begin name
kim2
end name

begin reactions
R1 {1.0}X1 = {1.0}X2
R10 {1.0}X9 = {1.0}X3 + {1.0}X10
R11 {1.0}X10 = {1.0}$EXTERNAL
R12 {1.0}$EXTERNAL = {1.0}X11
R13 {1.0}X11 = {1.0}$EXTERNAL
R14 {1.0}$EXTERNAL = {1.0}X12
R15 {1.0}X12 = {1.0}$EXTERNAL
R16 {1.0}X13 + {1.0}X11 = {1.0}X14
R17 {1.0}X11 + {1.0}X7 = {1.0}X15
R18 {1.0}X16 = {1.0}X17
R19 {1.0}X17 = {1.0}X16
R2 {1.0}X2 = {1.0}X1
R20 {1.0}X18 = {1.0}X19
R21 {1.0}X19 = {1.0}X18
R22 {1.0}X20 = {1.0}X21
R23 {1.0}X21 = {1.0}X20
R24 {1.0}X22 = {1.0}X23
R25 {1.0}X23 = {1.0}X22
R26 {1.0}X24 = {1.0}X18 + {1.0}X26
R27 {1.0}X18 + {1.0}X25 = {1.0}X24
R28 {1.0}X26 = {1.0}X25
R29 {1.0}$EXTERNAL = {1.0}X27
R3 {1.0}X4 = {1.0}X6 + {1.0}X5
R30 {1.0}X27 = {1.0}$EXTERNAL
R31 {1.0}X18 = {1.0}X19
R32 {1.0}X5 = {1.0}X28
R33 {1.0}X28 = {1.0}X5
R4 {1.0}X4 = {1.0}X3
R5 {1.0}X3 = {1.0}X4
R6 {1.0}X6 + {1.0}X5 = {1.0}X4
R7 {1.0}X12 + {1.0}X7 = {1.0}X6
R8 {1.0}X11 + {1.0}X3 = {1.0}X8
R9 {1.0}X8 = {1.0}X9
end reactions

begin rate equations
R1 = cytoplasm*k1*W*X1[t]
R10 = cytoplasm*k10*X9[t]
R11 = cytoplasm*k11*X10[t]
R12 = cytoplasm*V12
R13 = k13*nucleus*X11[t]
R14 = nucleus*(k14 + k21*(X11[t] + X14[t]))
R15 = cytoplasm*k15*X12[t]
R16 = nucleus*(kplus16*X11[t]*X13[t] - kminus16*X14[t])
R17 = cytoplasm*(-(kminus17*X15[t]) + kplus17*X11[t]*X7[t])
R18 = (cytoplasm*Ki*Vmax1*W*X16[t])/((Km1 + X16[t])*(Ki + X23[t]))
R19 = (cytoplasm*Vmax2*X17[t])/(Km2 + X17[t])
R2 = cytoplasm*k2*X2[t]
R20 = (cytoplasm*kcat1*X17[t]*X18[t])/(Km3 + X18[t])
R21 = (cytoplasm*Vmax3*X19[t])/(Km4 + X19[t])
R22 = (cytoplasm*kcat2*X19[t]*X20[t])/(Km5 + X20[t])
R23 = (cytoplasm*Vmax4*X21[t])/(Km6 + X21[t])
R24 = (cytoplasm*kcat3*X21[t]*X22[t])/(Km7 + X22[t])
R25 = (cytoplasm*Vmax5*X23[t])/(Km8 + X23[t])
R26 = (cytoplasm*kcat4*X23[t]*X24[t])/(Km9 + X24[t])
R27 = cytoplasm*(-(k19*X24[t]) + k18*X18[t]*X25[t])
R28 = (cytoplasm*Vmax6*X26[t])/(Km10 + X26[t])
R29 = (cytoplasm*kcat5*X14[t]^n1)/(Km11^n1 + X14[t]^n1)
R3 = cytoplasm*k3*X2[t]*X4[t]
R30 = cytoplasm*k20*X27[t]
R31 = (cytoplasm*kcat6*X18[t]*X27[t])/(Km12 + X18[t])
R32 = (cytoplasm*kcat7*X23[t]*X5[t])/(Km13 + X5[t])
R33 = (cytoplasm*Vmax7*X28[t])/(Km14 + X28[t])
R4 = cytoplasm*k4*X4[t]
R5 = cytoplasm*k5*X3[t]
R6 = cytoplasm*(-(kminus6*X4[t]) + kplus6*X5[t]*X6[t])
R7 = cytoplasm*(-(kminus7*X6[t]) + kplus7*X12[t]*X7[t])
R8 = cytoplasm*(kplus8*X11[t]*X3[t] - kminus8*X8[t])
R9 = cytoplasm*k9*X8[t]
end rate equations

begin parameters
Ki = 9.0
Km1 = 10.0
Km10 = 12.0
Km11 = 15.0
Km12 = 15.0
Km13 = 15.0
Km14 = 15.0
Km2 = 8.0
Km3 = 15.0
Km4 = 15.0
Km5 = 15.0
Km6 = 15.0
Km7 = 15.0
Km8 = 15.0
Km9 = 9.0
V12 = 0.423
Vmax1 = 150.0
Vmax2 = 15.0
Vmax3 = 45.0
Vmax4 = 45.0
Vmax5 = 45.0
Vmax6 = 45.0
Vmax7 = 45.0
W = 0.0
flagforwntsignal = 0.0
k1 = 0.182
k10 = 206.0
k11 = 0.417
k13 = 0.000257
k14 = "8.22e-05"
k15 = 0.167
k18 = 0.15
k19 = 39.0
k2 = 0.0182
k20 = 0.015
k21 = "1e-06"
k3 = 0.05
k4 = 0.267
k5 = 0.133
k9 = 206.0
kminus16 = 30.0
kminus17 = 1200.0
kminus6 = 0.909
kminus7 = 50.0
kminus8 = 120.0
kplus16 = 1.0
kplus17 = 1.0
kplus6 = 0.0909
kplus7 = 1.0
kplus8 = 1.0
kcat1 = 1.5
kcat2 = 1.5
kcat3 = 1.5
kcat4 = 1.5
kcat5 = 0.6
kcat6 = 1.5
kcat7 = 1.5
n1 = 2.0
cytoplasm = 1.0
nucleus = 1.0
end parameters

begin initial conditions
X1[0] = X1i
X10[0] = X10i
X11[0] = X11i
X12[0] = X12i
X13[0] = X13i
X14[0] = X14i
X15[0] = X15i
X16[0] = X16i
X17[0] = X17i
X18[0] = X18i
X19[0] = X19i
X2[0] = X2i
X20[0] = X20i
X21[0] = X21i
X22[0] = X22i
X23[0] = X23i
X24[0] = X24i
X25[0] = X25i
X26[0] = X26i
X27[0] = X27i
X28[0] = X28i
X3[0] = X3i
X4[0] = X4i
X5[0] = X5i
X6[0] = X6i
X7[0] = X7i
X8[0] = X8i
X9[0] = X9i
end initial conditions

begin initial values
X1i = 100.0
X10i = 0.9881
X11i = 42.7224
X12i = 0.0008
X13i = 6.1879
X14i = 8.8121
X15i = 3.4392
X16i = 200.0
X17i = 0.0
X18i = 112.5585
X19i = 6.486
X2i = 0.0
X20i = 296.1137
X21i = 3.8863
X22i = 297.8897
X23i = 2.1103
X24i = 180.9595
X25i = 418.1788
X26i = 0.8619
X27i = 10.263
X28i = 0.85544
X3i = 0.0153
X4i = 0.0076
X5i = 49.1372
X6i = 0.0015
X7i = 96.6019
X8i = 0.002
X9i = 0.002
end initial values

begin assignment rules
X13X14 := X13[t] + X14[t]
end assignment rules

begin function definitions
end function definitions

begin events
event_0000001 = (t >= 500 && t <= 1000, {W -> 1}, 0)
event_0000002 = (t > 1000, {W -> 0}, 0)
end events

begin process annotations
R18 http://identifiers.org/go/GO:0032856
R22 http://identifiers.org/ec-code/2.7.11.1
R22 http://identifiers.org/go/GO:0004709
R22 http://identifiers.org/go/GO:0000186
R32 http://identifiers.org/ec-code/2.7.11.24
R32 http://identifiers.org/go/GO:0004707
R32 http://identifiers.org/go/GO:0016310
R8 http://identifiers.org/go/GO:0008013
R9 http://identifiers.org/ec-code/2.7.11.26
R9 http://identifiers.org/go/GO:0004674
end process annotations

begin species annotations
end species annotations

begin units
end units