#olah

FIX: ADP ATP G23DP Glu H Lac P Pyr

#reactions
v_1:
 {1.0}Glu + {1.0}ATP = {1.0}G6P + {1.0}ADP
  VmaxHK*(Glu*ATP/(KmHK*Km1HK)-G6P*ADP/KeHK)/(1+Glu/KmHK+ATP/Km1HK+G6P/Km2HK+ADP/Km3HK+Glu*ATP/(KmHK*Km1HK)+ G6P*ADP/(Km2HK*Km3HK))
v_10:
 {1.0}PEP + {1.0}ADP = {1.0}Pyr + {1.0}ATP + {1.0}P
  (1/(1+(0.0631)**nPK*(1+ATP/Km4PK)**4/((1+PEP/Km5PK+Pyr/Km2PK)**4*(1+FBP/Km6PK)**4)))*VmaxPK*(PEP*ADP/(KmPK*Km1PK)-Pyr*ATP/(KePK*Km2PK*Km3PK))/(1+PEP/KmPK+ADP/Km1PK+Pyr/Km2PK+ATP/Km3PK+PEP*ADP/( KmPK*Km1PK)+ Pyr*ATP/(Km2PK*Km3PK))
v_11:
 {1.0}Pyr + {1.0}NADH = {1.0}Lac + {1.0}NAD
  VmaxLDH*((NADH*Pyr/(KmLDH*Km1LDH)-NAD*Lac/(KeLDH*Km2LDH*Km3LDH))/(NADH/KmLDH+NAD/Km3LDH+NADH*Pyr/(KmLDH*Km1LDH)+ NAD*Lac/(Km2LDH*Km3LDH)+ (1+Km4LDH*Pyr/(KmLDH*Km1LDH)+Km5LDH*Lac/(Km2LDH*Km3LDH))*(1+Pyr/Km6LDH)+ NADH*Lac*Km5LDH/(KmLDH*Km2LDH*Km3LDH)+ NAD*Pyr*Km4LDH/(KmLDH*Km1LDH*Km3LDH)+ NADH*Lac*Pyr/(KmLDH*Km1LDH*Km7LDH)+ NAD*Pyr*Lac/(Km8LDH*Km2LDH*Km3LDH)))
v_12:
 {1.0}G13DP = {1.0}G23DP
  VmaxBPGM*G13DP/(KmBPGM+Km1BPGM*G13DP+ G23DP)
v_13:
 {1.0}G23DP = {1.0}P3G + {1.0}P
  VmaxBPGP*G23DP/(KmBPGP*(1+(P2G+P3G)/Km1BPGP)+ G23DP)
v_2:
 {1.0}G6P = {1.0}F6P
  (VmaxGPI/KmGPI)*( G6P- F6P/KeGPI)/(1+G6P/KmGPI+F6P/Km1GPI)
v_3:
 {1.0}F6P + {1.0}ATP = {1.0}FBP + {1.0}ADP
  (1/(1+(0.1122)**nPFK*(1+ATP/Km1PFK)**4*(1+Mg/Km4PFK)**4/((1+F6P/KmPFK+FBP/Km2PFK)**4*(1+P/Km5PFK)**4)))*VmaxPFK*(F6P*ATP/(KmPFK*Km1PFK)-FBP*ADP/KePFK)/(1+F6P/KmPFK+ATP/Km1PFK+FBP/Km2PFK+ADP/Km3PFK+F6P*ATP/( KmPFK*Km1PFK)+ FBP*ADP/(Km2PFK*Km3PFK))
v_4:
 {1.0}FBP = {1.0}DHAP + {1.0}GAP
  VmaxALD*(FBP/KmALD-DHAP*GAP/KeALD)/(1+FBP/KmALD+DHAP/Km1ALD+(Km3ALD*GAP+DHAP*GAP)/(Km1ALD*Km2ALD)+(Km3ALD*FBP*GAP)/(Km1ALD*Km2ALD*Km4ALD))
v_5:
 {1.0}GAP = {1.0}DHAP
  (VmaxTPI/KmTPI)*(GAP- DHAP/KeTPI)/(1+GAP/KmTPI+DHAP/Km1TPI)
v_6:
 {1.0}GAP + {1.0}NAD + {1.0}P = {1.0}G13DP + {1.0}NADH + {1.0}H
  VmaxGAPDH*(GAP*NAD*P/(KmGAPDH*Km1GAPDH*Km2GAPDH)-G13DP*NADH*H/( KeGAPDH*Km3GAPDH*Km4GAPDH))/((GAP/Km2GAPDH+G13DP/Km3GAPDH+GAP*P/( Km1GAPDH*Km2GAPDH))*(1+GAP/Km5GAPDH)+ (Km6GAPDH*NADH*H/(Km3GAPDH*Km4GAPDH)+Km7GAPDH*NAD*P/(KmGAPDH*Km1GAPDH*Km2GAPDH)+NAD*GAP/(Km8GAPDH*Km2GAPDH))+ (NAD*G13DP/(Km3GAPDH*Km8GAPDH)+GAP*NAD*P/(KmGAPDH*Km1GAPDH*Km2GAPDH)+Km7GAPDH*NAD*P*G13DP/(KmGAPDH*Km2GAPDH* Km1GAPDH*Km9GAPDH))+ (NADH*G13DP*H/(Km3GAPDH*Km4GAPDH)+GAP*NADH*H/(Km2GAPDH*Km10GAPDH)+Km6GAPDH*NADH*P*H/(Km1GAPDH*Km3GAPDH* Km4GAPDH))+ (GAP*NADH*H*P/(Km1GAPDH*Km2GAPDH*Km10GAPDH)+Km6GAPDH*NADH*P*H*G13DP/(Km9GAPDH*Km1GAPDH*Km3GAPDH* Km4GAPDH)))
v_7:
 {1.0}G13DP + {1.0}ADP = {1.0}P3G + {1.0}ATP
  VmaxPGK*((G13DP*ADP/(KmPGK*Km1PGK)-P3G*ATP/(KePGK*Km2PGK*Km3PGK))/(1+G13DP/Km4PGK+ADP/KmPGK+P3G/Km5PGK+ATP/Km2PGK+G13DP*ADP/( KmPGK*Km1PGK)+ P3G*ATP/(Km2PGK*Km3PGK)))
v_8:
 {1.0}P3G = {1.0}P2G
  (VmaxPGM/KmPGM)*( P3G- P2G/KePGM)/(1+P3G/KmPGM+P2G/Km1PGM)
v_9:
 {1.0}P2G = {1.0}PEP
  VmaxENOLASE*(P2G*Mg/(KmENOLASE*Km1ENOLASE)-PEP*Mg/(KeENOLASE*Km2ENOLASE*Km3ENOLASE))/(1+P2G/Km4ENOLASE+Mg/KmENOLASE+PEP/Km2ENOLASE+P2G*Mg/( KmENOLASE*Km1ENOLASE)+ PEP*Mg/(Km2ENOLASE*Km3ENOLASE))


#parameters
KeALD = 140.0
KeENOLASE = 4.0
KeGAPDH = 1.34
KeGPI = 0.329
KeHK = 7750000.0
KeLDH = 4.0
KePFK = 14400000.0
KePGK = 2.5
KePGM = 0.17
KePK = 425.0
KeTPI = 9.0
Km10GAPDH = 64.0
Km1ALD = 10.0
Km1BPGM = 0.013
Km1BPGP = 0.006
Km1ENOLASE = 140.0
Km1GAPDH = 3200.0
Km1GPI = 80.0
Km1HK = 1000.0
Km1LDH = 137.0
Km1PFK = 100.0
Km1PGK = 2.0
Km1PGM = 26.0
Km1PK = 474.0
Km1TPI = 1300.0
Km2ALD = 40.0
Km2ENOLASE = 111.0
Km2GAPDH = 1.6e-14
Km2HK = 50.0
Km2LDH = 503.0
Km2PFK = 600.0
Km2PGK = 200.0
Km2PK = 2000.0
Km3ALD = 40.0
Km3ENOLASE = 46.0
Km3GAPDH = 1.6e-14
Km3HK = 1000.0
Km3LDH = 1070.0
Km3PFK = 600.0
Km3PGK = 1100.0
Km3PK = 3000.0
Km4ALD = 15.0
Km4ENOLASE = 140.0
Km4GAPDH = 21.0
Km4LDH = 8.44
Km4PFK = 4000.0
Km4PGK = 1600.0
Km4PK = 3400.0
Km5GAPDH = 31.0
Km5LDH = 107.0
Km5PFK = 30000.0
Km5PGK = 205.0
Km5PK = 255.0
Km6GAPDH = 0.67
Km6LDH = 101.0
Km6PK = 5.0
Km7GAPDH = 100.0
Km7LDH = 7330.0
Km8GAPDH = 45.0
Km8LDH = 228.0
Km9GAPDH = 1.0
KmALD = 8.0
KmBPGM = 40.0
KmBPGP = 20.0
KmENOLASE = 46.0
KmGAPDH = 45.0
KmGPI = 200.0
KmHK = 50.0
KmLDH = 2.45
KmPFK = 100.0
KmPGK = 80.0
KmPGM = 168.0
KmPK = 225.0
KmTPI = 650.0
Mg = 300.0
VmaxALD = 1380.0
VmaxBPGM = 51000.0
VmaxBPGP = 8.1
VmaxENOLASE = 3000.0
VmaxGAPDH = 39000.0
VmaxGPI = 9000.0
VmaxHK = 186.0
VmaxLDH = 55500.0
VmaxPFK = 5190.0
VmaxPGK = 87000.0
VmaxPGM = 6600.0
VmaxPK = 4200.0
VmaxTPI = 525000.0
nPFK = 5.0
nPK = 1.0
ADP = 300.0
ATP = 3000.0
G23DP = 4500.0
Glu = 5000.0
H = 0.01
Lac = 1200.0
P = 1000.0
Pyr = 60.0
default_compartment = 1.0


#initial values
DHAP = 0.0
F6P = 0.0
FBP = 0.0
G13DP = 0.0
G6P = 0.0
GAP = 0.0
NAD = 60.0
NADH = 1.0
P2G = 0.0
P3G = 0.0
PEP = 0.0


#assignment rules