begin name
levchenko1
end name

begin reactions
Reaction1 {1.0}RAF + {1.0}RAFK = {1.0}RAFRAFK
Reaction10 {1.0}MEKp + {1.0}MEKPH = {1.0}MEKpMEKPH
Reaction11 {1.0}MEKpMEKPH = {1.0}MEKp + {1.0}MEKPH
Reaction12 {1.0}MEKpMEKPH = {1.0}MEK + {1.0}MEKPH
Reaction13 {1.0}MEKp + {1.0}RAFp = {1.0}MEKpRAFp
Reaction14 {1.0}MEKpRAFp = {1.0}MEKp + {1.0}RAFp
Reaction15 {1.0}MEKpRAFp = {1.0}MEKpp + {1.0}RAFp
Reaction16 {1.0}MEKPH + {1.0}MEKpp = {1.0}MEKppMEKPH
Reaction17 {1.0}MEKppMEKPH = {1.0}MEKPH + {1.0}MEKpp
Reaction18 {1.0}MEKppMEKPH = {1.0}MEKp + {1.0}MEKPH
Reaction19 {1.0}MAPK + {1.0}MEKpp = {1.0}MAPKMEKpp
Reaction2 {1.0}RAFRAFK = {1.0}RAF + {1.0}RAFK
Reaction20 {1.0}MAPKMEKpp = {1.0}MAPK + {1.0}MEKpp
Reaction21 {1.0}MAPKMEKpp = {1.0}MAPKp + {1.0}MEKpp
Reaction22 {1.0}MAPKp + {1.0}MAPKPH = {1.0}MAPKpMAPKPH
Reaction23 {1.0}MAPKpMAPKPH = {1.0}MAPKp + {1.0}MAPKPH
Reaction24 {1.0}MAPKpMAPKPH = {1.0}MAPK + {1.0}MAPKPH
Reaction25 {1.0}MAPKp + {1.0}MEKpp = {1.0}MAPKpMEKpp
Reaction26 {1.0}MAPKpMEKpp = {1.0}MAPKp + {1.0}MEKpp
Reaction27 {1.0}MAPKpMEKpp = {1.0}MAPKpp + {1.0}MEKpp
Reaction28 {1.0}MAPKPH + {1.0}MAPKpp = {1.0}MAPKppMAPKPH
Reaction29 {1.0}MAPKppMAPKPH = {1.0}MAPKPH + {1.0}MAPKpp
Reaction3 {1.0}RAFRAFK = {1.0}RAFK + {1.0}RAFp
Reaction30 {1.0}MAPKppMAPKPH = {1.0}MAPKp + {1.0}MAPKPH
Reaction4 {1.0}RAFp + {1.0}RAFPH = {1.0}RAFpRAFPH
Reaction5 {1.0}RAFpRAFPH = {1.0}RAFp + {1.0}RAFPH
Reaction6 {1.0}RAFpRAFPH = {1.0}RAF + {1.0}RAFPH
Reaction7 {1.0}MEK + {1.0}RAFp = {1.0}MEKRAFp
Reaction8 {1.0}MEKRAFp = {1.0}MEK + {1.0}RAFp
Reaction9 {1.0}MEKRAFp = {1.0}MEKp + {1.0}RAFp
end reactions

begin rate equations
Reaction1 = Reaction1a1*RAF[t]*RAFK[t]
Reaction10 = Reaction10a4*MEKp[t]*MEKPH[t]
Reaction11 = Reaction11d4*MEKpMEKPH[t]
Reaction12 = Reaction12k4*MEKpMEKPH[t]
Reaction13 = Reaction13a5*MEKp[t]*RAFp[t]
Reaction14 = Reaction14d5*MEKpRAFp[t]
Reaction15 = Reaction15k5*MEKpRAFp[t]
Reaction16 = Reaction16a6*MEKPH[t]*MEKpp[t]
Reaction17 = Reaction17d6*MEKppMEKPH[t]
Reaction18 = Reaction18k6*MEKppMEKPH[t]
Reaction19 = Reaction19a7*MAPK[t]*MEKpp[t]
Reaction2 = Reaction2d1*RAFRAFK[t]
Reaction20 = Reaction20d7*MAPKMEKpp[t]
Reaction21 = Reaction21k7*MAPKMEKpp[t]
Reaction22 = Reaction22a8*MAPKp[t]*MAPKPH[t]
Reaction23 = Reaction23d8*MAPKpMAPKPH[t]
Reaction24 = Reaction24k8*MAPKpMAPKPH[t]
Reaction25 = Reaction25a9*MAPKp[t]*MEKpp[t]
Reaction26 = Reaction26d9*MAPKpMEKpp[t]
Reaction27 = Reaction27k9*MAPKpMEKpp[t]
Reaction28 = Reaction28a10*MAPKPH[t]*MAPKpp[t]
Reaction29 = Reaction29d10*MAPKppMAPKPH[t]
Reaction3 = Reaction3k1*RAFRAFK[t]
Reaction30 = Reaction30k10*MAPKppMAPKPH[t]
Reaction4 = Reaction4a2*RAFp[t]*RAFPH[t]
Reaction5 = Reaction5d2*RAFpRAFPH[t]
Reaction6 = Reaction6k2*RAFpRAFPH[t]
Reaction7 = Reaction7a3*MEK[t]*RAFp[t]
Reaction8 = Reaction8d3*MEKRAFp[t]
Reaction9 = Reaction9k3*MEKRAFp[t]
end rate equations

begin parameters
Reaction1a1 = 1.0
Reaction2d1 = 0.4
Reaction3k1 = 0.1
Reaction4a2 = 0.5
Reaction5d2 = 0.5
Reaction6k2 = 0.1
Reaction7a3 = 3.3
Reaction8d3 = 0.42
Reaction9k3 = 0.1
Reaction10a4 = 10.0
Reaction11d4 = 0.8
Reaction12k4 = 0.1
Reaction13a5 = 3.3
Reaction14d5 = 0.4
Reaction15k5 = 0.1
Reaction16a6 = 10.0
Reaction17d6 = 0.8
Reaction18k6 = 0.1
Reaction19a7 = 20.0
Reaction20d7 = 0.6
Reaction21k7 = 0.1
Reaction22a8 = 5.0
Reaction23d8 = 0.4
Reaction24k8 = 0.1
Reaction25a9 = 20.0
Reaction26d9 = 0.6
Reaction27k9 = 0.1
Reaction28a10 = 5.0
Reaction29d10 = 0.4
Reaction30k10 = 0.1
Cytoplasm = 1.0
end parameters

begin initial conditions
MAPK[0] = MAPKi
MAPKMEKpp[0] = MAPKMEKppi
MAPKPH[0] = MAPKPHi
MAPKp[0] = MAPKpi
MAPKpMAPKPH[0] = MAPKpMAPKPHi
MAPKpMEKpp[0] = MAPKpMEKppi
MAPKpp[0] = MAPKppi
MAPKppMAPKPH[0] = MAPKppMAPKPHi
MEK[0] = MEKi
MEKPH[0] = MEKPHi
MEKRAFp[0] = MEKRAFpi
MEKp[0] = MEKpi
MEKpMEKPH[0] = MEKpMEKPHi
MEKpRAFp[0] = MEKpRAFpi
MEKpp[0] = MEKppi
MEKppMEKPH[0] = MEKppMEKPHi
RAF[0] = RAFi
RAFK[0] = RAFKi
RAFPH[0] = RAFPHi
RAFRAFK[0] = RAFRAFKi
RAFp[0] = RAFpi
RAFpRAFPH[0] = RAFpRAFPHi
end initial conditions

begin initial values
MAPKi = 0.4
MAPKMEKppi = 0.0
MAPKPHi = 0.3
MAPKpi = 0.0
MAPKpMAPKPHi = 0.0
MAPKpMEKppi = 0.0
MAPKppi = 0.0
MAPKppMAPKPHi = 0.0
MEKi = 0.2
MEKPHi = 0.2
MEKRAFpi = 0.0
MEKpi = 0.0
MEKpMEKPHi = 0.0
MEKpRAFpi = 0.0
MEKppi = 0.0
MEKppMEKPHi = 0.0
RAFi = 0.3
RAFKi = 0.2
RAFPHi = 0.3
RAFRAFKi = 0.0
RAFpi = 0.0
RAFpRAFPHi = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
MAPKPH http://identifiers.org/uniprot/Q90W58
end species annotations

begin units
end units