begin name ma end name begin reactions v1 {1.0}$EXTERNAL = {1.0}ACA v10 {1.0}incAMP = {1.0}$EXTERNAL v11 {1.0}$EXTERNAL = {1.0}excAMP v12 {1.0}excAMP = {1.0}$EXTERNAL v13 {1.0}$EXTERNAL = {1.0}CAR1 v14 {1.0}CAR1 = {1.0}$EXTERNAL v2 {1.0}ACA = {1.0}$EXTERNAL v3 {1.0}$EXTERNAL = {1.0}PKA v4 {1.0}PKA = {1.0}$EXTERNAL v5 {1.0}$EXTERNAL = {1.0}ERK2 v6 {1.0}ERK2 = {1.0}$EXTERNAL v7 {1.0}$EXTERNAL = {1.0}REGA v8 {1.0}REGA = {1.0}$EXTERNAL v9 {1.0}$EXTERNAL = {1.0}incAMP end reactions begin rate equations v1 = k1*CAR1[t] v10 = k10*incAMP[t]*REGA[t] v11 = k11*ACA[t] v12 = k12*excAMP[t] v13 = k13*excAMP[t] v14 = k14*CAR1[t] v2 = k2*ACA[t]*PKA[t] v3 = k3*incAMP[t] v4 = k4*PKA[t] v5 = k5*CAR1[t] v6 = k6*ERK2[t]*PKA[t] v7 = k7 v8 = k8*ERK2[t]*REGA[t] v9 = k9*ACA[t] end rate equations begin parameters k1 = 2.0 k10 = 0.8 k11 = 0.7 k12 = 4.9 k13 = 23.0 k14 = 4.5 k2 = 0.9 k3 = 2.5 k4 = 1.5 k5 = 0.6 k6 = 0.8 k7 = 1.0 k8 = 1.3 k9 = 0.3 compartment = 1.0 end parameters begin initial conditions ACA[0] = ACAi CAR1[0] = CAR1i ERK2[0] = ERK2i PKA[0] = PKAi REGA[0] = REGAi excAMP[0] = excAMPi incAMP[0] = incAMPi end initial conditions begin initial values ACAi = 3.39 CAR1i = 2.45 ERK2i = 1.13 PKAi = 1.6 REGAi = 0.9 excAMPi = 0.48 incAMPi = 1.2 end initial values begin assignment rules end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations excAMP http://identifiers.org/chebi/CHEBI:17489 excAMP http://identifiers.org/kegg.compound/C000575 end species annotations begin units end units