#lee4



#reactions
r1:
 {1.0}E + {1.0}P = {1.0}E_P_1
  compartment * (k1 * E * P - j1 * E_P_1)
r10:
 {1.0}P2 = {1.0}P21
  compartment * k10 * P2
r11:
 {1.0}E + {1.0}P21 = {1.0}E_P21
  compartment * (k7 * E * P21 - j7 * E_P21)
r12:
 {1.0}E + {1.0}P2 = {1.0}E_P2
  compartment * (k7a * E * P2 - j7a * E_P2)
r13:
 {1.0}E_P21 = {1.0}E + {1.0}T
  compartment * k8 * E_P21
r14:
 {1.0}E_P2 = {1.0}E + {1.0}T
  compartment * k8a * E_P2
r15:
 {1.0}E_P_1 = {1.0}T
  compartment * kC1 * E_P_1
r16:
 {1.0}E_P_2 = {1.0}T
  compartment * kC2 * E_P_2
r2:
 {1.0}E_P_1 = {1.0}E + {1.0}M
  compartment * k2 * E_P_1
r3:
 {1.0}M = {1.0}M1
  compartment * k9 * M
r4:
 {1.0}E + {1.0}M1 = {1.0}E_M1
  compartment * (k3 * E * M1 - j3 * E_M1)
r5:
 {1.0}E + {1.0}M = {1.0}E_M
  compartment * (k3a * E * M - j3a * E_M)
r6:
 {1.0}E_M1 = {1.0}E + {1.0}T
  compartment * k4 * E_M1
r7:
 {1.0}E_M = {1.0}E + {1.0}T
  compartment * k4a * E_M
r8:
 {1.0}E + {1.0}P = {1.0}E_P_2
  compartment * (k5 * E * P - j5 * E_P_2)
r9:
 {1.0}E_P_2 = {1.0}E + {1.0}P2
  compartment * k6 * E_P_2


#parameters
j1 = 33.4
j3 = 1.58e-06
j3a = 0.185
j5 = 21.8
j7 = 4.46e-09
j7a = 2.66e-05
k1 = 91.8
k10 = 7.23e-10
k2 = 82.4
k3 = 38.1
k3a = 151.5
k4 = 38.1
k4a = 209.9
k5 = 5.16
k6 = 32.3
k7 = 6.76e-08
k7a = 4.7
k8 = 0.00599
k8a = 42.6
k9 = 3.12e-08
kC1 = 2.39e-06
kC2 = 0.031
compartment = 1.0


#initial values
E = 0.00015
E_M = 0.0
E_M1 = 0.0
E_P1 = 0.0
E_P2 = 0.0
E_P21 = 0.0
E_P_1 = 0.0
E_P_2 = 0.0
M = 0.0
M1 = 0.0
P = 1.0
P2 = 0.0
P21 = 0.0
T = 0.0


#assignment rules