(* Generated by JWS Online *) (* This is an experimental feature of JWS Online. Please report any mistakes.*) (* Note that the following notable SBML entities or features are not supported in notebook outputyet: *) (* Events *) (* Constraints *) (* Units and UnitDefinitions *) (* AlgebraicRules *) (* conversionFactors *) variables = { AMP[t], CDK5[t], CK1[t], CK1P[t], CK1P\[LetterSpace]PP2B[t], Ca[t], D[t], D137[t], D137\[LetterSpace]CDK5[t], D137\[LetterSpace]PKA[t], D137\[LetterSpace]PP2C[t], D34[t], D34\[LetterSpace]137[t], D34\[LetterSpace]137\[LetterSpace]CDK5[t], D34\[LetterSpace]137\[LetterSpace]PP2B[t], D34\[LetterSpace]137\[LetterSpace]PP2C[t], D34\[LetterSpace]75[t], D34\[LetterSpace]75\[LetterSpace]137[t], D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2A[t], D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2ACa[t], D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2AP[t], D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2APCa[t], D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2B[t], D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2C[t], D34\[LetterSpace]75\[LetterSpace]CK1[t], D34\[LetterSpace]75\[LetterSpace]PP2A[t], D34\[LetterSpace]75\[LetterSpace]PP2ACa[t], D34\[LetterSpace]75\[LetterSpace]PP2AP[t], D34\[LetterSpace]75\[LetterSpace]PP2APCa[t], D34\[LetterSpace]75\[LetterSpace]PP2B[t], D34\[LetterSpace]CDK5[t], D34\[LetterSpace]CK1[t], D34\[LetterSpace]PP2B[t], D75[t], D75CK1[t], D75\[LetterSpace]137[t], D75\[LetterSpace]137\[LetterSpace]PKA[t], D75\[LetterSpace]137\[LetterSpace]PP2A[t], D75\[LetterSpace]137\[LetterSpace]PP2ACa[t], D75\[LetterSpace]137\[LetterSpace]PP2AP[t], D75\[LetterSpace]137\[LetterSpace]PP2APCa[t], D75\[LetterSpace]137\[LetterSpace]PP2C[t], D75\[LetterSpace]PKA[t], D75\[LetterSpace]PP2A[t], D75\[LetterSpace]PP2ACa[t], D75\[LetterSpace]PP2AP[t], D75\[LetterSpace]PP2APCa[t], D\[LetterSpace]CDK5[t], D\[LetterSpace]CK1[t], D\[LetterSpace]PKA[t], PDE[t], PDEP[t], PDE\[LetterSpace]PKA[t], PKA[t], PP2A[t], PP2ACa[t], PP2ACa\[LetterSpace]PKA[t], PP2AP[t], PP2APCa[t], PP2A\[LetterSpace]PKA[t], PP2B[t], PP2Binactive[t], PP2BinactiveCa2[t], PP2C[t], R2C2[t], cAMP[t], cAMP2\[LetterSpace]R2C2[t], cAMP3\[LetterSpace]R2C2[t], cAMP4\[LetterSpace]R2[t], cAMP4\[LetterSpace]R2C[t], cAMP4\[LetterSpace]R2C2[t], cAMP\[LetterSpace]PDE[t], cAMP\[LetterSpace]PDEP[t], cAMP\[LetterSpace]R2C2[t] }; initialValues = { AMP[0] == 0.0, CDK5[0] == 2*^-07, CK1[0] == 1.66*^-07, CK1P[0] == 0.0, CK1P\[LetterSpace]PP2B[0] == 0.0, Ca[0] == 0.0, D[0] == 4.98*^-06, D137[0] == 0.0, D137\[LetterSpace]CDK5[0] == 0.0, D137\[LetterSpace]PKA[0] == 0.0, D137\[LetterSpace]PP2C[0] == 0.0, D34[0] == 0.0, D34\[LetterSpace]137[0] == 0.0, D34\[LetterSpace]137\[LetterSpace]CDK5[0] == 0.0, D34\[LetterSpace]137\[LetterSpace]PP2B[0] == 0.0, D34\[LetterSpace]137\[LetterSpace]PP2C[0] == 0.0, D34\[LetterSpace]75[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2A[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2ACa[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2AP[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2APCa[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2B[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2C[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]CK1[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]PP2A[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]PP2ACa[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]PP2AP[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]PP2APCa[0] == 0.0, D34\[LetterSpace]75\[LetterSpace]PP2B[0] == 0.0, D34\[LetterSpace]CDK5[0] == 0.0, D34\[LetterSpace]CK1[0] == 0.0, D34\[LetterSpace]PP2B[0] == 0.0, D75[0] == 0.0, D75CK1[0] == 0.0, D75\[LetterSpace]137[0] == 0.0, D75\[LetterSpace]137\[LetterSpace]PKA[0] == 0.0, D75\[LetterSpace]137\[LetterSpace]PP2A[0] == 0.0, D75\[LetterSpace]137\[LetterSpace]PP2ACa[0] == 0.0, D75\[LetterSpace]137\[LetterSpace]PP2AP[0] == 0.0, D75\[LetterSpace]137\[LetterSpace]PP2APCa[0] == 0.0, D75\[LetterSpace]137\[LetterSpace]PP2C[0] == 0.0, D75\[LetterSpace]PKA[0] == 0.0, D75\[LetterSpace]PP2A[0] == 0.0, D75\[LetterSpace]PP2ACa[0] == 0.0, D75\[LetterSpace]PP2AP[0] == 0.0, D75\[LetterSpace]PP2APCa[0] == 0.0, D\[LetterSpace]CDK5[0] == 0.0, D\[LetterSpace]CK1[0] == 0.0, D\[LetterSpace]PKA[0] == 0.0, PDE[0] == 2*^-06, PDEP[0] == 0.0, PDE\[LetterSpace]PKA[0] == 0.0, PKA[0] == 0.0, PP2A[0] == 2*^-07, PP2ACa[0] == 0.0, PP2ACa\[LetterSpace]PKA[0] == 0.0, PP2AP[0] == 0.0, PP2APCa[0] == 0.0, PP2A\[LetterSpace]PKA[0] == 0.0, PP2B[0] == 0.0, PP2Binactive[0] == 3.32*^-07, PP2BinactiveCa2[0] == 0.0, PP2C[0] == 1.33*^-07, R2C2[0] == 6.64*^-06, cAMP[0] == 0.0, cAMP2\[LetterSpace]R2C2[0] == 0.0, cAMP3\[LetterSpace]R2C2[0] == 0.0, cAMP4\[LetterSpace]R2[0] == 0.0, cAMP4\[LetterSpace]R2C[0] == 0.0, cAMP4\[LetterSpace]R2C2[0] == 0.0, cAMP\[LetterSpace]PDE[0] == 0.0, cAMP\[LetterSpace]PDEP[0] == 0.0, cAMP\[LetterSpace]R2C2[0] == 0.0 }; rates = { v57, v58, vcat1, vcat10, vcat11, vcat12, vcat13, vcat14, vcat15, vcat16, vcat17, vcat18, vcat19, vcat2, vcat20, vcat21, vcat22, vcat23, vcat24, vcat25, vcat26, vcat27, vcat28, vcat29, vcat3, vcat30, vcat31, vcat32, vcat33, vcat34, vcat4, vcat44, vcat45, vcat46, vcat47, vcat48, vcat49, vcat5, vcat50, vcat51, vcat52, vcat53, vcat55, vcat56, vcat6, vcat7, vcat8, vcat9, voff1, voff10, voff11, voff12, voff13, voff14, voff15, voff16, voff17, voff18, voff19, voff2, voff20, voff21, voff22, voff23, voff24, voff25, voff26, voff27, voff28, voff29, voff3, voff31, voff33, voff35, voff36, voff37, voff38, voff39, voff4, voff40, voff41, voff44, voff45, voff46, voff47, voff48, voff49, voff5, voff50, voff51, voff52, voff53, voff54, voff55, voff56, voff6, voff7, voff8, voff9, von1, von10, von11, von12, von13, von14, von15, von16, von17, von18, von19, von2, von20, von21, von22, von23, von24, von25, von26, von27, von28, von29, von3, von31, von33, von35, von36, von37, von38, von39, von4, von40, von41, von42, von43, von44, von45, von46, von47, von48, von49, von5, von50, von51, von52, von53, von54, von55, von56, von6, von7, von8, von9 }; rateEquations = { v57 -> k57*Spine, v58 -> Spine*v58\[LetterSpace]k58*Ca[t], vcat1 -> Spine*vcat1\[LetterSpace]kcat1*D\[LetterSpace]CDK5[t], vcat10 -> Spine*vcat10\[LetterSpace]kcat10*D75\[LetterSpace]PP2AP[t], vcat11 -> Spine*vcat11\[LetterSpace]kcat11*D137\[LetterSpace]CDK5[t], vcat12 -> Spine*vcat12\[LetterSpace]kcat12*D137\[LetterSpace]PKA[t], vcat13 -> Spine*vcat13\[LetterSpace]kcat13*D137\[LetterSpace]PP2C[t], vcat14 -> Spine*vcat14\[LetterSpace]kcat14*D34\[LetterSpace]75\[LetterSpace]CK1[t], vcat15 -> Spine*vcat15\[LetterSpace]kcat15*D34\[LetterSpace]75\[LetterSpace]PP2A[t], vcat16 -> Spine*vcat16\[LetterSpace]kcat16*D34\[LetterSpace]75\[LetterSpace]PP2AP[t], vcat17 -> Spine*vcat17\[LetterSpace]kcat17*D34\[LetterSpace]75\[LetterSpace]PP2B[t], vcat18 -> Spine*vcat18\[LetterSpace]kcat18*D34\[LetterSpace]137\[LetterSpace]CDK5[t], vcat19 -> Spine*vcat19\[LetterSpace]kcat19*D34\[LetterSpace]137\[LetterSpace]PP2B[t], vcat2 -> Spine*vcat2\[LetterSpace]kcat2*D\[LetterSpace]CK1[t], vcat20 -> Spine*vcat20\[LetterSpace]kcat20*D34\[LetterSpace]137\[LetterSpace]PP2C[t], vcat21 -> Spine*vcat21\[LetterSpace]kcat21*D75\[LetterSpace]137\[LetterSpace]PKA[t], vcat22 -> Spine*vcat22\[LetterSpace]kcat22*D75\[LetterSpace]137\[LetterSpace]PP2A[t], vcat23 -> Spine*vcat23\[LetterSpace]kcat23*D75\[LetterSpace]137\[LetterSpace]PP2AP[t], vcat24 -> Spine*vcat24\[LetterSpace]kcat24*D75\[LetterSpace]137\[LetterSpace]PP2C[t], vcat25 -> Spine*vcat25\[LetterSpace]kcat25*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2A[t], vcat26 -> Spine*vcat26\[LetterSpace]kcat26*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2AP[t], vcat27 -> Spine*vcat27\[LetterSpace]kcat27*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2B[t], vcat28 -> Spine*vcat28\[LetterSpace]kcat28*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2C[t], vcat29 -> Spine*vcat29\[LetterSpace]kcat29*CK1P\[LetterSpace]PP2B[t], vcat3 -> Spine*vcat3\[LetterSpace]kcat3*D\[LetterSpace]PKA[t], vcat30 -> Spine*vcat30\[LetterSpace]kcat30*CK1[t], vcat31 -> Spine*vcat31\[LetterSpace]kcat31*PDE\[LetterSpace]PKA[t], vcat32 -> Spine*vcat32\[LetterSpace]kcat32*PDEP[t], vcat33 -> Spine*vcat33\[LetterSpace]kcat33*PP2A\[LetterSpace]PKA[t], vcat34 -> Spine*vcat34\[LetterSpace]kcat34*PP2AP[t], vcat4 -> Spine*vcat4\[LetterSpace]kcat4*D34\[LetterSpace]CDK5[t], vcat44 -> Spine*vcat44\[LetterSpace]kcat44*cAMP\[LetterSpace]PDE[t], vcat45 -> Spine*vcat45\[LetterSpace]kcat45*cAMP\[LetterSpace]PDEP[t], vcat46 -> Spine*vcat46\[LetterSpace]kcat46*D34\[LetterSpace]75\[LetterSpace]PP2ACa[t], vcat47 -> Spine*vcat47\[LetterSpace]kcat47*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2ACa[t], vcat48 -> Spine*vcat48\[LetterSpace]kcat48*D75\[LetterSpace]PP2ACa[t], vcat49 -> Spine*vcat49\[LetterSpace]kcat49*D75\[LetterSpace]137\[LetterSpace]PP2ACa[t], vcat5 -> Spine*vcat5\[LetterSpace]kcat5*D34\[LetterSpace]CK1[t], vcat50 -> Spine*vcat50\[LetterSpace]kcat50*D34\[LetterSpace]75\[LetterSpace]PP2APCa[t], vcat51 -> Spine*vcat51\[LetterSpace]kcat51*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2APCa[t], vcat52 -> Spine*vcat52\[LetterSpace]kcat52*D75\[LetterSpace]PP2APCa[t], vcat53 -> Spine*vcat53\[LetterSpace]kcat53*D75\[LetterSpace]137\[LetterSpace]PP2APCa[t], vcat55 -> Spine*vcat55\[LetterSpace]kcat55*PP2ACa\[LetterSpace]PKA[t], vcat56 -> Spine*vcat56\[LetterSpace]kcat56*PP2APCa[t], vcat6 -> Spine*vcat6\[LetterSpace]kcat6*D34\[LetterSpace]PP2B[t], vcat7 -> Spine*vcat7\[LetterSpace]kcat7*D75CK1[t], vcat8 -> Spine*vcat8\[LetterSpace]kcat8*D75\[LetterSpace]PKA[t], vcat9 -> Spine*vcat9\[LetterSpace]kcat9*D75\[LetterSpace]PP2A[t], voff1 -> Spine*voff1\[LetterSpace]koff1*D\[LetterSpace]CDK5[t], voff10 -> Spine*voff10\[LetterSpace]koff10*D75\[LetterSpace]PP2AP[t], voff11 -> Spine*voff11\[LetterSpace]koff11*D137\[LetterSpace]CDK5[t], voff12 -> Spine*voff12\[LetterSpace]koff12*D137\[LetterSpace]PKA[t], voff13 -> Spine*voff13\[LetterSpace]koff13*D137\[LetterSpace]PP2C[t], voff14 -> Spine*voff14\[LetterSpace]koff14*D34\[LetterSpace]75\[LetterSpace]CK1[t], voff15 -> Spine*voff15\[LetterSpace]koff15*D34\[LetterSpace]75\[LetterSpace]PP2A[t], voff16 -> Spine*voff16\[LetterSpace]koff16*D34\[LetterSpace]75\[LetterSpace]PP2AP[t], voff17 -> Spine*voff17\[LetterSpace]koff17*D34\[LetterSpace]75\[LetterSpace]PP2B[t], voff18 -> Spine*voff18\[LetterSpace]koff18*D34\[LetterSpace]137\[LetterSpace]CDK5[t], voff19 -> Spine*voff19\[LetterSpace]koff19*D34\[LetterSpace]137\[LetterSpace]PP2B[t], voff2 -> Spine*voff2\[LetterSpace]koff2*D\[LetterSpace]CK1[t], voff20 -> Spine*voff20\[LetterSpace]koff20*D34\[LetterSpace]137\[LetterSpace]PP2C[t], voff21 -> Spine*voff21\[LetterSpace]koff21*D75\[LetterSpace]137\[LetterSpace]PKA[t], voff22 -> Spine*voff22\[LetterSpace]koff22*D75\[LetterSpace]137\[LetterSpace]PP2A[t], voff23 -> Spine*voff23\[LetterSpace]koff23*D75\[LetterSpace]137\[LetterSpace]PP2AP[t], voff24 -> Spine*voff24\[LetterSpace]koff24*D75\[LetterSpace]137\[LetterSpace]PP2C[t], voff25 -> Spine*voff25\[LetterSpace]koff25*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2A[t], voff26 -> Spine*voff26\[LetterSpace]koff26*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2AP[t], voff27 -> Spine*voff27\[LetterSpace]koff27*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2B[t], voff28 -> Spine*voff28\[LetterSpace]koff28*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2C[t], voff29 -> Spine*voff29\[LetterSpace]koff29*CK1P\[LetterSpace]PP2B[t], voff3 -> Spine*voff3\[LetterSpace]koff3*D\[LetterSpace]PKA[t], voff31 -> Spine*voff31\[LetterSpace]koff31*PDE\[LetterSpace]PKA[t], voff33 -> Spine*voff33\[LetterSpace]koff33*PP2A\[LetterSpace]PKA[t], voff35 -> Spine*voff35\[LetterSpace]koff35*PP2BinactiveCa2[t], voff36 -> Spine*voff36\[LetterSpace]koff36*PP2B[t], voff37 -> Spine*voff37\[LetterSpace]koff37*cAMP\[LetterSpace]R2C2[t], voff38 -> Spine*voff38\[LetterSpace]koff38*cAMP2\[LetterSpace]R2C2[t], voff39 -> Spine*voff39\[LetterSpace]koff39*cAMP3\[LetterSpace]R2C2[t], voff4 -> Spine*voff4\[LetterSpace]koff4*D34\[LetterSpace]CDK5[t], voff40 -> Spine*voff40\[LetterSpace]koff40*cAMP4\[LetterSpace]R2C2[t], voff41 -> Spine*voff41\[LetterSpace]koff41*cAMP4\[LetterSpace]R2C2[t], voff44 -> Spine*voff44\[LetterSpace]koff44*cAMP\[LetterSpace]PDE[t], voff45 -> Spine*voff45\[LetterSpace]koff45*cAMP\[LetterSpace]PDEP[t], voff46 -> Spine*voff46\[LetterSpace]koff46*D34\[LetterSpace]75\[LetterSpace]PP2ACa[t], voff47 -> Spine*voff47\[LetterSpace]koff47*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2ACa[t], voff48 -> Spine*voff48\[LetterSpace]koff48*D75\[LetterSpace]PP2ACa[t], voff49 -> Spine*voff49\[LetterSpace]koff49*D75\[LetterSpace]137\[LetterSpace]PP2ACa[t], voff5 -> Spine*voff5\[LetterSpace]koff5*D34\[LetterSpace]CK1[t], voff50 -> Spine*voff50\[LetterSpace]koff50*D34\[LetterSpace]75\[LetterSpace]PP2APCa[t], voff51 -> Spine*voff51\[LetterSpace]koff51*D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2APCa[t], voff52 -> Spine*voff52\[LetterSpace]koff52*D75\[LetterSpace]PP2APCa[t], voff53 -> Spine*voff53\[LetterSpace]koff53*D75\[LetterSpace]137\[LetterSpace]PP2APCa[t], voff54 -> Spine*voff54\[LetterSpace]koff54*PP2ACa[t], voff55 -> Spine*voff55\[LetterSpace]koff55*PP2ACa\[LetterSpace]PKA[t], voff56 -> Spine*voff56\[LetterSpace]koff56*PP2APCa[t], voff6 -> Spine*voff6\[LetterSpace]koff6*D34\[LetterSpace]PP2B[t], voff7 -> Spine*voff7\[LetterSpace]koff7*D75CK1[t], voff8 -> Spine*voff8\[LetterSpace]koff8*D75\[LetterSpace]PKA[t], voff9 -> Spine*voff9\[LetterSpace]koff9*D75\[LetterSpace]PP2A[t], von1 -> Spine*von1\[LetterSpace]kon1*CDK5[t]*D[t], von10 -> Spine*von10\[LetterSpace]kon10*D75[t]*PP2AP[t], von11 -> Spine*von11\[LetterSpace]kon11*CDK5[t]*D137[t], von12 -> Spine*von12\[LetterSpace]kon12*D137[t]*PKA[t], von13 -> Spine*von13\[LetterSpace]kon13*D137[t]*PP2C[t], von14 -> Spine*von14\[LetterSpace]kon14*CK1[t]*D34\[LetterSpace]75[t], von15 -> Spine*von15\[LetterSpace]kon15*D34\[LetterSpace]75[t]*PP2A[t], von16 -> Spine*von16\[LetterSpace]kon16*D34\[LetterSpace]75[t]*PP2AP[t], von17 -> Spine*von17\[LetterSpace]kon17*D34\[LetterSpace]75[t]*PP2B[t], von18 -> Spine*von18\[LetterSpace]kon18*CDK5[t]*D34\[LetterSpace]137[t], von19 -> Spine*von19\[LetterSpace]kon19*D34\[LetterSpace]137[t]*PP2B[t], von2 -> Spine*von2\[LetterSpace]kon2*CK1[t]*D[t], von20 -> Spine*von20\[LetterSpace]kon20*D34\[LetterSpace]137[t]*PP2C[t], von21 -> Spine*von21\[LetterSpace]kon21*D75\[LetterSpace]137[t]*PKA[t], von22 -> Spine*von22\[LetterSpace]kon22*D75\[LetterSpace]137[t]*PP2A[t], von23 -> Spine*von23\[LetterSpace]kon23*D75\[LetterSpace]137[t]*PP2AP[t], von24 -> Spine*von24\[LetterSpace]kon24*D75\[LetterSpace]137[t]*PP2C[t], von25 -> Spine*von25\[LetterSpace]kon25*D34\[LetterSpace]75\[LetterSpace]137[t]*PP2A[t], von26 -> Spine*von26\[LetterSpace]kon26*D34\[LetterSpace]75\[LetterSpace]137[t]*PP2AP[t], von27 -> Spine*von27\[LetterSpace]kon27*D34\[LetterSpace]75\[LetterSpace]137[t]*PP2B[t], von28 -> Spine*von28\[LetterSpace]kon28*D34\[LetterSpace]75\[LetterSpace]137[t]*PP2C[t], von29 -> Spine*von29\[LetterSpace]kon29*CK1P[t]*PP2B[t], von3 -> Spine*von3\[LetterSpace]kon3*D[t]*PKA[t], von31 -> Spine*von31\[LetterSpace]kon31*PDE[t]*PKA[t], von33 -> Spine*von33\[LetterSpace]kon33*PKA[t]*PP2A[t], von35 -> Spine*von35\[LetterSpace]kon35*Ca[t]^2*PP2Binactive[t], von36 -> Spine*von36\[LetterSpace]kon36*Ca[t]^2*PP2BinactiveCa2[t], von37 -> Spine*von37\[LetterSpace]kon37*cAMP[t]*R2C2[t], von38 -> Spine*von38\[LetterSpace]kon38*cAMP[t]*cAMP\[LetterSpace]R2C2[t], von39 -> Spine*von39\[LetterSpace]kon39*cAMP[t]*cAMP2\[LetterSpace]R2C2[t], von4 -> Spine*von4\[LetterSpace]kon4*CDK5[t]*D34[t], von40 -> Spine*von40\[LetterSpace]kon40*cAMP[t]*cAMP3\[LetterSpace]R2C2[t], von41 -> Spine*von41\[LetterSpace]kon41*cAMP4\[LetterSpace]R2C[t]*PKA[t], von42 -> Spine*von42\[LetterSpace]kon42*cAMP4\[LetterSpace]R2[t]*PKA[t], von43 -> Spine*von43\[LetterSpace]kon43*cAMP4\[LetterSpace]R2C[t], von44 -> Spine*von44\[LetterSpace]kon44*cAMP[t]*PDE[t], von45 -> Spine*von45\[LetterSpace]kon45*cAMP[t]*PDEP[t], von46 -> Spine*von46\[LetterSpace]kon46*D34\[LetterSpace]75[t]*PP2ACa[t], von47 -> Spine*von47\[LetterSpace]kon47*D34\[LetterSpace]75\[LetterSpace]137[t]*PP2ACa[t], von48 -> Spine*von48\[LetterSpace]kon48*D75[t]*PP2ACa[t], von49 -> Spine*von49\[LetterSpace]kon49*D75\[LetterSpace]137[t]*PP2ACa[t], von5 -> Spine*von5\[LetterSpace]kon5*CK1[t]*D34[t], von50 -> Spine*von50\[LetterSpace]kon50*D34\[LetterSpace]75[t]*PP2APCa[t], von51 -> Spine*von51\[LetterSpace]kon51*D34\[LetterSpace]75\[LetterSpace]137[t]*PP2APCa[t], von52 -> Spine*von52\[LetterSpace]kon52*D75[t]*PP2APCa[t], von53 -> Spine*von53\[LetterSpace]kon53*D75\[LetterSpace]137[t]*PP2APCa[t], von54 -> Spine*von54\[LetterSpace]kon54*Ca[t]*PP2A[t], von55 -> Spine*von55\[LetterSpace]kon55*PKA[t]*PP2ACa[t], von56 -> Spine*von56\[LetterSpace]kon56*Ca[t]*PP2AP[t], von6 -> Spine*von6\[LetterSpace]kon6*D34[t]*PP2B[t], von7 -> Spine*von7\[LetterSpace]kon7*CK1[t]*D75[t], von8 -> Spine*von8\[LetterSpace]kon8*D75[t]*PKA[t], von9 -> Spine*von9\[LetterSpace]kon9*D75[t]*PP2A[t] }; parameters = { cAMP\[LetterSpace]Ca\[LetterSpace]delay -> 50.0, cAMP\[LetterSpace]delay -> 400.0, k57 -> 2.5*^-08, kon\[LetterSpace]high -> 6.6*^-06, kon\[LetterSpace]low -> 2.5*^-08, spike\[LetterSpace]duration -> 2.0, spike\[LetterSpace]interval -> 2.0, Empty -> 0.0, von1\[LetterSpace]kon1 -> 5600000.0, voff1\[LetterSpace]koff1 -> 12.0, vcat1\[LetterSpace]kcat1 -> 3.0, von2\[LetterSpace]kon2 -> 4400000.0, voff2\[LetterSpace]koff2 -> 12.0, vcat2\[LetterSpace]kcat2 -> 3.0, von3\[LetterSpace]kon3 -> 5600000.0, voff3\[LetterSpace]koff3 -> 10.8, vcat3\[LetterSpace]kcat3 -> 2.7, von4\[LetterSpace]kon4 -> 5600000.0, von5\[LetterSpace]kon5 -> 4400000.0, von6\[LetterSpace]kon6 -> 10000000.0, voff4\[LetterSpace]koff4 -> 12.0, vcat4\[LetterSpace]kcat4 -> 3.0, voff5\[LetterSpace]koff5 -> 12.0, vcat5\[LetterSpace]kcat5 -> 3.0, vcat6\[LetterSpace]kcat6 -> 4.0, voff6\[LetterSpace]koff6 -> 16.0, von7\[LetterSpace]kon7 -> 4400000.0, von8\[LetterSpace]kon8 -> 5600000.0, von9\[LetterSpace]kon9 -> 3800000.0, von10\[LetterSpace]kon10 -> 17000000.0, voff7\[LetterSpace]koff7 -> 12.0, vcat7\[LetterSpace]kcat7 -> 3.0, vcat8\[LetterSpace]kcat8 -> 0.0, voff8\[LetterSpace]koff8 -> 10.8, vcat9\[LetterSpace]kcat9 -> 10.0, voff9\[LetterSpace]koff9 -> 24.0, vcat10\[LetterSpace]kcat10 -> 24.0, voff10\[LetterSpace]koff10 -> 40.0, von11\[LetterSpace]kon11 -> 5600000.0, von12\[LetterSpace]kon12 -> 5600000.0, von13\[LetterSpace]kon13 -> 7500000.0, voff11\[LetterSpace]koff11 -> 12.0, vcat11\[LetterSpace]kcat11 -> 3.0, voff12\[LetterSpace]koff12 -> 10.8, vcat12\[LetterSpace]kcat12 -> 2.7, vcat13\[LetterSpace]kcat13 -> 3.0, voff13\[LetterSpace]koff13 -> 12.0, von14\[LetterSpace]kon14 -> 4400000.0, von18\[LetterSpace]kon18 -> 5600000.0, voff18\[LetterSpace]koff18 -> 12.0, voff14\[LetterSpace]koff14 -> 12.0, vcat14\[LetterSpace]kcat14 -> 3.0, vcat18\[LetterSpace]kcat18 -> 3.0, von21\[LetterSpace]kon21 -> 5600000.0, vcat21\[LetterSpace]kcat21 -> 0.0, voff21\[LetterSpace]koff21 -> 10.8, von17\[LetterSpace]kon17 -> 10000000.0, voff17\[LetterSpace]koff17 -> 1600.0, vcat17\[LetterSpace]kcat17 -> 4.0, von19\[LetterSpace]kon19 -> 75000.0, vcat19\[LetterSpace]kcat19 -> 0.03, voff19\[LetterSpace]koff19 -> 0.12, von27\[LetterSpace]kon27 -> 75000.0, voff27\[LetterSpace]koff27 -> 120.0, vcat27\[LetterSpace]kcat27 -> 0.03, von15\[LetterSpace]kon15 -> 3800000.0, vcat15\[LetterSpace]kcat15 -> 10.0, voff15\[LetterSpace]koff15 -> 24.0, von22\[LetterSpace]kon22 -> 3800000.0, vcat22\[LetterSpace]kcat22 -> 10.0, voff22\[LetterSpace]koff22 -> 24.0, von25\[LetterSpace]kon25 -> 3800000.0, vcat25\[LetterSpace]kcat25 -> 10.0, voff25\[LetterSpace]koff25 -> 24.0, von16\[LetterSpace]kon16 -> 17000000.0, vcat16\[LetterSpace]kcat16 -> 24.0, voff16\[LetterSpace]koff16 -> 40.0, von23\[LetterSpace]kon23 -> 17000000.0, vcat23\[LetterSpace]kcat23 -> 24.0, voff23\[LetterSpace]koff23 -> 40.0, vcat26\[LetterSpace]kcat26 -> 24.0, von26\[LetterSpace]kon26 -> 17000000.0, voff26\[LetterSpace]koff26 -> 40.0, von20\[LetterSpace]kon20 -> 7500000.0, vcat20\[LetterSpace]kcat20 -> 3.0, voff20\[LetterSpace]koff20 -> 12.0, von24\[LetterSpace]kon24 -> 7500000.0, vcat24\[LetterSpace]kcat24 -> 3.0, voff24\[LetterSpace]koff24 -> 12.0, von28\[LetterSpace]kon28 -> 7500000.0, vcat28\[LetterSpace]kcat28 -> 3.0, voff28\[LetterSpace]koff28 -> 12.0, von29\[LetterSpace]kon29 -> 30000000.0, voff29\[LetterSpace]koff29 -> 24.0, vcat29\[LetterSpace]kcat29 -> 6.0, vcat30\[LetterSpace]kcat30 -> 1.0, von31\[LetterSpace]kon31 -> 6000000.0, vcat31\[LetterSpace]kcat31 -> 9.0, voff31\[LetterSpace]koff31 -> 36.0, vcat32\[LetterSpace]kcat32 -> 0.1, von33\[LetterSpace]kon33 -> 10000000.0, voff33\[LetterSpace]koff33 -> 16.0, vcat33\[LetterSpace]kcat33 -> 4.0, vcat34\[LetterSpace]kcat34 -> 5.0, von35\[LetterSpace]kon35 -> 1000000000000000.0, von36\[LetterSpace]kon36 -> 3000000000000000.0, voff35\[LetterSpace]koff35 -> 1.0, voff36\[LetterSpace]koff36 -> 1.0, von37\[LetterSpace]kon37 -> 54000000.0, von38\[LetterSpace]kon38 -> 54000000.0, von39\[LetterSpace]kon39 -> 75000000.0, von40\[LetterSpace]kon40 -> 75000000.0, voff37\[LetterSpace]koff37 -> 33.0, voff38\[LetterSpace]koff38 -> 33.0, voff39\[LetterSpace]koff39 -> 110.0, voff40\[LetterSpace]koff40 -> 32.5, von41\[LetterSpace]kon41 -> 18000000.0, voff41\[LetterSpace]koff41 -> 60.0, von42\[LetterSpace]kon42 -> 18000000.0, von43\[LetterSpace]kon43 -> 60.0, von44\[LetterSpace]kon44 -> 2520000.0, voff44\[LetterSpace]koff44 -> 40.0, vcat44\[LetterSpace]kcat44 -> 10.0, von45\[LetterSpace]kon45 -> 5040000.0, voff45\[LetterSpace]koff45 -> 80.0, vcat45\[LetterSpace]kcat45 -> 20.0, v58\[LetterSpace]k58 -> 1.7, von46\[LetterSpace]kon46 -> 3800000.0, von47\[LetterSpace]kon47 -> 3800000.0, vcat47\[LetterSpace]kcat47 -> 10.0, voff47\[LetterSpace]koff47 -> 6.0, vcat46\[LetterSpace]kcat46 -> 10.0, voff46\[LetterSpace]koff46 -> 6.0, von48\[LetterSpace]kon48 -> 3800000.0, von49\[LetterSpace]kon49 -> 3800000.0, vcat49\[LetterSpace]kcat49 -> 10.0, voff49\[LetterSpace]koff49 -> 6.0, vcat48\[LetterSpace]kcat48 -> 10.0, voff48\[LetterSpace]koff48 -> 6.0, von50\[LetterSpace]kon50 -> 17000000.0, von51\[LetterSpace]kon51 -> 17000000.0, vcat51\[LetterSpace]kcat51 -> 24.0, voff51\[LetterSpace]koff51 -> 10.0, vcat50\[LetterSpace]kcat50 -> 24.0, voff50\[LetterSpace]koff50 -> 10.0, von52\[LetterSpace]kon52 -> 17000000.0, von53\[LetterSpace]kon53 -> 17000000.0, vcat53\[LetterSpace]kcat53 -> 24.0, voff53\[LetterSpace]koff53 -> 10.0, vcat52\[LetterSpace]kcat52 -> 24.0, voff52\[LetterSpace]koff52 -> 10.0, von54\[LetterSpace]kon54 -> 200000.0, voff54\[LetterSpace]koff54 -> 1.0, von55\[LetterSpace]kon55 -> 10000000.0, vcat55\[LetterSpace]kcat55 -> 4.0, von56\[LetterSpace]kon56 -> 200000.0, voff56\[LetterSpace]koff56 -> 1.0, vcat56\[LetterSpace]kcat56 -> 5.0, voff55\[LetterSpace]koff55 -> 16.0, Spine -> 1*^-15 }; assignments = { }; events = { }; speciesAnnotations = { AMP[t]->"http://identifiers.org/obo.chebi/CHEBI:16027", CDK5[t]->"http://identifiers.org/uniprot/Q03114", Ca[t]->"http://identifiers.org/obo.chebi/CHEBI:29108", cAMP[t]->"http://identifiers.org/obo.chebi/CHEBI:17489" }; reactionAnnotations = { }; units = { {"time" -> "", "metabolite" -> "", "extent" -> ""} }; (* Time evolution *) odes = { AMP'[t] == 1.0*vcat44 +1.0*vcat45 , CDK5'[t] == 1.0*voff1 +1.0*vcat1 +1.0*voff4 +1.0*vcat4 +1.0*voff11 +1.0*vcat11 +1.0*voff18 +1.0*vcat18 -1.0*von1 -1.0*von4 -1.0*von11 -1.0*von18, CK1'[t] == 1.0*voff2 +1.0*vcat2 +1.0*voff5 +1.0*vcat5 +1.0*voff7 +1.0*vcat7 +1.0*voff14 +1.0*vcat14 +1.0*vcat29 -1.0*von2 -1.0*von5 -1.0*von7 -1.0*von14 -1.0*vcat30, CK1P'[t] == 1.0*voff29 +1.0*vcat30 -1.0*von29, CK1P\[LetterSpace]PP2B'[t] == 1.0*von29 -1.0*voff29 -1.0*vcat29, Ca'[t] == 2.0*voff35 +2.0*voff36 +1.0*v57 +1.0*voff54 +1.0*voff56 -2.0*von35 -2.0*von36 -1.0*v58 -1.0*von54 -1.0*von56, D'[t] == 1.0*voff1 +1.0*voff2 +1.0*voff3 +1.0*vcat6 +1.0*vcat9 +1.0*vcat10 +1.0*vcat13 +1.0*vcat48 +1.0*vcat52 -1.0*von1 -1.0*von2 -1.0*von3, D137'[t] == 1.0*vcat2 +1.0*voff11 +1.0*voff12 +1.0*voff13 +1.0*vcat19 +1.0*vcat22 +1.0*vcat23 +1.0*vcat49 +1.0*vcat53 -1.0*von11 -1.0*von12 -1.0*von13, D137\[LetterSpace]CDK5'[t] == 1.0*von11 -1.0*voff11 -1.0*vcat11, D137\[LetterSpace]PKA'[t] == 1.0*von12 -1.0*voff12 -1.0*vcat12, D137\[LetterSpace]PP2C'[t] == 1.0*von13 -1.0*vcat13 -1.0*voff13, D34'[t] == 1.0*vcat3 +1.0*voff4 +1.0*voff5 +1.0*voff6 +1.0*vcat15 +1.0*vcat16 +1.0*vcat20 +1.0*vcat46 +1.0*vcat50 -1.0*von4 -1.0*von5 -1.0*von6, D34\[LetterSpace]137'[t] == 1.0*vcat5 +1.0*vcat12 +1.0*voff18 +1.0*voff19 +1.0*vcat25 +1.0*vcat26 +1.0*voff20 +1.0*vcat47 +1.0*vcat51 -1.0*von18 -1.0*von19 -1.0*von20, D34\[LetterSpace]137\[LetterSpace]CDK5'[t] == 1.0*von18 -1.0*voff18 -1.0*vcat18, D34\[LetterSpace]137\[LetterSpace]PP2B'[t] == 1.0*von19 -1.0*vcat19 -1.0*voff19, D34\[LetterSpace]137\[LetterSpace]PP2C'[t] == 1.0*von20 -1.0*vcat20 -1.0*voff20, D34\[LetterSpace]75'[t] == 1.0*vcat4 +1.0*vcat8 +1.0*voff14 +1.0*voff17 +1.0*voff15 +1.0*voff16 +1.0*vcat28 +1.0*voff46 +1.0*voff50 -1.0*von14 -1.0*von17 -1.0*von15 -1.0*von16 -1.0*von46 -1.0*von50, D34\[LetterSpace]75\[LetterSpace]137'[t] == 1.0*vcat14 +1.0*vcat18 +1.0*vcat21 +1.0*voff27 +1.0*voff25 +1.0*voff26 +1.0*voff28 +1.0*voff47 +1.0*voff51 -1.0*von27 -1.0*von25 -1.0*von26 -1.0*von28 -1.0*von47 -1.0*von51, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2A'[t] == 1.0*von25 -1.0*vcat25 -1.0*voff25, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2ACa'[t] == 1.0*von47 -1.0*vcat47 -1.0*voff47, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2AP'[t] == 1.0*von26 -1.0*vcat26 -1.0*voff26, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2APCa'[t] == 1.0*von51 -1.0*vcat51 -1.0*voff51, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2B'[t] == 1.0*von27 -1.0*voff27 -1.0*vcat27, D34\[LetterSpace]75\[LetterSpace]137\[LetterSpace]PP2C'[t] == 1.0*von28 -1.0*vcat28 -1.0*voff28, D34\[LetterSpace]75\[LetterSpace]CK1'[t] == 1.0*von14 -1.0*voff14 -1.0*vcat14, D34\[LetterSpace]75\[LetterSpace]PP2A'[t] == 1.0*von15 -1.0*vcat15 -1.0*voff15, D34\[LetterSpace]75\[LetterSpace]PP2ACa'[t] == 1.0*von46 -1.0*vcat46 -1.0*voff46, D34\[LetterSpace]75\[LetterSpace]PP2AP'[t] == 1.0*von16 -1.0*vcat16 -1.0*voff16, D34\[LetterSpace]75\[LetterSpace]PP2APCa'[t] == 1.0*von50 -1.0*vcat50 -1.0*voff50, D34\[LetterSpace]75\[LetterSpace]PP2B'[t] == 1.0*von17 -1.0*voff17 -1.0*vcat17, D34\[LetterSpace]CDK5'[t] == 1.0*von4 -1.0*voff4 -1.0*vcat4, D34\[LetterSpace]CK1'[t] == 1.0*von5 -1.0*voff5 -1.0*vcat5, D34\[LetterSpace]PP2B'[t] == 1.0*von6 -1.0*vcat6 -1.0*voff6, D75'[t] == 1.0*vcat1 +1.0*voff7 +1.0*voff8 +1.0*voff9 +1.0*voff10 +1.0*vcat17 +1.0*vcat24 +1.0*voff48 +1.0*voff52 -1.0*von7 -1.0*von8 -1.0*von9 -1.0*von10 -1.0*von48 -1.0*von52, D75CK1'[t] == 1.0*von7 -1.0*voff7 -1.0*vcat7, D75\[LetterSpace]137'[t] == 1.0*vcat7 +1.0*vcat11 +1.0*voff21 +1.0*vcat27 +1.0*voff22 +1.0*voff23 +1.0*voff24 +1.0*voff49 +1.0*voff53 -1.0*von21 -1.0*von22 -1.0*von23 -1.0*von24 -1.0*von49 -1.0*von53, D75\[LetterSpace]137\[LetterSpace]PKA'[t] == 1.0*von21 -1.0*vcat21 -1.0*voff21, D75\[LetterSpace]137\[LetterSpace]PP2A'[t] == 1.0*von22 -1.0*vcat22 -1.0*voff22, D75\[LetterSpace]137\[LetterSpace]PP2ACa'[t] == 1.0*von49 -1.0*vcat49 -1.0*voff49, D75\[LetterSpace]137\[LetterSpace]PP2AP'[t] == 1.0*von23 -1.0*vcat23 -1.0*voff23, D75\[LetterSpace]137\[LetterSpace]PP2APCa'[t] == 1.0*von53 -1.0*vcat53 -1.0*voff53, D75\[LetterSpace]137\[LetterSpace]PP2C'[t] == 1.0*von24 -1.0*vcat24 -1.0*voff24, D75\[LetterSpace]PKA'[t] == 1.0*von8 -1.0*vcat8 -1.0*voff8, D75\[LetterSpace]PP2A'[t] == 1.0*von9 -1.0*vcat9 -1.0*voff9, D75\[LetterSpace]PP2ACa'[t] == 1.0*von48 -1.0*vcat48 -1.0*voff48, D75\[LetterSpace]PP2AP'[t] == 1.0*von10 -1.0*vcat10 -1.0*voff10, D75\[LetterSpace]PP2APCa'[t] == 1.0*von52 -1.0*vcat52 -1.0*voff52, D\[LetterSpace]CDK5'[t] == 1.0*von1 -1.0*voff1 -1.0*vcat1, D\[LetterSpace]CK1'[t] == 1.0*von2 -1.0*voff2 -1.0*vcat2, D\[LetterSpace]PKA'[t] == 1.0*von3 -1.0*voff3 -1.0*vcat3, PDE'[t] == 1.0*voff31 +1.0*vcat32 +1.0*voff44 +1.0*vcat44 -1.0*von31 -1.0*von44, PDEP'[t] == 1.0*vcat31 +1.0*voff45 +1.0*vcat45 -1.0*vcat32 -1.0*von45, PDE\[LetterSpace]PKA'[t] == 1.0*von31 -1.0*vcat31 -1.0*voff31, PKA'[t] == 1.0*voff3 +1.0*vcat3 +1.0*vcat8 +1.0*voff8 +1.0*voff12 +1.0*vcat12 +1.0*vcat21 +1.0*voff21 +1.0*vcat31 +1.0*voff31 +1.0*voff33 +1.0*vcat33 +1.0*voff41 +1.0*von43 +1.0*vcat55 +1.0*voff55 -1.0*von3 -1.0*von8 -1.0*von12 -1.0*von21 -1.0*von31 -1.0*von33 -1.0*von41 -1.0*von42 -1.0*von55, PP2A'[t] == 1.0*vcat9 +1.0*voff9 +1.0*vcat15 +1.0*voff15 +1.0*vcat22 +1.0*voff22 +1.0*vcat25 +1.0*voff25 +1.0*voff33 +1.0*vcat34 +1.0*voff54 -1.0*von9 -1.0*von15 -1.0*von22 -1.0*von25 -1.0*von33 -1.0*von54, PP2ACa'[t] == 1.0*vcat47 +1.0*voff47 +1.0*vcat46 +1.0*voff46 +1.0*vcat49 +1.0*voff49 +1.0*vcat48 +1.0*voff48 +1.0*von54 +1.0*vcat56 +1.0*voff55 -1.0*von46 -1.0*von47 -1.0*von48 -1.0*von49 -1.0*voff54 -1.0*von55, PP2ACa\[LetterSpace]PKA'[t] == 1.0*von55 -1.0*vcat55 -1.0*voff55, PP2AP'[t] == 1.0*vcat10 +1.0*voff10 +1.0*vcat16 +1.0*voff16 +1.0*vcat23 +1.0*voff23 +1.0*vcat26 +1.0*voff26 +1.0*vcat33 +1.0*voff56 -1.0*von10 -1.0*von16 -1.0*von23 -1.0*von26 -1.0*vcat34 -1.0*von56, PP2APCa'[t] == 1.0*vcat51 +1.0*voff51 +1.0*vcat50 +1.0*voff50 +1.0*vcat53 +1.0*voff53 +1.0*vcat52 +1.0*voff52 +1.0*vcat55 +1.0*von56 -1.0*von50 -1.0*von51 -1.0*von52 -1.0*von53 -1.0*voff56 -1.0*vcat56, PP2A\[LetterSpace]PKA'[t] == 1.0*von33 -1.0*voff33 -1.0*vcat33, PP2B'[t] == 1.0*vcat6 +1.0*voff6 +1.0*voff17 +1.0*vcat17 +1.0*vcat19 +1.0*voff19 +1.0*voff27 +1.0*vcat27 +1.0*voff29 +1.0*vcat29 +1.0*von36 -1.0*von6 -1.0*von17 -1.0*von19 -1.0*von27 -1.0*von29 -1.0*voff36, PP2Binactive'[t] == 1.0*voff35 -1.0*von35, PP2BinactiveCa2'[t] == 1.0*von35 +1.0*voff36 -1.0*von36 -1.0*voff35, PP2C'[t] == 1.0*vcat13 +1.0*voff13 +1.0*vcat20 +1.0*voff20 +1.0*vcat24 +1.0*voff24 +1.0*vcat28 +1.0*voff28 -1.0*von13 -1.0*von20 -1.0*von24 -1.0*von28, R2C2'[t] == 1.0*voff37 -1.0*von37, cAMP'[t] == 1.0*voff37 +1.0*voff38 +1.0*voff39 +1.0*voff40 +1.0*voff44 +1.0*voff45 -1.0*von37 -1.0*von38 -1.0*von39 -1.0*von40 -1.0*von44 -1.0*von45, cAMP2\[LetterSpace]R2C2'[t] == 1.0*von38 +1.0*voff39 -1.0*von39 -1.0*voff38, cAMP3\[LetterSpace]R2C2'[t] == 1.0*von39 +1.0*voff40 -1.0*von40 -1.0*voff39, cAMP4\[LetterSpace]R2'[t] == 1.0*von43 -1.0*von42, cAMP4\[LetterSpace]R2C'[t] == 1.0*voff41 +1.0*von42 -1.0*von41 -1.0*von43, cAMP4\[LetterSpace]R2C2'[t] == 1.0*von40 +1.0*von41 -1.0*voff40 -1.0*voff41, cAMP\[LetterSpace]PDE'[t] == 1.0*von44 -1.0*voff44 -1.0*vcat44, cAMP\[LetterSpace]PDEP'[t] == 1.0*von45 -1.0*voff45 -1.0*vcat45, cAMP\[LetterSpace]R2C2'[t] == 1.0*von37 +1.0*voff38 -1.0*von38 -1.0*voff37 }; timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}]; (* Steady-state solution initialized with result of time evolution *) findRootEquations = odes /.D[_[t],t]->0; findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2]; steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100] fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations (* Plot the time evolution of the variables *) plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]