SecondERKdephosphorylation*pERK1[t] reaction39 = cell*SecondERKdephosphorylation*pERK2[t] reaction4 = cell*SHP1delay*mSHP1[t] reaction40 = cell*ppERKnegfeedbackonmSOS*mSOS[t]*ppERK1[t] reaction41 = cell*ppERKnegfeedbackonmSOS*mSOS[t]*ppERK2[t] reaction42 = cell*pSOSdephosphorylation*pSOS[t] reaction5 = cell*SHP1delay*Delay01mSHP1[t] reaction6 = cell*SHP1delay*Delay02mSHP1[t] reaction7 = cell*SHP1delay*Delay03mSHP1[t] reaction8 = cell*SHP1delay*Delay04mSHP1[t] reaction9 = cell*SHP1delay*Delay05mSHP1[t] end rate equations begin parameters EpoRphosphorylationbypJAK2 = 3.15714 FirstERK1phosphorylationbyppMEK = 2.4927 FirstERK2phosphorylationbyppMEK = 2.44361 FirstERKdephosphorylation = 39.0886 FirstMEK1phosphorylationbypRaf = 0.687193 FirstMEK2phosphorylationbypRaf = 3.11919 FirstMEKdephosphorylation = 0.130937 JAK2phosphorylationbyEpo = 0.0122149 SHP1activationbypEpoR = 0.408408 SHP1delay = 0.408408 SOSrecruitmentbypEpoR = 0.10271 SecondERK1phosphorylationbyppMEK = 59.5251 SecondERK2phosphorylationbyppMEK = 53.0816 SecondERKdephosphorylation = 3.00453 SecondMEK1phosphorylationbypRaf = 667.957 SecondMEK2phosphorylationbypRaf = 215.158 SecondMEKdephosphorylation = 0.0732724 actSHP1deactivation = 0.0248773 mSOSinducedRafphosphorylation = 0.144515 mSOSreleasefrommembrane = 15.5956 pEpoRdephosphorylationbyactSHP1 = 1.19995 pJAK2dephosphorylationbyactSHP1 = 0.368384 pRafdephosphorylation = 0.374228 pSOSdephosphorylation = 0.124944 ppERKnegfeedbackonmSOS = 5122.68 scaleSOS = 1.10228 scalepEpoR = 0.493312 scalepJAK2 = 0.21008 scaleppERK = 13.5981 scaleppMEK = 40.5364 cell = 1.0 end parameters begin initial conditions Delay01mSHP1[0] = Delay01mSHP1i Delay02mSHP1[0] = Delay02mSHP1i Delay03mSHP1[0] = Delay03mSHP1i Delay04mSHP1[0] = Delay04mSHP1i Delay05mSHP1[0] = Delay05mSHP1i Delay06mSHP1[0] = Delay06mSHP1i Delay07mSHP1[0] = Delay07mSHP1i Delay08mSHP1[0] = Delay08mSHP1i ERK1[0] = ERK1i ERK2[0] = ERK2i Epo[0] = Epoi EpoR[0] = EpoRi JAK2[0] = JAK2i MEK1[0] = MEK1i MEK2[0] = MEK2i Raf[0] = Rafi SHP1[0] = SHP1i SOS[0] = SOSi actSHP1[0] = actSHP1i mSHP1[0] = mSHP1i mSOS[0] = mSOSi pERK1[0] = pERK1i pERK2[0] = pERK2i pEpoR[0] = pEpoRi pJAK2[0] = pJAK2i pMEK1[0] = pMEK1i pMEK2[0] = pMEK2i pRaf[0] = pRafi pSOS[0] = pSOSi ppERK1[0] = ppERK1i ppERK2[0] = ppERK2i ppMEK1[0] = ppMEK1i ppMEK2[0] = ppMEK2i end initial conditions begin initial values Delay01mSHP1i = 0.0 Delay02mSHP1i = 0.0 Delay03mSHP1i = 0.0 Delay04mSHP1i = 0.0 Delay05mSHP1i = 0.0 Delay06mSHP1i = 0.0 Delay07mSHP1i = 0.0 Delay08mSHP1i = 0.0 ERK1i = 7.0 ERK2i = 21.0 Epoi = 50.0 EpoRi = 1.0 JAK2i = 2.0 MEK1i = 24.0 MEK2i = 11.0 Rafi = 3.7719 SHP1i = 10.7991 SOSi = 2.5101 actSHP1i = 0.0 mSHP1i = 0.0 mSOSi = 0.0 pERK1i = 0.0 pERK2i = 0.0 pEpoRi = 0.0 pJAK2i = 0.0 pMEK1i = 0.0 pMEK2i = 0.0 pRafi = 0.0 pSOSi = 0.0 ppERK1i = 0.0 ppERK2i = 0.0 ppMEK1i = 0.0 ppMEK2i = 0.0 end initial values begin assignment rules rescaledSOS := scaleSOS*SOS[t] rescaledpSOS := scaleSOS*pSOS[t] rescaledmSOS := scaleSOS*mSOS[t] rescaledppMEK2 := scaleppMEK*ppMEK2[t] rescaledppMEK1 := scaleppMEK*ppMEK1[t] rescaledppERK2 := scaleppERK*ppERK2[t] rescaledppERK1 := scaleppERK*ppERK1[t] rescaledpJAK2 := scalepJAK2*pJAK2[t] rescaledpEpoR := scalepEpoR*pEpoR[t] end assignment rules begin function definitions end function definitions begin events end events begin process annotations reaction_40 http://identifiers.org/go/GO:0004707 reaction_40 http://identifiers.org/ec-code/2.7.11.24 reaction_40 http://identifiers.org/go/GO:0006468 reaction_40 http://identifiers.org/reactome/REACT_1420.5 reaction_41 http://identifiers.org/go/GO:0004707 reaction_41 http://identifiers.org/ec-code/2.7.11.24 reaction_41 http://identifiers.org/go/GO:0006468 reaction_41 http://identifiers.org/reactome/REACT_1420.5 end process annotations begin species annotations end species annotations begin units end units