#ehrenstein1



#reactions
Abeta_formation_from_APP:
 $pool = {1.0}b
  Brain * Constant_flux__irreversible(k2)
Decrease_in_the_extracellular_concentration_of_beta_amyloid:
 {1.0}b = $pool
  Brain * Decrease_in_the_extracellular_concentration_of_beta_amyloid_0(k4, b)
Effect_of_extracellular_ACh:
 {1.0}b = $pool
  Brain * Effect_of_extracellular_ACh_0(k3, a)
Loss_of_intracellular_choline:
 {1.0}a = $pool
  Brain * Loss_of_intracellular_choline_0(k1, a, b)


#parameters
k1 = 0.007
k2 = 0.33
k3 = 0.0042
k4 = 0.01
Brain = 1.0


#initial values
a = 50.0
b = 0.0


#assignment rules
!F aRel = a / 50.0