#romond1



#reactions
R1:
 $pool = {1.0}C1
  compartment * vi1 * Kim1 / (Kim1 + M2)
R10:
 {1.0}C2 = $pool
  compartment * kd2 * C2
R2:
 {1.0}C1 = $pool
  compartment * vd1 * X1 * C1 / (K_d1 + C1)
R3:
 {1.0}C1 = $pool
  compartment * kd1 * C1
R8:
 $pool = {1.0}C2
  compartment * vi2 * Kim2 / (Kim2 + M1)
R9:
 {1.0}C2 = $pool
  compartment * vd2 * X2 * C2 / (K_d2 + C2)


#parameters
H1 = 0.01
H2 = 0.01
H3 = 0.01
H4 = 0.01
K1 = 0.01
K2 = 0.01
K3 = 0.01
K4 = 0.01
K_d1 = 0.02
K_d2 = 0.02
Kc1 = 0.5
Kc2 = 0.5
Kim1 = 0.03
Kim2 = 0.03
U2 = 0.15
U4 = 0.05
U_M1 = 0.3
U_M3 = 0.1
V2 = 0.15
V4 = 0.05
V_M1 = 0.3
V_M3 = 0.1
kd1 = 0.001
kd2 = 0.001
vd1 = 0.025
vd2 = 0.025
vi1 = 0.05
vi2 = 0.05
compartment = 1.0


#initial values
C1 = 2.0
C2 = 0.0
M1 = 1.0
M2 = 0.0
X1 = 0.0
X2 = 0.0
X2 = 0.0
M2 = 0.0
X1 = 0.0
M1 = 1.0


#assignment rules
!F U3 = M2 * U_M3
!F U1 = C2 / (Kc2 + C2) * U_M1
!F V3 = M1 * V_M3
!F V1 = C1 / (Kc1 + C1) * V_M1