begin name
marhl
end name

begin reactions
v1 {0.25}CaER = {1.0}Cacyt
v11 {1.0}CaPr = {1.0}Pr + {1.0}Cacyt
v12 {1.0}Pr + {1.0}Cacyt = {1.0}CaPr
v3 {0.25}CaER = {1.0}Cacyt
v5 {1.0}Cacyt = {0.25}CaER
v7 {0.25}CaM = {1.0}Cacyt
v9 {1.0}Cacyt = {0.25}CaM
end reactions

begin rate equations
v1 = (Cytosol*v1Kch*(CaER[t] - Cacyt[t])*Cacyt[t]^2)/(v1K1^2 + Cacyt[t]^2)
v11 = Cytosol*v11Kminus*CaPr[t]
v12 = Cytosol*v12Kplus*Cacyt[t]*Pr[t]
v3 = Cytosol*v3Kleak*(CaER[t] - Cacyt[t])
v5 = EndoplasmicReticulum*v5Kpump*Cacyt[t]
v7 = Cytosol*CaM[t]*(v7Km + (v7Kout*Cacyt[t]^2)/(v7K3^2 + Cacyt[t]^2))
v9 = (Mitochondria*v9Kin*Cacyt[t]^8)/(v9K2^8 + Cacyt[t]^8)
end rate equations

begin parameters
v1Kch = 4100.0
v1K1 = 5.0
v3Kleak = 0.05
v5Kpump = 20.0
v7Kout = 125.0
v7K3 = 5.0
v7Km = 0.00625
v9Kin = 300.0
v9K2 = 0.8
v11Kminus = 0.01
v12Kplus = 0.1
Cytosol = 1.0
EndoplasmicReticulum = 1.0
Mitochondria = 1.0
end parameters

begin initial conditions
CaER[0] = CaERi
CaM[0] = CaMi
CaPr[0] = CaPri
Cacyt[0] = Cacyti
Pr[0] = Pri
end initial conditions

begin initial values
CaERi = 0.76
CaMi = 0.29
CaPri = 85.45
Cacyti = 0.35
Pri = 34.55
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
v7 http://identifiers.org/go/GO:0006816
v7 http://identifiers.org/go/GO:0007204
end process annotations

begin species annotations
CaER http://identifiers.org/chebi/CHEBI:29108
CaM http://identifiers.org/chebi/CHEBI:29108
Ca_cyt http://identifiers.org/chebi/CHEBI:29108
end species annotations

begin units
end units