begin name
nakakuki1
end name

begin reactions
re106 {1.0}ERKc = {1.0}ERKn
re107 {1.0}pERKc = {1.0}pERKn
re108 {1.0}ppERKc = {1.0}ppERKn
re109 {1.0}$EXTERNAL = {1.0}PreDUSPmRNA
re110 {1.0}PreDUSPmRNA = {1.0}DUSPmRNA
re111 {1.0}DUSPc = {1.0}DUSPn
re112 {1.0}pDUSPc = {1.0}pDUSPn
re113 {1.0}pRSKc = {1.0}pRSKn
re115 {1.0}PreFOSmRNA = {1.0}cFOSmRNA
re116 {1.0}cFOSc = {1.0}FOSn
re117 {1.0}pcFOSc = {1.0}FOSn2
re118 {1.0}PreFmRNA = {1.0}FmRNA
re119 {1.0}F = {1.0}Fn
re85 {1.0}pERKc = {1.0}ERKc
re86 {1.0}ppERKc = {1.0}pERKc
re87 {1.0}pERKn = {1.0}ERKn
re88 {1.0}ppERKn = {1.0}pERKn
re89 {1.0}$EXTERNAL = {1.0}DUSPc
re90 {1.0}$EXTERNAL = {1.0}cFOSc
re92 {1.0}$EXTERNAL = {1.0}PreFmRNA
re94 {1.0}FmRNA = {1.0}$EXTERNAL
re95 {1.0}$EXTERNAL = {1.0}F
re96 {1.0}F = {1.0}$EXTERNAL
re99 {1.0}Fn = {1.0}$EXTERNAL
reaction12 {1.0}DUSPn = {1.0}pDUSPn
reaction13 {1.0}pDUSPn = {1.0}DUSPn
reaction14 {1.0}DUSPn = {1.0}$EXTERNAL
reaction15 {1.0}pDUSPn = {1.0}$EXTERNAL
reaction17 {1.0}DUSPmRNA = {1.0}$EXTERNAL
reaction21 {1.0}ppERKn + {1.0}DUSPn = {1.0}DUSPnppERKn
reaction22 {1.0}DUSPnppERKn = {1.0}pERKn + {1.0}DUSPn
reaction23 {1.0}pERKn + {1.0}DUSPn = {1.0}DUSPnpERKn
reaction24 {1.0}DUSPnpERKn = {1.0}ERKn + {1.0}DUSPn
reaction25 {1.0}ppERKn + {1.0}pDUSPn = {1.0}pDUSPnppERKn
reaction26 {1.0}pDUSPnppERKn = {1.0}pERKn + {1.0}pDUSPn
reaction27 {1.0}pERKn + {1.0}pDUSPn = {1.0}pDUSPnpERKn
reaction28 {1.0}pDUSPnpERKn = {1.0}ERKn + {1.0}pDUSPn
reaction29 {1.0}ERKn + {1.0}DUSPn = {1.0}DUSPnERKn
reaction30 {1.0}ERKn + {1.0}pDUSPn = {1.0}pDUSPnERKn
reaction31 {1.0}A1 = {1.0}A12
reaction32 {1.0}ERKc = {1.0}pERKc
reaction33 {1.0}DUSPc = {1.0}pDUSPc
reaction34 {1.0}pDUSPc = {1.0}DUSPc
reaction35 {1.0}DUSPc = {1.0}$EXTERNAL
reaction36 {1.0}pDUSPc = {1.0}$EXTERNAL
reaction41 {1.0}RSKc = {1.0}pRSKc
reaction42 {1.0}pRSKc = {1.0}RSKc
reaction45 {1.0}CREBn = {1.0}pCREBn
reaction46 {1.0}pCREBn = {1.0}CREBn
reaction47 {1.0}$EXTERNAL = {1.0}PreFOSmRNA
reaction50 {1.0}cFOSmRNA = {1.0}$EXTERNAL
reaction52 {1.0}FOSn = {1.0}FOSn2
reaction53 {1.0}FOSn = {1.0}FOSn2
reaction54 {1.0}FOSn2 = {1.0}FOSn
reaction55 {1.0}FOSn = {1.0}$EXTERNAL
reaction56 {1.0}FOSn2 = {1.0}$EXTERNAL
reaction57 {1.0}Elk1n = {1.0}pElk1n
reaction58 {1.0}pElk1n = {1.0}Elk1n
reaction59 {1.0}cFOSc = {1.0}pcFOSc
reaction6 {1.0}pERKc = {1.0}ppERKc
reaction60 {1.0}pcFOSc = {1.0}cFOSc
reaction61 {1.0}cFOSc = {1.0}$EXTERNAL
reaction62 {1.0}pcFOSc = {1.0}$EXTERNAL
reaction67 {1.0}cFOSc = {1.0}pcFOSc
reaction68 {1.0}A12 = {1.0}A1
reaction69 {1.0}A2 = {1.0}A22
reaction70 {1.0}A22 = {1.0}A2
reaction71 {1.0}RsD = {1.0}RsT
reaction72 {1.0}RsD = {1.0}RsT
reaction73 {1.0}RsT = {1.0}RsD
reaction74 {1.0}RsT = {1.0}RsD
reaction75 {1.0}A3 = {1.0}A32
reaction76 {1.0}A32 = {1.0}A3
reaction77 {1.0}Kin = {1.0}Kin2
reaction78 {1.0}Kin2 = {1.0}Kin
reaction79 {1.0}MEK = {1.0}pMEK
reaction80 {1.0}MEK = {1.0}pMEK
reaction81 {1.0}pMEK = {1.0}MEK
end reactions

begin rate equations
re106 = function4v007[KexERK, KimERK, Vc, Vn, ERKc[t], ERKn[t]]
re107 = function4v008[KexERKP, KimERKP, Vc, Vn, pERKc[t], pERKn[t]]
re108 = function4v009[KexERKPP, KimERKPP, Vc, Vn, ppERKc[t], ppERKn[t]]
re109 = nucleus*function4v010[K10, V10, n10, ppERKn[t]]
re110 = function4v011[Vn, p11, PreDUSPmRNA[t]]
re111 = function4v018[KexDUSP, KimDUSP, Vc, Vn, DUSPn[t], DUSPc[t]]
re112 = function4v019[KexDUSPP, KimDUSPP, Vc, Vn, pDUSPc[t], pDUSPn[t]]
re113 = function4v026[KexRSKP, KimRSKP, Vc, Vn, pRSKn[t], pRSKc[t]]
re115 = function4v032[Vn, p32, PreFOSmRNA[t]]
re116 = function4v040[KexFOS, KimFOS, Vc, Vn, cFOSc[t], FOSn[t]]
re117 = function4v041[KexFOSP, KimFOSP, Vc, Vn, pcFOSc[t], FOSn2[t]]
re118 = function4v058[Vn, p58, PreFmRNA[t]]
re119 = function4v062[KexF, KimF, Vc, Vn, F[t], Fn[t]]
re85 = cytoplasm*function4v003[K3, K4, V3, pERKc[t], ppERKc[t]]
re86 = cytoplasm*function4v004[K3, K4, V4, pERKc[t], ppERKc[t]]
re87 = nucleus*function4v005[K5, K6, V5, pERKn[t], ppERKn[t]]
re88 = nucleus*function4v006[K5, K6, V6, pERKn[t], ppERKn[t]]
re89 = cytoplasm*function4v013[p13, DUSPmRNA[t]]
re90 = cytoplasm*function4v034[p34, cFOSmRNA[t]]
re92 = nucleus*function4v057[K57, V57, n57, FOSn2[t]]
re94 = cytoplasm*p59*FmRNA[t]
re95 = cytoplasm*function4v060[p60, FmRNA[t]]
re96 = cytoplasm*p61*F[t]
re99 = nucleus*function4v063[cytoplasm, nucleus, p63, Fn[t]]
reaction12 = nucleus*function4v020[K20, V20, ppERKn[t], DUSPn[t]]
reaction13 = nucleus*function4v021[K21, V21, pDUSPn[t]]
reaction14 = nucleus*p22*DUSPn[t]
reaction15 = nucleus*p23*pDUSPn[t]
reaction17 = cytoplasm*p12*DUSPmRNA[t]
reaction21 = nucleus*(-(m47*DUSPnppERKn[t]) + p47*DUSPn[t]*ppERKn[t])
reaction22 = nucleus*p48*DUSPnppERKn[t]
reaction23 = nucleus*(-(m49*DUSPnpERKn[t]) + p49*DUSPn[t]*pERKn[t])
reaction24 = nucleus*p50*DUSPnpERKn[t]
reaction25 = nucleus*(-(m52*pDUSPnppERKn[t]) + p52*pDUSPn[t]*ppERKn[t])
reaction26 = nucleus*p53*pDUSPnppERKn[t]
reaction27 = nucleus*(-(m54*pDUSPnpERKn[t]) + p54*pDUSPn[t]*pERKn[t])
reaction28 = nucleus*p55*pDUSPnpERKn[t]
reaction29 = nucleus*(-(m51*DUSPnERKn[t]) + p51*DUSPn[t]*ERKn[t])
reaction30 = nucleus*(p56*ERKn[t]*pDUSPn[t] - m56*pDUSPnERKn[t])
reaction31 = cytoplasm*EGFm*function4v101[K101, V101, A1[t], EGF]
reaction32 = cytoplasm*function4v001[Fct, K1, K2, V1, ERKc[t], pERKc[t], pMEK[t]]
reaction33 = cytoplasm*function4v014[K14, V14, ppERKc[t], DUSPc[t]]
reaction34 = cytoplasm*function4v015[K15, V15, pDUSPc[t]]
reaction35 = cytoplasm*p16*DUSPc[t]
reaction36 = cytoplasm*p17*pDUSPc[t]
reaction41 = cytoplasm*function4v024[K24, V24, ppERKc[t], RSKc[t]]
reaction42 = cytoplasm*function4v025[K25, V25, pRSKc[t]]
reaction45 = nucleus*function4v027[K27, V27, CREBn[t], pRSKn[t]]
reaction46 = nucleus*function4v028[K28, V28, pCREBn[t]]
reaction47 = nucleus*function4v031[K31, KF31, V31, n31, nF31, Fn[t], pCREBn[t], pElk1n[t]]
reaction50 = cytoplasm*p33*cFOSmRNA[t]
reaction52 = nucleus*function4v042[K42, V42, ppERKn[t], FOSn[t]]
reaction53 = nucleus*function4v043[K43, V43, FOSn[t], pRSKn[t]]
reaction54 = nucleus*function4v044[K44, V44, FOSn2[t]]
reaction55 = nucleus*p45*FOSn[t]
reaction56 = nucleus*p46*FOSn2[t]
reaction57 = nucleus*function4v029[K29, V29, ppERKn[t], Elk1n[t]]
reaction58 = nucleus*function4v030[K30, V30, pElk1n[t]]
reaction59 = cytoplasm*function4v035[K35, V35, cFOSc[t], ppERKc[t]]
reaction6 = cytoplasm*function4v002[Fct, K1, K2, V2, ERKc[t], pERKc[t], pMEK[t]]
reaction60 = cytoplasm*function4v037[K37, V37, pcFOSc[t]]
reaction61 = cytoplasm*p38*cFOSc[t]
reaction62 = cytoplasm*p39*pcFOSc[t]
reaction67 = cytoplasm*function4v036[K36, V36, cFOSc[t], pRSKc[t]]
reaction68 = cytoplasm*function4v102[K102, V102, A12[t]]
reaction69 = cytoplasm*HRGm*function4v103[K103, V103, A2[t], HRG]
reaction70 = cytoplasm*function4v104[K104, V104, A22[t]]
reaction71 = cytoplasm*EGFm*function4v105[K105, V105, EGF, RsD[t]]
reaction72 = cytoplasm*HRGm*function4v106[K106, V106, HRG, RsD[t]]
reaction73 = cytoplasm*function4v107[K107, V107, A12[t], RsT[t]]
reaction74 = cytoplasm*function4v108[K108, V108, A22[t], RsT[t]]
reaction75 = cytoplasm*HRGm*function4v109[K109, V109, HRG, A3[t]]
reaction76 = cytoplasm*function4v110[K110, V110, A32[t]]
reaction77 = cytoplasm*HRGm*function4v111[K111, V111, HRG, Kin[t]]
reaction78 = cytoplasm*function4v112[K112, V112, A32[t], Kin2[t]]
reaction79 = cytoplasm*function4v113[K113, V113, RsT[t], MEK[t]]
reaction80 = cytoplasm*function4v114[K114, V114, Kin2[t], MEK[t]]
reaction81 = cytoplasm*function4v115[K115, V115, pMEK[t]]
end rate equations

begin parameters
EGFm = 1.0
Fct = 0.7485
HRGm = 1.0
K1 = 307.041525298866
K10 = 169.0473748
K101 = 3475.168
K102 = 237.2001
K103 = 1334.132
K104 = 4046.71
K105 = 1.027895
K106 = 606.871
K107 = 424.6884
K108 = 11.5048
K109 = 7424.816
K110 = 425.5268
K111 = 858.3423
K112 = 4665.217
K113 = 20.50809
K114 = 7.774197
K115 = 2122.045
K14 = 34180.48
K15 = 0.001172165
K2 = 350.0
K20 = 735598.6967
K21 = 387.8377182
K24 = 29516.06587
K25 = 0.913939859
K27 = 441.5834425
K28 = 14.99180922
K29 = 21312.69109
K3 = 160.0
K30 = 15.04396629
K31 = 185.9760682
K35 = 8562.744184
K36 = 528.552427
K37 = 0.070379236
K4 = 60.0
K42 = 3992.061328
K43 = 1157.116021
K44 = 0.051168202
K5 = 29.94073716
K57 = 0.637490056
K6 = 29.9407371620698
KF31 = 0.013844393
KexDUSP = 0.070467899
KexDUSPP = 0.070467899
KexERK = 0.018
KexERKP = 0.018
KexERKPP = 0.013
KexF = 0.396950616
KexFOS = 0.133249762
KexFOSP = 0.133249762
KexRSKP = 0.129803956
KimDUSP = 0.024269764
KimDUSPP = 0.024269764
KimERK = 0.012
KimERKP = 0.012
KimERKPP = 0.011
KimF = 0.019898797
KimFOS = 0.54528521
KimFOSP = 0.54528521
KimRSKP = 0.025925065
V1 = 0.342848369838443
V10 = 29.24109258
V101 = 0.01807448
V102 = 0.09858154
V103 = 0.3573399
V104 = 4.635749
V105 = 0.05393704
V106 = 0.109304
V107 = 5.291093
V108 = 0.03436149
V109 = 0.1374307
V110 = 0.08258693
V111 = 0.02487469
V112 = 0.8850982
V113 = 0.05377297
V114 = 0.03957055
V115 = 13.74244
V14 = 5.636949216
V15 = 2.992346912
V2 = 0.22
V20 = 0.157678678
V21 = 0.005648117
V24 = 0.550346114
V25 = 10.09063736
V27 = 19.23118154
V28 = 6.574759504
V29 = 0.518529841
V3 = 0.72
V30 = 13.79479021
V31 = 0.655214248
V35 = 8.907637012
V36 = 0.000597315
V37 = 1.745848179
V4 = 0.648
V42 = 0.909968714
V43 = 0.076717457
V44 = 0.078344305
V5 = 19.49872346
V57 = 1.026834758
V6 = 19.4987234631759
Vc = 940.0
Vn = 220.0
m47 = 15.80783969
m49 = 2.335459127
m51 = 9.544308421
m52 = 15.80783969
m54 = 2.335459127
m56 = 9.544308421
n10 = 3.970849295
n31 = 1.988003164
n57 = 3.584464176
nF31 = 2.800340453
p11 = 0.000126129
p12 = 0.007875765
p13 = 0.001245747
p16 = 0.000257
p17 = "4.81e-05"
p22 = 0.000257
p23 = "4.81e-05"
p32 = 0.003284434
p33 = 0.000601234209304622
p34 = "7.64816282169636e-05"
p38 = 0.000257
p39 = "4.81e-05"
p45 = 0.000257
p46 = "4.81e-05"
p47 = 0.001670815
p48 = 0.686020478
p49 = 0.314470502
p50 = 26.59483436
p51 = 0.01646825
p52 = 0.001670815
p53 = 0.686020478
p54 = 0.314470502
p55 = 26.59483436
p56 = 0.01646825
p58 = 0.000270488
p59 = 0.001443889
p60 = 0.002448164
p61 = "3.49860901414122e-05"
p63 = "4.13466150826031e-05"
EGF = 1.0
HRG = 1.0
cytoplasm = 940.0
default = 1.0
nucleus = 220.0
end parameters

begin initial conditions
A1[0] = A1i
A12[0] = A12i
A2[0] = A2i
A22[0] = A22i
A3[0] = A3i
A32[0] = A32i
CREBn[0] = CREBni
DUSPc[0] = DUSPci
DUSPn[0] = DUSPni
DUSPnERKn[0] = DUSPnERKni
DUSPnpERKn[0] = DUSPnpERKni
DUSPnppERKn[0] = DUSPnppERKni
DUSPmRNA[0] = DUSPmRNAi
ERKc[0] = ERKci
ERKn[0] = ERKni
Elk1n[0] = Elk1ni
F[0] = Fi
FOSn[0] = FOSni
FOSn2[0] = FOSn2i
FmRNA[0] = FmRNAi
Fn[0] = Fni
Kin[0] = Kini
Kin2[0] = Kin2i
MEK[0] = MEKi
PreDUSPmRNA[0] = PreDUSPmRNAi
PreFOSmRNA[0] = PreFOSmRNAi
PreFmRNA[0] = PreFmRNAi
RSKc[0] = RSKci
RsD[0] = RsDi
RsT[0] = RsTi
cFOSc[0] = cFOSci
cFOSmRNA[0] = cFOSmRNAi
pCREBn[0] = pCREBni
pDUSPc[0] = pDUSPci
pDUSPn[0] = pDUSPni
pDUSPnERKn[0] = pDUSPnERKni
pDUSPnpERKn[0] = pDUSPnpERKni
pDUSPnppERKn[0] = pDUSPnppERKni
pERKc[0] = pERKci
pERKn[0] = pERKni
pElk1n[0] = pElk1ni
pMEK[0] = pMEKi
pRSKc[0] = pRSKci
pRSKn[0] = pRSKni
pcFOSc[0] = pcFOSci
ppERKc[0] = ppERKci
ppERKn[0] = ppERKni
end initial conditions

begin initial values
A1i = 182.3524
A12i = 0.0
A2i = 25.38702
A22i = 0.0
A3i = 13.09262
A32i = 0.0
CREBni = 1000.0
DUSPci = 0.0
DUSPni = 0.0
DUSPnERKni = 0.0
DUSPnpERKni = 0.0
DUSPnppERKni = 0.0
DUSPmRNAi = 0.0
ERKci = 570.4179
ERKni = 1624.9
Elk1ni = 1510.0
Fi = 0.0
FOSni = 0.0
FOSn2i = 0.0
FmRNAi = 0.0
Fni = 0.0
Kini = 82.66574
Kin2i = 0.0
MEKi = 637.3212
PreDUSPmRNAi = 0.0
PreFOSmRNAi = 0.0
PreFmRNAi = 0.0
RSKci = 353.0
RsDi = 247.4035
RsTi = 0.0
cFOSci = 0.0
cFOSmRNAi = 0.0
pCREBni = 0.0
pDUSPci = 0.0
pDUSPni = 0.0
pDUSPnERKni = 0.0
pDUSPnpERKni = 0.0
pDUSPnppERKni = 0.0
pERKci = 0.0
pERKni = 0.0
pElk1ni = 0.0
pMEKi = 0.0
pRSKci = 0.0
pRSKni = 0.0
pcFOSci = 0.0
ppERKci = 0.0
ppERKni = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
function4v062[KexF_,KimF_,Vc_,Vn_,F_,Fn_] := F*KimF*Vc - Fn*KexF*Vn
function4v109[K109_,V109_,HRG_,A3_] := (A3*HRG*V109)/(A3 + K109)
function4v043[K43_,V43_,FOSn_,pRSKn_] := (FOSn*pRSKn*V43)/(FOSn + K43)
function4v104[K104_,V104_,A22_] := (A22*V104)/(A22 + K104)
function4v115[K115_,V115_,MEKc_] := (MEKc*V115)/(K115 + MEKc)
function4v035[K35_,V35_,cFOSc_,ppERKc_] := (cFOSc*ppERKc*V35)/(cFOSc + K35)
function4v041[KexFOSP_,KimFOSP_,Vc_,Vn_,pcFOSc_,FOSn2_] := KimFOSP*pcFOSc*Vc - FOSn2*KexFOSP*Vn
function4v008[KexERKP_,KimERKP_,Vc_,Vn_,pERKc_,pERKn_] := KimERKP*pERKc*Vc - KexERKP*pERKn*Vn
function4v015[K15_,V15_,pDUSPc_] := (pDUSPc*V15)/(K15 + pDUSPc)
function4v018[KexDUSP_,KimDUSP_,Vc_,Vn_,DUSPn_,DUSPc_] := DUSPc*KimDUSP*Vc - DUSPn*KexDUSP*Vn
function4v003[K3_,K4_,V3_,pERKc_,ppERKc_] := (pERKc*V3)/(pERKc + K3*(1 + ppERKc/K4))
function4v005[K5_,K6_,V5_,pERKn_,ppERKn_] := (pERKn*V5)/(pERKn + K5*(1 + ppERKn/K6))
function4v006[K5_,K6_,V6_,pERKn_,ppERKn_] := (ppERKn*V6)/(K6*(1 + pERKn/K5) + ppERKn)
function4v020[K20_,V20_,ppERKn_,DUSPn_] := (DUSPn*ppERKn*V20)/(DUSPn + K20)
function4v021[K21_,V21_,pDUSPn_] := (pDUSPn*V21)/(K21 + pDUSPn)
function4v024[K24_,V24_,ppERKc_,RSKc_] := (ppERKc*RSKc*V24)/(K24 + RSKc)
function4v002[Fct_,K1_,K2_,V2_,ERKc_,pERKc_,MEKc_] := (Fct*MEKc*pERKc*V2)/((1 + ERKc/K1)*K2 + pERKc)
function4v036[K36_,V36_,cFOSc_,pRSKc_] := (cFOSc*pRSKc*V36)/(cFOSc + K36)
function4v037[K37_,V37_,pcFOSc_] := (pcFOSc*V37)/(K37 + pcFOSc)
function4v040[KexFOS_,KimFOS_,Vc_,Vn_,cFOSc_,FOSn_] := cFOSc*KimFOS*Vc - FOSn*KexFOS*Vn
function4v107[K107_,V107_,A12_,RsT_] := (A12*RsT*V107)/(K107 + RsT)
function4v014[K14_,V14_,ppERKc_,DUSPc_] := (DUSPc*ppERKc*V14)/(DUSPc + K14)
function4v110[K110_,V110_,A32_] := (A32*V110)/(A32 + K110)
function4v114[K114_,V114_,Kin2_,pMEKc_] := (Kin2*pMEKc*V114)/(K114 + pMEKc)
function4v031[K31_,KF31_,V31_,n31_,nF31_,Fn_,pCREBn_,pElk1n_] := ((pCREBn*pElk1n)^n31*V31)/(K31^n31 + (Fn/KF31)^nF31 + (pCREBn*pElk1n)^n31)
function4v007[KexERK_,KimERK_,Vc_,Vn_,ERKc_,ERKn_] := ERKc*KimERK*Vc - ERKn*KexERK*Vn
function4v004[K3_,K4_,V4_,pERKc_,ppERKc_] := (ppERKc*V4)/(K4*(1 + pERKc/K3) + ppERKc)
function4v001[Fct_,K1_,K2_,V1_,ERKc_,pERKc_,MEKc_] := (ERKc*Fct*MEKc*V1)/(ERKc + K1*(1 + pERKc/K2))
function4v010[K10_,V10_,n10_,ppERKn_] := (ppERKn^n10*V10)/(K10^n10 + ppERKn^n10)
function4v113[K113_,V113_,RsT_,pMEKc_] := (pMEKc*RsT*V113)/(K113 + pMEKc)
function4v111[K111_,V111_,HRG_,Kin_] := (HRG*Kin*V111)/(K111 + Kin)
function4v112[K112_,V112_,A32_,Kin2_] := (A32*Kin2*V112)/(K112 + Kin2)
function4v108[K108_,V108_,A22_,RsT_] := (A22*RsT*V108)/(K108 + RsT)
function4v106[K106_,V106_,HRG_,RsD_] := (HRG*RsD*V106)/(K106 + RsD)
function4v105[K105_,V105_,EGF_,RsD_] := (EGF*RsD*V105)/(K105 + RsD)
function4v103[K103_,V103_,A2_,HRG_] := (A2*HRG*V103)/(A2 + K103)
function4v102[K102_,V102_,A12_] := (A12*V102)/(A12 + K102)
function4v101[K101_,V101_,A1_,EGF_] := (A1*EGF*V101)/(A1 + K101)
function4v063[cytoplasm_,nucleus_,p63_,Fn_] := (cytoplasm*Fn*p63)/nucleus
function4v060[p60_,FmRNA_] := FmRNA*p60
function4v057[K57_,V57_,n57_,FOSn2_] := (FOSn2^n57*V57)/(FOSn2^n57 + K57^n57)
function4v044[K44_,V44_,FOSn2_] := (FOSn2*V44)/(FOSn2 + K44)
function4v042[K42_,V42_,ppERKn_,FOSn_] := (FOSn*ppERKn*V42)/(FOSn + K42)
function4v030[K30_,V30_,pElk1n_] := (pElk1n*V30)/(K30 + pElk1n)
function4v028[K28_,V28_,pCREBn_] := (pCREBn*V28)/(K28 + pCREBn)
function4v027[K27_,V27_,CREBn_,pRSKn_] := (CREBn*pRSKn*V27)/(CREBn + K27)
function4v058[Vn_,p58_,PreFmRNA_] := p58*PreFmRNA*Vn
function4v034[p34_,cFOSmRNA_] := cFOSmRNA*p34
function4v026[KexRSKP_,KimRSKP_,Vc_,Vn_,pRSKn_,pRSKc_] := KimRSKP*pRSKc*Vc - KexRSKP*pRSKn*Vn
function4v025[K25_,V25_,pRSKc_] := (pRSKc*V25)/(K25 + pRSKc)
function4v032[Vn_,p32_,PreFOSmRNA_] := p32*PreFOSmRNA*Vn
function4v013[p13_,DUSPmRNA_] := DUSPmRNA*p13
function4v011[Vn_,p11_,PreDUSPmRNA_] := p11*PreDUSPmRNA*Vn
function4v009[KexERKPP_,KimERKPP_,Vc_,Vn_,ppERKc_,ppERKn_] := KimERKPP*ppERKc*Vc - KexERKPP*ppERKn*Vn
function4v029[K29_,V29_,ppERKn_,Elk1n_] := (Elk1n*ppERKn*V29)/(Elk1n + K29)
function4v019[KexDUSPP_,KimDUSPP_,Vc_,Vn_,pDUSPc_,pDUSPn_] := KimDUSPP*pDUSPc*Vc - KexDUSPP*pDUSPn*Vn
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units