#ibrahim1



#reactions
R1:
 {1.0}Mad1_CMad2 + {1.0}OMad2 = {1.0}Mad1_CMad2_OMad2
  Cytoplasm * (u * k1f * Mad1_CMad2 * OMad2 - k1r * Mad1_CMad2_OMad2)
R2:
 {1.0}Mad1_CMad2_OMad2 + {1.0}Cdc20 = {1.0}Mad1_CMad2 + {1.0}Cdc20_CMad2
  u * k2f * Mad1_CMad2_OMad2 * Cytoplasm * Cdc20
R3:
 {1.0}Cdc20_CMad2 = {1.0}Cdc20 + {1.0}OMad2
  k3f * Cdc20_CMad2 * Cytoplasm
R4:
 {1.0}Cdc20_CMad2 + {1.0}Bub3_BubR1 = {1.0}MCC
  Cytoplasm * (u * k4f * Cdc20_CMad2 * Bub3_BubR1 - k4r * MCC)
R5:
 {1.0}Bub3_BubR1 + {1.0}Cdc20 = {1.0}Bub3_BubR1_Cdc20
  Cytoplasm * (u * k5f * Bub3_BubR1 * Cdc20 - k5r * Bub3_BubR1_Cdc20)
R6:
 {1.0}OMad2 + {1.0}Cdc20 = {1.0}Cdc20_CMad2
  kf6 * OMad2 * Cdc20 * Cytoplasm
R7:
 {1.0}MCC + {1.0}APC = {1.0}MCC_APC
  u * k7f * MCC * APC * Cytoplasm
R7a:
 {1.0}MCC_APC = {1.0}MCC + {1.0}APC
  u_prime * k7r * MCC_APC * Cytoplasm
R8:
 {1.0}APC + {1.0}Cdc20 = {1.0}APC_Cdc20
  Cytoplasm * (k8f * APC * Cdc20 - k8r * APC_Cdc20)


#parameters
const_val_0 = 0.0
const_val_1 = 1.0
k1f = 200000.0
k1r = 0.2
k2f = 100000000.0
k3f = 0.01
k4f = 10000000.0
k4r = 0.02
k5f = 10000.0
k5r = 0.2
k7f = 100000000.0
k7r = 0.08
k8f = 5000000.0
k8r = 0.08
kf6 = 1000.0
u = 1.0
u_prime = 0.0
Cytoplasm = 1.0


#initial values
APC = 9e-08
APC_Cdc20 = 0.0
Bub3_BubR1 = 1.27e-07
Bub3_BubR1_Cdc20 = 0.0
Cdc20 = 2.2e-07
Cdc20_CMad2 = 0.0
MCC = 0.0
MCC_APC = 0.0
Mad1_CMad2 = 5e-08
Mad1_CMad2_OMad2 = 0.0
OMad2 = 1.3e-07


#assignment rules