#galazzo1

FIX: Carbo EtOH Glco Gly X

#reactions
v_1:
 {1.0}Glco = {1.0}Glci
  Vm1 - Ki1G6P * G6P
v_2:
 {1.0}Glci + {1.0}ATP = {1.0}G6P
  Vm2/(1 + Km2Glc/Glci + Km2ATP/ATP + (Ks2Glc*Km2ATP)/(Glci*ATP))
v_3:
 {1.0}G6P + {1.0}ATP = {1.0}Carbo
  (1.1*Vm3*G6P**n3/(K3Gly**n3 + G6P**n3))/(1 + Km30/0.7*(1 + Km3G6P/G6P))
v_4:
 {1.0}G6P + {1.0}ATP = {1.0}FDP
  (Vm4*g4R*0.3*G6P/K4F6P*ATP/K4ATP*(1 + 0.3*G6P/K4F6P + ATP/K4ATP + g4R*0.3*G6P/K4F6P*ATP/K4ATP))/((1 + 0.3*G6P/K4F6P + ATP/K4ATP + g4R*0.3*G6P/K4F6P*ATP/K4ATP)**2 + L40*((1 + c4AMP*(3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP**2)**0.5))/K4AMP)/(1 + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP**2)**0.5))/K4AMP ))**2*(1 + c4F6P*0.3*G6P/K4F6P + c4ATP*ATP/K4ATP + gT*c4F6P*0.3*G6P/K4F6P*c4ATP*ATP/K4ATP)**2)
v_5:
 {0.5}FDP = {1.0}Gly
  Vm7 * PEP / K6PEP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP * (g6R * (1 + PEP / K6PEP + 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6R * PEP / K6PEP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP) + q6 * L60 * ((1 + c6FDP * FDP / K6FDP) / (1 + FDP / K6FDP))**2 * g6T * c6PEP * PEP / K6PEP * c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP * (1 + c6PEP * PEP / K6PEP + c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6T * c6PEP * PEP / K6PEP * c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP)) / ((1 + 9.55 * 10**-9 / h6) * ((1 + PEP / K6PEP + 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6R * PEP / K6PEP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP)**2 + L60 * ((1 + c6FDP * FDP / K6FDP) / (1 + FDP / K6FDP))**2 * (1 + c6PEP * PEP / K6PEP + c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6T * c6PEP * PEP / K6PEP * c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP)**2))
v_6:
 {1.0}FDP = {2.0}PEP + {2.0}ATP
  Vm5/((1 + K5G3P/(0.01*FDP)) + (K5NAD/NAD + K5G3P*K5NAD /(NAD*0.01*FDP) + K5G3P*K5NAD*NADH/(NAD*0.01*FDP*K5NADH))*(1 + (0.5*(-ATP + (12*ATP - 3*ATP**2)**0.5))/K5ADP + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP**2)**0.5))/K5AMP + ATP/K5ATP))
v_7:
 {1.0}PEP = {1.0}EtOH + {1.0}ATP
  Vm6 * PEP / K6PEP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP * (g6R * (1 + PEP / K6PEP + 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6R * PEP / K6PEP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP) + q6 * L60 * ((1 + c6FDP * FDP / K6FDP) / (1 + FDP / K6FDP))**2 * g6T * c6PEP * PEP / K6PEP * c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP * (1 + c6PEP * PEP / K6PEP + c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6T * c6PEP * PEP / K6PEP * c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP)) / ((1 + 9.55 * 10**-9 / h6) * ((1 + PEP / K6PEP + 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6R * PEP / K6PEP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP)**2 + L60 * ((1 + c6FDP * FDP / K6FDP) / (1 + FDP / K6FDP))**2 * (1 + c6PEP * PEP / K6PEP + c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP + g6T * c6PEP * PEP / K6PEP * c6ADP * 0.5 * (-ATP + (12 * ATP - 3 * ATP**2)**0.5) / K6ADP)**2))
v_8:
 {1.0}ATP = {1.0}X
  Vm8*ATP


#parameters
K3Gly = 2.0
K4AMP = 0.025
K4ATP = 0.06
K4F6P = 1.0
K5ADP = 1.5
K5AMP = 1.1
K5ATP = 2.5
K5G3P = 0.0025
K5NAD = 0.18
K5NADH = 0.0003
K6ADP = 5.0
K6FDP = 0.2
K6PEP = 0.00793966
Ki1G6P = 3.7
Km2ATP = 0.1
Km2Glc = 0.11
Km30 = 1.0
Km3G6P = 1.1
Ks2Glc = 0.0062
L40 = 3342.0
L60 = 164.084
NAD = 1.91939
NADH = 0.0806142
Vm1 = 19.7
Vm2 = 68.5
Vm3 = 14.31
Vm4 = 31.7
Vm5 = 49.9
Vm6 = 3440.0
Vm7 = 203.0
Vm8 = 25.1
c4AMP = 0.019
c4ATP = 1.0
c4F6P = 0.0005
c6ADP = 1.0
c6FDP = 0.01
c6PEP = 0.000158793
g4R = 10.0
g6R = 0.1
g6T = 1.0
gT = 1.0
h6 = 1.14815e-07
n3 = 8.25
q6 = 1.0
Carbo = 0.0
EtOH = 0.0
Glco = 1.0
Gly = 0.0
X = 0.0
default_compartment = 1.0


#initial values
ATP = 1.1278
FDP = 9.144
G6P = 1.011
Glci = 0.0345
PEP = 0.0095


#assignment rules