begin name fernandez2 end name begin reactions v57 {1.0}$Empty = {1.0}Ca v58 {1.0}Ca = {1.0}$Empty vcat1 {1.0}DCDK5 = {1.0}D75 + {1.0}CDK5 vcat10 {1.0}D75PP2AP = {1.0}D + {1.0}PP2AP vcat11 {1.0}D137CDK5 = {1.0}D75137 + {1.0}CDK5 vcat12 {1.0}D137PKA = {1.0}D34137 + {1.0}PKA vcat13 {1.0}D137PP2C = {1.0}D + {1.0}PP2C vcat14 {1.0}D3475CK1 = {1.0}D3475137 + {1.0}CK1 vcat15 {1.0}D3475PP2A = {1.0}D34 + {1.0}PP2A vcat16 {1.0}D3475PP2AP = {1.0}D34 + {1.0}PP2AP vcat17 {1.0}D3475PP2B = {1.0}D75 + {1.0}PP2B vcat18 {1.0}D34137CDK5 = {1.0}D3475137 + {1.0}CDK5 vcat19 {1.0}D34137PP2B = {1.0}D137 + {1.0}PP2B vcat2 {1.0}DCK1 = {1.0}D137 + {1.0}CK1 vcat20 {1.0}D34137PP2C = {1.0}D34 + {1.0}PP2C vcat21 {1.0}D75137PKA = {1.0}D3475137 + {1.0}PKA vcat22 {1.0}D75137PP2A = {1.0}D137 + {1.0}PP2A vcat23 {1.0}D75137PP2AP = {1.0}D137 + {1.0}PP2AP vcat24 {1.0}D75137PP2C = {1.0}D75 + {1.0}PP2C vcat25 {1.0}D3475137PP2A = {1.0}D34137 + {1.0}PP2A vcat26 {1.0}D3475137PP2AP = {1.0}D34137 + {1.0}PP2AP vcat27 {1.0}D3475137PP2B = {1.0}D75137 + {1.0}PP2B vcat28 {1.0}D3475137PP2C = {1.0}D3475 + {1.0}PP2C vcat29 {1.0}CK1PPP2B = {1.0}CK1 + {1.0}PP2B vcat3 {1.0}DPKA = {1.0}D34 + {1.0}PKA vcat30 {1.0}CK1 = {1.0}CK1P vcat31 {1.0}PDEPKA = {1.0}PDEP + {1.0}PKA vcat32 {1.0}PDEP = {1.0}PDE vcat33 {1.0}PP2APKA = {1.0}PP2AP + {1.0}PKA vcat34 {1.0}PP2AP = {1.0}PP2A vcat4 {1.0}D34CDK5 = {1.0}D3475 + {1.0}CDK5 vcat44 {1.0}cAMPPDE = {1.0}AMP + {1.0}PDE vcat45 {1.0}cAMPPDEP = {1.0}AMP + {1.0}PDEP vcat46 {1.0}D3475PP2ACa = {1.0}D34 + {1.0}PP2ACa vcat47 {1.0}D3475137PP2ACa = {1.0}D34137 + {1.0}PP2ACa vcat48 {1.0}D75PP2ACa = {1.0}D + {1.0}PP2ACa vcat49 {1.0}D75137PP2ACa = {1.0}D137 + {1.0}PP2ACa vcat5 {1.0}D34CK1 = {1.0}D34137 + {1.0}CK1 vcat50 {1.0}D3475PP2APCa = {1.0}D34 + {1.0}PP2APCa vcat51 {1.0}D3475137PP2APCa = {1.0}PP2APCa + {1.0}D34137 vcat52 {1.0}D75PP2APCa = {1.0}D + {1.0}PP2APCa vcat53 {1.0}D75137PP2APCa = {1.0}D137 + {1.0}PP2APCa vcat55 {1.0}PP2ACaPKA = {1.0}PP2APCa + {1.0}PKA vcat56 {1.0}PP2APCa = {1.0}PP2ACa vcat6 {1.0}D34PP2B = {1.0}D + {1.0}PP2B vcat7 {1.0}D75CK1 = {1.0}CK1 + {1.0}D75137 vcat8 {1.0}D75PKA = {1.0}D3475 + {1.0}PKA vcat9 {1.0}D75PP2A = {1.0}D + {1.0}PP2A voff1 {1.0}DCDK5 = {1.0}D + {1.0}CDK5 voff10 {1.0}D75PP2AP = {1.0}D75 + {1.0}PP2AP voff11 {1.0}D137CDK5 = {1.0}D137 + {1.0}CDK5 voff12 {1.0}D137PKA = {1.0}D137 + {1.0}PKA voff13 {1.0}D137PP2C = {1.0}D137 + {1.0}PP2C voff14 {1.0}D3475CK1 = {1.0}D3475 + {1.0}CK1 voff15 {1.0}D3475PP2A = {1.0}D3475 + {1.0}PP2A voff16 {1.0}D3475PP2AP = {1.0}D3475 + {1.0}PP2AP voff17 {1.0}D3475PP2B = {1.0}D3475 + {1.0}PP2B voff18 {1.0}D34137CDK5 = {1.0}D34137 + {1.0}CDK5 voff19 {1.0}D34137PP2B = {1.0}D34137 + {1.0}PP2B voff2 {1.0}DCK1 = {1.0}D + {1.0}CK1 voff20 {1.0}D34137PP2C = {1.0}D34137 + {1.0}PP2C voff21 {1.0}D75137PKA = {1.0}D75137 + {1.0}PKA voff22 {1.0}D75137PP2A = {1.0}D75137 + {1.0}PP2A voff23 {1.0}D75137PP2AP = {1.0}D75137 + {1.0}PP2AP voff24 {1.0}D75137PP2C = {1.0}D75137 + {1.0}PP2C voff25 {1.0}D3475137PP2A = {1.0}D3475137 + {1.0}PP2A voff26 {1.0}D3475137PP2AP = {1.0}D3475137 + {1.0}PP2AP voff27 {1.0}D3475137PP2B = {1.0}D3475137 + {1.0}PP2B voff28 {1.0}D3475137PP2C = {1.0}D3475137 + {1.0}PP2C voff29 {1.0}CK1PPP2B = {1.0}CK1P + {1.0}PP2B voff3 {1.0}DPKA = {1.0}D + {1.0}PKA voff31 {1.0}PDEPKA = {1.0}PDE + {1.0}PKA voff33 {1.0}PP2APKA = {1.0}PP2A + {1.0}PKA voff35 {1.0}PP2BinactiveCa2 = {1.0}PP2Binactive + {2.0}Ca voff36 {1.0}PP2B = {1.0}PP2BinactiveCa2 + {2.0}Ca voff37 {1.0}cAMPR2C2 = {1.0}R2C2 + {1.0}cAMP voff38 {1.0}cAMP2R2C2 = {1.0}cAMPR2C2 + {1.0}cAMP voff39 {1.0}cAMP3R2C2 = {1.0}cAMP2R2C2 + {1.0}cAMP voff4 {1.0}D34CDK5 = {1.0}D34 + {1.0}CDK5 voff40 {1.0}cAMP4R2C2 = {1.0}cAMP3R2C2 + {1.0}cAMP voff41 {1.0}cAMP4R2C2 = {1.0}cAMP4R2C + {1.0}PKA voff44 {1.0}cAMPPDE = {1.0}cAMP + {1.0}PDE voff45 {1.0}cAMPPDEP = {1.0}cAMP + {1.0}PDEP voff46 {1.0}D3475PP2ACa = {1.0}D3475 + {1.0}PP2ACa voff47 {1.0}D3475137PP2ACa = {1.0}D3475137 + {1.0}PP2ACa voff48 {1.0}D75PP2ACa = {1.0}D75 + {1.0}PP2ACa voff49 {1.0}D75137PP2ACa = {1.0}D75137 + {1.0}PP2ACa voff5 {1.0}D34CK1 = {1.0}D34 + {1.0}CK1 voff50 {1.0}D3475PP2APCa = {1.0}D3475 + {1.0}PP2APCa voff51 {1.0}D3475137PP2APCa = {1.0}D3475137 + {1.0}PP2APCa voff52 {1.0}D75PP2APCa = {1.0}D75 + {1.0}PP2APCa voff53 {1.0}D75137PP2APCa = {1.0}D75137 + {1.0}PP2APCa voff54 {1.0}PP2ACa = {1.0}PP2A + {1.0}Ca voff55 {1.0}PP2ACaPKA = {1.0}PP2ACa + {1.0}PKA voff56 {1.0}PP2APCa = {1.0}PP2AP + {1.0}Ca voff6 {1.0}D34PP2B = {1.0}D34 + {1.0}PP2B voff7 {1.0}D75CK1 = {1.0}D75 + {1.0}CK1 voff8 {1.0}D75PKA = {1.0}D75 + {1.0}PKA voff9 {1.0}D75PP2A = {1.0}D75 + {1.0}PP2A von1 {1.0}D + {1.0}CDK5 = {1.0}DCDK5 von10 {1.0}D75 + {1.0}PP2AP = {1.0}D75PP2AP von11 {1.0}D137 + {1.0}CDK5 = {1.0}D137CDK5 von12 {1.0}D137 + {1.0}PKA = {1.0}D137PKA von13 {1.0}D137 + {1.0}PP2C = {1.0}D137PP2C von14 {1.0}D3475 + {1.0}CK1 = {1.0}D3475CK1 von15 {1.0}D3475 + {1.0}PP2A = {1.0}D3475PP2A von16 {1.0}D3475 + {1.0}PP2AP = {1.0}D3475PP2AP von17 {1.0}D3475 + {1.0}PP2B = {1.0}D3475PP2B von18 {1.0}D34137 + {1.0}CDK5 = {1.0}D34137CDK5 von19 {1.0}D34137 + {1.0}PP2B = {1.0}D34137PP2B von2 {1.0}D + {1.0}CK1 = {1.0}DCK1 von20 {1.0}D34137 + {1.0}PP2C = {1.0}D34137PP2C von21 {1.0}D75137 + {1.0}PKA = {1.0}D75137PKA von22 {1.0}D75137 + {1.0}PP2A = {1.0}D75137PP2A von23 {1.0}D75137 + {1.0}PP2AP = {1.0}D75137PP2AP von24 {1.0}D75137 + {1.0}PP2C = {1.0}D75137PP2C von25 {1.0}D3475137 + {1.0}PP2A = {1.0}D3475137PP2A von26 {1.0}D3475137 + {1.0}PP2AP = {1.0}D3475137PP2AP von27 {1.0}D3475137 + {1.0}PP2B = {1.0}D3475137PP2B von28 {1.0}D3475137 + {1.0}PP2C = {1.0}D3475137PP2C von29 {1.0}CK1P + {1.0}PP2B = {1.0}CK1PPP2B von3 {1.0}D + {1.0}PKA = {1.0}DPKA von31 {1.0}PDE + {1.0}PKA = {1.0}PDEPKA von33 {1.0}PP2A + {1.0}PKA = {1.0}PP2APKA von35 {1.0}PP2Binactive + {2.0}Ca = {1.0}PP2BinactiveCa2 von36 {1.0}PP2BinactiveCa2 + {2.0}Ca = {1.0}PP2B von37 {1.0}R2C2 + {1.0}cAMP = {1.0}cAMPR2C2 von38 {1.0}cAMPR2C2 + {1.0}cAMP = {1.0}cAMP2R2C2 von39 {1.0}cAMP2R2C2 + {1.0}cAMP = {1.0}cAMP3R2C2 von4 {1.0}D34 + {1.0}CDK5 = {1.0}D34CDK5 von40 {1.0}cAMP3R2C2 + {1.0}cAMP = {1.0}cAMP4R2C2 von41 {1.0}cAMP4R2C + {1.0}PKA = {1.0}cAMP4R2C2 von42 {1.0}cAMP4R2 + {1.0}PKA = {1.0}cAMP4R2C von43 {1.0}cAMP4R2C = {1.0}cAMP4R2 + {1.0}PKA von44 {1.0}cAMP + {1.0}PDE = {1.0}cAMPPDE von45 {1.0}cAMP + {1.0}PDEP = {1.0}cAMPPDEP von46 {1.0}D3475 + {1.0}PP2ACa = {1.0}D3475PP2ACa von47 {1.0}D3475137 + {1.0}PP2ACa = {1.0}D3475137PP2ACa von48 {1.0}D75 + {1.0}PP2ACa = {1.0}D75PP2ACa von49 {1.0}D75137 + {1.0}PP2ACa = {1.0}D75137PP2ACa von5 {1.0}D34 + {1.0}CK1 = {1.0}D34CK1 von50 {1.0}D3475 + {1.0}PP2APCa = {1.0}D3475PP2APCa von51 {1.0}D3475137 + {1.0}PP2APCa = {1.0}D3475137PP2APCa von52 {1.0}D75 + {1.0}PP2APCa = {1.0}D75PP2APCa von53 {1.0}D75137 + {1.0}PP2APCa = {1.0}D75137PP2APCa von54 {1.0}Ca + {1.0}PP2A = {1.0}PP2ACa von55 {1.0}PP2ACa + {1.0}PKA = {1.0}PP2ACaPKA von56 {1.0}PP2AP + {1.0}Ca = {1.0}PP2APCa von6 {1.0}D34 + {1.0}PP2B = {1.0}D34PP2B von7 {1.0}D75 + {1.0}CK1 = {1.0}D75CK1 von8 {1.0}D75 + {1.0}PKA = {1.0}D75PKA von9 {1.0}D75 + {1.0}PP2A = {1.0}D75PP2A end reactions begin rate equations v57 = k57*Spine v58 = Spine*v58k58*Ca[t] vcat1 = Spine*vcat1kcat1*DCDK5[t] vcat10 = Spine*vcat10kcat10*D75PP2AP[t] vcat11 = Spine*vcat11kcat11*D137CDK5[t] vcat12 = Spine*vcat12kcat12*D137PKA[t] vcat13 = Spine*vcat13kcat13*D137PP2C[t] vcat14 = Spine*vcat14kcat14*D3475CK1[t] vcat15 = Spine*vcat15kcat15*D3475PP2A[t] vcat16 = Spine*vcat16kcat16*D3475PP2AP[t] vcat17 = Spine*vcat17kcat17*D3475PP2B[t] vcat18 = Spine*vcat18kcat18*D34137CDK5[t] vcat19 = Spine*vcat19kcat19*D34137PP2B[t] vcat2 = Spine*vcat2kcat2*DCK1[t] vcat20 = Spine*vcat20kcat20*D34137PP2C[t] vcat21 = Spine*vcat21kcat21*D75137PKA[t] vcat22 = Spine*vcat22kcat22*D75137PP2A[t] vcat23 = Spine*vcat23kcat23*D75137PP2AP[t] vcat24 = Spine*vcat24kcat24*D75137PP2C[t] vcat25 = Spine*vcat25kcat25*D3475137PP2A[t] vcat26 = Spine*vcat26kcat26*D3475137PP2AP[t] vcat27 = Spine*vcat27kcat27*D3475137PP2B[t] vcat28 = Spine*vcat28kcat28*D3475137PP2C[t] vcat29 = Spine*vcat29kcat29*CK1PPP2B[t] vcat3 = Spine*vcat3kcat3*DPKA[t] vcat30 = Spine*vcat30kcat30*CK1[t] vcat31 = Spine*vcat31kcat31*PDEPKA[t] vcat32 = Spine*vcat32kcat32*PDEP[t] vcat33 = Spine*vcat33kcat33*PP2APKA[t] vcat34 = Spine*vcat34kcat34*PP2AP[t] vcat4 = Spine*vcat4kcat4*D34CDK5[t] vcat44 = Spine*vcat44kcat44*cAMPPDE[t] vcat45 = Spine*vcat45kcat45*cAMPPDEP[t] vcat46 = Spine*vcat46kcat46*D3475PP2ACa[t] vcat47 = Spine*vcat47kcat47*D3475137PP2ACa[t] vcat48 = Spine*vcat48kcat48*D75PP2ACa[t] vcat49 = Spine*vcat49kcat49*D75137PP2ACa[t] vcat5 = Spine*vcat5kcat5*D34CK1[t] vcat50 = Spine*vcat50kcat50*D3475PP2APCa[t] vcat51 = Spine*vcat51kcat51*D3475137PP2APCa[t] vcat52 = Spine*vcat52kcat52*D75PP2APCa[t] vcat53 = Spine*vcat53kcat53*D75137PP2APCa[t] vcat55 = Spine*vcat55kcat55*PP2ACaPKA[t] vcat56 = Spine*vcat56kcat56*PP2APCa[t] vcat6 = Spine*vcat6kcat6*D34PP2B[t] vcat7 = Spine*vcat7kcat7*D75CK1[t] vcat8 = Spine*vcat8kcat8*D75PKA[t] vcat9 = Spine*vcat9kcat9*D75PP2A[t] voff1 = Spine*voff1koff1*DCDK5[t] voff10 = Spine*voff10koff10*D75PP2AP[t] voff11 = Spine*voff11koff11*D137CDK5[t] voff12 = Spine*voff12koff12*D137PKA[t] voff13 = Spine*voff13koff13*D137PP2C[t] voff14 = Spine*voff14koff14*D3475CK1[t] voff15 = Spine*voff15koff15*D3475PP2A[t] voff16 = Spine*voff16koff16*D3475PP2AP[t] voff17 = Spine*voff17koff17*D3475PP2B[t] voff18 = Spine*voff18koff18*D34137CDK5[t] voff19 = Spine*voff19koff19*D34137PP2B[t] voff2 = Spine*voff2koff2*DCK1[t] voff20 = Spine*voff20koff20*D34137PP2C[t] voff21 = Spine*voff21koff21*D75137PKA[t] voff22 = Spine*voff22koff22*D75137PP2A[t] voff23 = Spine*voff23koff23*D75137PP2AP[t] voff24 = Spine*voff24koff24*D75137PP2C[t] voff25 = Spine*voff25koff25*D3475137PP2A[t] voff26 = Spine*voff26koff26*D3475137PP2AP[t] voff27 = Spine*voff27koff27*D3475137PP2B[t] voff28 = Spine*voff28koff28*D3475137PP2C[t] voff29 = Spine*voff29koff29*CK1PPP2B[t] voff3 = Spine*voff3koff3*DPKA[t] voff31 = Spine*voff31koff31*PDEPKA[t] voff33 = Spine*voff33koff33*PP2APKA[t] voff35 = Spine*voff35koff35*PP2BinactiveCa2[t] voff36 = Spine*voff36koff36*PP2B[t] voff37 = Spine*voff37koff37*cAMPR2C2[t] voff38 = Spine*voff38koff38*cAMP2R2C2[t] voff39 = Spine*voff39koff39*cAMP3R2C2[t] voff4 = Spine*voff4koff4*D34CDK5[t] voff40 = Spine*voff40koff40*cAMP4R2C2[t] voff41 = Spine*voff41koff41*cAMP4R2C2[t] voff44 = Spine*voff44koff44*cAMPPDE[t] voff45 = Spine*voff45koff45*cAMPPDEP[t] voff46 = Spine*voff46koff46*D3475PP2ACa[t] voff47 = Spine*voff47koff47*D3475137PP2ACa[t] voff48 = Spine*voff48koff48*D75PP2ACa[t] voff49 = Spine*voff49koff49*D75137PP2ACa[t] voff5 = Spine*voff5koff5*D34CK1[t] voff50 = Spine*voff50koff50*D3475PP2APCa[t] voff51 = Spine*voff51koff51*D3475137PP2APCa[t] voff52 = Spine*voff52koff52*D75PP2APCa[t] voff53 = Spine*voff53koff53*D75137PP2APCa[t] voff54 = Spine*voff54koff54*PP2ACa[t] voff55 = Spine*voff55koff55*PP2ACaPKA[t] voff56 = Spine*voff56koff56*PP2APCa[t] voff6 = Spine*voff6koff6*D34PP2B[t] voff7 = Spine*voff7koff7*D75CK1[t] voff8 = Spine*voff8koff8*D75PKA[t] voff9 = Spine*voff9koff9*D75PP2A[t] von1 = Spine*von1kon1*CDK5[t]*D[t] von10 = Spine*von10kon10*D75[t]*PP2AP[t] von11 = Spine*von11kon11*CDK5[t]*D137[t] von12 = Spine*von12kon12*D137[t]*PKA[t] von13 = Spine*von13kon13*D137[t]*PP2C[t] von14 = Spine*von14kon14*CK1[t]*D3475[t] von15 = Spine*von15kon15*D3475[t]*PP2A[t] von16 = Spine*von16kon16*D3475[t]*PP2AP[t] von17 = Spine*von17kon17*D3475[t]*PP2B[t] von18 = Spine*von18kon18*CDK5[t]*D34137[t] von19 = Spine*von19kon19*D34137[t]*PP2B[t] von2 = Spine*von2kon2*CK1[t]*D[t] von20 = Spine*von20kon20*D34137[t]*PP2C[t] von21 = Spine*von21kon21*D75137[t]*PKA[t] von22 = Spine*von22kon22*D75137[t]*PP2A[t] von23 = Spine*von23kon23*D75137[t]*PP2AP[t] von24 = Spine*von24kon24*D75137[t]*PP2C[t] von25 = Spine*von25kon25*D3475137[t]*PP2A[t] von26 = Spine*von26kon26*D3475137[t]*PP2AP[t] von27 = Spine*von27kon27*D3475137[t]*PP2B[t] von28 = Spine*von28kon28*D3475137[t]*PP2C[t] von29 = Spine*von29kon29*CK1P[t]*PP2B[t] von3 = Spine*von3kon3*D[t]*PKA[t] von31 = Spine*von31kon31*PDE[t]*PKA[t] von33 = Spine*von33kon33*PKA[t]*PP2A[t] von35 = Spine*von35kon35*Ca[t]^2*PP2Binactive[t] von36 = Spine*von36kon36*Ca[t]^2*PP2BinactiveCa2[t] von37 = Spine*von37kon37*cAMP[t]*R2C2[t] von38 = Spine*von38kon38*cAMP[t]*cAMPR2C2[t] von39 = Spine*von39kon39*cAMP[t]*cAMP2R2C2[t] von4 = Spine*von4kon4*CDK5[t]*D34[t] von40 = Spine*von40kon40*cAMP[t]*cAMP3R2C2[t] von41 = Spine*von41kon41*cAMP4R2C[t]*PKA[t] von42 = Spine*von42kon42*cAMP4R2[t]*PKA[t] von43 = Spine*von43kon43*cAMP4R2C[t] von44 = Spine*von44kon44*cAMP[t]*PDE[t] von45 = Spine*von45kon45*cAMP[t]*PDEP[t] von46 = Spine*von46kon46*D3475[t]*PP2ACa[t] von47 = Spine*von47kon47*D3475137[t]*PP2ACa[t] von48 = Spine*von48kon48*D75[t]*PP2ACa[t] von49 = Spine*von49kon49*D75137[t]*PP2ACa[t] von5 = Spine*von5kon5*CK1[t]*D34[t] von50 = Spine*von50kon50*D3475[t]*PP2APCa[t] von51 = Spine*von51kon51*D3475137[t]*PP2APCa[t] von52 = Spine*von52kon52*D75[t]*PP2APCa[t] von53 = Spine*von53kon53*D75137[t]*PP2APCa[t] von54 = Spine*von54kon54*Ca[t]*PP2A[t] von55 = Spine*von55kon55*PKA[t]*PP2ACa[t] von56 = Spine*von56kon56*Ca[t]*PP2AP[t] von6 = Spine*von6kon6*D34[t]*PP2B[t] von7 = Spine*von7kon7*CK1[t]*D75[t] von8 = Spine*von8kon8*D75[t]*PKA[t] von9 = Spine*von9kon9*D75[t]*PP2A[t] end rate equations begin parameters cAMPCadelay = 50.0 cAMPdelay = 400.0 k57 = "2.5e-08" konhigh = "6.6e-06" konlow = "2.5e-08" spikeduration = 2.0 spikeinterval = 2.0 Empty = 0.0 von1kon1 = 5600000.0 voff1koff1 = 12.0 vcat1kcat1 = 3.0 von2kon2 = 4400000.0 voff2koff2 = 12.0 vcat2kcat2 = 3.0 von3kon3 = 5600000.0 voff3koff3 = 10.8 vcat3kcat3 = 2.7 von4kon4 = 5600000.0 von5kon5 = 4400000.0 von6kon6 = 10000000.0 voff4koff4 = 12.0 vcat4kcat4 = 3.0 voff5koff5 = 12.0 vcat5kcat5 = 3.0 vcat6kcat6 = 4.0 voff6koff6 = 16.0 von7kon7 = 4400000.0 von8kon8 = 5600000.0 von9kon9 = 3800000.0 von10kon10 = 17000000.0 voff7koff7 = 12.0 vcat7kcat7 = 3.0 vcat8kcat8 = 0.0 voff8koff8 = 10.8 vcat9kcat9 = 10.0 voff9koff9 = 24.0 vcat10kcat10 = 24.0 voff10koff10 = 40.0 von11kon11 = 5600000.0 von12kon12 = 5600000.0 von13kon13 = 7500000.0 voff11koff11 = 12.0 vcat11kcat11 = 3.0 voff12koff12 = 10.8 vcat12kcat12 = 2.7 vcat13kcat13 = 3.0 voff13koff13 = 12.0 von14kon14 = 4400000.0 von18kon18 = 5600000.0 voff18koff18 = 12.0 voff14koff14 = 12.0 vcat14kcat14 = 3.0 vcat18kcat18 = 3.0 von21kon21 = 5600000.0 vcat21kcat21 = 0.0 voff21koff21 = 10.8 von17kon17 = 10000000.0 voff17koff17 = 1600.0 vcat17kcat17 = 4.0 von19kon19 = 75000.0 vcat19kcat19 = 0.03 voff19koff19 = 0.12 von27kon27 = 75000.0 voff27koff27 = 120.0 vcat27kcat27 = 0.03 von15kon15 = 3800000.0 vcat15kcat15 = 10.0 voff15koff15 = 24.0 von22kon22 = 3800000.0 vcat22kcat22 = 10.0 voff22koff22 = 24.0 von25kon25 = 3800000.0 vcat25kcat25 = 10.0 voff25koff25 = 24.0 von16kon16 = 17000000.0 vcat16kcat16 = 24.0 voff16koff16 = 40.0 von23kon23 = 17000000.0 vcat23kcat23 = 24.0 voff23koff23 = 40.0 vcat26kcat26 = 24.0 von26kon26 = 17000000.0 voff26koff26 = 40.0 von20kon20 = 7500000.0 vcat20kcat20 = 3.0 voff20koff20 = 12.0 von24kon24 = 7500000.0 vcat24kcat24 = 3.0 voff24koff24 = 12.0 von28kon28 = 7500000.0 vcat28kcat28 = 3.0 voff28koff28 = 12.0 von29kon29 = 30000000.0 voff29koff29 = 24.0 vcat29kcat29 = 6.0 vcat30kcat30 = 1.0 von31kon31 = 6000000.0 vcat31kcat31 = 9.0 voff31koff31 = 36.0 vcat32kcat32 = 0.1 von33kon33 = 10000000.0 voff33koff33 = 16.0 vcat33kcat33 = 4.0 vcat34kcat34 = 5.0 von35kon35 = 1000000000000000.0 von36kon36 = 3000000000000000.0 voff35koff35 = 1.0 voff36koff36 = 1.0 von37kon37 = 54000000.0 von38kon38 = 54000000.0 von39kon39 = 75000000.0 von40kon40 = 75000000.0 voff37koff37 = 33.0 voff38koff38 = 33.0 voff39koff39 = 110.0 voff40koff40 = 32.5 von41kon41 = 18000000.0 voff41koff41 = 60.0 von42kon42 = 18000000.0 von43kon43 = 60.0 von44kon44 = 2520000.0 voff44koff44 = 40.0 vcat44kcat44 = 10.0 von45kon45 = 5040000.0 voff45koff45 = 80.0 vcat45kcat45 = 20.0 v58k58 = 1.7 von46kon46 = 3800000.0 von47kon47 = 3800000.0 vcat47kcat47 = 10.0 voff47koff47 = 6.0 vcat46kcat46 = 10.0 voff46koff46 = 6.0 von48kon48 = 3800000.0 von49kon49 = 3800000.0 vcat49kcat49 = 10.0 voff49koff49 = 6.0 vcat48kcat48 = 10.0 voff48koff48 = 6.0 von50kon50 = 17000000.0 von51kon51 = 17000000.0 vcat51kcat51 = 24.0 voff51koff51 = 10.0 vcat50kcat50 = 24.0 voff50koff50 = 10.0 von52kon52 = 17000000.0 von53kon53 = 17000000.0 vcat53kcat53 = 24.0 voff53koff53 = 10.0 vcat52kcat52 = 24.0 voff52koff52 = 10.0 von54kon54 = 200000.0 voff54koff54 = 1.0 von55kon55 = 10000000.0 vcat55kcat55 = 4.0 von56kon56 = 200000.0 voff56koff56 = 1.0 vcat56kcat56 = 5.0 voff55koff55 = 16.0 Spine = "1e-15" end parameters begin initial conditions AMP[0] = AMPi CDK5[0] = CDK5i CK1[0] = CK1i CK1P[0] = CK1Pi CK1PPP2B[0] = CK1PPP2Bi Ca[0] = Cai D[0] = Di D137[0] = D137i D137CDK5[0] = D137CDK5i D137PKA[0] = D137PKAi D137PP2C[0] = D137PP2Ci D34[0] = D34i D34137[0] = D34137i D34137CDK5[0] = D34137CDK5i D34137PP2B[0] = D34137PP2Bi D34137PP2C[0] = D34137PP2Ci D3475[0] = D3475i D3475137[0] = D3475137i D3475137PP2A[0] = D3475137PP2Ai D3475137PP2ACa[0] = D3475137PP2ACai D3475137PP2AP[0] = D3475137PP2APi D3475137PP2APCa[0] = D3475137PP2APCai D3475137PP2B[0] = D3475137PP2Bi D3475137PP2C[0] = D3475137PP2Ci D3475CK1[0] = D3475CK1i D3475PP2A[0] = D3475PP2Ai D3475PP2ACa[0] = D3475PP2ACai D3475PP2AP[0] = D3475PP2APi D3475PP2APCa[0] = D3475PP2APCai D3475PP2B[0] = D3475PP2Bi D34CDK5[0] = D34CDK5i D34CK1[0] = D34CK1i D34PP2B[0] = D34PP2Bi D75[0] = D75i D75CK1[0] = D75CK1i D75137[0] = D75137i D75137PKA[0] = D75137PKAi D75137PP2A[0] = D75137PP2Ai D75137PP2ACa[0] = D75137PP2ACai D75137PP2AP[0] = D75137PP2APi D75137PP2APCa[0] = D75137PP2APCai D75137PP2C[0] = D75137PP2Ci D75PKA[0] = D75PKAi D75PP2A[0] = D75PP2Ai D75PP2ACa[0] = D75PP2ACai D75PP2AP[0] = D75PP2APi D75PP2APCa[0] = D75PP2APCai DCDK5[0] = DCDK5i DCK1[0] = DCK1i DPKA[0] = DPKAi PDE[0] = PDEi PDEP[0] = PDEPi PDEPKA[0] = PDEPKAi PKA[0] = PKAi PP2A[0] = PP2Ai PP2ACa[0] = PP2ACai PP2ACaPKA[0] = PP2ACaPKAi PP2AP[0] = PP2APi PP2APCa[0] = PP2APCai PP2APKA[0] = PP2APKAi PP2B[0] = PP2Bi PP2Binactive[0] = PP2Binactivei PP2BinactiveCa2[0] = PP2BinactiveCa2i PP2C[0] = PP2Ci R2C2[0] = R2C2i cAMP[0] = cAMPi cAMP2R2C2[0] = cAMP2R2C2i cAMP3R2C2[0] = cAMP3R2C2i cAMP4R2[0] = cAMP4R2i cAMP4R2C[0] = cAMP4R2Ci cAMP4R2C2[0] = cAMP4R2C2i cAMPPDE[0] = cAMPPDEi cAMPPDEP[0] = cAMPPDEPi cAMPR2C2[0] = cAMPR2C2i end initial conditions begin initial values AMPi = 0.0 CDK5i = 2e-07 CK1i = 1.66e-07 CK1Pi = 0.0 CK1PPP2Bi = 0.0 Cai = 0.0 Di = 4.98e-06 D137i = 0.0 D137CDK5i = 0.0 D137PKAi = 0.0 D137PP2Ci = 0.0 D34i = 0.0 D34137i = 0.0 D34137CDK5i = 0.0 D34137PP2Bi = 0.0 D34137PP2Ci = 0.0 D3475i = 0.0 D3475137i = 0.0 D3475137PP2Ai = 0.0 D3475137PP2ACai = 0.0 D3475137PP2APi = 0.0 D3475137PP2APCai = 0.0 D3475137PP2Bi = 0.0 D3475137PP2Ci = 0.0 D3475CK1i = 0.0 D3475PP2Ai = 0.0 D3475PP2ACai = 0.0 D3475PP2APi = 0.0 D3475PP2APCai = 0.0 D3475PP2Bi = 0.0 D34CDK5i = 0.0 D34CK1i = 0.0 D34PP2Bi = 0.0 D75i = 0.0 D75CK1i = 0.0 D75137i = 0.0 D75137PKAi = 0.0 D75137PP2Ai = 0.0 D75137PP2ACai = 0.0 D75137PP2APi = 0.0 D75137PP2APCai = 0.0 D75137PP2Ci = 0.0 D75PKAi = 0.0 D75PP2Ai = 0.0 D75PP2ACai = 0.0 D75PP2APi = 0.0 D75PP2APCai = 0.0 DCDK5i = 0.0 DCK1i = 0.0 DPKAi = 0.0 PDEi = 2e-06 PDEPi = 0.0 PDEPKAi = 0.0 PKAi = 0.0 PP2Ai = 2e-07 PP2ACai = 0.0 PP2ACaPKAi = 0.0 PP2APi = 0.0 PP2APCai = 0.0 PP2APKAi = 0.0 PP2Bi = 0.0 PP2Binactivei = 3.32e-07 PP2BinactiveCa2i = 0.0 PP2Ci = 1.33e-07 R2C2i = 6.64e-06 cAMPi = 0.0 cAMP2R2C2i = 0.0 cAMP3R2C2i = 0.0 cAMP4R2i = 0.0 cAMP4R2Ci = 0.0 cAMP4R2C2i = 0.0 cAMPPDEi = 0.0 cAMPPDEPi = 0.0 cAMPR2C2i = 0.0 end initial values begin assignment rules end assignment rules begin function definitions end function definitions begin events ca_on1 = (t >= cAMPCadelay + cAMPdelay, {k57 -> konhigh}, 0) ca_off6 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 5*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_on5 = (t >= cAMPCadelay + cAMPdelay + 4*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_off10 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 9*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_on10 = (t >= cAMPCadelay + cAMPdelay + 9*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_on9 = (t >= cAMPCadelay + cAMPdelay + 8*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_off3 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 2*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_on7 = (t >= cAMPCadelay + cAMPdelay + 6*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_on2 = (t >= cAMPCadelay + cAMPdelay + spikeduration + spikeinterval, {k57 -> konhigh}, 0) ca_off5 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 4*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_off2 = (t >= cAMPCadelay + cAMPdelay + 2*spikeduration + spikeinterval, {k57 -> konlow}, 0) ca_off8 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 7*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_off9 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 8*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_on4 = (t >= cAMPCadelay + cAMPdelay + 3*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_on6 = (t >= cAMPCadelay + cAMPdelay + 5*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_off7 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 6*(spikeduration + spikeinterval), {k57 -> konlow}, 0) ca_on8 = (t >= cAMPCadelay + cAMPdelay + 7*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) Ca_on3 = (t >= cAMPCadelay + cAMPdelay + 2*(spikeduration + spikeinterval), {k57 -> konhigh}, 0) ca_off4 = (t >= cAMPCadelay + cAMPdelay + spikeduration + 3*(spikeduration + spikeinterval), {k57 -> konlow}, 0) cAMP_pulse = (t >= cAMPdelay, {cAMP[t] -> 6.5999999999999995*^-6}, 0) ca_off1 = (t >= cAMPCadelay + cAMPdelay + spikeduration, {k57 -> konlow}, 0) end events begin process annotations end process annotations begin species annotations AMP http://identifiers.org/obo.chebi/CHEBI:16027 CDK5 http://identifiers.org/uniprot/Q03114 Ca http://identifiers.org/obo.chebi/CHEBI:29108 cAMP http://identifiers.org/obo.chebi/CHEBI:17489 end species annotations begin units end units