begin name
kummer1
end name

begin reactions
R1 {1.0}$EXTERNAL = {1.0}a
R2 {1.0}$EXTERNAL = {1.0}a
R3 {1.0}a = {1.0}$EXTERNAL
R4 {1.0}a = {1.0}$EXTERNAL
R5 {1.0}$EXTERNAL = {1.0}b
R6 {1.0}b = {1.0}$EXTERNAL
R7 {1.0}$EXTERNAL = {1.0}c
R8 {1.0}c = {1.0}$EXTERNAL
end reactions

begin rate equations
R1 = compartment*Constantfluxirreversible[R1v]
R2 = compartment*linearactivation[R2constant, a[t]]
R3 = compartment*IrrMichaelisMentenenzymeuserdefined[R3V, b[t], a[t], R3Km]
R4 = compartment*IrrMichaelisMentenenzymeuserdefined[R4V, c[t], a[t], R4Km]
R5 = compartment*linearactivation[R5constant, a[t]]
R6 = compartment*HenriMichaelisMentenirreversible[b[t], R6Km, R6V]
R7 = compartment*linearactivation[R7constant, a[t]]
R8 = compartment*HenriMichaelisMentenirreversible[c[t], R8Km, R8V]
end rate equations

begin parameters
R1v = 0.212
R2constant = 2.9
R3V = 1.52
R3Km = 0.19
R4V = 4.88
R4Km = 1.18
R5constant = 1.24
R6Km = 29.09
R6V = 32.24
R7constant = 13.58
R8Km = 0.16
R8V = 153.0
compartment = "1e-13"
end parameters

begin initial conditions
a[0] = ai
b[0] = bi
c[0] = ci
end initial conditions

begin initial values
ai = 0.01
bi = 0.01
ci = 0.01
end initial values

begin assignment rules
end assignment rules

begin function definitions
Constantfluxirreversible[v_] := v
HenriMichaelisMentenirreversible[substrate_,Km_,V_] := (substrate*V)/(Km + substrate)
linearactivation[constant_,Activator_] := Activator*constant
IrrMichaelisMentenenzymeuserdefined[V_,E_,S_,Km_] := (E*S*V)/(Km + S)
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units