begin name
gorlich1
end name

begin reactions
Cytoplasmictransfer {1.0}RanGTPnuc = {1.0}RanGTPcy
GDPdissociation {1.0}RCC1RanGDP = {1.0}RCC1Ran + {1.0}$GDP
GTPbinding {1.0}RCC1Ran + {1.0}$GTP = {1.0}RCC1RanGTP
Nucleoplasmictransfer {1.0}RanGDPnuc = {1.0}RanGDPcy
RCC1binding {1.0}RanGDPnuc + {1.0}RCC1 = {1.0}RCC1RanGDP
RanBP1RanGDP {1.0}RanGTPRanBP1 = {1.0}RanGDPcy + {1.0}RanBP1
RanGAPRanGDP {1.0}RanGTPcy = {1.0}RanGDPcy
RanGTPbinding {1.0}RanGTPcy + {1.0}RanBP1 = {1.0}RanGTPRanBP1
RanGTPrelease {1.0}RCC1RanGTP = {1.0}RanGTPnuc + {1.0}RCC1
end reactions

begin rate equations
Cytoplasmictransfer = CytoplasmictransferkpermRanGTP*nucleus*(-RanGTPcy[t] + RanGTPnuc[t])
GDPdissociation = nucleus*(-(GDP*GDPdissociationr7*RCC1Ran[t]) + GDPdissociationr2*RCC1RanGDP[t])
GTPbinding = nucleus*(GTP*GTPbindingr3*RCC1Ran[t] - GTPbindingr6*RCC1RanGTP[t])
Nucleoplasmictransfer = NucleoplasmictransferkpermRanGDP*nucleus*(-RanGDPcy[t] + RanGDPnuc[t])
RCC1binding = nucleus*(RCC1bindingr1*RanGDPnuc[t]*RCC1[t] - RCC1bindingr8*RCC1RanGDP[t])
RanBP1RanGDP = (cytoplasm*RanBP1RanGDPkcat*RanGAP[t]*RanGTPRanBP1[t])/(RanBP1RanGDPKm + RanGTPRanBP1[t])
RanGAPRanGDP = (cytoplasm*RanGAPRanGDPkcatGAP*RanGAP[t]*RanGTPcy[t])/(RanGAPRanGDPKmGAP + RanGTPcy[t])
RanGTPbinding = cytoplasm*(RanGTPbindingkon*RanBP1[t]*RanGTPcy[t] - RanGTPbindingkoff*RanGTPRanBP1[t])
RanGTPrelease = nucleus*(-(RanGTPreleaser5*RanGTPnuc[t]*RCC1[t]) + RanGTPreleaser4*RCC1RanGTP[t])
end rate equations

begin parameters
GDP = 1.6
GTP = 500.0
RCC1bindingr1 = 74.0
RCC1bindingr8 = 55.0
GDPdissociationr2 = 21.0
GDPdissociationr7 = 11.0
GTPbindingr3 = 0.6
GTPbindingr6 = 19.0
RanGTPreleaser4 = 55.0
RanGTPreleaser5 = 100.0
CytoplasmictransferkpermRanGTP = 0.03
NucleoplasmictransferkpermRanGDP = 0.12
RanGTPbindingkon = 0.3
RanGTPbindingkoff = 0.0004
RanBP1RanGDPkcat = 10.8
RanBP1RanGDPKm = 0.1
RanGAPRanGDPkcatGAP = 10.6
RanGAPRanGDPKmGAP = 0.7
cytoplasm = "1.8e-11"
nucleus = "1.2e-11"
end parameters

begin initial conditions
RCC1[0] = RCC1i
RCC1Ran[0] = RCC1Rani
RCC1RanGDP[0] = RCC1RanGDPi
RCC1RanGTP[0] = RCC1RanGTPi
RanBP1[0] = RanBP1i
RanGAP[0] = RanGAPi
RanGDPcy[0] = RanGDPcyi
RanGDPnuc[0] = RanGDPnuci
RanGTPRanBP1[0] = RanGTPRanBP1i
RanGTPcy[0] = RanGTPcyi
RanGTPnuc[0] = RanGTPnuci
end initial conditions

begin initial values
RCC1i = 0.7
RCC1Rani = 0.0
RCC1RanGDPi = 0.0
RCC1RanGTPi = 0.0
RanBP1i = 2.0
RanGAPi = 0.7
RanGDPcyi = 5.0
RanGDPnuci = 0.0
RanGTPRanBP1i = 0.0
RanGTPcyi = 0.0
RanGTPnuci = 0.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
GDP http://identifiers.org/chebi/CHEBI:17552
GDP http://identifiers.org/kegg.compound/C00035
GTP http://identifiers.org/chebi/CHEBI:15996
GTP http://identifiers.org/kegg.compound/C00044
end species annotations

begin units
end units