#keizer1



#reactions
Closed_State_2:
 {1.0}Po1 = {1.0}Pc2
  kc_plus * Po1 - kc_minus * Pc2
Closed_state_1:
 {1.0}Po1 = {1.0}Pc1
  ka_minus * Po1 - ka_plus * pow(Ca, n) * Pc1
Open_state_2:
 {1.0}Po1 = {1.0}Po2
  kb_plus * pow(Ca, m) * Po1 - kb_minus * Po2


#parameters
Closed_state_1_ka_minus = 28.8
Closed_state_1_ka_plus = 1500.0
Closed_state_1_Ca = 0.9
Closed_state_1_n = 4.0
Open_state_2_kb_plus = 1500.0
Open_state_2_Ca = 0.9
Open_state_2_m = 3.0
Open_state_2_kb_minus = 385.9
Closed_State_2_kc_plus = 1.75
Closed_State_2_kc_minus = 0.1
compartment = 1.0


#initial values
Pc1 = 0.963
Pc2 = 0.037
Po1 = 0.0
Po2 = 0.0


#assignment rules
!F Open_probability = Po1 + Po2