#palini1

FIX: L

#reactions
A_degradation:
 {1.0}A = $pool
  cell * kdegA * A
C_I_binding:
 {1.0}C + {1.0}I = {1.0}X
  cell * (k1 * C * I - k2 * X)
C_degradation:
 {1.0}C = $pool
  cell * kdegC * C
I_activation:
 {1.0}X = {1.0}C + {1.0}A
  cell * k3 * X
I_degradation:
 {1.0}I = $pool
  cell * kdegI * I
I_expression:
 $pool = {1.0}I
  cell * (BI + TFs * A / (KD + A))
R_L_binding:
 {1.0}R + {1.0}L = {1.0}C
  cell * (kon * L * R - koff * C)
R_degradation:
 {1.0}R = $pool
  cell * kdegR * R
R_expression:
 $pool = {1.0}R
  cell * (BR + Rs * A / (KD + A))
X_degradation:
 {1.0}X = $pool
  cell * kdegX * X


#parameters
BI = 0.005
BR = 0.005
KD = 200.0
Rs = 3.0
TFs = 3.0
k1 = 1.0
k2 = 5.0
k3 = 45.0
kdegA = 0.005
kdegC = 0.01
kdegI = 0.005
kdegR = 0.005
kdegX = 0.005
koff = 0.05
kon = 0.001
L = 0.1
cell = 1.0


#initial values
A = 0.0
C = 0.0
I = 1.0
R = 1.0
X = 0.0


#assignment rules