begin name
ehrenstein1
end name

begin reactions
AbetaformationfromAPP {1.0}$EXTERNAL = {1.0}b
Decreaseintheextracellularconcentrationofbetaamyloid {1.0}b = {1.0}$EXTERNAL
EffectofextracellularACh {1.0}b = {1.0}$EXTERNAL
Lossofintracellularcholine {1.0}a = {1.0}$EXTERNAL
end reactions

begin rate equations
AbetaformationfromAPP = Brain*Constantfluxirreversible[k2]
Decreaseintheextracellularconcentrationofbetaamyloid = Brain*Decreaseintheextracellularconcentrationofbetaamyloid0[k4, b[t]]
EffectofextracellularACh = Brain*EffectofextracellularACh0[k3, a[t]]
Lossofintracellularcholine = Brain*Lossofintracellularcholine0[k1, a[t], b[t]]
end rate equations

begin parameters
k1 = 0.007
k2 = 0.33
k3 = 0.0042
k4 = 0.01
Brain = 1.0
end parameters

begin initial conditions
a[0] = ai
b[0] = bi
end initial conditions

begin initial values
ai = 50.0
bi = 0.0
end initial values

begin assignment rules
aRel := a[t]/50
end assignment rules

begin function definitions
Decreaseintheextracellularconcentrationofbetaamyloid0[k4_,b_] := b*k4
EffectofextracellularACh0[k3_,a_] := a*k3
Lossofintracellularcholine0[k1_,a_,b_] := a*b*k1
Constantfluxirreversible[v_] := v
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
a http://identifiers.org/chebi/CHEBI:15355
aRel http://identifiers.org/chebi/CHEBI:15355
b http://identifiers.org/uniprot/P05067
end species annotations

begin units
end units