#hynne

FIX: CNX0 GlcX0 P

#reactions
v_1:
 {1.0}GlcX0 = {1.0}GlcX
  k0*(GlcX0-GlcX)
v_10:
 {1.0}PEP + {1.0}ADP = {1.0}Pyr + {1.0}ATP
  V10m*ADP*PEP/((K10PEP+PEP)*(K10ADP+ADP))
v_11:
 {1.0}Pyr = {1.0}ACA
  V11m*Pyr/(K11+Pyr)
v_12:
 {1.0}ACA + {1.0}NADH = {1.0}EtOH + {1.0}NAD
  V12m*ACA*NADH/((K12NADH+NADH)*(K12ACA+ACA))
v_13:
 {59.0}EtOH = {1.0}EtOHX
  k13/Yvol*(EtOH-EtOHX)
v_14:
 {1.0}EtOHX = {1.0}P
  k0*EtOHX
v_15:
 {1.0}DHAP + {1.0}NADH = {1.0}Glyc + {1.0}NAD
  V15m*DHAP/(K15DHAP*(1+(K15INADH/NADH)*(1+(NAD/K15INAD)))+DHAP*(1+(K15NADH/NADH)*(1+(NAD/K15INAD))))
v_16:
 {59.0}Glyc = {1.0}GlycX
  k16/Yvol*(Glyc-GlycX)
v_17:
 {1.0}GlycX = {1.0}P
  k0*GlycX
v_18:
 {59.0}ACA = {1.0}ACAX
  k18/Yvol*(ACA-ACAX)
v_19:
 {1.0}ACAX = {1.0}P
  k0*ACAX
v_2:
 {1.0}GlcX = {59.0}Glc
  V2f/Yvol*((GlcX/K2Glc)/(1+(GlcX/K2Glc)+((P2*(GlcX/K2Glc)+1)/(P2*(Glc/K2Glc)+1)*(1+(Glc/K2Glc)+(G6P/K2IG6P)+(Glc*G6P/(K2Glc*K2IIG6P))))))- V2r/Yvol*((Glc/K2Glc)/(1+(Glc/K2Glc)+((P2*(Glc/K2Glc)+1)/(P2*(GlcX/K2Glc)+1)*(1+(GlcX/K2Glc))+(G6P/K2IG6P)+(Glc*G6P/(K2Glc*K2IIG6P)))))
v_20:
 {1.0}ACAX + {1.0}CNX = {1.0}P
  k20*ACAX*CNX
v_21:
 {1.0}CNX0 = {1.0}CNX
  k0*(CNX0-CNX)
v_22:
 {1.0}ATP + {1.0}G6P = {1.0}ADP
  k22*ATP*G6P
v_23:
 {1.0}ATP = {1.0}ADP
  k23*ATP
v_24:
 {1.0}AMP + {1.0}ATP = {2.0}ADP
  k24f*AMP*ATP-k24r*ADP**2
v_3:
 {1.0}Glc + {1.0}ATP = {1.0}G6P + {1.0}ADP
  V3m*ATP*Glc/(K3DGlc*K3ATP+K3Glc*ATP+K3ATP*Glc+Glc*ATP)
v_4:
 {1.0}G6P = {1.0}F6P
  V4f*G6P/(K4G6P+G6P+(K4G6P/K4F6P)*F6P)-V4r*(F6P/K4eq)/(K4G6P+G6P+(K4G6P/K4F6P)*F6P)
v_5:
 {1.0}F6P + {1.0}ATP = {1.0}FBP + {1.0}ADP
  V5m*(F6P**2)/(K5*(1+kappa5*(ATP/AMP)*(ATP/AMP))+F6P**2)
v_6:
 {1.0}FBP = {1.0}GAP + {1.0}DHAP
  V6f*FBP/(K6FBP+FBP+GAP*K6DHAP*V6f/(K6eq*V6f*ratio6)+DHAP*K6GAP*V6f/(K6eq*V6f*ratio6)+FBP*GAP/K6IGAP+GAP*DHAP*V6f/(K6eq*V6f*ratio6))-(V6f*GAP*DHAP/K6eq)/(K6FBP+FBP+GAP*K6DHAP*V6f/(K6eq*V6f*ratio6)+DHAP*K6GAP*V6f/(K6eq*V6f*ratio6)+FBP*GAP/K6IGAP+GAP*DHAP*V6f/(K6eq*V6f*ratio6))
v_7:
 {1.0}DHAP = {1.0}GAP
  V7f*DHAP/(K7DHAP+DHAP+(K7DHAP/K7GAP)*GAP)-V7r*(GAP/K7eq)/(K7DHAP+DHAP+(K7DHAP/K7GAP)*GAP)
v_8:
 {1.0}GAP + {1.0}NAD = {1.0}BPG + {1.0}NADH
  V8f*GAP*NAD/K8GAP/K8NAD/((1+GAP/K8GAP+BPG/K8BPG)*(1+NAD/K8NAD+NADH/K8NADH))-V8r*BPG*NADH/K8eq/K8GAP/K8NAD/((1+GAP/K8GAP+BPG/K8BPG)*(1+NAD/K8NAD+NADH/K8NADH))
v_9:
 {1.0}BPG + {1.0}ADP = {1.0}PEP + {1.0}ATP
  k9f*(BPG*ADP) - k9r*(PEP*ATP)


#parameters
Atot = 3.93
K10ADP = 0.17
K10PEP = 0.2
K11 = 0.3
K12ACA = 0.71
K12NADH = 0.1
K15DHAP = 25.0
K15INAD = 0.13
K15INADH = 0.034
K15NADH = 0.13
K2Glc = 1.7
K2IG6P = 1.2
K2IIG6P = 7.2
K3ATP = 0.1
K3DGlc = 0.37
K3Glc = 0.0
K4F6P = 0.15
K4G6P = 0.8
K4eq = 0.13
K5 = 0.021
K6DHAP = 2.0
K6FBP = 0.3
K6GAP = 4.0
K6IGAP = 10.0
K6eq = 0.081
K7DHAP = 1.23
K7GAP = 1.27
K7eq = 0.055
K8BPG = 0.01
K8GAP = 0.6
K8NAD = 0.1
K8NADH = 0.06
K8eq = 0.0055
Ntot = 0.98
P2 = 1.0
V10m = 343.096
V11m = 53.1328
V12m = 89.8023
V15m = 81.4797
V2f = 1014.96
V2r = 1014.96
V3m = 51.7547
V4f = 496.042
V4r = 496.042
V5m = 45.4327
V6f = 2207.82
V7f = 116.365
V7r = 116.365
V8f = 833.858
V8r = 833.858
Yvol = 59.0
k0 = 0.048
k13 = 16.72
k16 = 1.9
k18 = 24.7
k20 = 0.00283828
k22 = 2.25932
k23 = 3.2076
k24f = 432.9
k24r = 133.333
k9f = 443866.0
k9r = 1528.62
kappa5 = 0.15
ratio6 = 5.0
CNX0 = 5.6
GlcX0 = 18.5
P = 0.0
default_compartment = 1.0


#initial values
ACA = 1.48153
ACAX = 1.28836
ADP = 1.5
AMP = 0.33
ATP = 2.1
BPG = 0.00027
CNX = 5.20358
DHAP = 2.95
EtOH = 19.2379
EtOHX = 16.4514
F6P = 0.49
FBP = 4.64
G6P = 4.2
GAP = 0.115
Glc = 0.573074
GlcX = 1.55307
Glyc = 4.196
GlycX = 1.68478
NAD = 0.65
NADH = 0.33
PEP = 0.04
Pyr = 8.7


#assignment rules