begin name mulquiney1 end name begin reactions vRBCvAK {1.0}mgadpRBC + {1.0}adpRBC = {1.0}mgatpRBC + {1.0}ampRBC vRBCvALD {1.0}f16p2RBC = {1.0}dhapRBC + {1.0}gapRBC vRBCvATPASE {1.0}mgatpRBC = {1.0}mgadpRBC + {1.0}phosRBC vRBCvBPGSP1 {1.0}b13pgRBC + {1.0}bpgspRBC = {1.0}bpgspb13pgRBC vRBCvBPGSP2 {1.0}bpgspb13pgRBC = {1.0}bpgsppRBC + {1.0}p3gRBC vRBCvBPGSP3 {1.0}bpgsppRBC + {1.0}p3gRBC = {1.0}bpgsppp3gRBC vRBCvBPGSP4 {1.0}bpgsppRBC + {1.0}p2gRBC = {1.0}bpgsppp2gRBC vRBCvBPGSP5 {1.0}bpgsppp3gRBC = {1.0}bpgspb23pgRBC vRBCvBPGSP6 {1.0}bpgsppp2gRBC = {1.0}bpgspb23pgRBC vRBCvBPGSP7 {1.0}bpgspb23pgRBC = {1.0}bpgspRBC + {1.0}b23pgRBC vRBCvBPGSP8 {1.0}bpgsppRBC + {1.0}phosRBC = {1.0}bpgsppphosRBC vRBCvBPGSP9 {1.0}bpgsppphosRBC = {1.0}bpgspRBC + {2.0}phosRBC vRBCvENO {1.0}p2gRBC = {1.0}pepRBC vRBCvG6PDH {1.0}g6pRBC + {1.0}nadpRBC = {1.0}nadphRBC + {1.0}p6glRBC vRBCvGAPDH {1.0}gapRBC + {1.0}phosRBC + {1.0}nadRBC = {1.0}nadhRBC + {1.0}b13pgRBC vRBCvGSSGR {1.0}nadphRBC + {1.0}gssgRBC = {2.0}gshRBC + {1.0}nadpRBC vRBCvHBADP {1.0}hbRBC + {1.0}adpRBC = {1.0}hbadpRBC vRBCvHBATP {1.0}hbRBC + {1.0}atpRBC = {1.0}hbatpRBC vRBCvHBB13PG {1.0}hbRBC + {1.0}b13pgRBC = {1.0}hbb13pgRBC vRBCvHBB23PG {1.0}hbRBC + {1.0}b23pgRBC = {1.0}hbb23pgRBC vRBCvHBMGATP {1.0}mgatpRBC + {1.0}hbRBC = {1.0}hbmgatpRBC vRBCvHK {1.0}mgatpRBC = {1.0}g6pRBC + {1.0}mgadpRBC vRBCvLACTRANSPORT {1.0}lacRBC = {1.0}$EXTERNAL vRBCvLDH {1.0}nadhRBC + {1.0}pyrRBC = {1.0}lacRBC + {1.0}nadRBC vRBCvLDHP {1.0}nadphRBC + {1.0}pyrRBC = {1.0}lacRBC + {1.0}nadpRBC vRBCvMGADP {1.0}mgRBC + {1.0}adpRBC = {1.0}mgadpRBC vRBCvMGATP {1.0}mgRBC + {1.0}atpRBC = {1.0}mgatpRBC vRBCvMGB13PG {1.0}mgRBC + {1.0}b13pgRBC = {1.0}mgb13pgRBC vRBCvMGB23PG {1.0}mgRBC + {1.0}b23pgRBC = {1.0}mgb23pgRBC vRBCvMGF16P2 {1.0}mgRBC + {1.0}f16p2RBC = {1.0}mgf16p2RBC vRBCvMGG16P2 {1.0}mgRBC + {1.0}g16p2RBC = {1.0}mgg16p2RBC vRBCvMGPHOS {1.0}mgRBC + {1.0}phosRBC = {1.0}mgphosRBC vRBCvOX {2.0}gshRBC = {1.0}gssgRBC vRBCvOXNADH {1.0}nadhRBC = {1.0}nadRBC vRBCvP6GDH {1.0}p6gRBC + {1.0}nadpRBC = {1.0}nadphRBC + {1.0}ru5pRBC vRBCvPFK {1.0}mgatpRBC + {1.0}f6pRBC = {1.0}f16p2RBC + {1.0}mgadpRBC vRBCvPGI {1.0}g6pRBC = {1.0}f6pRBC vRBCvPGK {1.0}b13pgRBC + {1.0}mgadpRBC = {1.0}mgatpRBC + {1.0}p3gRBC vRBCvPGLHYDROLYSIS {1.0}p6glRBC = {1.0}p6gRBC vRBCvPGM {1.0}p3gRBC = {1.0}p2gRBC vRBCvPHOSTRANSPORT {1.0}phosRBC = {1.0}$EXTERNAL vRBCvPK {1.0}pepRBC + {1.0}mgadpRBC = {1.0}pyrRBC + {1.0}mgatpRBC vRBCvPYRTRANSPORT {1.0}pyrRBC = {1.0}$EXTERNAL vRBCvR5PI {1.0}ru5pRBC = {1.0}rib5pRBC vRBCvRu5PE {1.0}ru5pRBC = {1.0}xu5pRBC vRBCvTA {1.0}sed7pRBC + {1.0}gapRBC = {1.0}ery4pRBC + {1.0}f6pRBC vRBCvTIM {1.0}gapRBC = {1.0}dhapRBC vRBCvTK1 {1.0}xu5pRBC + {1.0}tkRBC = {1.0}tkxu5pRBC vRBCvTK2 {1.0}tkxu5pRBC = {1.0}tkgRBC + {1.0}gapRBC vRBCvTK3 {1.0}tkgRBC + {1.0}rib5pRBC = {1.0}tkgrib5pRBC vRBCvTK4 {1.0}tkgrib5pRBC = {1.0}tkRBC + {1.0}sed7pRBC vRBCvTK5 {1.0}tkgRBC + {1.0}ery4pRBC = {1.0}tkgery4pRBC vRBCvTK6 {1.0}tkgery4pRBC = {1.0}tkRBC + {1.0}f6pRBC end reactions begin rate equations vRBCvAK = TsRBC*Vrbc*((K1appRBCvAK*adpRBC[t]*mgadpRBC[t])/Vrbc^2 - (K2appRBCvAK*ampRBC[t]*mgatpRBC[t])/Vrbc^2) vRBCvALD = (TsRBC*Vrbc*VRBCvALD*((KcatfRBCvALD*f16p2RBC[t])/(Kmf16p2RBCvALD*Vrbc) - (KcatrRBCvALD*dhapRBC[t]*gapRBC[t])/(KidhapRBCvALD*KmgapRBCvALD*Vrbc^2)))/(1 + dhapRBC[t]/(KidhapRBCvALD*Vrbc) + f16p2RBC[t]/(Kmf16p2RBCvALD*Vrbc) + (dhapRBC[t]*gapRBC[t])/(KidhapRBCvALD*KmgapRBCvALD*Vrbc^2) + (KmdhapRBCvALD*f16p2RBC[t]*gapRBC[t])/(KidhapRBCvALD*Kif16p2RBCvALD*KmgapRBCvALD*Vrbc^2) + (b23pgRBC[t]/Vrbc + mgb23pgRBC[t]/Vrbc)/Kib23pgRBCvALD + (KmdhapRBCvALD*gapRBC[t]*(1 + (b23pgRBC[t]/Vrbc + mgb23pgRBC[t]/Vrbc)/Kib23pgRBCvALD))/(KidhapRBCvALD*KmgapRBCvALD*Vrbc)) vRBCvATPASE = KRBCvATPASE*TsRBC*mgatpRBC[t] vRBCvBPGSP1 = TsRBC*Vrbc*(-((K2RBCvBPGSP1*bpgspb13pgRBC[t])/Vrbc) + (K1appRBCvBPGSP1*b13pgRBC[t]*bpgspRBC[t])/Vrbc^2) vRBCvBPGSP2 = K3appRBCvBPGSP2*TsRBC*bpgspb13pgRBC[t] vRBCvBPGSP3 = TsRBC*Vrbc*(-((K5RBCvBPGSP3*bpgsppp3gRBC[t])/Vrbc) + (K4appRBCvBPGSP3*bpgsppRBC[t]*p3gRBC[t])/Vrbc^2) vRBCvBPGSP4 = TsRBC*Vrbc*(-((K7RBCvBPGSP4*bpgsppp2gRBC[t])/Vrbc) + (K6appRBCvBPGSP4*bpgsppRBC[t]*p2gRBC[t])/Vrbc^2) vRBCvBPGSP5 = TsRBC*Vrbc*(-((K9RBCvBPGSP5*bpgspb23pgRBC[t])/Vrbc) + (K8RBCvBPGSP5*bpgsppp3gRBC[t])/Vrbc) vRBCvBPGSP6 = TsRBC*Vrbc*(-((K11RBCvBPGSP6*bpgspb23pgRBC[t])/Vrbc) + (K10RBCvBPGSP6*bpgsppp2gRBC[t])/Vrbc) vRBCvBPGSP7 = TsRBC*Vrbc*((K12RBCvBPGSP7*bpgspb23pgRBC[t])/Vrbc - (K13appRBCvBPGSP7*b23pgRBC[t]*bpgspRBC[t])/Vrbc^2) vRBCvBPGSP8 = TsRBC*Vrbc*(-((K15RBCvBPGSP8*bpgsppphosRBC[t])/Vrbc) + (K14RBCvBPGSP8*bpgsppRBC[t]*phosRBC[t])/Vrbc^2) vRBCvBPGSP9 = K16RBCvBPGSP9*TsRBC*bpgsppphosRBC[t] vRBCvENO = (TsRBC*Vrbc*VRBCvENO*((KcatfRBCvENO*mgRBC[t]*p2gRBC[t])/(KimgRBCvENO*Kmp2gRBCvENO*Vrbc^2) - (KcatrRBCvENO*mgRBC[t]*pepRBC[t])/(KipepRBCvENO*KmmgRBCvENO*Vrbc^2)))/(1 + mgRBC[t]/(KimgRBCvENO*Vrbc) + p2gRBC[t]/(Kip2gRBCvENO*Vrbc) + (mgRBC[t]*p2gRBC[t])/(KimgRBCvENO*Kmp2gRBCvENO*Vrbc^2) + pepRBC[t]/(KipepRBCvENO*Vrbc) + (mgRBC[t]*pepRBC[t])/(KipepRBCvENO*KmmgRBCvENO*Vrbc^2)) vRBCvG6PDH = (TsRBC*Vrbc*VRBCvG6PDH*((K1RBCvG6PDH*K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*K9RBCvG6PDH*g6pRBC[t]*nadpRBC[t])/Vrbc^2 - (K10RBCvG6PDH*K2RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*nadphRBC[t]*p6glRBC[t])/Vrbc^2))/(K2RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*K9RBCvG6PDH + (K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*K9RBCvG6PDH*g6pRBC[t])/Vrbc + (K10RBCvG6PDH*K2RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K5RBCvG6PDH*K6RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*nadphRBC[t])/Vrbc + (K10RBCvG6PDH*K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*g6pRBC[t]*nadphRBC[t])/Vrbc^2 + (K1RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*K9RBCvG6PDH*nadpRBC[t])/Vrbc + (K1RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K9RBCvG6PDH + K6RBCvG6PDH*K9RBCvG6PDH + K7RBCvG6PDH*K9RBCvG6PDH)*g6pRBC[t]*nadpRBC[t])/Vrbc^2 + (K2RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*p6glRBC[t])/Vrbc + (K10RBCvG6PDH*(K2RBCvG6PDH*K4RBCvG6PDH + K2RBCvG6PDH*K5RBCvG6PDH + K2RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K6RBCvG6PDH)*K8RBCvG6PDH*nadphRBC[t]*p6glRBC[t])/Vrbc^2 + (K10RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH + K6RBCvG6PDH)*K8RBCvG6PDH*g6pRBC[t]*nadphRBC[t]*p6glRBC[t])/Vrbc^3 + (K1RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*nadpRBC[t]*p6glRBC[t])/Vrbc^2 + (K1RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH + K6RBCvG6PDH)*K8RBCvG6PDH*g6pRBC[t]*nadpRBC[t]*p6glRBC[t])/Vrbc^3) vRBCvGAPDH = (TsRBC*Vrbc*VRBCvGAPDH*(-((KcatrappRBCvGAPDH*b13pgRBC[t]*nadhRBC[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbc^2)) + (KcatfappRBCvGAPDH*gapRBC[t]*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbc^3)))/((b13pgRBC[t]*(1 + gapRBC[t]/(KidgapRBCvGAPDH*Vrbc)))/(Kiappb13pgRBCvGAPDH*Vrbc) + (gapRBC[t]*(1 + gapRBC[t]/(KidgapRBCvGAPDH*Vrbc)))/(KiappgapRBCvGAPDH*Vrbc) + (Kmb13pgRBCvGAPDH*nadhRBC[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbc) + (b13pgRBC[t]*nadhRBC[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbc^2) + (gapRBC[t]*nadhRBC[t])/(KiappgapRBCvGAPDH*KiappnadhRBCvGAPDH*Vrbc^2) + (b13pgRBC[t]*nadRBC[t])/(Kiappb13pgRBCvGAPDH*KinadRBCvGAPDH*Vrbc^2) + (gapRBC[t]*nadRBC[t])/(KiappgapRBCvGAPDH*KinadRBCvGAPDH*Vrbc^2) + (gapRBC[t]*(1 + gapRBC[t]/(KidgapRBCvGAPDH*Vrbc))*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*Vrbc^2) + (Kmb13pgRBCvGAPDH*nadhRBC[t]*phosRBC[t])/(Kiappb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbc^2) + (Kmb13pgRBCvGAPDH*b13pgRBC[t]*nadhRBC[t]*phosRBC[t])/(Kiappb13pgRBCvGAPDH*Kidb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbc^3) + (gapRBC[t]*nadhRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiappnadhRBCvGAPDH*KiphosRBCvGAPDH*Vrbc^3) + (KmgapRBCvGAPDH*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbc^2) + (KmgapRBCvGAPDH*b13pgRBC[t]*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*Kidb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbc^3) + (gapRBC[t]*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbc^3)) vRBCvGSSGR = (TsRBC*Vrbc*VRBCvGSSGR*((K11RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBC[t]*nadphRBC[t])/Vrbc^2 - (K10RBCvGSSGR*K12RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]^2*nadpRBC[t])/Vrbc^3))/(K11RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR + (K11RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t])/Vrbc + (K10RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]^2)/Vrbc^2 + (K11RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBC[t])/Vrbc + (K11RBCvGSSGR*K1RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR*nadphRBC[t])/Vrbc + (K11RBCvGSSGR*K1RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]*nadphRBC[t])/Vrbc^2 + (K10RBCvGSSGR*K1RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]^2*nadphRBC[t])/Vrbc^3 + (K1RBCvGSSGR*K3RBCvGSSGR*(K11RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR + K11RBCvGSSGR*K5RBCvGSSGR*K9RBCvGSSGR + K11RBCvGSSGR*K6RBCvGSSGR*K9RBCvGSSGR + K11RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR)*gssgRBC[t]*nadphRBC[t])/Vrbc^2 + (K10RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*gshRBC[t]*gssgRBC[t]*nadphRBC[t])/Vrbc^3 + (K11RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]*gssgRBC[t]*nadphRBC[t])/Vrbc^3 + (K10RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]^2*gssgRBC[t]*nadphRBC[t])/Vrbc^4 + (K12RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR*nadpRBC[t])/Vrbc + (K10RBCvGSSGR*K12RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*gshRBC[t]*nadpRBC[t])/Vrbc^2 + (K12RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]*nadpRBC[t])/Vrbc^2 + (K10RBCvGSSGR*K12RBCvGSSGR*(K2RBCvGSSGR*K4RBCvGSSGR + K2RBCvGSSGR*K5RBCvGSSGR + K2RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]^2*nadpRBC[t])/Vrbc^3 + (K12RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBC[t]*nadpRBC[t])/Vrbc^2 + (K10RBCvGSSGR*K12RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*gshRBC[t]*gssgRBC[t]*nadpRBC[t])/Vrbc^3 + (K10RBCvGSSGR*K12RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]^2*gssgRBC[t]*nadpRBC[t])/Vrbc^4) vRBCvHBADP = TsRBC*Vrbc*(-((KdRBCvHBADP*hbadpRBC[t])/Vrbc) + (KaappRBCvHBADP*adpRBC[t]*hbRBC[t])/Vrbc^2) vRBCvHBATP = TsRBC*Vrbc*(-((KdRBCvHBATP*hbatpRBC[t])/Vrbc) + (KaappRBCvHBATP*atpRBC[t]*hbRBC[t])/Vrbc^2) vRBCvHBB13PG = TsRBC*Vrbc*(-((KdRBCvHBB13PG*hbb13pgRBC[t])/Vrbc) + (KaappRBCvHBB13PG*b13pgRBC[t]*hbRBC[t])/Vrbc^2) vRBCvHBB23PG = TsRBC*Vrbc*(-((KdRBCvHBBPG*hbb23pgRBC[t])/Vrbc) + (KaappRBCvHBBPG*b23pgRBC[t]*hbRBC[t])/Vrbc^2) vRBCvHBMGATP = TsRBC*Vrbc*(-((KdRBCvHBMGATP*hbmgatpRBC[t])/Vrbc) + (KaappRBCvHBMGATP*hbRBC[t]*mgatpRBC[t])/Vrbc^2) vRBCvHK = (TsRBC*Vrbc*(-((ERBCvHK*KcatrappRBCvHK*g6pRBC[t]*mgadpRBC[t])/(Kig6pRBCvHK*KmmgadpRBCvHK*Vrbc^2)) + (ERBCvHK*glcRBC*KcatfappRBCvHK*mgatpRBC[t])/(KiglcRBCvHK*KmmgatpRBCvHK*Vrbc^2)))/(1 + glcRBC/(KiglcRBCvHK*Vrbc) + (glcRBC*b23pgRBC[t])/(KdibpgRBCvHK*KiglcRBCvHK*Vrbc^2) + (glcRBC*g16p2RBC[t])/(Kdig16p2RBCvHK*KiglcRBCvHK*Vrbc^2) + (glcRBC*g6pRBC[t])/(Kdig6pRBCvHK*KiglcRBCvHK*Vrbc^2) + g6pRBC[t]/(Kig6pRBCvHK*Vrbc) + (glcRBC*gshRBC[t])/(KdigshRBCvHK*KiglcRBCvHK*Vrbc^2) + mgadpRBC[t]/(KimgadpRBCvHK*Vrbc) + (g6pRBC[t]*mgadpRBC[t])/(Kig6pRBCvHK*KmmgadpRBCvHK*Vrbc^2) + (glcRBC*mgatpRBC[t])/(KiglcRBCvHK*KmmgatpRBCvHK*Vrbc^2) + mgatpRBC[t]/(KimgatpRBCvHK*Vrbc)) vRBCvLACTRANSPORT = TsRBC*vBld*(-((KiRBCvLACTRANSPORT*lacEXT)/vBld) + (KoRBCvLACTRANSPORT*lacRBC[t])/Vrbc) vRBCvLDH = (TsRBC*Vrbc*VRBCvLDH*(-((KcatrRBCvLDH*lacRBC[t]*nadRBC[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbc^2)) + (KcatfRBCvLDH*nadhRBC[t]*pyrRBC[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbc^2)))/(nadhRBC[t]/(KinadhRBCvLDH*Vrbc) + (KmnadRBCvLDH*lacRBC[t]*nadhRBC[t])/(KinadhRBCvLDH*KinadRBCvLDH*KmapplacRBCvLDH*Vrbc^2) + nadRBC[t]/(KinadRBCvLDH*Vrbc) + (lacRBC[t]*nadRBC[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbc^2) + (nadhRBC[t]*pyrRBC[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbc^2) + (lacRBC[t]*nadhRBC[t]*pyrRBC[t])/(KiapplacRBCvLDH*KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbc^3) + (KmnadhRBCvLDH*nadRBC[t]*pyrRBC[t])/(KinadhRBCvLDH*KinadRBCvLDH*KmapppyrRBCvLDH*Vrbc^2) + (lacRBC[t]*nadRBC[t]*pyrRBC[t])/(KiapppyrRBCvLDH*KinadRBCvLDH*KmapplacRBCvLDH*Vrbc^3) + (1 + pyrRBC[t]/(KidpyrRBCvLDH*Vrbc))*(1 + (KmnadRBCvLDH*lacRBC[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbc) + (KmnadhRBCvLDH*pyrRBC[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbc))) vRBCvLDHP = (TsRBC*Vrbc*(-((KrRBCvLDHP*lacRBC[t]*nadpRBC[t])/(KmlacRBCvLDHP*Vrbc^2)) + (KfRBCvLDHP*nadphRBC[t]*pyrRBC[t])/(KmpyrRBCvLDHP*Vrbc^2)))/(1 + lacRBC[t]/(KmlacRBCvLDHP*Vrbc) + pyrRBC[t]/(KmpyrRBCvLDHP*Vrbc)) vRBCvMGADP = TsRBC*Vrbc*(-((KdRBCvMGADP*mgadpRBC[t])/Vrbc) + (KaappRBCvMGADP*adpRBC[t]*mgRBC[t])/Vrbc^2) vRBCvMGATP = TsRBC*Vrbc*(-((KdRBCvMGATP*mgatpRBC[t])/Vrbc) + (KaappRBCvMGATP*atpRBC[t]*mgRBC[t])/Vrbc^2) vRBCvMGB13PG = TsRBC*Vrbc*(-((KdRBCvMGB13PG*mgb13pgRBC[t])/Vrbc) + (KaappRBCvMGB13PG*b13pgRBC[t]*mgRBC[t])/Vrbc^2) vRBCvMGB23PG = TsRBC*Vrbc*(-((KdRBCvMGB23PG*mgb23pgRBC[t])/Vrbc) + (KaappRBCvMGB23PG*b23pgRBC[t]*mgRBC[t])/Vrbc^2) vRBCvMGF16P2 = TsRBC*Vrbc*(-((KdRBCvMGF16P2*mgf16p2RBC[t])/Vrbc) + (KaappRBCvMGF16P2*f16p2RBC[t]*mgRBC[t])/Vrbc^2) vRBCvMGG16P2 = TsRBC*Vrbc*(-((KdRBCvMGG16P2*mgg16p2RBC[t])/Vrbc) + (KaappRBCvMGG16P2*g16p2RBC[t]*mgRBC[t])/Vrbc^2) vRBCvMGPHOS = TsRBC*Vrbc*(-((KdRBCvMGPHOS*mgphosRBC[t])/Vrbc) + (KaappRBCvMGPHOS*mgRBC[t]*phosRBC[t])/Vrbc^2) vRBCvOX = KRBCvOX*TsRBC*gshRBC[t] vRBCvOXNADH = KRBCvOXNADH*TsRBC*nadhRBC[t] vRBCvP6GDH = (TsRBC*Vrbc*VRBCvP6GDH*((K11RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*nadpRBC[t]*p6gRBC[t])/Vrbc^2 - (co2RBC*K10RBCvP6GDH*K12RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadphRBC[t]*ru5pRBC[t])/Vrbc^3))/(K11RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH + (co2RBC*K11RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH)/Vrbc + (co2RBC*K12RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadphRBC[t])/Vrbc^2 + (K12RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH*nadphRBC[t])/Vrbc + (co2RBC*K11RBCvP6GDH*K1RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadpRBC[t])/Vrbc^2 + (K11RBCvP6GDH*K1RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH*nadpRBC[t])/Vrbc + (K11RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*p6gRBC[t])/Vrbc + (K12RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*nadphRBC[t]*p6gRBC[t])/Vrbc^2 + (co2RBC*K11RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadpRBC[t]*p6gRBC[t])/Vrbc^3 + (K1RBCvP6GDH*K3RBCvP6GDH*(K11RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH + K11RBCvP6GDH*K5RBCvP6GDH*K9RBCvP6GDH + K11RBCvP6GDH*K6RBCvP6GDH*K9RBCvP6GDH + K11RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH)*nadpRBC[t]*p6gRBC[t])/Vrbc^2 + (co2RBC*K10RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*ru5pRBC[t])/Vrbc^2 + (co2RBC*K10RBCvP6GDH*K12RBCvP6GDH*(K2RBCvP6GDH*K4RBCvP6GDH + K2RBCvP6GDH*K5RBCvP6GDH + K2RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K6RBCvP6GDH)*K8RBCvP6GDH*nadphRBC[t]*ru5pRBC[t])/Vrbc^3 + (K10RBCvP6GDH*K12RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*nadphRBC[t]*ru5pRBC[t])/Vrbc^2 + (co2RBC*K10RBCvP6GDH*K1RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadpRBC[t]*ru5pRBC[t])/Vrbc^3 + (co2RBC*K10RBCvP6GDH*K12RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadphRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbc^4 + (K10RBCvP6GDH*K12RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*nadphRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbc^3 + (co2RBC*K10RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadpRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbc^4 + (K10RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*nadpRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbc^3) vRBCvPFK = (TsRBC*Vrbc*VRBCvPFK*(-((KcatfRBCvPFK*f16p2RBC[t]*mgadpRBC[t])/(Kmf16p2RBCvPFK*KmmgadpRBCvPFK*Vrbc^2)) + (KcatfRBCvPFK*f6pRBC[t]*mgatpRBC[t])/(Kmf6pRBCvPFK*KmmgatpRBCvPFK*Vrbc^2)))/((1 + f16p2RBC[t]/(Kmf16p2RBCvPFK*Vrbc) + f6pRBC[t]/(Kmf6pRBCvPFK*Vrbc) + mgadpRBC[t]/(KmmgadpRBCvPFK*Vrbc) + (f16p2RBC[t]*mgadpRBC[t])/(Kmf16p2RBCvPFK*KmmgadpRBCvPFK*Vrbc^2) + mgatpRBC[t]/(KmmgatpRBCvPFK*Vrbc) + (f6pRBC[t]*mgatpRBC[t])/(Kmf6pRBCvPFK*KmmgatpRBCvPFK*Vrbc^2))*(1 + ((hRBC/KaRBCvPFK)^nRBCvPFK*(1 + atpRBC[t]/(KtatpRBCvPFK*Vrbc))^4*(1 + b23pgRBC[t]/(Ktb23pgRBCvPFK*Vrbc))^4*(1 + mgRBC[t]/(KtmgRBCvPFK*Vrbc))^4)/((1 + ampRBC[t]/(KrampRBCvPFK*Vrbc))^4*(1 + f16p2RBC[t]/(Kmf16p2RBCvPFK*Vrbc) + f6pRBC[t]/(Kmf6pRBCvPFK*Vrbc))^4*(1 + g16p2RBC[t]/(Krg16p2RBCvPFK*Vrbc))^4*(1 + phosRBC[t]/(KrphosRBCvPFK*Vrbc))^4))) vRBCvPGI = (ERBCvPGI*TsRBC*Vrbc*(-((KcatrRBCvPGI*f6pRBC[t])/(Kmf6pRBCvPGI*Vrbc)) + (KcatfRBCvPGI*g6pRBC[t])/(Kmg6pRBCvPGI*Vrbc)))/(1 + f6pRBC[t]/(Kmf6pRBCvPGI*Vrbc) + g6pRBC[t]/(Kmg6pRBCvPGI*Vrbc)) vRBCvPGK = (TsRBC*Vrbc*VRBCvPGK*((KcatfRBCvPGK*b13pgRBC[t]*mgadpRBC[t])/(KimgadpRBCvPGK*Kmb13pgRBCvPGK*Vrbc^2) - (KcatrRBCvPGK*mgatpRBC[t]*p3gRBC[t])/(KimgatpRBCvPGK*Kmp3gRBCvPGK*Vrbc^2)))/(1 + b13pgRBC[t]/(Kib13pgRBCvPGK*Vrbc) + mgadpRBC[t]/(KimgadpRBCvPGK*Vrbc) + (b13pgRBC[t]*mgadpRBC[t])/(KimgadpRBCvPGK*Kmb13pgRBCvPGK*Vrbc^2) + mgatpRBC[t]/(KimgatpRBCvPGK*Vrbc) + p3gRBC[t]/(Kip3gRBCvPGK*Vrbc) + (mgatpRBC[t]*p3gRBC[t])/(KimgatpRBCvPGK*Kmp3gRBCvPGK*Vrbc^2)) vRBCvPGLHYDROLYSIS = TsRBC*Vrbc*((KhydrolRBCvPGLHYDROLYSIS*p6glRBC[t])/Vrbc + (Klactonase3RBCvPGLHYDROLYSIS*VRBCvPGLHYDROLYSIS*p6glRBC[t])/(Vrbc*((Klactonase2RBCvPGLHYDROLYSIS + Klactonase3RBCvPGLHYDROLYSIS)/Klactonase1RBCvPGLHYDROLYSIS + p6glRBC[t]/Vrbc))) vRBCvPGM = (TsRBC*Vrbc*VRBCvPGM*(-((KcatrRBCvPGM*p2gRBC[t])/(Kmp2gRBCvPGM*Vrbc)) + (KcatfRBCvPGM*p3gRBC[t])/(Kmp3gRBCvPGM*Vrbc)))/(1 + p2gRBC[t]/(Kmp2gRBCvPGM*Vrbc) + p3gRBC[t]/(Kmp3gRBCvPGM*Vrbc)) vRBCvPHOSTRANSPORT = TsRBC*vBld*(-((KiRBCvPHOSTRANSPORT*phosEXT)/vBld) + (KoRBCvPHOSTRANSPORT*phosRBC[t])/Vrbc) vRBCvPK = (TsRBC*Vrbc*VRBCvPK*((KcatfRBCvPK*mgadpRBC[t]*pepRBC[t])/(KrmgadpRBCvPK*KrpepRBCvPK*Vrbc^2) - (KcatrRBCvPK*mgatpRBC[t]*pyrRBC[t])/(KrmgatpRBCvPK*KrpyrRBCvPK*Vrbc^2)))/((1 + LRBCvPK)*(1 + mgadpRBC[t]/(KrmgadpRBCvPK*Vrbc) + mgatpRBC[t]/(KrmgatpRBCvPK*Vrbc) + pepRBC[t]/(KrpepRBCvPK*Vrbc) + (mgadpRBC[t]*pepRBC[t])/(KrmgadpRBCvPK*KrpepRBCvPK*Vrbc^2) + pyrRBC[t]/(KrpyrRBCvPK*Vrbc) + (mgatpRBC[t]*pyrRBC[t])/(KrmgatpRBCvPK*KrpyrRBCvPK*Vrbc^2))) vRBCvPYRTRANSPORT = TsRBC*vBld*(-((KiRBCvPYRTRANSPORT*pyrEXT)/vBld) + (KoRBCvPYRTRANSPORT*pyrRBC[t])/Vrbc) vRBCvR5PI = (TsRBC*Vrbc*VRBCvR5PI*(-((K2RBCvR5PI*K4RBCvR5PI*rib5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbc)) + (K1RBCvR5PI*K3RBCvR5PI*ru5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbc)))/(1 + (K1RBCvR5PI*ru5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbc) + (K4RBCvR5PI*xu5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbc)) vRBCvRu5PE = (TsRBC*Vrbc*VRBCvRu5PE*((K1RBCvRu5PE*K3RBCvRu5PE*ru5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbc) - (K2RBCvRu5PE*K4RBCvRu5PE*xu5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbc)))/(1 + (K1RBCvRu5PE*ru5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbc) + (K4RBCvRu5PE*xu5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbc)) vRBCvTA = (TsRBC*Vrbc*VRBCvTA*(-((K2RBCvTA*K4RBCvTA*K6RBCvTA*K8RBCvTA*ery4pRBC[t]*f6pRBC[t])/Vrbc^2) + (K1RBCvTA*K3RBCvTA*K5RBCvTA*K7RBCvTA*gapRBC[t]*sed7pRBC[t])/Vrbc^2))/((K2RBCvTA*K4RBCvTA*(K6RBCvTA + K7RBCvTA)*ery4pRBC[t])/Vrbc + ((K2RBCvTA + K3RBCvTA)*K6RBCvTA*K8RBCvTA*f6pRBC[t])/Vrbc + (K4RBCvTA*(K2RBCvTA + K6RBCvTA)*K8RBCvTA*ery4pRBC[t]*f6pRBC[t])/Vrbc^2 + ((K2RBCvTA + K3RBCvTA)*K5RBCvTA*K7RBCvTA*gapRBC[t])/Vrbc + ((K2RBCvTA + K3RBCvTA)*K5RBCvTA*K8RBCvTA*f6pRBC[t]*gapRBC[t])/Vrbc^2 + (K1RBCvTA*K3RBCvTA*(K6RBCvTA + K7RBCvTA)*sed7pRBC[t])/Vrbc + (K1RBCvTA*K4RBCvTA*(K6RBCvTA + K7RBCvTA)*ery4pRBC[t]*sed7pRBC[t])/Vrbc^2 + (K1RBCvTA*K5RBCvTA*(K3RBCvTA + K7RBCvTA)*gapRBC[t]*sed7pRBC[t])/Vrbc^2) vRBCvTIM = (TsRBC*Vrbc*VRBCvTIM*(-((KcatrRBCvTIM*dhapRBC[t])/(KmdhapRBCvTIM*Vrbc)) + (KcatfRBCvTIM*gapRBC[t])/(KmgapRBCvTIM*Vrbc)))/(1 + dhapRBC[t]/(KmdhapRBCvTIM*Vrbc) + gapRBC[t]/(KmgapRBCvTIM*Vrbc)) vRBCvTK1 = TsRBC*Vrbc*(-((K2RBCvTK1*tkxu5pRBC[t])/Vrbc) + (K1RBCvTK1*tkRBC[t]*xu5pRBC[t])/Vrbc^2) vRBCvTK2 = TsRBC*Vrbc*(-((K4RBCvTK2*gapRBC[t]*tkgRBC[t])/Vrbc^2) + (K3RBCvTK2*tkxu5pRBC[t])/Vrbc) vRBCvTK3 = TsRBC*Vrbc*((K5RBCvTK3*rib5pRBC[t]*tkgRBC[t])/Vrbc^2 - (K6RBCvTK3*tkgrib5pRBC[t])/Vrbc) vRBCvTK4 = TsRBC*Vrbc*((K7RBCvTK4*tkgrib5pRBC[t])/Vrbc - (K8RBCvTK4*sed7pRBC[t]*tkRBC[t])/Vrbc^2) vRBCvTK5 = TsRBC*Vrbc*(-((K10RBCvTK5*tkgery4pRBC[t])/Vrbc) + (K9RBCvTK5*ery4pRBC[t]*tkgRBC[t])/Vrbc^2) vRBCvTK6 = TsRBC*Vrbc*((K11RBCvTK6*tkgery4pRBC[t])/Vrbc - (K12RBCvTK6*f6pRBC[t]*tkRBC[t])/Vrbc^2) end rate equations begin parameters AlphaCellWaterFraction = 0.7 CRBCvMGADP = 0.00062 CRBCvMGATP = "8.4e-05" CRBCvMGB13PG = 0.0032 CRBCvMGB23PG = 0.0032 CRBCvMGF16P2 = 0.0083 CRBCvMGG16P2 = 0.0083 CRBCvMGPHOS = 40800.0 ConcADPRBC = 0.00031 ConcAMPRBC = "3e-05" ConcATPRBC = 0.0021 ConcB13PGRBC = "7e-07" ConcB23PGRBC = 0.0067 ConcBPGSPB13PGRBC = 0.0 ConcBPGSPB23PGRBC = 0.0 ConcBPGSPPP2GRBC = 0.0 ConcBPGSPPP3GRBC = 0.0 ConcBPGSPPRBC = 0.0 ConcBPGSPRBC = "3.8e-06" ConcBpgsppphosRBC = 0.0 ConcCo2RBC = 0.0012 ConcDhapRBC = "1.9e-05" ConcEry4PRBC = "1e-05" ConcF16P2RBC = "2.7e-06" ConcF6PRBC = "1.3e-05" ConcG16P2RBC = 0.000122 ConcG6PRBC = "4e-05" ConcGSHRBC = 0.0032 ConcGapRBC = "5.7e-06" ConcGlcRBC = 0.005 ConcGssgRBC = "9e-08" ConcHbADPRBC = 0.0 ConcHbATPRBC = 0.0 ConcHbB13PGRBC = 0.0 ConcHbB23PGRBC = 0.0 ConcHbRBC = 0.007 ConcHbmgatpRBC = 0.0 ConcLacEXT = 0.00182 ConcLacRBC = 0.0014 ConcMgADPRBC = 0.0 ConcMgB13PGRBC = 0.0 ConcMgB23PGRBC = 0.0 ConcMgF16P2RBC = 0.0 ConcMgRBC = 0.003 ConcMgatpRBC = 0.0 ConcMgg16p2RBC = 0.0 ConcMgphosRBC = 0.0 ConcNADPRBC = "1.25e-07" ConcNADRBC = "6e-05" ConcNadhRBC = "1.4e-07" ConcNadphRBC = "6.4e-05" ConcP2GARBC = "1e-05" ConcP3GARBC = "6.4e-05" ConcP6GLRBC = "1.4e-10" ConcP6GRBC = "1.4e-07" ConcPEPRBC = "2.3e-05" ConcPhosEXT = 0.00192 ConcPhosRBC = 0.001 ConcPyrEXT = "8.5e-05" ConcPyrRBC = "6e-05" ConcRib5PRBC = "1e-05" ConcRu5PRBC = "1e-05" ConcSed7PRBC = "1e-05" ConcTKGEry4PRBC = 0.0 ConcTKGRBC = 0.0 ConcTKGRib5PRBC = 0.0 ConcTKRBC = "3.3e-07" ConcTkxu5pRBC = 0.0 ConcXu5PRBC = "1e-06" ERBCvHK = "2.5e-08" ERBCvPGI = "2.18e-07" K10RBCvBPGSP6 = 1979.0 K10RBCvG6PDH = 1400000000.0 K10RBCvGSSGR = 50000000.0 K10RBCvP6GDH = 225000.0 K10RBCvTK5 = 175.0 K11RBCvBPGSP6 = 0.01 K11RBCvGSSGR = 7000.0 K11RBCvP6GDH = 300.0 K11RBCvTK6 = 40.0 K12RBCvBPGSP7 = 1000.0 K12RBCvGSSGR = 100000000.0 K12RBCvP6GDH = 4950000.0 K12RBCvTK6 = 21300.0 K13RBCvBPGSP7 = 1800000.0 K14RBCvBPGSP8 = 1000000000.0 K15RBCvBPGSP8 = 610000.0 K16RBCvBPGSP9 = 0.19 K1RBCvAK = 4300.0 K1RBCvBPGSP1 = 80000000.0 K1RBCvG6PDH = 110000000.0 K1RBCvGSSGR = 85000000.0 K1RBCvP6GDH = 2400000.0 K1RBCvR5PI = 60900.0 K1RBCvRu5PE = 3910000.0 K1RBCvTA = 580000.0 K1RBCvTK1 = 216000.0 K2RBCvAK = 1400.0 K2RBCvBPGSP1 = 400.0 K2RBCvG6PDH = 870.0 K2RBCvGSSGR = 510.0 K2RBCvP6GDH = 410.0 K2RBCvR5PI = 33.3 K2RBCvRu5PE = 438.0 K2RBCvTA = 45.3 K2RBCvTK1 = 38.0 K3RBCvBPGSP2 = 9.9 K3RBCvG6PDH = 26000000.0 K3RBCvGSSGR = 1000000000.0 K3RBCvP6GDH = 2000000000.0 K3RBCvR5PI = 14.2 K3RBCvRu5PE = 305.0 K3RBCvTA = 16.3 K3RBCvTK2 = 34.0 K4RBCvBPGSP3 = 185000000.0 K4RBCvG6PDH = 300.0 K4RBCvGSSGR = 72000.0 K4RBCvP6GDH = 26000.0 K4RBCvR5PI = 21600.0 K4RBCvRu5PE = 1490000.0 K4RBCvTA = 1010000.0 K4RBCvTK2 = 156000.0 K5RBCvBPGSP3 = 100000000.0 K5RBCvG6PDH = 750.0 K5RBCvGSSGR = 810.0 K5RBCvP6GDH = 48.0 K5RBCvTA = 490000.0 K5RBCvTK3 = 329000.0 K6RBCvBPGSP4 = 1000.0 K6RBCvG6PDH = 2000.0 K6RBCvGSSGR = 1000.0 K6RBCvP6GDH = 30.0 K6RBCvTA = 60.0 K6RBCvTK3 = 175.0 K7RBCvBPGSP4 = 1000.0 K7RBCvG6PDH = 220000.0 K7RBCvGSSGR = 1000000.0 K7RBCvP6GDH = 630.0 K7RBCvTA = 17.0 K7RBCvTK4 = 40.0 K8RBCvBPGSP5 = 10000.0 K8RBCvG6PDH = 1100000000.0 K8RBCvGSSGR = 50000000.0 K8RBCvP6GDH = 36000.0 K8RBCvTA = 79000.0 K8RBCvTK4 = 44800.0 K9RBCvBPGSP5 = 0.55 K9RBCvG6PDH = 10000.0 K9RBCvGSSGR = 1000000.0 K9RBCvP6GDH = 800.0 K9RBCvTK5 = 2240000.0 KRBCvATPASE = 0.000585 KRBCvMGADP = 3290.0 KRBCvMGATP = 43200.0 KRBCvMGB13PG = 7410.0 KRBCvMGB23PG = 7410.0 KRBCvMGF16P2 = 363.0 KRBCvMGG16P2 = 363.0 KRBCvOX = "3.4e-05" KRBCvOXNADH = 0.0163 KaRBCvHBADP = 300000.0 KaRBCvHBATP = 432000.0 KaRBCvHBB13PG = 380000.0 KaRBCvHBBPG = 300000.0 KaRBCvHBMGATP = 46800.0 KaRBCvMGADP = 2760000.0 KaRBCvMGATP = 31200000.0 KaRBCvMGB13PG = 228000.0 KaRBCvMGB23PG = 804000.0 KaRBCvMGF16P2 = 480000.0 KaRBCvMGG16P2 = 480000.0 KaRBCvMGPHOS = 40800.0 KaRBCvPFK = "8.91251e-08" KahbRBC = "2.51189e-07" KcatfRBCvALD = 68.0 KcatfRBCvENO = 190.0 KcatfRBCvGAPDH = 695.304 KcatfRBCvHK = 299.16 KcatfRBCvLDH = 458.0 KcatfRBCvPFK = 822.0 KcatfRBCvPGI = 1470.0 KcatfRBCvPGK = 2290.0 KcatfRBCvPGM = 795.0 KcatfRBCvPK = 1386.0 KcatfRBCvTIM = 14560.0 KcatrRBCvALD = 234.0 KcatrRBCvENO = 50.0 KcatrRBCvGAPDH = 512.487 KcatrRBCvHK = 1.92792 KcatrRBCvLDH = 115.0 KcatrRBCvPFK = 36.0 KcatrRBCvPGI = 1760.0 KcatrRBCvPGK = 917.0 KcatrRBCvPGM = 714.0 KcatrRBCvPK = 3.26 KcatrRBCvTIM = 1280.0 KdRBCvHBADP = 1200.0 KdRBCvHBATP = 1200.0 KdRBCvHBB13PG = 1200.0 KdRBCvHBBPG = 1200.0 KdRBCvHBMGATP = 1200.0 KdRBCvMGADP = 1200.0 KdRBCvMGATP = 1200.0 KdRBCvMGB13PG = 1200.0 KdRBCvMGB23PG = 1200.0 KdRBCvMGF16P2 = 1200.0 KdRBCvMGG16P2 = 1200.0 KdRBCvMGPHOS = 1200.0 KdibpgRBCvHK = 0.004 Kdig16p2RBCvHK = "3e-05" Kdig6pRBCvHK = "1e-05" KdigshRBCvHK = 0.003 KfRBCvLDHP = 0.00346 Kh2bpgRBCvMGB13PG = 4270000.0 Kh2bpgRBCvMGB23PG = 4270000.0 Kh2fRBCvMGF16P2 = 1120000.0 Kh2fRBCvMGG16P2 = 1120000.0 KhadpRBCvAK = 5420000.0 KhadpRBCvMGADP = 5420000.0 KhampRBCvAK = 3090000.0 KhatpRBCvMGATP = 9070000.0 KhbpgRBCvMGB13PG = 162000000.0 KhbpgRBCvMGB23PG = 162000000.0 KhfRBCvMGF16P2 = 7560000.0 KhfRBCvMGG16P2 = 7560000.0 KhphosRBCvMGPHOS = 5680000.0 KhydrolRBCvPGLHYDROLYSIS = 0.00071 KiRBCvLACTRANSPORT = 0.0036 KiRBCvPHOSTRANSPORT = 0.00056 KiRBCvPYRTRANSPORT = 0.018 Kib13pgRBCvGAPDH = "4.55544e-21" Kib13pgRBCvPGK = "1.6e-06" Kib23pgRBCvALD = 0.0015 Kidb13pgRBCvGAPDH = "1e-06" KidgapRBCvGAPDH = "3.1e-05" KidhapRBCvALD = "1.1e-05" KidpyrRBCvLDH = 0.000101 Kif16p2RBCvALD = "1.98e-05" Kig6pRBCvHK = "4.7e-05" KigapRBCvGAPDH = "4.76523e-19" KiglcRBCvHK = "4.7e-05" KilacRBCvLDH = 0.00733 KimgRBCvENO = "4.6e-05" KimgadpRBCvHK = 0.001 KimgadpRBCvPGK = "8e-05" KimgatpRBCvHK = 0.001 KimgatpRBCvPGK = 0.000186 KinadRBCvGAPDH = "4.5e-05" KinadRBCvLDH = 0.000503 KinadhRBCvGAPDH = "1e-05" KinadhRBCvLDH = "2.45e-06" Kip2gRBCvENO = 0.00014 Kip3gRBCvPGK = 0.000205 KipepRBCvENO = 0.0001105 KiphosRBCvGAPDH = 0.00316 KipyrRBCvLDH = 0.000228 KkadpRBCvAK = 4.8 KkadpRBCvMGADP = 4.8 KkampRBCvAK = 1.8 KkatpRBCvMGATP = 14.0 KkbpgRBCvMGB13PG = 85.1 KkbpgRBCvMGB23PG = 85.1 KkfRBCvMGF16P2 = 10.7 KkfRBCvMGG16P2 = 10.7 KkhbpgRBCvMGB13PG = 8.9 KkhbpgRBCvMGB23PG = 8.9 KkhfRBCvMGF16P2 = 3.3 KkhfRBCvMGG16P2 = 3.3 KkphosRBCvMGPHOS = 3.0 Klactonase1RBCvPGLHYDROLYSIS = 13000000.0 Klactonase2RBCvPGLHYDROLYSIS = 1000.0 Klactonase3RBCvPGLHYDROLYSIS = 29.0 Kmb13pgRBCvGAPDH = "6.71e-07" Kmb13pgRBCvPGK = "2e-06" KmdhapRBCvALD = "3.5e-05" KmdhapRBCvTIM = 0.0001624 Kmf16p2RBCvALD = "7.1e-06" Kmf16p2RBCvPFK = 0.0005 Kmf6pRBCvPFK = "7.5e-05" Kmf6pRBCvPGI = "7.1e-05" Kmg6pRBCvPGI = 0.000181 KmgapRBCvALD = 0.000189 KmgapRBCvGAPDH = "9.5e-05" KmgapRBCvTIM = 0.000446 KmghadpRBCvMGADP = 107.0 KmghatpRBCvMGATP = 748.0 KmghbpgRBCvMGB13PG = 513.0 KmghbpgRBCvMGB23PG = 513.0 KmghfRBCvMGF16P2 = 89.0 KmghfRBCvMGG16P2 = 89.0 KmlacRBCvLDH = 0.00107 KmlacRBCvLDHP = 0.000414 KmmgRBCvENO = "4.6e-05" KmmgadpRBCvHK = 0.001 KmmgadpRBCvPFK = 0.00054 KmmgadpRBCvPGK = 0.0001 KmmgatpRBCvHK = 0.001 KmmgatpRBCvPFK = "6.8e-05" KmmgatpRBCvPGK = 0.001 KmnadRBCvGAPDH = "4.5e-05" KmnadRBCvLDH = 0.000107 KmnadhRBCvGAPDH = "3.3e-06" KmnadhRBCvLDH = "8.44e-06" Kmp2gRBCvENO = 0.00014 Kmp2gRBCvPGM = "2.56e-05" Kmp3gRBCvPGK = 0.0011 Kmp3gRBCvPGM = 0.000168 KmpepRBCvENO = 0.0001105 KmphosRBCvGAPDH = 0.00316 KmpyrRBCvLDH = 0.000137 KmpyrRBCvLDHP = 0.000414 KrRBCvLDHP = "5.43e-07" KrampRBCvPFK = 0.0003 Krf16p2RBCvPK = "5e-06" Krg16p2RBCvPFK = 0.01 Krg16p2RBCvPK = 0.0001 KrmgadpRBCvPK = 0.000474 KrmgatpRBCvPK = 0.003 KrpepRBCvPK = 0.000225 KrphosRBCvPFK = 0.03 KrpyrRBCvPK = 0.002 KtatpRBCvPFK = 0.0001 KtatpRBCvPK = 0.00339 Ktb23pgRBCvPFK = 0.005 KtmgRBCvPFK = 0.004 RtvRBC = 0.69 TsRBC = 60.0 VRBCvALD = "3.7e-07" VRBCvENO = "2.2e-07" VRBCvG6PDH = "9.3e-08" VRBCvGAPDH = "7.66e-06" VRBCvGSSGR = "1.25e-07" VRBCvLDH = "3.43e-06" VRBCvP6GDH = "2.1e-06" VRBCvPFK = "1.1e-07" VRBCvPGK = "2.74e-06" VRBCvPGLHYDROLYSIS = "1.4e-05" VRBCvPGM = "4.1e-07" VRBCvPK = "8.7e-08" VRBCvR5PI = "1.42e-05" VRBCvRu5PE = "4.22e-06" VRBCvTA = "6.9e-07" VRBCvTIM = "1.14e-06" bpgxRBC = "3.8e-06" gssgxRBC = 0.00160009 hbxRBC = 0.007 kRBC = 0.15 nRBCvPFK = 5.0 nadpxRBC = "6.4125e-05" pHConversionFactor = 1.0 phRBC = 7.2 tkxRBC = "3.3e-07" xatpRBC = -0.00456 xg16p2RBC = 0.000122 xphosRBC = 0.000438 Vrbc = 90.0 vBld = 128.5 end parameters begin initial conditions adpRBC[0] = adpRBCi ampRBC[0] = ampRBCi atpRBC[0] = atpRBCi b13pgRBC[0] = b13pgRBCi b23pgRBC[0] = b23pgRBCi bpgspRBC[0] = bpgspRBCi bpgspb13pgRBC[0] = bpgspb13pgRBCi bpgspb23pgRBC[0] = bpgspb23pgRBCi bpgsppRBC[0] = bpgsppRBCi bpgsppp2gRBC[0] = bpgsppp2gRBCi bpgsppp3gRBC[0] = bpgsppp3gRBCi bpgsppphosRBC[0] = bpgsppphosRBCi dhapRBC[0] = dhapRBCi ery4pRBC[0] = ery4pRBCi f16p2RBC[0] = f16p2RBCi f6pRBC[0] = f6pRBCi g16p2RBC[0] = g16p2RBCi g6pRBC[0] = g6pRBCi gapRBC[0] = gapRBCi gshRBC[0] = gshRBCi gssgRBC[0] = gssgRBCi hbRBC[0] = hbRBCi hbadpRBC[0] = hbadpRBCi hbatpRBC[0] = hbatpRBCi hbb13pgRBC[0] = hbb13pgRBCi hbb23pgRBC[0] = hbb23pgRBCi hbmgatpRBC[0] = hbmgatpRBCi lacRBC[0] = lacRBCi mgRBC[0] = mgRBCi mgadpRBC[0] = mgadpRBCi mgatpRBC[0] = mgatpRBCi mgb13pgRBC[0] = mgb13pgRBCi mgb23pgRBC[0] = mgb23pgRBCi mgf16p2RBC[0] = mgf16p2RBCi mgg16p2RBC[0] = mgg16p2RBCi mgphosRBC[0] = mgphosRBCi nadRBC[0] = nadRBCi nadhRBC[0] = nadhRBCi nadpRBC[0] = nadpRBCi nadphRBC[0] = nadphRBCi p2gRBC[0] = p2gRBCi p3gRBC[0] = p3gRBCi p6gRBC[0] = p6gRBCi p6glRBC[0] = p6glRBCi pepRBC[0] = pepRBCi phosRBC[0] = phosRBCi pyrRBC[0] = pyrRBCi rib5pRBC[0] = rib5pRBCi ru5pRBC[0] = ru5pRBCi sed7pRBC[0] = sed7pRBCi tkRBC[0] = tkRBCi tkgRBC[0] = tkgRBCi tkgery4pRBC[0] = tkgery4pRBCi tkgrib5pRBC[0] = tkgrib5pRBCi tkxu5pRBC[0] = tkxu5pRBCi xu5pRBC[0] = xu5pRBCi end initial conditions begin initial values adpRBCi = 0.0279 ampRBCi = 27/10000 atpRBCi = 0.189 b13pgRBCi = 63/1000000 b23pgRBCi = 0.603 bpgspRBCi = 0.00034199999999999996 bpgspb13pgRBCi = 0 bpgspb23pgRBCi = 0 bpgsppRBCi = 0 bpgsppp2gRBCi = 0 bpgsppp3gRBCi = 0 bpgsppphosRBCi = 0 dhapRBCi = 0.0017100000000000001 ery4pRBCi = 9/10000 f16p2RBCi = 0.00024300000000000002 f6pRBCi = 0.00117 g16p2RBCi = 0.01098 g6pRBCi = 9/2500 gapRBCi = 0.000513 gshRBCi = 0.28800000000000003 gssgRBCi = 81/10000000 hbRBCi = 0.63 hbadpRBCi = 0 hbatpRBCi = 0 hbb13pgRBCi = 0 hbb23pgRBCi = 0 hbmgatpRBCi = 0 lacRBCi = 0.126 mgRBCi = 0.27 mgadpRBCi = 0 mgatpRBCi = 0 mgb13pgRBCi = 0 mgb23pgRBCi = 0 mgf16p2RBCi = 0 mgg16p2RBCi = 0 mgphosRBCi = 0 nadRBCi = 27/5000 nadhRBCi = 0.000012599999999999998 nadpRBCi = 0.000011249999999999999 nadphRBCi = 0.00576 p2gRBCi = 9/10000 p3gRBCi = 0.00576 p6gRBCi = 0.000012599999999999998 p6glRBCi = 1.2599999999999999*^-8 pepRBCi = 0.00207 phosRBCi = 0.09 pyrRBCi = 27/5000 rib5pRBCi = 9/10000 ru5pRBCi = 9/10000 sed7pRBCi = 9/10000 tkRBCi = 0.0000297 tkgRBCi = 0 tkgery4pRBCi = 0 tkgrib5pRBCi = 0 tkxu5pRBCi = 0 xu5pRBCi = 9/100000 end initial values begin assignment rules KaappRBCvHBB13PG := HbpHRBC*KaRBCvHBB13PG KiappgapRBCvGAPDH := KigapRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.1622776601683795*^7/10^phRBC) K13appRBCvBPGSP7 := (1.758577575029182*K13RBCvBPGSP7)/(1 + 4.786300923226383*^28/10^(4*phRBC)) KaappRBCvMGB23PG := (CRBCvMGB23PG*KaRBCvMGB23PG*(hRBC*KhbpgRBCvMGB23PG*KmghbpgRBCvMGB23PG + KRBCvMGB23PG))/(1 + hRBC*KhbpgRBCvMGB23PG + hRBC^2*Kh2bpgRBCvMGB23PG*KhbpgRBCvMGB23PG + KkbpgRBCvMGB23PG*kRBC + hRBC*KhbpgRBCvMGB23PG*KkhbpgRBCvMGB23PG*kRBC) KaappRBCvMGF16P2 := (CRBCvMGF16P2*KaRBCvMGF16P2*(hRBC*KhfRBCvMGF16P2*KmghfRBCvMGF16P2 + KRBCvMGF16P2))/(1 + hRBC*KhfRBCvMGF16P2 + hRBC^2*Kh2fRBCvMGF16P2*KhfRBCvMGF16P2 + KkfRBCvMGF16P2*kRBC + hRBC*KhfRBCvMGF16P2*KkhfRBCvMGF16P2*kRBC) K6appRBCvBPGSP4 := (1.758577575029182*K6RBCvBPGSP4)/(1 + 4.786300923226383*^28/10^(4*phRBC)) K1appRBCvAK := K1RBCvAK*(1 + KkadpRBCvAK*kRBC + (KhadpRBCvAK*pHConversionFactor)/10^phRBC) KaappRBCvMGATP := (CRBCvMGATP*KaRBCvMGATP*(hRBC*KhatpRBCvMGATP*KmghatpRBCvMGATP + KRBCvMGATP))/(1 + KkatpRBCvMGATP*kRBC + KhatpRBCvMGATP/(10^phRBC*pHConversionFactor)) KaappRBCvMGG16P2 := (CRBCvMGG16P2*KaRBCvMGG16P2*(hRBC*KhfRBCvMGG16P2*KmghfRBCvMGG16P2 + KRBCvMGG16P2))/(1 + hRBC*KhfRBCvMGG16P2 + hRBC^2*Kh2fRBCvMGG16P2*KhfRBCvMGG16P2 + KkfRBCvMGG16P2*kRBC + hRBC*KhfRBCvMGG16P2*KkhfRBCvMGG16P2*kRBC) K2appRBCvAK := K2RBCvAK*(1 + hRBC*KhampRBCvAK + KkampRBCvAK*kRBC) KaappRBCvMGB13PG := (CRBCvMGB13PG*KaRBCvMGB13PG*(hRBC*KhbpgRBCvMGB13PG*KmghbpgRBCvMGB13PG + KRBCvMGB13PG))/(1 + hRBC*KhbpgRBCvMGB13PG + hRBC^2*Kh2bpgRBCvMGB13PG*KhbpgRBCvMGB13PG + KkbpgRBCvMGB13PG*kRBC + hRBC*KhbpgRBCvMGB13PG*KkhbpgRBCvMGB13PG*kRBC) KaappRBCvMGPHOS := (KaRBCvMGPHOS*(1 + KkphosRBCvMGPHOS*kRBC + 6.30957344480193*^-8*KhphosRBCvMGPHOS*pHConversionFactor))/(1 + hRBC*KhphosRBCvMGPHOS + KkphosRBCvMGPHOS*kRBC) KoRBCvPHOSTRANSPORT := KiRBCvPHOSTRANSPORT/KeqRBCvPHOSTRANSPORT KaappRBCvMGADP := (CRBCvMGADP*KaRBCvMGADP*(hRBC*KhadpRBCvMGADP*KmghadpRBCvMGADP + KRBCvMGADP))/(1 + hRBC*KhadpRBCvMGADP + KkadpRBCvMGADP*kRBC) KiapppyrRBCvLDH := 0.2847472489508012*(1 + 1.584893192461114*^-7*10^phRBC)*KipyrRBCvLDH KcatrappRBCvGAPDH := KcatrRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.1622776601683795*^7/10^phRBC) KmapplacRBCvLDH := 0.7152527510491988*(1 + 6.30957344480193*^6/10^phRBC)*KmlacRBCvLDH KeqRBCvLACTRANSPORT := (1 + 10^(-3.73 + phRBC))/(1 + 10^(-3.73 + phRBC)/RtvRBC) KmappnadhRBCvGAPDH := 6.30957344480193*^-8*10^phRBC*KmnadhRBCvGAPDH KmapppyrRBCvLDH := 0.2847472489508012*(1 + 1.584893192461114*^-7*10^phRBC)*KmpyrRBCvLDH KcatrappRBCvHK := KcatrRBCvHK/(1 + 1.0471285480508985*^7/10^phRBC + 2.8183829312644494*^-10*10^phRBC) HbpHRBC := (1 + (2.5118864315095825*^14*KahbRBC^2)/pHConversionFactor^2 + (3.1697863849222284*^7*KahbRBC)/pHConversionFactor)/(1 + (2*KahbRBC)/hRBC + KahbRBC^2/hRBC^2) KeqRBCvPHOSTRANSPORT := (1 + 10^(-6.75 + phRBC))/(10^(-6.75 + phRBC)/RtvRBC^2 + RtvRBC^(-1)) KcatfappRBCvHK := KcatfRBCvHK/(1 + 1.0471285480508985*^7/10^phRBC + 2.8183829312644494*^-10*10^phRBC) KiapplacRBCvLDH := 0.7152527510491988*(1 + 6.30957344480193*^6/10^phRBC)*KilacRBCvLDH K4appRBCvBPGSP3 := (1.758577575029182*K4RBCvBPGSP3)/(1 + 4.786300923226383*^28/10^(4*phRBC)) KcatfappRBCvGAPDH := KcatfRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.1622776601683795*^7/10^phRBC) atpRBCsum := adpRBC[t] + ampRBC[t] + atpRBC[t] KoRBCvPYRTRANSPORT := KiRBCvPYRTRANSPORT/RtvRBC hRBC := pHConversionFactor/10^phRBC KaappRBCvHBATP := HbpHRBC*KaRBCvHBATP KaappRBCvHBADP := HbpHRBC*KaRBCvHBADP KoRBCvLACTRANSPORT := KiRBCvLACTRANSPORT/KeqRBCvLACTRANSPORT K3appRBCvBPGSP2 := (1.758577575029182*K3RBCvBPGSP2)/(1 + 4.786300923226383*^28/10^(4*phRBC)) KaappRBCvHBBPG := HbpHRBC*KaRBCvHBBPG KiappnadhRBCvGAPDH := 6.30957344480193*^-8*10^phRBC*KinadhRBCvGAPDH KaappRBCvHBMGATP := HbpHRBC*KaRBCvHBMGATP K1appRBCvBPGSP1 := (3.5118864315095824*K1RBCvBPGSP1)/(1 + 1.584893192461114*^-7*10^phRBC) testsum := adpRBC[t] + ampRBC[t] + atpRBC[t] + mgadpRBC[t] + mgatpRBC[t] + mgb13pgRBC[t] + mgb23pgRBC[t] + mgf16p2RBC[t] + mgg16p2RBC[t] + mgphosRBC[t] + mgRBC[t] Kiappb13pgRBCvGAPDH := Kib13pgRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.1622776601683795*^7/10^phRBC) LRBCvPK := (1.584893192461114*^-7*pHConversionFactor*(1 + atpRBC[t]/(KtatpRBCvPK*Vrbc))^4)/(hRBC*(1 + f16p2RBC[t]/(Krf16p2RBCvPK*Vrbc) + g16p2RBC[t]/(Krg16p2RBCvPK*Vrbc))^4*(1 + pepRBC[t]/(KrpepRBCvPK*Vrbc) + pyrRBC[t]/(KrpyrRBCvPK*Vrbc))^4) lacEXT := ConcLacEXT*vBld phosEXT := ConcPhosEXT*vBld pyrEXT := ConcPyrEXT*vBld glcRBC := ConcGlcRBC*Vrbc co2RBC := ConcCo2RBC*Vrbc end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units