begin name
fuss1
end name

begin reactions
CSKtranslocation {1.0}CSKcytoplasm + {1.0}CbpP = {1.0}CbpPCSK
Cbpphosphorylation {1.0}Cbp = {1.0}CbpP
PTPphosphorylation {1.0}PTP = {1.0}PTPpY789
v1 {1.0}srci = {1.0}srco
v2 {1.0}srco = {1.0}srca
v3 {1.0}srca = {1.0}srcc
v4 {1.0}srcc = {1.0}srci
end reactions

begin rate equations
CSKtranslocation = default*(-(kCSKoff*CbpPCSK[t]) + kCSKon*CbpP[t]*CSKcytoplasm[t])
Cbpphosphorylation = default*kCbp*srcactivity*Cbp[t]
PTPphosphorylation = default*((p3 + kPTP*srcactivity)*PTP[t] - p2*PTPpY789[t])
v1 = default*(k2*ptpactivity*srci[t] - k1*CbpPCSK[t]*srco[t])
v2 = default*(-(p1*srca[t]) + k3*srcactivity*srco[t])
v3 = default*(k1*CbpPCSK[t]*srca[t] - k2*ptpactivity*srcc[t])
v4 = default*k4*p1*srcc[t]
end rate equations

begin parameters
Kser = 1.0
PTPbackground = 0.0
acsk0 = 0.0
k1 = 1.0
k2 = 0.8
k3 = 1.0
k4 = 10.0
kCSKoff = 0.01
kCSKon = 0.1
kCbp = 1.0
kPTP = 1.0
p1 = 0.05
p2 = 0.15
p3 = 0.035
rhosrca = 1.0
rhosrcc = 1.0
rhosrco = 0.0
srcbackground = 0.0001
default = 1.0
end parameters

begin initial conditions
CSKcytoplasm[0] = CSKcytoplasmi
Cbp[0] = Cbpi
CbpP[0] = CbpPi
CbpPCSK[0] = CbpPCSKi
PTP[0] = PTPi
PTPpY789[0] = PTPpY789i
srca[0] = srcai
srcc[0] = srcci
srci[0] = srcii
srco[0] = srcoi
end initial conditions

begin initial values
CSKcytoplasmi = 1.0
Cbpi = 1.0
CbpPi = 0.0
CbpPCSKi = 0.0
PTPi = 1.0
PTPpY789i = 0.0
srcai = 0.0
srcci = 0.0
srcii = 1.0
srcoi = 0.0
end initial values

begin assignment rules
ptpactivity := PTPbackground + Kser*PTPpY789[t]
srcactivity := srcbackground + rhosrca*srca[t] + rhosrcc*srcc[t] + rhosrco*srco[t]
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
CSK_cytoplasm http://identifiers.org/uniprot/P41240
end species annotations

begin units
end units