begin name dutoit3 end name begin reactions vPFvALD {1.0}f16bpPF = {1.0}gapPF + {1.0}dhapPF vPFvATPASE {1.0}atpPF = {1.0}adpPF vPFvENO {1.0}p2gPF = {1.0}pepPF vPFvG3PDH {1.0}nadhPF + {1.0}dhapPF = {1.0}nadPF + {1.0}g3pPF vPFvGAPDH {1.0}nadPF + {1.0}gapPF = {1.0}nadhPF + {1.0}b13pgPF vPFvGLCtr {1.0}glcRBCi = {1.0}glcPF vPFvGLYtr {1.0}g3pPF = {1.0}$EXTERNAL vPFvHK {1.0}glcPF + {1.0}atpPF = {1.0}g6pPF + {1.0}adpPF vPFvLACtr {1.0}lacPF = {1.0}lacRBCi vPFvLDH {1.0}pyrPF + {1.0}nadhPF = {1.0}nadPF + {1.0}lacPF vPFvPFK {1.0}f6pPF + {1.0}atpPF = {1.0}f16bpPF + {1.0}adpPF vPFvPGI {1.0}g6pPF = {1.0}f6pPF vPFvPGK {1.0}b13pgPF + {1.0}adpPF = {1.0}p3gPF + {1.0}atpPF vPFvPGM {1.0}p3gPF = {1.0}p2gPF vPFvPK {1.0}pepPF + {1.0}adpPF = {1.0}pyrPF + {1.0}atpPF vPFvPYRtr {1.0}pyrPF = {1.0}pyrRBCi vPFvTPI {1.0}dhapPF = {1.0}gapPF vRBCivAK {1.0}mgadpRBCi + {1.0}adpRBCi = {1.0}mgatpRBCi + {1.0}ampRBCi vRBCivALD {1.0}f16p2RBCi = {1.0}gapRBCi + {1.0}dhapRBCi vRBCivATPASE {1.0}mgatpRBCi = {1.0}phosRBCi + {1.0}mgadpRBCi vRBCivBPGSP1 {1.0}bpgspRBCi + {1.0}b13pgRBCi = {1.0}bpgspb13pgRBCi vRBCivBPGSP2 {1.0}bpgspb13pgRBCi = {1.0}p3gRBCi + {1.0}bpgsppRBCi vRBCivBPGSP3 {1.0}p3gRBCi + {1.0}bpgsppRBCi = {1.0}bpgsppp3gRBCi vRBCivBPGSP4 {1.0}p2gRBCi + {1.0}bpgsppRBCi = {1.0}bpgsppp2gRBCi vRBCivBPGSP5 {1.0}bpgsppp3gRBCi = {1.0}bpgspb23pgRBCi vRBCivBPGSP6 {1.0}bpgsppp2gRBCi = {1.0}bpgspb23pgRBCi vRBCivBPGSP7 {1.0}bpgspb23pgRBCi = {1.0}bpgspRBCi + {1.0}b23pgRBCi vRBCivBPGSP8 {1.0}phosRBCi + {1.0}bpgsppRBCi = {1.0}bpgsppphosRBCi vRBCivBPGSP9 {1.0}bpgsppphosRBCi = {2.0}phosRBCi + {1.0}bpgspRBCi vRBCivENO {1.0}p2gRBCi = {1.0}pepRBCi vRBCivG6PDH {1.0}nadpRBCi + {1.0}g6pRBCi = {1.0}p6glRBCi + {1.0}nadphRBCi vRBCivGAPDH {1.0}phosRBCi + {1.0}nadRBCi + {1.0}gapRBCi = {1.0}nadhRBCi + {1.0}b13pgRBCi vRBCivGLCTRANSPORT {1.0}$EXTERNAL = {1.0}glcRBCi vRBCivGSSGR {1.0}nadphRBCi + {1.0}gssgRBCi = {1.0}nadpRBCi + {2.0}gshRBCi vRBCivHBADP {1.0}hbRBCi + {1.0}adpRBCi = {1.0}hbadpRBCi vRBCivHBATP {1.0}hbRBCi + {1.0}atpRBCi = {1.0}hbatpRBCi vRBCivHBB13PG {1.0}hbRBCi + {1.0}b13pgRBCi = {1.0}hbb13pgRBCi vRBCivHBB23PG {1.0}hbRBCi + {1.0}b23pgRBCi = {1.0}hbb23pgRBCi vRBCivHBMGATP {1.0}mgatpRBCi + {1.0}hbRBCi = {1.0}hbmgatpRBCi vRBCivHK {1.0}mgatpRBCi + {1.0}glcRBCi = {1.0}mgadpRBCi + {1.0}g6pRBCi vRBCivLACTRANSPORT {1.0}lacRBCi = {1.0}$EXTERNAL vRBCivLDH {1.0}pyrRBCi + {1.0}nadhRBCi = {1.0}nadRBCi + {1.0}lacRBCi vRBCivLDHP {1.0}pyrRBCi + {1.0}nadphRBCi = {1.0}nadpRBCi + {1.0}lacRBCi vRBCivMGADP {1.0}mgRBCi + {1.0}adpRBCi = {1.0}mgadpRBCi vRBCivMGATP {1.0}atpRBCi + {1.0}mgRBCi = {1.0}mgatpRBCi vRBCivMGB13PG {1.0}mgRBCi + {1.0}b13pgRBCi = {1.0}mgb13pgRBCi vRBCivMGB23PG {1.0}mgRBCi + {1.0}b23pgRBCi = {1.0}mgb23pgRBCi vRBCivMGF16P2 {1.0}mgRBCi + {1.0}f16p2RBCi = {1.0}mgf16p2RBCi vRBCivMGG16P2 {1.0}mgRBCi + {1.0}g16p2RBCi = {1.0}mgg16p2RBCi vRBCivMGPHOS {1.0}phosRBCi + {1.0}mgRBCi = {1.0}mgphosRBCi vRBCivOX {2.0}gshRBCi = {1.0}gssgRBCi vRBCivOXNADH {1.0}nadhRBCi = {1.0}nadRBCi vRBCivP6GDH {1.0}p6gRBCi + {1.0}nadpRBCi = {1.0}ru5pRBCi + {1.0}nadphRBCi vRBCivPFK {1.0}mgatpRBCi + {1.0}f6pRBCi = {1.0}mgadpRBCi + {1.0}f16p2RBCi vRBCivPGI {1.0}g6pRBCi = {1.0}f6pRBCi vRBCivPGK {1.0}mgadpRBCi + {1.0}b13pgRBCi = {1.0}p3gRBCi + {1.0}mgatpRBCi vRBCivPGLHYDROLYSIS {1.0}p6glRBCi = {1.0}p6gRBCi vRBCivPGM {1.0}p3gRBCi = {1.0}p2gRBCi vRBCivPHOSTRANSPORT {1.0}phosRBCi = {1.0}$EXTERNAL vRBCivPK {1.0}pepRBCi + {1.0}mgadpRBCi = {1.0}pyrRBCi + {1.0}mgatpRBCi vRBCivPYRTRANSPORT {1.0}pyrRBCi = {1.0}$EXTERNAL vRBCivR5PI {1.0}ru5pRBCi = {1.0}rib5pRBCi vRBCivRu5PE {1.0}ru5pRBCi = {1.0}xu5pRBCi vRBCivTA {1.0}sed7pRBCi + {1.0}gapRBCi = {1.0}f6pRBCi + {1.0}ery4pRBCi vRBCivTIM {1.0}gapRBCi = {1.0}dhapRBCi vRBCivTK1 {1.0}xu5pRBCi + {1.0}tkRBCi = {1.0}tkxu5pRBCi vRBCivTK2 {1.0}tkxu5pRBCi = {1.0}tkgRBCi + {1.0}gapRBCi vRBCivTK3 {1.0}tkgRBCi + {1.0}rib5pRBCi = {1.0}tkgrib5pRBCi vRBCivTK4 {1.0}tkgrib5pRBCi = {1.0}tkRBCi + {1.0}sed7pRBCi vRBCivTK5 {1.0}tkgRBCi + {1.0}ery4pRBCi = {1.0}tkgery4pRBCi vRBCivTK6 {1.0}tkgery4pRBCi = {1.0}tkRBCi + {1.0}f6pRBCi vRBCvAK {1.0}mgadpRBC + {1.0}adpRBC = {1.0}mgatpRBC + {1.0}ampRBC vRBCvALD {1.0}f16p2RBC = {1.0}gapRBC + {1.0}dhapRBC vRBCvATPASE {1.0}mgatpRBC = {1.0}phosRBC + {1.0}mgadpRBC vRBCvBPGSP1 {1.0}bpgspRBC + {1.0}b13pgRBC = {1.0}bpgspb13pgRBC vRBCvBPGSP2 {1.0}bpgspb13pgRBC = {1.0}p3gRBC + {1.0}bpgsppRBC vRBCvBPGSP3 {1.0}p3gRBC + {1.0}bpgsppRBC = {1.0}bpgsppp3gRBC vRBCvBPGSP4 {1.0}p2gRBC + {1.0}bpgsppRBC = {1.0}bpgsppp2gRBC vRBCvBPGSP5 {1.0}bpgsppp3gRBC = {1.0}bpgspb23pgRBC vRBCvBPGSP6 {1.0}bpgsppp2gRBC = {1.0}bpgspb23pgRBC vRBCvBPGSP7 {1.0}bpgspb23pgRBC = {1.0}bpgspRBC + {1.0}b23pgRBC vRBCvBPGSP8 {1.0}phosRBC + {1.0}bpgsppRBC = {1.0}bpgsppphosRBC vRBCvBPGSP9 {1.0}bpgsppphosRBC = {2.0}phosRBC + {1.0}bpgspRBC vRBCvENO {1.0}p2gRBC = {1.0}pepRBC vRBCvG6PDH {1.0}nadpRBC + {1.0}g6pRBC = {1.0}p6glRBC + {1.0}nadphRBC vRBCvGAPDH {1.0}phosRBC + {1.0}nadRBC + {1.0}gapRBC = {1.0}nadhRBC + {1.0}b13pgRBC vRBCvGLCTRANSPORT {1.0}$EXTERNAL = {1.0}glcRBC vRBCvGSSGR {1.0}nadphRBC + {1.0}gssgRBC = {1.0}nadpRBC + {2.0}gshRBC vRBCvHBADP {1.0}hbRBC + {1.0}adpRBC = {1.0}hbadpRBC vRBCvHBATP {1.0}hbRBC + {1.0}atpRBC = {1.0}hbatpRBC vRBCvHBB13PG {1.0}hbRBC + {1.0}b13pgRBC = {1.0}hbb13pgRBC vRBCvHBB23PG {1.0}hbRBC + {1.0}b23pgRBC = {1.0}hbb23pgRBC vRBCvHBMGATP {1.0}mgatpRBC + {1.0}hbRBC = {1.0}hbmgatpRBC vRBCvHK {1.0}mgatpRBC + {1.0}glcRBC = {1.0}mgadpRBC + {1.0}g6pRBC vRBCvLACTRANSPORT {1.0}lacRBC = {1.0}$EXTERNAL vRBCvLDH {1.0}pyrRBC + {1.0}nadhRBC = {1.0}nadRBC + {1.0}lacRBC vRBCvLDHP {1.0}pyrRBC + {1.0}nadphRBC = {1.0}nadpRBC + {1.0}lacRBC vRBCvMGADP {1.0}mgRBC + {1.0}adpRBC = {1.0}mgadpRBC vRBCvMGATP {1.0}mgRBC + {1.0}atpRBC = {1.0}mgatpRBC vRBCvMGB13PG {1.0}mgRBC + {1.0}b13pgRBC = {1.0}mgb13pgRBC vRBCvMGB23PG {1.0}mgRBC + {1.0}b23pgRBC = {1.0}mgb23pgRBC vRBCvMGF16P2 {1.0}mgRBC + {1.0}f16p2RBC = {1.0}mgf16p2RBC vRBCvMGG16P2 {1.0}mgRBC + {1.0}g16p2RBC = {1.0}mgg16p2RBC vRBCvMGPHOS {1.0}phosRBC + {1.0}mgRBC = {1.0}mgphosRBC vRBCvOX {2.0}gshRBC = {1.0}gssgRBC vRBCvOXNADH {1.0}nadhRBC = {1.0}nadRBC vRBCvP6GDH {1.0}p6gRBC + {1.0}nadpRBC = {1.0}ru5pRBC + {1.0}nadphRBC vRBCvPFK {1.0}mgatpRBC + {1.0}f6pRBC = {1.0}mgadpRBC + {1.0}f16p2RBC vRBCvPGI {1.0}g6pRBC = {1.0}f6pRBC vRBCvPGK {1.0}mgadpRBC + {1.0}b13pgRBC = {1.0}p3gRBC + {1.0}mgatpRBC vRBCvPGLHYDROLYSIS {1.0}p6glRBC = {1.0}p6gRBC vRBCvPGM {1.0}p3gRBC = {1.0}p2gRBC vRBCvPHOSTRANSPORT {1.0}phosRBC = {1.0}$EXTERNAL vRBCvPK {1.0}pepRBC + {1.0}mgadpRBC = {1.0}pyrRBC + {1.0}mgatpRBC vRBCvPYRTRANSPORT {1.0}pyrRBC = {1.0}$EXTERNAL vRBCvR5PI {1.0}ru5pRBC = {1.0}rib5pRBC vRBCvRu5PE {1.0}ru5pRBC = {1.0}xu5pRBC vRBCvTA {1.0}sed7pRBC + {1.0}gapRBC = {1.0}f6pRBC + {1.0}ery4pRBC vRBCvTIM {1.0}gapRBC = {1.0}dhapRBC vRBCvTK1 {1.0}xu5pRBC + {1.0}tkRBC = {1.0}tkxu5pRBC vRBCvTK2 {1.0}tkxu5pRBC = {1.0}tkgRBC + {1.0}gapRBC vRBCvTK3 {1.0}tkgRBC + {1.0}rib5pRBC = {1.0}tkgrib5pRBC vRBCvTK4 {1.0}tkgrib5pRBC = {1.0}tkRBC + {1.0}sed7pRBC vRBCvTK5 {1.0}tkgRBC + {1.0}ery4pRBC = {1.0}tkgery4pRBC vRBCvTK6 {1.0}tkgery4pRBC = {1.0}tkRBC + {1.0}f6pRBC end reactions begin rate equations vPFvALD = (parMulti*VPFvALD*f16bpPF[t]*(1 - (dhapPF[t]*gapPF[t])/(KeqPFvALD*Vpf*f16bpPF[t])))/(Kf16bpPFvALD*(1 + dhapPF[t]/(KdhapPFvALD*Vpf) + f16bpPF[t]/(Kf16bpPFvALD*Vpf) + gapPF[t]/(KgapPFvALD*Vpf) + (dhapPF[t]*gapPF[t])/(KdhapPFvALD*KgapPFvALD*Vpf^2))) vPFvATPASE = (parMulti*VPFvATPASE*atpPF[t]^5)/(KmPFvATPASE^5*Vpf^4*(1 + atpPF[t]^5/(KmPFvATPASE^5*Vpf^5))) vPFvENO = (parMulti*VPFvENO*p2gPF[t]*(1 - pepPF[t]/(KeqPFvENO*p2gPF[t])))/(Kp2gPFvENO*(1 + p2gPF[t]/(Kp2gPFvENO*Vpf) + pepPF[t]/(KpepPFvENO*Vpf))) vPFvG3PDH = (parMulti*VfPFvG3PDH*dhapPF[t]*nadhPF[t]*(1 - (g3pPF[t]*nadPF[t])/(KeqPFvG3PDH*dhapPF[t]*nadhPF[t])))/(KdhapPFvG3PDH*KnadhPFvG3PDH*Vpf*(1 + dhapPF[t]/(KdhapPFvG3PDH*Vpf) + g3pPF[t]/(Kg3pPFvG3PDH*Vpf))*(1 + nadhPF[t]/(KnadhPFvG3PDH*Vpf) + nadPF[t]/(KnadPFvG3PDH*Vpf))) vPFvGAPDH = (parMulti*(-((VrPFvGAPDH*b13pgPF[t]*nadhPF[t])/(Kb13pgPFvGAPDH*KnadhPFvGAPDH*Vpf)) + (VPFvGAPDH*gapPF[t]*nadPF[t])/(KgapPFvGAPDH*KnadPFvGAPDH*Vpf)))/((1 + b13pgPF[t]/(Kb13pgPFvGAPDH*Vpf) + gapPF[t]/(KgapPFvGAPDH*Vpf))*(1 + nadhPF[t]/(KnadhPFvGAPDH*Vpf) + nadPF[t]/(KnadPFvGAPDH*Vpf))) vPFvGLCtr = (parMulti*(-((VPFvGLCtr*glcPF[t])/((1 + cyt/ki1)*KmPFvGLCtr)) + (Vpf*VPFvGLCtr*glcRBCi[t])/((1 + cyt/ki1)*KmPFvGLCtr*Vrbci)))/(1 + ((1 + cyt/ki2)*glcPF[t])/((1 + cyt/ki1)*KmPFvGLCtr*Vpf) + ((1 + cyt/ki2)*glcRBCi[t])/((1 + cyt/ki1)*KmPFvGLCtr*Vrbci) + (alphaPFvGLCtr*glcPF[t]*glcRBCi[t])/((1 + cyt/ki1)*KmPFvGLCtr^2*Vpf*Vrbci)) vPFvGLYtr = kPFvGLYtr*parMulti*Vpf*(-(glyEXT/vBld) + g3pPF[t]/Vpf) vPFvHK = (parMulti*VPFvHK*atpPF[t]*(1 - (adpPF[t]*g6pPF[t])/(KeqPFvHK*atpPF[t]*glcPF[t]))*glcPF[t])/(KatpPFvHK*KglcPFvHK*Vpf*(1 + adpPF[t]/(KadpPFvHK*Vpf) + atpPF[t]/(KatpPFvHK*Vpf))*(1 + atpPF[t]/(KiatpPFvHK*Vpf))*(1 + g6pPF[t]/(Kg6pPFvHK*Vpf) + glcPF[t]/(KglcPFvHK*Vpf))) vPFvLACtr = parMulti*(KdPFvLACtr*lacPF[t]*(1 - (hRBC*Vpf*lacRBCi[t])/(hPF*Vrbci*lacPF[t])) + (VPFvLACtr*lacPF[t]*(1 - (hRBC*Vpf*lacRBCi[t])/(hPF*Vrbci*lacPF[t])))/(KlacPFvLACtr*(1 + lacPF[t]/(KlacPFvLACtr*Vpf) + lacRBCi[t]/(KlacPFvLACtr*Vrbci) + pyrPF[t]/(KipyrPFvLACtr*Vpf) + pyrRBCi[t]/(KipyrPFvLACtr*Vrbci)))) vPFvLDH = (parMulti*(-((VrPFvLDH*lacPF[t]*nadPF[t])/(KlacPFvLDH*KnadPFvLDH*Vpf)) + (VfPFvLDH*nadhPF[t]*pyrPF[t])/(KnadhPFvLDH*KpyrPFvLDH*Vpf)))/((1 + nadhPF[t]/(KnadhPFvLDH*Vpf) + nadPF[t]/(KnadPFvLDH*Vpf))*(1 + lacPF[t]/(KlacPFvLDH*Vpf) + pyrPF[t]/(KpyrPFvLDH*Vpf))) vPFvPFK = (parMulti*VPFvPFK*atpPF[t]*f6pPF[t])/(KatpPFvPFK*Kf6pPFvPFK*Vpf*(1 + atpPF[t]/(KatpPFvPFK*Vpf))*(1 + adpPF[t]/(KadpPFvPFK*Vpf) + atpPF[t]/(KatpPFvPFK*Vpf))*(1 + f16bpPF[t]/(Kf16bpPFvPFK*Vpf) + f6pPF[t]/(Kf6pPFvPFK*Vpf))) vPFvPGI = (parMulti*VPFvPGI*(1 - f6pPF[t]/(KeqPFvPGI*g6pPF[t]))*g6pPF[t])/(Kg6pPFvPGI*(1 + f6pPF[t]/(Kf6pPFvPGI*Vpf) + g6pPF[t]/(Kg6pPFvPGI*Vpf))) vPFvPGK = (KadpPFvPGK*Kb13pgPFvPGK*KeqPFvPGK*parMulti*VrPFvPGK*atpPF[t]*(-1 + (KeqPFvPGK*adpPF[t]*b13pgPF[t])/(atpPF[t]*p3gPF[t]))*p3gPF[t])/(KatpPFvPGK^2*Kp3gPFvPGK^2*Vpf*(1 + adpPF[t]/(KadpPFvPGK*Vpf) + atpPF[t]/(KatpPFvPGK*Vpf))*(1 + b13pgPF[t]/(Kb13pgPFvPGK*Vpf) + p3gPF[t]/(Kp3gPFvPGK*Vpf))) vPFvPGM = (parMulti*VPFvPGM*(1 - p2gPF[t]/(KeqPFvPGM*p3gPF[t]))*p3gPF[t])/(Kp3gPFvPGM*(1 + p2gPF[t]/(Kp2gPFvPGM*Vpf) + p3gPF[t]/(Kp3gPFvPGM*Vpf))) vPFvPK = (parMulti*VPFvPK*adpPF[t]*pepPF[t])/(KadpPFvPK*KpepPFvPK*Vpf*(1 + adpPF[t]/(KadpPFvPK*Vpf))*(1 + pepPF[t]/(KpepPFvPK*Vpf))*(1 + LPFvPK*(1 + (adpPF[t]/(KiadpPFvPK*Vpf) + atpPF[t]/(KiatpPFvPK*Vpf))^h)*(1 + (pepPF[t]/(KipepPFvPK*Vpf) + pyrPF[t]/(KipyrPFvPK*Vpf))^h))) vPFvPYRtr = parMulti*(KdPFvPYRtr*pyrPF[t]*(1 - (hRBC*Vpf*pyrRBCi[t])/(hPF*Vrbci*pyrPF[t])) + (VPFvPYRtr*pyrPF[t]*(1 - (hRBC*Vpf*pyrRBCi[t])/(hPF*Vrbci*pyrPF[t])))/(KpyrPFvPYRtr*(1 + lacPF[t]/(KilacPFvPYRtr*Vpf) + lacRBCi[t]/(KilacPFvPYRtr*Vrbci) + pyrPF[t]/(KpyrPFvPYRtr*Vpf) + pyrRBCi[t]/(KpyrPFvPYRtr*Vrbci)))) vPFvTPI = (parMulti*VPFvTPI*dhapPF[t]*(1 - gapPF[t]/(KeqPFvTPI*dhapPF[t])))/(KdhapPFvTPI*(1 + dhapPF[t]/(KdhapPFvTPI*Vpf) + gapPF[t]/(KgapPFvTPI*Vpf) + pepPF[t]/(KipepPFvTPI*Vpf))) vRBCivAK = parMulti*TsRBC*Vrbci*((K1appRBCvAK*adpRBCi[t]*mgadpRBCi[t])/Vrbci^2 - (K2appRBCvAK*ampRBCi[t]*mgatpRBCi[t])/Vrbci^2) vRBCivALD = (parMulti*TsRBC*Vrbci*VRBCvALD*((KcatfRBCvALD*f16p2RBCi[t])/(Kmf16p2RBCvALD*Vrbci) - (KcatrRBCvALD*dhapRBCi[t]*gapRBCi[t])/(KidhapRBCvALD*KmgapRBCvALD*Vrbci^2)))/(1 + dhapRBCi[t]/(KidhapRBCvALD*Vrbci) + f16p2RBCi[t]/(Kmf16p2RBCvALD*Vrbci) + (dhapRBCi[t]*gapRBCi[t])/(KidhapRBCvALD*KmgapRBCvALD*Vrbci^2) + (KmdhapRBCvALD*f16p2RBCi[t]*gapRBCi[t])/(KidhapRBCvALD*Kif16p2RBCvALD*KmgapRBCvALD*Vrbci^2) + (b23pgRBCi[t]/Vrbci + mgb23pgRBCi[t]/Vrbci)/Kib23pgRBCvALD + (KmdhapRBCvALD*gapRBCi[t]*(1 + (b23pgRBCi[t]/Vrbci + mgb23pgRBCi[t]/Vrbci)/Kib23pgRBCvALD))/(KidhapRBCvALD*KmgapRBCvALD*Vrbci)) vRBCivATPASE = KRBCvATPASE*parMulti*TsRBC*mgatpRBCi[t] vRBCivBPGSP1 = parMulti*TsRBC*Vrbci*(-((K2RBCvBPGSP1*bpgspb13pgRBCi[t])/Vrbci) + (K1appRBCvBPGSP1*b13pgRBCi[t]*bpgspRBCi[t])/Vrbci^2) vRBCivBPGSP2 = K3appRBCvBPGSP2*parMulti*TsRBC*bpgspb13pgRBCi[t] vRBCivBPGSP3 = parMulti*TsRBC*Vrbci*(-((K5RBCvBPGSP3*bpgsppp3gRBCi[t])/Vrbci) + (K4appRBCvBPGSP3*bpgsppRBCi[t]*p3gRBCi[t])/Vrbci^2) vRBCivBPGSP4 = parMulti*TsRBC*Vrbci*(-((K7RBCvBPGSP4*bpgsppp2gRBCi[t])/Vrbci) + (K6appRBCvBPGSP4*bpgsppRBCi[t]*p2gRBCi[t])/Vrbci^2) vRBCivBPGSP5 = parMulti*TsRBC*Vrbci*(-((K9RBCvBPGSP5*bpgspb23pgRBCi[t])/Vrbci) + (K8RBCvBPGSP5*bpgsppp3gRBCi[t])/Vrbci) vRBCivBPGSP6 = parMulti*TsRBC*Vrbci*(-((K11RBCvBPGSP6*bpgspb23pgRBCi[t])/Vrbci) + (K10RBCvBPGSP6*bpgsppp2gRBCi[t])/Vrbci) vRBCivBPGSP7 = parMulti*TsRBC*Vrbci*((K12RBCvBPGSP7*bpgspb23pgRBCi[t])/Vrbci - (K13appRBCvBPGSP7*b23pgRBCi[t]*bpgspRBCi[t])/Vrbci^2) vRBCivBPGSP8 = parMulti*TsRBC*Vrbci*(-((K15RBCvBPGSP8*bpgsppphosRBCi[t])/Vrbci) + (K14RBCvBPGSP8*bpgsppRBCi[t]*phosRBCi[t])/Vrbci^2) vRBCivBPGSP9 = K16RBCvBPGSP9*parMulti*TsRBC*bpgsppphosRBCi[t] vRBCivENO = (parMulti*TsRBC*Vrbci*VRBCvENO*((KcatfRBCvENO*mgRBCi[t]*p2gRBCi[t])/(KimgRBCvENO*Kmp2gRBCvENO*Vrbci^2) - (KcatrRBCvENO*mgRBCi[t]*pepRBCi[t])/(KipepRBCvENO*KmmgRBCvENO*Vrbci^2)))/(1 + mgRBCi[t]/(KimgRBCvENO*Vrbci) + p2gRBCi[t]/(Kip2gRBCvENO*Vrbci) + (mgRBCi[t]*p2gRBCi[t])/(KimgRBCvENO*Kmp2gRBCvENO*Vrbci^2) + pepRBCi[t]/(KipepRBCvENO*Vrbci) + (mgRBCi[t]*pepRBCi[t])/(KipepRBCvENO*KmmgRBCvENO*Vrbci^2)) vRBCivG6PDH = (parMulti*TsRBC*Vrbci*VRBCvG6PDH*((K1RBCvG6PDH*K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*K9RBCvG6PDH*g6pRBCi[t]*nadpRBCi[t])/Vrbci^2 - (K10RBCvG6PDH*K2RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*nadphRBCi[t]*p6glRBCi[t])/Vrbci^2))/(K2RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*K9RBCvG6PDH + (K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*K9RBCvG6PDH*g6pRBCi[t])/Vrbci + (K10RBCvG6PDH*K2RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K5RBCvG6PDH*K6RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*nadphRBCi[t])/Vrbci + (K10RBCvG6PDH*K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*g6pRBCi[t]*nadphRBCi[t])/Vrbci^2 + (K1RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*K9RBCvG6PDH*nadpRBCi[t])/Vrbci + (K1RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K9RBCvG6PDH + K6RBCvG6PDH*K9RBCvG6PDH + K7RBCvG6PDH*K9RBCvG6PDH)*g6pRBCi[t]*nadpRBCi[t])/Vrbci^2 + (K2RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*p6glRBCi[t])/Vrbci + (K10RBCvG6PDH*(K2RBCvG6PDH*K4RBCvG6PDH + K2RBCvG6PDH*K5RBCvG6PDH + K2RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K6RBCvG6PDH)*K8RBCvG6PDH*nadphRBCi[t]*p6glRBCi[t])/Vrbci^2 + (K10RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH + K6RBCvG6PDH)*K8RBCvG6PDH*g6pRBCi[t]*nadphRBCi[t]*p6glRBCi[t])/Vrbci^3 + (K1RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*nadpRBCi[t]*p6glRBCi[t])/Vrbci^2 + (K1RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH + K6RBCvG6PDH)*K8RBCvG6PDH*g6pRBCi[t]*nadpRBCi[t]*p6glRBCi[t])/Vrbci^3) vRBCivGAPDH = (parMulti*TsRBC*Vrbci*VRBCvGAPDH*(-((KcatrappRBCvGAPDH*b13pgRBCi[t]*nadhRBCi[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbci^2)) + (KcatfappRBCvGAPDH*gapRBCi[t]*nadRBCi[t]*phosRBCi[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbci^3)))/((b13pgRBCi[t]*(1 + gapRBCi[t]/(KidgapRBCvGAPDH*Vrbci)))/(Kiappb13pgRBCvGAPDH*Vrbci) + (gapRBCi[t]*(1 + gapRBCi[t]/(KidgapRBCvGAPDH*Vrbci)))/(KiappgapRBCvGAPDH*Vrbci) + (Kmb13pgRBCvGAPDH*nadhRBCi[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbci) + (b13pgRBCi[t]*nadhRBCi[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbci^2) + (gapRBCi[t]*nadhRBCi[t])/(KiappgapRBCvGAPDH*KiappnadhRBCvGAPDH*Vrbci^2) + (b13pgRBCi[t]*nadRBCi[t])/(Kiappb13pgRBCvGAPDH*KinadRBCvGAPDH*Vrbci^2) + (gapRBCi[t]*nadRBCi[t])/(KiappgapRBCvGAPDH*KinadRBCvGAPDH*Vrbci^2) + (gapRBCi[t]*(1 + gapRBCi[t]/(KidgapRBCvGAPDH*Vrbci))*phosRBCi[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*Vrbci^2) + (Kmb13pgRBCvGAPDH*nadhRBCi[t]*phosRBCi[t])/(Kiappb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbci^2) + (Kmb13pgRBCvGAPDH*b13pgRBCi[t]*nadhRBCi[t]*phosRBCi[t])/(Kiappb13pgRBCvGAPDH*Kidb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbci^3) + (gapRBCi[t]*nadhRBCi[t]*phosRBCi[t])/(KiappgapRBCvGAPDH*KiappnadhRBCvGAPDH*KiphosRBCvGAPDH*Vrbci^3) + (KmgapRBCvGAPDH*nadRBCi[t]*phosRBCi[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbci^2) + (KmgapRBCvGAPDH*b13pgRBCi[t]*nadRBCi[t]*phosRBCi[t])/(KiappgapRBCvGAPDH*Kidb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbci^3) + (gapRBCi[t]*nadRBCi[t]*phosRBCi[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbci^3)) vRBCivGLCTRANSPORT = parMulti*TsRBC*Vrbci*((glcAlpha*glcEXT*VRBCvGLCTRANSPORT)/((kAlpha + (glcAlpha*glcEXT)/vBld + ((1 - glcAlpha)*glcEXT*kAlpha)/(kBeta*vBld))*vBld) + ((1 - glcAlpha)*glcEXT*VRBCvGLCTRANSPORT)/((kBeta + ((1 - glcAlpha)*glcEXT)/vBld + (glcAlpha*glcEXT*kBeta)/(kAlpha*vBld))*vBld) - (glcAlpha*VRBCvGLCTRANSPORT*glcRBCi[t])/(Vrbci*(kAlpha + (glcAlpha*glcRBCi[t])/Vrbci + ((1 - glcAlpha)*kAlpha*glcRBCi[t])/(kBeta*Vrbci))) - ((1 - glcAlpha)*VRBCvGLCTRANSPORT*glcRBCi[t])/(Vrbci*(kBeta + ((1 - glcAlpha)*glcRBCi[t])/Vrbci + (glcAlpha*kBeta*glcRBCi[t])/(kAlpha*Vrbci)))) vRBCivGSSGR = (parMulti*TsRBC*Vrbci*VRBCvGSSGR*((K11RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBCi[t]*nadphRBCi[t])/Vrbci^2 - (K10RBCvGSSGR*K12RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBCi[t]^2*nadpRBCi[t])/Vrbci^3))/(K11RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR + (K11RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBCi[t])/Vrbci + (K10RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBCi[t]^2)/Vrbci^2 + (K11RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBCi[t])/Vrbci + (K11RBCvGSSGR*K1RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR*nadphRBCi[t])/Vrbci + (K11RBCvGSSGR*K1RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBCi[t]*nadphRBCi[t])/Vrbci^2 + (K10RBCvGSSGR*K1RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBCi[t]^2*nadphRBCi[t])/Vrbci^3 + (K1RBCvGSSGR*K3RBCvGSSGR*(K11RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR + K11RBCvGSSGR*K5RBCvGSSGR*K9RBCvGSSGR + K11RBCvGSSGR*K6RBCvGSSGR*K9RBCvGSSGR + K11RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR)*gssgRBCi[t]*nadphRBCi[t])/Vrbci^2 + (K10RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*gshRBCi[t]*gssgRBCi[t]*nadphRBCi[t])/Vrbci^3 + (K11RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBCi[t]*gssgRBCi[t]*nadphRBCi[t])/Vrbci^3 + (K10RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBCi[t]^2*gssgRBCi[t]*nadphRBCi[t])/Vrbci^4 + (K12RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR*nadpRBCi[t])/Vrbci + (K10RBCvGSSGR*K12RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*gshRBCi[t]*nadpRBCi[t])/Vrbci^2 + (K12RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBCi[t]*nadpRBCi[t])/Vrbci^2 + (K10RBCvGSSGR*K12RBCvGSSGR*(K2RBCvGSSGR*K4RBCvGSSGR + K2RBCvGSSGR*K5RBCvGSSGR + K2RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K6RBCvGSSGR)*K8RBCvGSSGR*gshRBCi[t]^2*nadpRBCi[t])/Vrbci^3 + (K12RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBCi[t]*nadpRBCi[t])/Vrbci^2 + (K10RBCvGSSGR*K12RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*gshRBCi[t]*gssgRBCi[t]*nadpRBCi[t])/Vrbci^3 + (K10RBCvGSSGR*K12RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBCi[t]^2*gssgRBCi[t]*nadpRBCi[t])/Vrbci^4) vRBCivHBADP = parMulti*TsRBC*Vrbci*(-((KdRBCvHBADP*hbadpRBCi[t])/Vrbci) + (KaappRBCvHBADP*adpRBCi[t]*hbRBCi[t])/Vrbci^2) vRBCivHBATP = parMulti*TsRBC*Vrbci*(-((KdRBCvHBATP*hbatpRBCi[t])/Vrbci) + (KaappRBCvHBATP*atpRBCi[t]*hbRBCi[t])/Vrbci^2) vRBCivHBB13PG = parMulti*TsRBC*Vrbci*(-((KdRBCvHBB13PG*hbb13pgRBCi[t])/Vrbci) + (KaappRBCvHBB13PG*b13pgRBCi[t]*hbRBCi[t])/Vrbci^2) vRBCivHBB23PG = parMulti*TsRBC*Vrbci*(-((KdRBCvHBBPG*hbb23pgRBCi[t])/Vrbci) + (KaappRBCvHBBPG*b23pgRBCi[t]*hbRBCi[t])/Vrbci^2) vRBCivHBMGATP = parMulti*TsRBC*Vrbci*(-((KdRBCvHBMGATP*hbmgatpRBCi[t])/Vrbci) + (KaappRBCvHBMGATP*hbRBCi[t]*mgatpRBCi[t])/Vrbci^2) vRBCivHK = (parMulti*TsRBC*Vrbci*(-((ERBCvHK*KcatrappRBCvHK*g6pRBCi[t]*mgadpRBCi[t])/(Kig6pRBCvHK*KmmgadpRBCvHK*Vrbci^2)) + (ERBCvHK*KcatfappRBCvHK*glcRBCi[t]*mgatpRBCi[t])/(KiglcRBCvHK*KmmgatpRBCvHK*Vrbci^2)))/(1 + g6pRBCi[t]/(Kig6pRBCvHK*Vrbci) + glcRBCi[t]/(KiglcRBCvHK*Vrbci) + (b23pgRBCi[t]*glcRBCi[t])/(KdibpgRBCvHK*KiglcRBCvHK*Vrbci^2) + (g16p2RBCi[t]*glcRBCi[t])/(Kdig16p2RBCvHK*KiglcRBCvHK*Vrbci^2) + (g6pRBCi[t]*glcRBCi[t])/(Kdig6pRBCvHK*KiglcRBCvHK*Vrbci^2) + (glcRBCi[t]*gshRBCi[t])/(KdigshRBCvHK*KiglcRBCvHK*Vrbci^2) + mgadpRBCi[t]/(KimgadpRBCvHK*Vrbci) + (g6pRBCi[t]*mgadpRBCi[t])/(Kig6pRBCvHK*KmmgadpRBCvHK*Vrbci^2) + mgatpRBCi[t]/(KimgatpRBCvHK*Vrbci) + (glcRBCi[t]*mgatpRBCi[t])/(KiglcRBCvHK*KmmgatpRBCvHK*Vrbci^2)) vRBCivLACTRANSPORT = parMulti*TsRBC*vBld*(-((KiRBCvLACTRANSPORT*lacEXT)/vBld) + (KoRBCvLACTRANSPORT*lacRBCi[t])/Vrbci) vRBCivLDH = (parMulti*TsRBC*Vrbci*VRBCvLDH*(-((KcatrRBCvLDH*lacRBCi[t]*nadRBCi[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbci^2)) + (KcatfRBCvLDH*nadhRBCi[t]*pyrRBCi[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbci^2)))/(nadhRBCi[t]/(KinadhRBCvLDH*Vrbci) + (KmnadRBCvLDH*lacRBCi[t]*nadhRBCi[t])/(KinadhRBCvLDH*KinadRBCvLDH*KmapplacRBCvLDH*Vrbci^2) + nadRBCi[t]/(KinadRBCvLDH*Vrbci) + (lacRBCi[t]*nadRBCi[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbci^2) + (nadhRBCi[t]*pyrRBCi[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbci^2) + (lacRBCi[t]*nadhRBCi[t]*pyrRBCi[t])/(KiapplacRBCvLDH*KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbci^3) + (KmnadhRBCvLDH*nadRBCi[t]*pyrRBCi[t])/(KinadhRBCvLDH*KinadRBCvLDH*KmapppyrRBCvLDH*Vrbci^2) + (lacRBCi[t]*nadRBCi[t]*pyrRBCi[t])/(KiapppyrRBCvLDH*KinadRBCvLDH*KmapplacRBCvLDH*Vrbci^3) + (1 + pyrRBCi[t]/(KidpyrRBCvLDH*Vrbci))*(1 + (KmnadRBCvLDH*lacRBCi[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbci) + (KmnadhRBCvLDH*pyrRBCi[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbci))) vRBCivLDHP = (parMulti*TsRBC*Vrbci*(-((KrRBCvLDHP*lacRBCi[t]*nadpRBCi[t])/(KmlacRBCvLDHP*Vrbci^2)) + (KfRBCvLDHP*nadphRBCi[t]*pyrRBCi[t])/(KmpyrRBCvLDHP*Vrbci^2)))/(1 + lacRBCi[t]/(KmlacRBCvLDHP*Vrbci) + pyrRBCi[t]/(KmpyrRBCvLDHP*Vrbci)) vRBCivMGADP = parMulti*TsRBC*Vrbci*(-((KdRBCvMGADP*mgadpRBCi[t])/Vrbci) + (KaappRBCvMGADP*adpRBCi[t]*mgRBCi[t])/Vrbci^2) vRBCivMGATP = parMulti*TsRBC*Vrbci*(-((KdRBCvMGATP*mgatpRBCi[t])/Vrbci) + (KaappRBCvMGATP*atpRBCi[t]*mgRBCi[t])/Vrbci^2) vRBCivMGB13PG = parMulti*TsRBC*Vrbci*(-((KdRBCvMGB13PG*mgb13pgRBCi[t])/Vrbci) + (KaappRBCvMGB13PG*b13pgRBCi[t]*mgRBCi[t])/Vrbci^2) vRBCivMGB23PG = parMulti*TsRBC*Vrbci*(-((KdRBCvMGB23PG*mgb23pgRBCi[t])/Vrbci) + (KaappRBCvMGB23PG*b23pgRBCi[t]*mgRBCi[t])/Vrbci^2) vRBCivMGF16P2 = parMulti*TsRBC*Vrbci*(-((KdRBCvMGF16P2*mgf16p2RBCi[t])/Vrbci) + (KaappRBCvMGF16P2*f16p2RBCi[t]*mgRBCi[t])/Vrbci^2) vRBCivMGG16P2 = parMulti*TsRBC*Vrbci*(-((KdRBCvMGG16P2*mgg16p2RBCi[t])/Vrbci) + (KaappRBCvMGG16P2*g16p2RBCi[t]*mgRBCi[t])/Vrbci^2) vRBCivMGPHOS = parMulti*TsRBC*Vrbci*(-((KdRBCvMGPHOS*mgphosRBCi[t])/Vrbci) + (KaappRBCvMGPHOS*mgRBCi[t]*phosRBCi[t])/Vrbci^2) vRBCivOX = KRBCvOX*parMulti*TsRBC*gshRBCi[t] vRBCivOXNADH = KRBCvOXNADH*parMulti*TsRBC*nadhRBCi[t] vRBCivP6GDH = (parMulti*TsRBC*Vrbci*VRBCvP6GDH*((K11RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*nadpRBCi[t]*p6gRBCi[t])/Vrbci^2 - (co2RBCi*K10RBCvP6GDH*K12RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadphRBCi[t]*ru5pRBCi[t])/Vrbci^3))/(K11RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH + (co2RBCi*K11RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH)/Vrbci + (co2RBCi*K12RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadphRBCi[t])/Vrbci^2 + (K12RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH*nadphRBCi[t])/Vrbci + (co2RBCi*K11RBCvP6GDH*K1RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadpRBCi[t])/Vrbci^2 + (K11RBCvP6GDH*K1RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH*nadpRBCi[t])/Vrbci + (K11RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*p6gRBCi[t])/Vrbci + (K12RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*nadphRBCi[t]*p6gRBCi[t])/Vrbci^2 + (co2RBCi*K11RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadpRBCi[t]*p6gRBCi[t])/Vrbci^3 + (K1RBCvP6GDH*K3RBCvP6GDH*(K11RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH + K11RBCvP6GDH*K5RBCvP6GDH*K9RBCvP6GDH + K11RBCvP6GDH*K6RBCvP6GDH*K9RBCvP6GDH + K11RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH)*nadpRBCi[t]*p6gRBCi[t])/Vrbci^2 + (co2RBCi*K10RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*ru5pRBCi[t])/Vrbci^2 + (co2RBCi*K10RBCvP6GDH*K12RBCvP6GDH*(K2RBCvP6GDH*K4RBCvP6GDH + K2RBCvP6GDH*K5RBCvP6GDH + K2RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K6RBCvP6GDH)*K8RBCvP6GDH*nadphRBCi[t]*ru5pRBCi[t])/Vrbci^3 + (K10RBCvP6GDH*K12RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*nadphRBCi[t]*ru5pRBCi[t])/Vrbci^2 + (co2RBCi*K10RBCvP6GDH*K1RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadpRBCi[t]*ru5pRBCi[t])/Vrbci^3 + (co2RBCi*K10RBCvP6GDH*K12RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadphRBCi[t]*p6gRBCi[t]*ru5pRBCi[t])/Vrbci^4 + (K10RBCvP6GDH*K12RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*nadphRBCi[t]*p6gRBCi[t]*ru5pRBCi[t])/Vrbci^3 + (co2RBCi*K10RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadpRBCi[t]*p6gRBCi[t]*ru5pRBCi[t])/Vrbci^4 + (K10RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*nadpRBCi[t]*p6gRBCi[t]*ru5pRBCi[t])/Vrbci^3) vRBCivPFK = (parMulti*TsRBC*Vrbci*VRBCvPFK*(-((KcatfRBCvPFK*f16p2RBCi[t]*mgadpRBCi[t])/(Kmf16p2RBCvPFK*KmmgadpRBCvPFK*Vrbci^2)) + (KcatfRBCvPFK*f6pRBCi[t]*mgatpRBCi[t])/(Kmf6pRBCvPFK*KmmgatpRBCvPFK*Vrbci^2)))/((1 + f16p2RBCi[t]/(Kmf16p2RBCvPFK*Vrbci) + f6pRBCi[t]/(Kmf6pRBCvPFK*Vrbci) + mgadpRBCi[t]/(KmmgadpRBCvPFK*Vrbci) + (f16p2RBCi[t]*mgadpRBCi[t])/(Kmf16p2RBCvPFK*KmmgadpRBCvPFK*Vrbci^2) + mgatpRBCi[t]/(KmmgatpRBCvPFK*Vrbci) + (f6pRBCi[t]*mgatpRBCi[t])/(Kmf6pRBCvPFK*KmmgatpRBCvPFK*Vrbci^2))*(1 + ((hRBC/KaRBCvPFK)^nRBCvPFK*(1 + atpRBCi[t]/(KtatpRBCvPFK*Vrbci))^4*(1 + b23pgRBCi[t]/(Ktb23pgRBCvPFK*Vrbci))^4*(1 + mgRBCi[t]/(KtmgRBCvPFK*Vrbci))^4)/((1 + ampRBCi[t]/(KrampRBCvPFK*Vrbci))^4*(1 + f16p2RBCi[t]/(Kmf16p2RBCvPFK*Vrbci) + f6pRBCi[t]/(Kmf6pRBCvPFK*Vrbci))^4*(1 + g16p2RBCi[t]/(Krg16p2RBCvPFK*Vrbci))^4*(1 + phosRBCi[t]/(KrphosRBCvPFK*Vrbci))^4))) vRBCivPGI = (ERBCvPGI*parMulti*TsRBC*Vrbci*(-((KcatrRBCvPGI*f6pRBCi[t])/(Kmf6pRBCvPGI*Vrbci)) + (KcatfRBCvPGI*g6pRBCi[t])/(Kmg6pRBCvPGI*Vrbci)))/(1 + f6pRBCi[t]/(Kmf6pRBCvPGI*Vrbci) + g6pRBCi[t]/(Kmg6pRBCvPGI*Vrbci)) vRBCivPGK = (parMulti*TsRBC*Vrbci*VRBCvPGK*((KcatfRBCvPGK*b13pgRBCi[t]*mgadpRBCi[t])/(KimgadpRBCvPGK*Kmb13pgRBCvPGK*Vrbci^2) - (KcatrRBCvPGK*mgatpRBCi[t]*p3gRBCi[t])/(KimgatpRBCvPGK*Kmp3gRBCvPGK*Vrbci^2)))/(1 + b13pgRBCi[t]/(Kib13pgRBCvPGK*Vrbci) + mgadpRBCi[t]/(KimgadpRBCvPGK*Vrbci) + (b13pgRBCi[t]*mgadpRBCi[t])/(KimgadpRBCvPGK*Kmb13pgRBCvPGK*Vrbci^2) + mgatpRBCi[t]/(KimgatpRBCvPGK*Vrbci) + p3gRBCi[t]/(Kip3gRBCvPGK*Vrbci) + (mgatpRBCi[t]*p3gRBCi[t])/(KimgatpRBCvPGK*Kmp3gRBCvPGK*Vrbci^2)) vRBCivPGLHYDROLYSIS = parMulti*TsRBC*Vrbci*((KhydrolRBCvPGLHYDROLYSIS*p6glRBCi[t])/Vrbci + (Klactonase3RBCvPGLHYDROLYSIS*VRBCvPGLHYDROLYSIS*p6glRBCi[t])/(Vrbci*((Klactonase2RBCvPGLHYDROLYSIS + Klactonase3RBCvPGLHYDROLYSIS)/Klactonase1RBCvPGLHYDROLYSIS + p6glRBCi[t]/Vrbci))) vRBCivPGM = (parMulti*TsRBC*Vrbci*VRBCvPGM*(-((KcatrRBCvPGM*p2gRBCi[t])/(Kmp2gRBCvPGM*Vrbci)) + (KcatfRBCvPGM*p3gRBCi[t])/(Kmp3gRBCvPGM*Vrbci)))/(1 + p2gRBCi[t]/(Kmp2gRBCvPGM*Vrbci) + p3gRBCi[t]/(Kmp3gRBCvPGM*Vrbci)) vRBCivPHOSTRANSPORT = parMulti*TsRBC*vBld*(-((KiRBCvPHOSTRANSPORT*phosEXT)/vBld) + (KoRBCvPHOSTRANSPORT*phosRBCi[t])/Vrbci) vRBCivPK = (parMulti*TsRBC*Vrbci*VRBCvPK*((KcatfRBCvPK*mgadpRBCi[t]*pepRBCi[t])/(KrmgadpRBCvPK*KrpepRBCvPK*Vrbci^2) - (KcatrRBCvPK*mgatpRBCi[t]*pyrRBCi[t])/(KrmgatpRBCvPK*KrpyrRBCvPK*Vrbci^2)))/((1 + LRBCivPK)*(1 + mgadpRBCi[t]/(KrmgadpRBCvPK*Vrbci) + mgatpRBCi[t]/(KrmgatpRBCvPK*Vrbci) + pepRBCi[t]/(KrpepRBCvPK*Vrbci) + (mgadpRBCi[t]*pepRBCi[t])/(KrmgadpRBCvPK*KrpepRBCvPK*Vrbci^2) + pyrRBCi[t]/(KrpyrRBCvPK*Vrbci) + (mgatpRBCi[t]*pyrRBCi[t])/(KrmgatpRBCvPK*KrpyrRBCvPK*Vrbci^2))) vRBCivPYRTRANSPORT = parMulti*TsRBC*vBld*(-((KiRBCvPYRTRANSPORT*pyrEXT)/vBld) + (KoRBCvPYRTRANSPORT*pyrRBCi[t])/Vrbci) vRBCivR5PI = (parMulti*TsRBC*Vrbci*VRBCvR5PI*(-((K2RBCvR5PI*K4RBCvR5PI*rib5pRBCi[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbci)) + (K1RBCvR5PI*K3RBCvR5PI*ru5pRBCi[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbci)))/(1 + (K1RBCvR5PI*ru5pRBCi[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbci) + (K4RBCvR5PI*xu5pRBCi[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbci)) vRBCivRu5PE = (parMulti*TsRBC*Vrbci*VRBCvRu5PE*((K1RBCvRu5PE*K3RBCvRu5PE*ru5pRBCi[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbci) - (K2RBCvRu5PE*K4RBCvRu5PE*xu5pRBCi[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbci)))/(1 + (K1RBCvRu5PE*ru5pRBCi[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbci) + (K4RBCvRu5PE*xu5pRBCi[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbci)) vRBCivTA = (parMulti*TsRBC*Vrbci*VRBCvTA*(-((K2RBCvTA*K4RBCvTA*K6RBCvTA*K8RBCvTA*ery4pRBCi[t]*f6pRBCi[t])/Vrbci^2) + (K1RBCvTA*K3RBCvTA*K5RBCvTA*K7RBCvTA*gapRBCi[t]*sed7pRBCi[t])/Vrbci^2))/((K2RBCvTA*K4RBCvTA*(K6RBCvTA + K7RBCvTA)*ery4pRBCi[t])/Vrbci + ((K2RBCvTA + K3RBCvTA)*K6RBCvTA*K8RBCvTA*f6pRBCi[t])/Vrbci + (K4RBCvTA*(K2RBCvTA + K6RBCvTA)*K8RBCvTA*ery4pRBCi[t]*f6pRBCi[t])/Vrbci^2 + ((K2RBCvTA + K3RBCvTA)*K5RBCvTA*K7RBCvTA*gapRBCi[t])/Vrbci + ((K2RBCvTA + K3RBCvTA)*K5RBCvTA*K8RBCvTA*f6pRBCi[t]*gapRBCi[t])/Vrbci^2 + (K1RBCvTA*K3RBCvTA*(K6RBCvTA + K7RBCvTA)*sed7pRBCi[t])/Vrbci + (K1RBCvTA*K4RBCvTA*(K6RBCvTA + K7RBCvTA)*ery4pRBCi[t]*sed7pRBCi[t])/Vrbci^2 + (K1RBCvTA*K5RBCvTA*(K3RBCvTA + K7RBCvTA)*gapRBCi[t]*sed7pRBCi[t])/Vrbci^2) vRBCivTIM = (parMulti*TsRBC*Vrbci*VRBCvTIM*(-((KcatrRBCvTIM*dhapRBCi[t])/(KmdhapRBCvTIM*Vrbci)) + (KcatfRBCvTIM*gapRBCi[t])/(KmgapRBCvTIM*Vrbci)))/(1 + dhapRBCi[t]/(KmdhapRBCvTIM*Vrbci) + gapRBCi[t]/(KmgapRBCvTIM*Vrbci)) vRBCivTK1 = parMulti*TsRBC*Vrbci*(-((K2RBCvTK1*tkxu5pRBCi[t])/Vrbci) + (K1RBCvTK1*tkRBCi[t]*xu5pRBCi[t])/Vrbci^2) vRBCivTK2 = parMulti*TsRBC*Vrbci*(-((K4RBCvTK2*gapRBCi[t]*tkgRBCi[t])/Vrbci^2) + (K3RBCvTK2*tkxu5pRBCi[t])/Vrbci) vRBCivTK3 = parMulti*TsRBC*Vrbci*((K5RBCvTK3*rib5pRBCi[t]*tkgRBCi[t])/Vrbci^2 - (K6RBCvTK3*tkgrib5pRBCi[t])/Vrbci) vRBCivTK4 = parMulti*TsRBC*Vrbci*((K7RBCvTK4*tkgrib5pRBCi[t])/Vrbci - (K8RBCvTK4*sed7pRBCi[t]*tkRBCi[t])/Vrbci^2) vRBCivTK5 = parMulti*TsRBC*Vrbci*(-((K10RBCvTK5*tkgery4pRBCi[t])/Vrbci) + (K9RBCvTK5*ery4pRBCi[t]*tkgRBCi[t])/Vrbci^2) vRBCivTK6 = parMulti*TsRBC*Vrbci*((K11RBCvTK6*tkgery4pRBCi[t])/Vrbci - (K12RBCvTK6*f6pRBCi[t]*tkRBCi[t])/Vrbci^2) vRBCvAK = parMultiUninf*TsRBC*Vrbcu*((K1appRBCvAK*adpRBC[t]*mgadpRBC[t])/Vrbcu^2 - (K2appRBCvAK*ampRBC[t]*mgatpRBC[t])/Vrbcu^2) vRBCvALD = (parMultiUninf*TsRBC*Vrbcu*VRBCvALD*((KcatfRBCvALD*f16p2RBC[t])/(Kmf16p2RBCvALD*Vrbcu) - (KcatrRBCvALD*dhapRBC[t]*gapRBC[t])/(KidhapRBCvALD*KmgapRBCvALD*Vrbcu^2)))/(1 + dhapRBC[t]/(KidhapRBCvALD*Vrbcu) + f16p2RBC[t]/(Kmf16p2RBCvALD*Vrbcu) + (dhapRBC[t]*gapRBC[t])/(KidhapRBCvALD*KmgapRBCvALD*Vrbcu^2) + (KmdhapRBCvALD*f16p2RBC[t]*gapRBC[t])/(KidhapRBCvALD*Kif16p2RBCvALD*KmgapRBCvALD*Vrbcu^2) + (b23pgRBC[t]/Vrbcu + mgb23pgRBC[t]/Vrbcu)/Kib23pgRBCvALD + (KmdhapRBCvALD*gapRBC[t]*(1 + (b23pgRBC[t]/Vrbcu + mgb23pgRBC[t]/Vrbcu)/Kib23pgRBCvALD))/(KidhapRBCvALD*KmgapRBCvALD*Vrbcu)) vRBCvATPASE = KRBCvATPASE*parMultiUninf*TsRBC*mgatpRBC[t] vRBCvBPGSP1 = parMultiUninf*TsRBC*Vrbcu*(-((K2RBCvBPGSP1*bpgspb13pgRBC[t])/Vrbcu) + (K1appRBCvBPGSP1*b13pgRBC[t]*bpgspRBC[t])/Vrbcu^2) vRBCvBPGSP2 = K3appRBCvBPGSP2*parMultiUninf*TsRBC*bpgspb13pgRBC[t] vRBCvBPGSP3 = parMultiUninf*TsRBC*Vrbcu*(-((K5RBCvBPGSP3*bpgsppp3gRBC[t])/Vrbcu) + (K4appRBCvBPGSP3*bpgsppRBC[t]*p3gRBC[t])/Vrbcu^2) vRBCvBPGSP4 = parMultiUninf*TsRBC*Vrbcu*(-((K7RBCvBPGSP4*bpgsppp2gRBC[t])/Vrbcu) + (K6appRBCvBPGSP4*bpgsppRBC[t]*p2gRBC[t])/Vrbcu^2) vRBCvBPGSP5 = parMultiUninf*TsRBC*Vrbcu*(-((K9RBCvBPGSP5*bpgspb23pgRBC[t])/Vrbcu) + (K8RBCvBPGSP5*bpgsppp3gRBC[t])/Vrbcu) vRBCvBPGSP6 = parMultiUninf*TsRBC*Vrbcu*(-((K11RBCvBPGSP6*bpgspb23pgRBC[t])/Vrbcu) + (K10RBCvBPGSP6*bpgsppp2gRBC[t])/Vrbcu) vRBCvBPGSP7 = parMultiUninf*TsRBC*Vrbcu*((K12RBCvBPGSP7*bpgspb23pgRBC[t])/Vrbcu - (K13appRBCvBPGSP7*b23pgRBC[t]*bpgspRBC[t])/Vrbcu^2) vRBCvBPGSP8 = parMultiUninf*TsRBC*Vrbcu*(-((K15RBCvBPGSP8*bpgsppphosRBC[t])/Vrbcu) + (K14RBCvBPGSP8*bpgsppRBC[t]*phosRBC[t])/Vrbcu^2) vRBCvBPGSP9 = K16RBCvBPGSP9*parMultiUninf*TsRBC*bpgsppphosRBC[t] vRBCvENO = (parMultiUninf*TsRBC*Vrbcu*VRBCvENO*((KcatfRBCvENO*mgRBC[t]*p2gRBC[t])/(KimgRBCvENO*Kmp2gRBCvENO*Vrbcu^2) - (KcatrRBCvENO*mgRBC[t]*pepRBC[t])/(KipepRBCvENO*KmmgRBCvENO*Vrbcu^2)))/(1 + mgRBC[t]/(KimgRBCvENO*Vrbcu) + p2gRBC[t]/(Kip2gRBCvENO*Vrbcu) + (mgRBC[t]*p2gRBC[t])/(KimgRBCvENO*Kmp2gRBCvENO*Vrbcu^2) + pepRBC[t]/(KipepRBCvENO*Vrbcu) + (mgRBC[t]*pepRBC[t])/(KipepRBCvENO*KmmgRBCvENO*Vrbcu^2)) vRBCvG6PDH = (parMultiUninf*TsRBC*Vrbcu*VRBCvG6PDH*((K1RBCvG6PDH*K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*K9RBCvG6PDH*g6pRBC[t]*nadpRBC[t])/Vrbcu^2 - (K10RBCvG6PDH*K2RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*nadphRBC[t]*p6glRBC[t])/Vrbcu^2))/(K2RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*K9RBCvG6PDH + (K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*K9RBCvG6PDH*g6pRBC[t])/Vrbcu + (K10RBCvG6PDH*K2RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K5RBCvG6PDH*K6RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*nadphRBC[t])/Vrbcu + (K10RBCvG6PDH*K3RBCvG6PDH*K5RBCvG6PDH*K7RBCvG6PDH*g6pRBC[t]*nadphRBC[t])/Vrbcu^2 + (K1RBCvG6PDH*(K4RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K7RBCvG6PDH)*K9RBCvG6PDH*nadpRBC[t])/Vrbcu + (K1RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH*K7RBCvG6PDH + K5RBCvG6PDH*K9RBCvG6PDH + K6RBCvG6PDH*K9RBCvG6PDH + K7RBCvG6PDH*K9RBCvG6PDH)*g6pRBC[t]*nadpRBC[t])/Vrbcu^2 + (K2RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*p6glRBC[t])/Vrbcu + (K10RBCvG6PDH*(K2RBCvG6PDH*K4RBCvG6PDH + K2RBCvG6PDH*K5RBCvG6PDH + K2RBCvG6PDH*K6RBCvG6PDH + K4RBCvG6PDH*K6RBCvG6PDH)*K8RBCvG6PDH*nadphRBC[t]*p6glRBC[t])/Vrbcu^2 + (K10RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH + K6RBCvG6PDH)*K8RBCvG6PDH*g6pRBC[t]*nadphRBC[t]*p6glRBC[t])/Vrbcu^3 + (K1RBCvG6PDH*K4RBCvG6PDH*K6RBCvG6PDH*K8RBCvG6PDH*nadpRBC[t]*p6glRBC[t])/Vrbcu^2 + (K1RBCvG6PDH*K3RBCvG6PDH*(K5RBCvG6PDH + K6RBCvG6PDH)*K8RBCvG6PDH*g6pRBC[t]*nadpRBC[t]*p6glRBC[t])/Vrbcu^3) vRBCvGAPDH = (parMultiUninf*TsRBC*Vrbcu*VRBCvGAPDH*(-((KcatrappRBCvGAPDH*b13pgRBC[t]*nadhRBC[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbcu^2)) + (KcatfappRBCvGAPDH*gapRBC[t]*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbcu^3)))/((b13pgRBC[t]*(1 + gapRBC[t]/(KidgapRBCvGAPDH*Vrbcu)))/(Kiappb13pgRBCvGAPDH*Vrbcu) + (gapRBC[t]*(1 + gapRBC[t]/(KidgapRBCvGAPDH*Vrbcu)))/(KiappgapRBCvGAPDH*Vrbcu) + (Kmb13pgRBCvGAPDH*nadhRBC[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbcu) + (b13pgRBC[t]*nadhRBC[t])/(Kiappb13pgRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbcu^2) + (gapRBC[t]*nadhRBC[t])/(KiappgapRBCvGAPDH*KiappnadhRBCvGAPDH*Vrbcu^2) + (b13pgRBC[t]*nadRBC[t])/(Kiappb13pgRBCvGAPDH*KinadRBCvGAPDH*Vrbcu^2) + (gapRBC[t]*nadRBC[t])/(KiappgapRBCvGAPDH*KinadRBCvGAPDH*Vrbcu^2) + (gapRBC[t]*(1 + gapRBC[t]/(KidgapRBCvGAPDH*Vrbcu))*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*Vrbcu^2) + (Kmb13pgRBCvGAPDH*nadhRBC[t]*phosRBC[t])/(Kiappb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbcu^2) + (Kmb13pgRBCvGAPDH*b13pgRBC[t]*nadhRBC[t]*phosRBC[t])/(Kiappb13pgRBCvGAPDH*Kidb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmappnadhRBCvGAPDH*Vrbcu^3) + (gapRBC[t]*nadhRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiappnadhRBCvGAPDH*KiphosRBCvGAPDH*Vrbcu^3) + (KmgapRBCvGAPDH*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbcu^2) + (KmgapRBCvGAPDH*b13pgRBC[t]*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*Kidb13pgRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbcu^3) + (gapRBC[t]*nadRBC[t]*phosRBC[t])/(KiappgapRBCvGAPDH*KiphosRBCvGAPDH*KmnadRBCvGAPDH*Vrbcu^3)) vRBCvGLCTRANSPORT = parMultiUninf*TsRBC*Vrbcu*((glcAlpha*glcEXT*VRBCvGLCTRANSPORT)/((kAlpha + (glcAlpha*glcEXT)/vBld + ((1 - glcAlpha)*glcEXT*kAlpha)/(kBeta*vBld))*vBld) + ((1 - glcAlpha)*glcEXT*VRBCvGLCTRANSPORT)/((kBeta + ((1 - glcAlpha)*glcEXT)/vBld + (glcAlpha*glcEXT*kBeta)/(kAlpha*vBld))*vBld) - (glcAlpha*VRBCvGLCTRANSPORT*glcRBC[t])/(Vrbcu*(kAlpha + (glcAlpha*glcRBC[t])/Vrbcu + ((1 - glcAlpha)*kAlpha*glcRBC[t])/(kBeta*Vrbcu))) - ((1 - glcAlpha)*VRBCvGLCTRANSPORT*glcRBC[t])/(Vrbcu*(kBeta + ((1 - glcAlpha)*glcRBC[t])/Vrbcu + (glcAlpha*kBeta*glcRBC[t])/(kAlpha*Vrbcu)))) vRBCvGSSGR = (parMultiUninf*TsRBC*Vrbcu*VRBCvGSSGR*((K11RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBC[t]*nadphRBC[t])/Vrbcu^2 - (K10RBCvGSSGR*K12RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]^2*nadpRBC[t])/Vrbcu^3))/(K11RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR + (K11RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t])/Vrbcu + (K10RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]^2)/Vrbcu^2 + (K11RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBC[t])/Vrbcu + (K11RBCvGSSGR*K1RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR*nadphRBC[t])/Vrbcu + (K11RBCvGSSGR*K1RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]*nadphRBC[t])/Vrbcu^2 + (K10RBCvGSSGR*K1RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]^2*nadphRBC[t])/Vrbcu^3 + (K1RBCvGSSGR*K3RBCvGSSGR*(K11RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR + K11RBCvGSSGR*K5RBCvGSSGR*K9RBCvGSSGR + K11RBCvGSSGR*K6RBCvGSSGR*K9RBCvGSSGR + K11RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR)*gssgRBC[t]*nadphRBC[t])/Vrbcu^2 + (K10RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*gshRBC[t]*gssgRBC[t]*nadphRBC[t])/Vrbcu^3 + (K11RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]*gssgRBC[t]*nadphRBC[t])/Vrbcu^3 + (K10RBCvGSSGR*K1RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]^2*gssgRBC[t]*nadphRBC[t])/Vrbcu^4 + (K12RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*K9RBCvGSSGR*nadpRBC[t])/Vrbcu + (K10RBCvGSSGR*K12RBCvGSSGR*K2RBCvGSSGR*(K4RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K7RBCvGSSGR + K5RBCvGSSGR*K7RBCvGSSGR)*gshRBC[t]*nadpRBC[t])/Vrbcu^2 + (K12RBCvGSSGR*K2RBCvGSSGR*K4RBCvGSSGR*K6RBCvGSSGR*K8RBCvGSSGR*gshRBC[t]*nadpRBC[t])/Vrbcu^2 + (K10RBCvGSSGR*K12RBCvGSSGR*(K2RBCvGSSGR*K4RBCvGSSGR + K2RBCvGSSGR*K5RBCvGSSGR + K2RBCvGSSGR*K6RBCvGSSGR + K4RBCvGSSGR*K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]^2*nadpRBC[t])/Vrbcu^3 + (K12RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*K9RBCvGSSGR*gssgRBC[t]*nadpRBC[t])/Vrbcu^2 + (K10RBCvGSSGR*K12RBCvGSSGR*K3RBCvGSSGR*K5RBCvGSSGR*K7RBCvGSSGR*gshRBC[t]*gssgRBC[t]*nadpRBC[t])/Vrbcu^3 + (K10RBCvGSSGR*K12RBCvGSSGR*K3RBCvGSSGR*(K5RBCvGSSGR + K6RBCvGSSGR)*K8RBCvGSSGR*gshRBC[t]^2*gssgRBC[t]*nadpRBC[t])/Vrbcu^4) vRBCvHBADP = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvHBADP*hbadpRBC[t])/Vrbcu) + (KaappRBCvHBADP*adpRBC[t]*hbRBC[t])/Vrbcu^2) vRBCvHBATP = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvHBATP*hbatpRBC[t])/Vrbcu) + (KaappRBCvHBATP*atpRBC[t]*hbRBC[t])/Vrbcu^2) vRBCvHBB13PG = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvHBB13PG*hbb13pgRBC[t])/Vrbcu) + (KaappRBCvHBB13PG*b13pgRBC[t]*hbRBC[t])/Vrbcu^2) vRBCvHBB23PG = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvHBBPG*hbb23pgRBC[t])/Vrbcu) + (KaappRBCvHBBPG*b23pgRBC[t]*hbRBC[t])/Vrbcu^2) vRBCvHBMGATP = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvHBMGATP*hbmgatpRBC[t])/Vrbcu) + (KaappRBCvHBMGATP*hbRBC[t]*mgatpRBC[t])/Vrbcu^2) vRBCvHK = (parMultiUninf*TsRBC*Vrbcu*(-((ERBCvHK*KcatrappRBCvHK*g6pRBC[t]*mgadpRBC[t])/(Kig6pRBCvHK*KmmgadpRBCvHK*Vrbcu^2)) + (ERBCvHK*KcatfappRBCvHK*glcRBC[t]*mgatpRBC[t])/(KiglcRBCvHK*KmmgatpRBCvHK*Vrbcu^2)))/(1 + g6pRBC[t]/(Kig6pRBCvHK*Vrbcu) + glcRBC[t]/(KiglcRBCvHK*Vrbcu) + (b23pgRBC[t]*glcRBC[t])/(KdibpgRBCvHK*KiglcRBCvHK*Vrbcu^2) + (g16p2RBC[t]*glcRBC[t])/(Kdig16p2RBCvHK*KiglcRBCvHK*Vrbcu^2) + (g6pRBC[t]*glcRBC[t])/(Kdig6pRBCvHK*KiglcRBCvHK*Vrbcu^2) + (glcRBC[t]*gshRBC[t])/(KdigshRBCvHK*KiglcRBCvHK*Vrbcu^2) + mgadpRBC[t]/(KimgadpRBCvHK*Vrbcu) + (g6pRBC[t]*mgadpRBC[t])/(Kig6pRBCvHK*KmmgadpRBCvHK*Vrbcu^2) + mgatpRBC[t]/(KimgatpRBCvHK*Vrbcu) + (glcRBC[t]*mgatpRBC[t])/(KiglcRBCvHK*KmmgatpRBCvHK*Vrbcu^2)) vRBCvLACTRANSPORT = parMultiUninf*TsRBC*vBld*(-((KiRBCvLACTRANSPORT*lacEXT)/vBld) + (KoRBCvLACTRANSPORT*lacRBC[t])/Vrbcu) vRBCvLDH = (parMultiUninf*TsRBC*Vrbcu*VRBCvLDH*(-((KcatrRBCvLDH*lacRBC[t]*nadRBC[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbcu^2)) + (KcatfRBCvLDH*nadhRBC[t]*pyrRBC[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbcu^2)))/(nadhRBC[t]/(KinadhRBCvLDH*Vrbcu) + (KmnadRBCvLDH*lacRBC[t]*nadhRBC[t])/(KinadhRBCvLDH*KinadRBCvLDH*KmapplacRBCvLDH*Vrbcu^2) + nadRBC[t]/(KinadRBCvLDH*Vrbcu) + (lacRBC[t]*nadRBC[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbcu^2) + (nadhRBC[t]*pyrRBC[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbcu^2) + (lacRBC[t]*nadhRBC[t]*pyrRBC[t])/(KiapplacRBCvLDH*KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbcu^3) + (KmnadhRBCvLDH*nadRBC[t]*pyrRBC[t])/(KinadhRBCvLDH*KinadRBCvLDH*KmapppyrRBCvLDH*Vrbcu^2) + (lacRBC[t]*nadRBC[t]*pyrRBC[t])/(KiapppyrRBCvLDH*KinadRBCvLDH*KmapplacRBCvLDH*Vrbcu^3) + (1 + pyrRBC[t]/(KidpyrRBCvLDH*Vrbcu))*(1 + (KmnadRBCvLDH*lacRBC[t])/(KinadRBCvLDH*KmapplacRBCvLDH*Vrbcu) + (KmnadhRBCvLDH*pyrRBC[t])/(KinadhRBCvLDH*KmapppyrRBCvLDH*Vrbcu))) vRBCvLDHP = (parMultiUninf*TsRBC*Vrbcu*(-((KrRBCvLDHP*lacRBC[t]*nadpRBC[t])/(KmlacRBCvLDHP*Vrbcu^2)) + (KfRBCvLDHP*nadphRBC[t]*pyrRBC[t])/(KmpyrRBCvLDHP*Vrbcu^2)))/(1 + lacRBC[t]/(KmlacRBCvLDHP*Vrbcu) + pyrRBC[t]/(KmpyrRBCvLDHP*Vrbcu)) vRBCvMGADP = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGADP*mgadpRBC[t])/Vrbcu) + (KaappRBCvMGADP*adpRBC[t]*mgRBC[t])/Vrbcu^2) vRBCvMGATP = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGATP*mgatpRBC[t])/Vrbcu) + (KaappRBCvMGATP*atpRBC[t]*mgRBC[t])/Vrbcu^2) vRBCvMGB13PG = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGB13PG*mgb13pgRBC[t])/Vrbcu) + (KaappRBCvMGB13PG*b13pgRBC[t]*mgRBC[t])/Vrbcu^2) vRBCvMGB23PG = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGB23PG*mgb23pgRBC[t])/Vrbcu) + (KaappRBCvMGB23PG*b23pgRBC[t]*mgRBC[t])/Vrbcu^2) vRBCvMGF16P2 = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGF16P2*mgf16p2RBC[t])/Vrbcu) + (KaappRBCvMGF16P2*f16p2RBC[t]*mgRBC[t])/Vrbcu^2) vRBCvMGG16P2 = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGG16P2*mgg16p2RBC[t])/Vrbcu) + (KaappRBCvMGG16P2*g16p2RBC[t]*mgRBC[t])/Vrbcu^2) vRBCvMGPHOS = parMultiUninf*TsRBC*Vrbcu*(-((KdRBCvMGPHOS*mgphosRBC[t])/Vrbcu) + (KaappRBCvMGPHOS*mgRBC[t]*phosRBC[t])/Vrbcu^2) vRBCvOX = KRBCvOX*parMultiUninf*TsRBC*gshRBC[t] vRBCvOXNADH = KRBCvOXNADH*parMultiUninf*TsRBC*nadhRBC[t] vRBCvP6GDH = (parMultiUninf*TsRBC*Vrbcu*VRBCvP6GDH*((K11RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*nadpRBC[t]*p6gRBC[t])/Vrbcu^2 - (co2RBC*K10RBCvP6GDH*K12RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadphRBC[t]*ru5pRBC[t])/Vrbcu^3))/(K11RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH + (co2RBC*K11RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH)/Vrbcu + (co2RBC*K12RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadphRBC[t])/Vrbcu^2 + (K12RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH*nadphRBC[t])/Vrbcu + (co2RBC*K11RBCvP6GDH*K1RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadpRBC[t])/Vrbcu^2 + (K11RBCvP6GDH*K1RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*K9RBCvP6GDH*nadpRBC[t])/Vrbcu + (K11RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*p6gRBC[t])/Vrbcu + (K12RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH*nadphRBC[t]*p6gRBC[t])/Vrbcu^2 + (co2RBC*K11RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadpRBC[t]*p6gRBC[t])/Vrbcu^3 + (K1RBCvP6GDH*K3RBCvP6GDH*(K11RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH + K11RBCvP6GDH*K5RBCvP6GDH*K9RBCvP6GDH + K11RBCvP6GDH*K6RBCvP6GDH*K9RBCvP6GDH + K11RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH*K9RBCvP6GDH)*nadpRBC[t]*p6gRBC[t])/Vrbcu^2 + (co2RBC*K10RBCvP6GDH*K2RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*ru5pRBC[t])/Vrbcu^2 + (co2RBC*K10RBCvP6GDH*K12RBCvP6GDH*(K2RBCvP6GDH*K4RBCvP6GDH + K2RBCvP6GDH*K5RBCvP6GDH + K2RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K6RBCvP6GDH)*K8RBCvP6GDH*nadphRBC[t]*ru5pRBC[t])/Vrbcu^3 + (K10RBCvP6GDH*K12RBCvP6GDH*K2RBCvP6GDH*(K4RBCvP6GDH*K6RBCvP6GDH + K4RBCvP6GDH*K7RBCvP6GDH + K5RBCvP6GDH*K7RBCvP6GDH)*nadphRBC[t]*ru5pRBC[t])/Vrbcu^2 + (co2RBC*K10RBCvP6GDH*K1RBCvP6GDH*K4RBCvP6GDH*K6RBCvP6GDH*K8RBCvP6GDH*nadpRBC[t]*ru5pRBC[t])/Vrbcu^3 + (co2RBC*K10RBCvP6GDH*K12RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadphRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbcu^4 + (K10RBCvP6GDH*K12RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*nadphRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbcu^3 + (co2RBC*K10RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*(K5RBCvP6GDH + K6RBCvP6GDH)*K8RBCvP6GDH*nadpRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbcu^4 + (K10RBCvP6GDH*K1RBCvP6GDH*K3RBCvP6GDH*K5RBCvP6GDH*K7RBCvP6GDH*nadpRBC[t]*p6gRBC[t]*ru5pRBC[t])/Vrbcu^3) vRBCvPFK = (parMultiUninf*TsRBC*Vrbcu*VRBCvPFK*(-((KcatfRBCvPFK*f16p2RBC[t]*mgadpRBC[t])/(Kmf16p2RBCvPFK*KmmgadpRBCvPFK*Vrbcu^2)) + (KcatfRBCvPFK*f6pRBC[t]*mgatpRBC[t])/(Kmf6pRBCvPFK*KmmgatpRBCvPFK*Vrbcu^2)))/((1 + f16p2RBC[t]/(Kmf16p2RBCvPFK*Vrbcu) + f6pRBC[t]/(Kmf6pRBCvPFK*Vrbcu) + mgadpRBC[t]/(KmmgadpRBCvPFK*Vrbcu) + (f16p2RBC[t]*mgadpRBC[t])/(Kmf16p2RBCvPFK*KmmgadpRBCvPFK*Vrbcu^2) + mgatpRBC[t]/(KmmgatpRBCvPFK*Vrbcu) + (f6pRBC[t]*mgatpRBC[t])/(Kmf6pRBCvPFK*KmmgatpRBCvPFK*Vrbcu^2))*(1 + ((hRBC/KaRBCvPFK)^nRBCvPFK*(1 + atpRBC[t]/(KtatpRBCvPFK*Vrbcu))^4*(1 + b23pgRBC[t]/(Ktb23pgRBCvPFK*Vrbcu))^4*(1 + mgRBC[t]/(KtmgRBCvPFK*Vrbcu))^4)/((1 + ampRBC[t]/(KrampRBCvPFK*Vrbcu))^4*(1 + f16p2RBC[t]/(Kmf16p2RBCvPFK*Vrbcu) + f6pRBC[t]/(Kmf6pRBCvPFK*Vrbcu))^4*(1 + g16p2RBC[t]/(Krg16p2RBCvPFK*Vrbcu))^4*(1 + phosRBC[t]/(KrphosRBCvPFK*Vrbcu))^4))) vRBCvPGI = (ERBCvPGI*parMultiUninf*TsRBC*Vrbcu*(-((KcatrRBCvPGI*f6pRBC[t])/(Kmf6pRBCvPGI*Vrbcu)) + (KcatfRBCvPGI*g6pRBC[t])/(Kmg6pRBCvPGI*Vrbcu)))/(1 + f6pRBC[t]/(Kmf6pRBCvPGI*Vrbcu) + g6pRBC[t]/(Kmg6pRBCvPGI*Vrbcu)) vRBCvPGK = (parMultiUninf*TsRBC*Vrbcu*VRBCvPGK*((KcatfRBCvPGK*b13pgRBC[t]*mgadpRBC[t])/(KimgadpRBCvPGK*Kmb13pgRBCvPGK*Vrbcu^2) - (KcatrRBCvPGK*mgatpRBC[t]*p3gRBC[t])/(KimgatpRBCvPGK*Kmp3gRBCvPGK*Vrbcu^2)))/(1 + b13pgRBC[t]/(Kib13pgRBCvPGK*Vrbcu) + mgadpRBC[t]/(KimgadpRBCvPGK*Vrbcu) + (b13pgRBC[t]*mgadpRBC[t])/(KimgadpRBCvPGK*Kmb13pgRBCvPGK*Vrbcu^2) + mgatpRBC[t]/(KimgatpRBCvPGK*Vrbcu) + p3gRBC[t]/(Kip3gRBCvPGK*Vrbcu) + (mgatpRBC[t]*p3gRBC[t])/(KimgatpRBCvPGK*Kmp3gRBCvPGK*Vrbcu^2)) vRBCvPGLHYDROLYSIS = parMultiUninf*TsRBC*Vrbcu*((KhydrolRBCvPGLHYDROLYSIS*p6glRBC[t])/Vrbcu + (Klactonase3RBCvPGLHYDROLYSIS*VRBCvPGLHYDROLYSIS*p6glRBC[t])/(Vrbcu*((Klactonase2RBCvPGLHYDROLYSIS + Klactonase3RBCvPGLHYDROLYSIS)/Klactonase1RBCvPGLHYDROLYSIS + p6glRBC[t]/Vrbcu))) vRBCvPGM = (parMultiUninf*TsRBC*Vrbcu*VRBCvPGM*(-((KcatrRBCvPGM*p2gRBC[t])/(Kmp2gRBCvPGM*Vrbcu)) + (KcatfRBCvPGM*p3gRBC[t])/(Kmp3gRBCvPGM*Vrbcu)))/(1 + p2gRBC[t]/(Kmp2gRBCvPGM*Vrbcu) + p3gRBC[t]/(Kmp3gRBCvPGM*Vrbcu)) vRBCvPHOSTRANSPORT = parMultiUninf*TsRBC*vBld*(-((KiRBCvPHOSTRANSPORT*phosEXT)/vBld) + (KoRBCvPHOSTRANSPORT*phosRBC[t])/Vrbcu) vRBCvPK = (parMultiUninf*TsRBC*Vrbcu*VRBCvPK*((KcatfRBCvPK*mgadpRBC[t]*pepRBC[t])/(KrmgadpRBCvPK*KrpepRBCvPK*Vrbcu^2) - (KcatrRBCvPK*mgatpRBC[t]*pyrRBC[t])/(KrmgatpRBCvPK*KrpyrRBCvPK*Vrbcu^2)))/((1 + LRBCvPK)*(1 + mgadpRBC[t]/(KrmgadpRBCvPK*Vrbcu) + mgatpRBC[t]/(KrmgatpRBCvPK*Vrbcu) + pepRBC[t]/(KrpepRBCvPK*Vrbcu) + (mgadpRBC[t]*pepRBC[t])/(KrmgadpRBCvPK*KrpepRBCvPK*Vrbcu^2) + pyrRBC[t]/(KrpyrRBCvPK*Vrbcu) + (mgatpRBC[t]*pyrRBC[t])/(KrmgatpRBCvPK*KrpyrRBCvPK*Vrbcu^2))) vRBCvPYRTRANSPORT = parMultiUninf*TsRBC*vBld*(-((KiRBCvPYRTRANSPORT*pyrEXT)/vBld) + (KoRBCvPYRTRANSPORT*pyrRBC[t])/Vrbcu) vRBCvR5PI = (parMultiUninf*TsRBC*Vrbcu*VRBCvR5PI*(-((K2RBCvR5PI*K4RBCvR5PI*rib5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbcu)) + (K1RBCvR5PI*K3RBCvR5PI*ru5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbcu)))/(1 + (K1RBCvR5PI*ru5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbcu) + (K4RBCvR5PI*xu5pRBC[t])/((K2RBCvR5PI + K3RBCvR5PI)*Vrbcu)) vRBCvRu5PE = (parMultiUninf*TsRBC*Vrbcu*VRBCvRu5PE*((K1RBCvRu5PE*K3RBCvRu5PE*ru5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbcu) - (K2RBCvRu5PE*K4RBCvRu5PE*xu5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbcu)))/(1 + (K1RBCvRu5PE*ru5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbcu) + (K4RBCvRu5PE*xu5pRBC[t])/((K2RBCvRu5PE + K3RBCvRu5PE)*Vrbcu)) vRBCvTA = (parMultiUninf*TsRBC*Vrbcu*VRBCvTA*(-((K2RBCvTA*K4RBCvTA*K6RBCvTA*K8RBCvTA*ery4pRBC[t]*f6pRBC[t])/Vrbcu^2) + (K1RBCvTA*K3RBCvTA*K5RBCvTA*K7RBCvTA*gapRBC[t]*sed7pRBC[t])/Vrbcu^2))/((K2RBCvTA*K4RBCvTA*(K6RBCvTA + K7RBCvTA)*ery4pRBC[t])/Vrbcu + ((K2RBCvTA + K3RBCvTA)*K6RBCvTA*K8RBCvTA*f6pRBC[t])/Vrbcu + (K4RBCvTA*(K2RBCvTA + K6RBCvTA)*K8RBCvTA*ery4pRBC[t]*f6pRBC[t])/Vrbcu^2 + ((K2RBCvTA + K3RBCvTA)*K5RBCvTA*K7RBCvTA*gapRBC[t])/Vrbcu + ((K2RBCvTA + K3RBCvTA)*K5RBCvTA*K8RBCvTA*f6pRBC[t]*gapRBC[t])/Vrbcu^2 + (K1RBCvTA*K3RBCvTA*(K6RBCvTA + K7RBCvTA)*sed7pRBC[t])/Vrbcu + (K1RBCvTA*K4RBCvTA*(K6RBCvTA + K7RBCvTA)*ery4pRBC[t]*sed7pRBC[t])/Vrbcu^2 + (K1RBCvTA*K5RBCvTA*(K3RBCvTA + K7RBCvTA)*gapRBC[t]*sed7pRBC[t])/Vrbcu^2) vRBCvTIM = (parMultiUninf*TsRBC*Vrbcu*VRBCvTIM*(-((KcatrRBCvTIM*dhapRBC[t])/(KmdhapRBCvTIM*Vrbcu)) + (KcatfRBCvTIM*gapRBC[t])/(KmgapRBCvTIM*Vrbcu)))/(1 + dhapRBC[t]/(KmdhapRBCvTIM*Vrbcu) + gapRBC[t]/(KmgapRBCvTIM*Vrbcu)) vRBCvTK1 = parMultiUninf*TsRBC*Vrbcu*(-((K2RBCvTK1*tkxu5pRBC[t])/Vrbcu) + (K1RBCvTK1*tkRBC[t]*xu5pRBC[t])/Vrbcu^2) vRBCvTK2 = parMultiUninf*TsRBC*Vrbcu*(-((K4RBCvTK2*gapRBC[t]*tkgRBC[t])/Vrbcu^2) + (K3RBCvTK2*tkxu5pRBC[t])/Vrbcu) vRBCvTK3 = parMultiUninf*TsRBC*Vrbcu*((K5RBCvTK3*rib5pRBC[t]*tkgRBC[t])/Vrbcu^2 - (K6RBCvTK3*tkgrib5pRBC[t])/Vrbcu) vRBCvTK4 = parMultiUninf*TsRBC*Vrbcu*((K7RBCvTK4*tkgrib5pRBC[t])/Vrbcu - (K8RBCvTK4*sed7pRBC[t]*tkRBC[t])/Vrbcu^2) vRBCvTK5 = parMultiUninf*TsRBC*Vrbcu*(-((K10RBCvTK5*tkgery4pRBC[t])/Vrbcu) + (K9RBCvTK5*ery4pRBC[t]*tkgRBC[t])/Vrbcu^2) vRBCvTK6 = parMultiUninf*TsRBC*Vrbcu*((K11RBCvTK6*tkgery4pRBC[t])/Vrbcu - (K12RBCvTK6*f6pRBC[t]*tkRBC[t])/Vrbcu^2) end rate equations begin parameters CRBCvMGADP = 0.00062 CRBCvMGATP = "8.4e-05" CRBCvMGB13PG = 0.0032 CRBCvMGB23PG = 0.0032 CRBCvMGF16P2 = 0.0083 CRBCvMGG16P2 = 0.0083 CRBCvMGPHOS = 40800.0 ConcADPRBC = 0.00031 ConcAMPRBC = "3e-05" ConcATPRBC = 0.0021 ConcAdpPF = 0.001 ConcAtpPF = 0.002 ConcB13PGRBC = "7e-07" ConcB13pgPF = 0.0001 ConcB23PGRBC = 0.0067 ConcBPGSPB13PGRBC = 0.0 ConcBPGSPB23PGRBC = 0.0 ConcBPGSPPP2GRBC = 0.0 ConcBPGSPPP3GRBC = 0.0 ConcBPGSPPRBC = 0.0 ConcBPGSPRBC = "3.8e-06" ConcBpgsppphosRBC = 0.0 ConcCo2RBC = 0.0012 ConcDhapPF = 0.0001 ConcDhapRBC = "1.9e-05" ConcEry4PRBC = "1e-05" ConcF16P2RBC = "2.7e-06" ConcF16bpPF = 0.0001 ConcF6PRBC = "1.3e-05" ConcF6pPF = 0.0001 ConcG16P2RBC = 0.000122 ConcG6PRBC = "4e-05" ConcG6pPF = 0.0001 ConcGSHRBC = 0.0032 ConcGapPF = 0.0001 ConcGapRBC = "5.7e-06" ConcGlcEXT = 0.005 ConcGlcPF = 0.0001 ConcGlcRBC = 0.001 ConcGly3pPF = 0.0001 ConcGlyEXT = 0.0 ConcGssgRBC = "9e-08" ConcHbADPRBC = 0.0 ConcHbATPRBC = 0.0 ConcHbB13PGRBC = 0.0 ConcHbB23PGRBC = 0.0 ConcHbRBC = 0.007 ConcHbmgatpRBC = 0.0 ConcLacEXT = 0.00182 ConcLacPF = 0.0001 ConcLacRBC = 0.0014 ConcMgADPRBC = 0.0 ConcMgB13PGRBC = 0.0 ConcMgB23PGRBC = 0.0 ConcMgF16P2RBC = 0.0 ConcMgRBC = 0.003 ConcMgatpRBC = 0.0 ConcMgg16p2RBC = 0.0 ConcMgphosRBC = 0.0 ConcNADPRBC = "1.25e-07" ConcNADRBC = "6e-05" ConcNadPF = 0.0025 ConcNadhPF = 0.0005 ConcNadhRBC = "1.4e-07" ConcNadphRBC = "6.4e-05" ConcP2GARBC = "1e-05" ConcP2gPF = 0.0001 ConcP3GARBC = "6.4e-05" ConcP3gPF = 0.0001 ConcP6GLRBC = "1.4e-10" ConcP6GRBC = "1.4e-07" ConcPEPRBC = "2.3e-05" ConcPepPF = 0.0001 ConcPhosEXT = 0.00192 ConcPhosRBC = 0.001 ConcPyrEXT = "8.5e-05" ConcPyrPF = 0.0001 ConcPyrRBC = "6e-05" ConcRib5PRBC = "1e-05" ConcRu5PRBC = "1e-05" ConcSed7PRBC = "1e-05" ConcTKGEry4PRBC = 0.0 ConcTKGRBC = 0.0 ConcTKGRib5PRBC = 0.0 ConcTKRBC = "3.3e-07" ConcTkxu5pRBC = 0.0 ConcXu5PRBC = "1e-06" ERBCvHK = "2.5e-08" ERBCvPGI = "2.18e-07" K10RBCvBPGSP6 = 1979.0 K10RBCvG6PDH = 1400000000.0 K10RBCvGSSGR = 50000000.0 K10RBCvP6GDH = 225000.0 K10RBCvTK5 = 175.0 K11RBCvBPGSP6 = 0.01 K11RBCvGSSGR = 7000.0 K11RBCvP6GDH = 300.0 K11RBCvTK6 = 40.0 K12RBCvBPGSP7 = 1000.0 K12RBCvGSSGR = 100000000.0 K12RBCvP6GDH = 4950000.0 K12RBCvTK6 = 21300.0 K13RBCvBPGSP7 = 1800000.0 K14RBCvBPGSP8 = 1000000000.0 K15RBCvBPGSP8 = 610000.0 K16RBCvBPGSP9 = 0.19 K1RBCvAK = 4300.0 K1RBCvBPGSP1 = 80000000.0 K1RBCvG6PDH = 110000000.0 K1RBCvGSSGR = 85000000.0 K1RBCvP6GDH = 2400000.0 K1RBCvR5PI = 60900.0 K1RBCvRu5PE = 3910000.0 K1RBCvTA = 580000.0 K1RBCvTK1 = 216000.0 K2RBCvAK = 1400.0 K2RBCvBPGSP1 = 400.0 K2RBCvG6PDH = 870.0 K2RBCvGSSGR = 510.0 K2RBCvP6GDH = 410.0 K2RBCvR5PI = 33.3 K2RBCvRu5PE = 438.0 K2RBCvTA = 45.3 K2RBCvTK1 = 38.0 K3RBCvBPGSP2 = 9.9 K3RBCvG6PDH = 26000000.0 K3RBCvGSSGR = 1000000000.0 K3RBCvP6GDH = 2000000000.0 K3RBCvR5PI = 14.2 K3RBCvRu5PE = 305.0 K3RBCvTA = 16.3 K3RBCvTK2 = 34.0 K4RBCvBPGSP3 = 185000000.0 K4RBCvG6PDH = 300.0 K4RBCvGSSGR = 72000.0 K4RBCvP6GDH = 26000.0 K4RBCvR5PI = 21600.0 K4RBCvRu5PE = 1490000.0 K4RBCvTA = 1010000.0 K4RBCvTK2 = 156000.0 K5RBCvBPGSP3 = 100000000.0 K5RBCvG6PDH = 750.0 K5RBCvGSSGR = 810.0 K5RBCvP6GDH = 48.0 K5RBCvTA = 490000.0 K5RBCvTK3 = 329000.0 K6RBCvBPGSP4 = 1000.0 K6RBCvG6PDH = 2000.0 K6RBCvGSSGR = 1000.0 K6RBCvP6GDH = 30.0 K6RBCvTA = 60.0 K6RBCvTK3 = 175.0 K7RBCvBPGSP4 = 1000.0 K7RBCvG6PDH = 220000.0 K7RBCvGSSGR = 1000000.0 K7RBCvP6GDH = 630.0 K7RBCvTA = 17.0 K7RBCvTK4 = 40.0 K8RBCvBPGSP5 = 10000.0 K8RBCvG6PDH = 1100000000.0 K8RBCvGSSGR = 50000000.0 K8RBCvP6GDH = 36000.0 K8RBCvTA = 79000.0 K8RBCvTK4 = 44800.0 K9RBCvBPGSP5 = 0.55 K9RBCvG6PDH = 10000.0 K9RBCvGSSGR = 1000000.0 K9RBCvP6GDH = 800.0 K9RBCvTK5 = 2240000.0 KRBCvATPASE = 0.000585 KRBCvMGADP = 3290.0 KRBCvMGATP = 43200.0 KRBCvMGB13PG = 7410.0 KRBCvMGB23PG = 7410.0 KRBCvMGF16P2 = 363.0 KRBCvMGG16P2 = 363.0 KRBCvOX = "3.4e-05" KRBCvOXNADH = 0.0163 KaRBCvHBADP = 300000.0 KaRBCvHBATP = 432000.0 KaRBCvHBB13PG = 380000.0 KaRBCvHBBPG = 300000.0 KaRBCvHBMGATP = 46800.0 KaRBCvMGADP = 2760000.0 KaRBCvMGATP = 31200000.0 KaRBCvMGB13PG = 228000.0 KaRBCvMGB23PG = 804000.0 KaRBCvMGF16P2 = 480000.0 KaRBCvMGG16P2 = 480000.0 KaRBCvMGPHOS = 40800.0 KaRBCvPFK = "8.91251e-08" KadpPFvHK = 0.000846735 KadpPFvPFK = 0.00074176 KadpPFvPGK = 0.00015 KadpPFvPK = 0.000317 KahbRBC = "2.51189e-07" KatpPFvHK = 0.00069647 KatpPFvPFK = 0.0007862 KatpPFvPGK = 0.00077 Kb13pgPFvGAPDH = "2.359e-05" Kb13pgPFvPGK = "1.34e-05" KcatfRBCvALD = 68.0 KcatfRBCvENO = 190.0 KcatfRBCvGAPDH = 695.304 KcatfRBCvHK = 299.16 KcatfRBCvLDH = 458.0 KcatfRBCvPFK = 822.0 KcatfRBCvPGI = 1470.0 KcatfRBCvPGK = 2290.0 KcatfRBCvPGM = 795.0 KcatfRBCvPK = 1386.0 KcatfRBCvTIM = 14560.0 KcatrRBCvALD = 234.0 KcatrRBCvENO = 50.0 KcatrRBCvGAPDH = 512.487 KcatrRBCvHK = 1.92792 KcatrRBCvLDH = 115.0 KcatrRBCvPFK = 36.0 KcatrRBCvPGI = 1760.0 KcatrRBCvPGK = 917.0 KcatrRBCvPGM = 714.0 KcatrRBCvPK = 3.26 KcatrRBCvTIM = 1280.0 KdPFvLACtr = 0.005 KdPFvPYRtr = 0.0007 KdRBCvHBADP = 1200.0 KdRBCvHBATP = 1200.0 KdRBCvHBB13PG = 1200.0 KdRBCvHBBPG = 1200.0 KdRBCvHBMGATP = 1200.0 KdRBCvMGADP = 1200.0 KdRBCvMGATP = 1200.0 KdRBCvMGB13PG = 1200.0 KdRBCvMGB23PG = 1200.0 KdRBCvMGF16P2 = 1200.0 KdRBCvMGG16P2 = 1200.0 KdRBCvMGPHOS = 1200.0 KdhapPFvALD = 0.00011 KdhapPFvG3PDH = 0.00034 KdhapPFvTPI = 0.001954 KdibpgRBCvHK = 0.004 Kdig16p2RBCvHK = "3e-05" Kdig6pRBCvHK = "1e-05" KdigshRBCvHK = 0.003 KeqPFvALD = "9e-05" KeqPFvENO = 4.6 KeqPFvG3PDH = 32600.0 KeqPFvHK = 1310.0 KeqPFvPGI = 0.33 KeqPFvPGK = 3200.0 KeqPFvPGM = 0.19 KeqPFvTPI = 0.04545 Kf16bpPFvALD = "6.84e-05" Kf16bpPFvPFK = 0.003626 Kf6pPFvPFK = 0.00109454 Kf6pPFvPGI = "9.6651e-05" KfRBCvLDHP = 0.00346 Kg3pPFvG3PDH = 0.00398 Kg6pPFvHK = "4.3e-05" Kg6pPFvPGI = 0.00100774 KgapPFvALD = "4.6e-05" KgapPFvGAPDH = 0.000917 KgapPFvTPI = 0.000337 KglcPFvHK = 0.000168613 Kh2bpgRBCvMGB13PG = 4270000.0 Kh2bpgRBCvMGB23PG = 4270000.0 Kh2fRBCvMGF16P2 = 1120000.0 Kh2fRBCvMGG16P2 = 1120000.0 KhadpRBCvAK = 5420000.0 KhadpRBCvMGADP = 5420000.0 KhampRBCvAK = 3090000.0 KhatpRBCvMGATP = 9070000.0 KhbpgRBCvMGB13PG = 162000000.0 KhbpgRBCvMGB23PG = 162000000.0 KhfRBCvMGF16P2 = 7560000.0 KhfRBCvMGG16P2 = 7560000.0 KhphosRBCvMGPHOS = 5680000.0 KhydrolRBCvPGLHYDROLYSIS = 0.00071 KiRBCvLACTRANSPORT = 0.0036 KiRBCvPHOSTRANSPORT = 0.00056 KiRBCvPYRTRANSPORT = 0.018 KiadpPFvPK = 0.002 KiatpPFvHK = 0.026 KiatpPFvPK = 0.00182 Kib13pgRBCvGAPDH = "4.55544e-21" Kib13pgRBCvPGK = "1.6e-06" Kib23pgRBCvALD = 0.0015 Kidb13pgRBCvGAPDH = "1e-06" KidgapRBCvGAPDH = "3.1e-05" KidhapRBCvALD = "1.1e-05" KidpyrRBCvLDH = 0.000101 Kif16p2RBCvALD = "1.98e-05" Kig6pRBCvHK = "4.7e-05" KigapRBCvGAPDH = "4.76523e-19" KiglcRBCvHK = "4.7e-05" KilacPFvPYRtr = 0.000358 KilacRBCvLDH = 0.00733 KimgRBCvENO = "4.6e-05" KimgadpRBCvHK = 0.001 KimgadpRBCvPGK = "8e-05" KimgatpRBCvHK = 0.001 KimgatpRBCvPGK = 0.000186 KinadRBCvGAPDH = "4.5e-05" KinadRBCvLDH = 0.000503 KinadhRBCvGAPDH = "1e-05" KinadhRBCvLDH = "2.45e-06" Kip2gRBCvENO = 0.00014 Kip3gRBCvPGK = 0.000205 KipepPFvPK = 0.00292 KipepPFvTPI = "1.59e-05" KipepRBCvENO = 0.0001105 KiphosRBCvGAPDH = 0.00316 KipyrPFvLACtr = 0.00163 KipyrPFvPK = 0.105 KipyrRBCvLDH = 0.000228 KkadpRBCvAK = 4.8 KkadpRBCvMGADP = 4.8 KkampRBCvAK = 1.8 KkatpRBCvMGATP = 14.0 KkbpgRBCvMGB13PG = 85.1 KkbpgRBCvMGB23PG = 85.1 KkfRBCvMGF16P2 = 10.7 KkfRBCvMGG16P2 = 10.7 KkhbpgRBCvMGB13PG = 8.9 KkhbpgRBCvMGB23PG = 8.9 KkhfRBCvMGF16P2 = 3.3 KkhfRBCvMGG16P2 = 3.3 KkphosRBCvMGPHOS = 3.0 KlacPFvLACtr = 0.0038 KlacPFvLDH = 0.003611 Klactonase1RBCvPGLHYDROLYSIS = 13000000.0 Klactonase2RBCvPGLHYDROLYSIS = 1000.0 Klactonase3RBCvPGLHYDROLYSIS = 29.0 KmPFvATPASE = 0.0045 KmPFvGLCtr = 0.000213 Kmb13pgRBCvGAPDH = "6.71e-07" Kmb13pgRBCvPGK = "2e-06" KmdhapRBCvALD = "3.5e-05" KmdhapRBCvTIM = 0.0001624 Kmf16p2RBCvALD = "7.1e-06" Kmf16p2RBCvPFK = 0.0005 Kmf6pRBCvPFK = "7.5e-05" Kmf6pRBCvPGI = "7.1e-05" Kmg6pRBCvPGI = 0.000181 KmgapRBCvALD = 0.000189 KmgapRBCvGAPDH = "9.5e-05" KmgapRBCvTIM = 0.000446 KmghadpRBCvMGADP = 107.0 KmghatpRBCvMGATP = 748.0 KmghbpgRBCvMGB13PG = 513.0 KmghbpgRBCvMGB23PG = 513.0 KmghfRBCvMGF16P2 = 89.0 KmghfRBCvMGG16P2 = 89.0 KmlacRBCvLDH = 0.00107 KmlacRBCvLDHP = 0.000414 KmmgRBCvENO = "4.6e-05" KmmgadpRBCvHK = 0.001 KmmgadpRBCvPFK = 0.00054 KmmgadpRBCvPGK = 0.0001 KmmgatpRBCvHK = 0.001 KmmgatpRBCvPFK = "6.8e-05" KmmgatpRBCvPGK = 0.001 KmnadRBCvGAPDH = "4.5e-05" KmnadRBCvLDH = 0.000107 KmnadhRBCvGAPDH = "3.3e-06" KmnadhRBCvLDH = "8.44e-06" Kmp2gRBCvENO = 0.00014 Kmp2gRBCvPGM = "2.56e-05" Kmp3gRBCvPGK = 0.0011 Kmp3gRBCvPGM = 0.000168 KmpepRBCvENO = 0.0001105 KmphosRBCvGAPDH = 0.00316 KmpyrRBCvLDH = 0.000137 KmpyrRBCvLDHP = 0.000414 KnadPFvG3PDH = 0.00051 KnadPFvGAPDH = 0.0005662 KnadPFvLDH = 0.000234 KnadhPFvG3PDH = "9e-05" KnadhPFvGAPDH = "2.87e-05" KnadhPFvLDH = "4.6e-05" Kp2gPFvENO = 0.000521 Kp2gPFvPGM = 0.000318 Kp3gPFvPGK = 0.000267 Kp3gPFvPGM = 0.00173 KpepPFvENO = 0.00129 KpepPFvPK = 0.000406 KpyrPFvLDH = 0.000133 KpyrPFvPYRtr = 0.0157 KrRBCvLDHP = "5.43e-07" KrampRBCvPFK = 0.0003 Krf16p2RBCvPK = "5e-06" Krg16p2RBCvPFK = 0.01 Krg16p2RBCvPK = 0.0001 KrmgadpRBCvPK = 0.000474 KrmgatpRBCvPK = 0.003 KrpepRBCvPK = 0.000225 KrphosRBCvPFK = 0.03 KrpyrRBCvPK = 0.002 KtatpRBCvPFK = 0.0001 KtatpRBCvPK = 0.00339 Ktb23pgRBCvPFK = 0.005 KtmgRBCvPFK = 0.004 LPFvPK = 0.255 RtvRBC = 0.69 TsRBC = 60.0 VPFvALD = 0.0569593147718 VPFvATPASE = 0.345 VPFvENO = 0.286295503195 VPFvGAPDH = 0.656263383259 VPFvGLCtr = 0.0469 VPFvHK = 0.083 VPFvLACtr = 0.598 VPFvPFK = 0.41 VPFvPGI = 0.800428265477 VPFvPGM = 0.186937901488 VPFvPK = 0.762 VPFvPYRtr = 0.216 VPFvTPI = 1.50599571726 VRBCvALD = "3.7e-07" VRBCvENO = "2.2e-07" VRBCvG6PDH = "9.3e-08" VRBCvGAPDH = "7.66e-06" VRBCvGLCTRANSPORT = 0.047 VRBCvGSSGR = "1.25e-07" VRBCvLDH = "3.43e-06" VRBCvP6GDH = "2.1e-06" VRBCvPFK = "1.1e-07" VRBCvPGK = "2.74e-06" VRBCvPGLHYDROLYSIS = "1.4e-05" VRBCvPGM = "4.1e-07" VRBCvPK = "8.7e-08" VRBCvR5PI = "1.42e-05" VRBCvRu5PE = "4.22e-06" VRBCvTA = "6.9e-07" VRBCvTIM = "1.14e-06" VfPFvG3PDH = 0.012 VfPFvLDH = 0.542612419668 VrPFvGAPDH = 0.243199143455 VrPFvLDH = 0.290792291203 VrPFvPGK = 0.353533190557 alphaPFvGLCtr = 0.91 bpgxRBC = "3.8e-06" cyt = 0.0 glcAlpha = 0.36 gssgxRBC = 0.00160009 h = 4.0 hbxRBC = 0.007 kAlpha = 0.0083 kBeta = 0.007 kPFvGLYtr = 2.0 kRBC = 0.15 ki1 = "8.86746e-08" ki2 = "2.08e-05" nRBCvPFK = 5.0 nadpxRBC = "6.4125e-05" pHConversionFactor = 1.0 par = 1.0 phPF = 7.2 phRBC = 7.2 tkxRBC = "3.3e-07" trophToRBC = 0.355555555556 xatpRBC = -0.00456 xg16p2RBC = 0.000122 xphosRBC = 0.000438 Vrbc = 90.0 vBld = 128.5 end parameters begin initial conditions adpPF[0] = adpPFi adpRBC[0] = adpRBCi adpRBCi[0] = adpRBCii ampRBC[0] = ampRBCi ampRBCi[0] = ampRBCii atpPF[0] = atpPFi atpRBC[0] = atpRBCi atpRBCi[0] = atpRBCii b13pgPF[0] = b13pgPFi b13pgRBC[0] = b13pgRBCi b13pgRBCi[0] = b13pgRBCii b23pgRBC[0] = b23pgRBCi b23pgRBCi[0] = b23pgRBCii bpgspRBC[0] = bpgspRBCi bpgspRBCi[0] = bpgspRBCii bpgspb13pgRBC[0] = bpgspb13pgRBCi bpgspb13pgRBCi[0] = bpgspb13pgRBCii bpgspb23pgRBC[0] = bpgspb23pgRBCi bpgspb23pgRBCi[0] = bpgspb23pgRBCii bpgsppRBC[0] = bpgsppRBCi bpgsppRBCi[0] = bpgsppRBCii bpgsppp2gRBC[0] = bpgsppp2gRBCi bpgsppp2gRBCi[0] = bpgsppp2gRBCii bpgsppp3gRBC[0] = bpgsppp3gRBCi bpgsppp3gRBCi[0] = bpgsppp3gRBCii bpgsppphosRBC[0] = bpgsppphosRBCi bpgsppphosRBCi[0] = bpgsppphosRBCii dhapPF[0] = dhapPFi dhapRBC[0] = dhapRBCi dhapRBCi[0] = dhapRBCii ery4pRBC[0] = ery4pRBCi ery4pRBCi[0] = ery4pRBCii f16bpPF[0] = f16bpPFi f16p2RBC[0] = f16p2RBCi f16p2RBCi[0] = f16p2RBCii f6pPF[0] = f6pPFi f6pRBC[0] = f6pRBCi f6pRBCi[0] = f6pRBCii g16p2RBC[0] = g16p2RBCi g16p2RBCi[0] = g16p2RBCii g3pPF[0] = g3pPFi g6pPF[0] = g6pPFi g6pRBC[0] = g6pRBCi g6pRBCi[0] = g6pRBCii gapPF[0] = gapPFi gapRBC[0] = gapRBCi gapRBCi[0] = gapRBCii glcPF[0] = glcPFi glcRBC[0] = glcRBCi glcRBCi[0] = glcRBCii gshRBC[0] = gshRBCi gshRBCi[0] = gshRBCii gssgRBC[0] = gssgRBCi gssgRBCi[0] = gssgRBCii hbRBC[0] = hbRBCi hbRBCi[0] = hbRBCii hbadpRBC[0] = hbadpRBCi hbadpRBCi[0] = hbadpRBCii hbatpRBC[0] = hbatpRBCi hbatpRBCi[0] = hbatpRBCii hbb13pgRBC[0] = hbb13pgRBCi hbb13pgRBCi[0] = hbb13pgRBCii hbb23pgRBC[0] = hbb23pgRBCi hbb23pgRBCi[0] = hbb23pgRBCii hbmgatpRBC[0] = hbmgatpRBCi hbmgatpRBCi[0] = hbmgatpRBCii lacPF[0] = lacPFi lacRBC[0] = lacRBCi lacRBCi[0] = lacRBCii mgRBC[0] = mgRBCi mgRBCi[0] = mgRBCii mgadpRBC[0] = mgadpRBCi mgadpRBCi[0] = mgadpRBCii mgatpRBC[0] = mgatpRBCi mgatpRBCi[0] = mgatpRBCii mgb13pgRBC[0] = mgb13pgRBCi mgb13pgRBCi[0] = mgb13pgRBCii mgb23pgRBC[0] = mgb23pgRBCi mgb23pgRBCi[0] = mgb23pgRBCii mgf16p2RBC[0] = mgf16p2RBCi mgf16p2RBCi[0] = mgf16p2RBCii mgg16p2RBC[0] = mgg16p2RBCi mgg16p2RBCi[0] = mgg16p2RBCii mgphosRBC[0] = mgphosRBCi mgphosRBCi[0] = mgphosRBCii nadPF[0] = nadPFi nadRBC[0] = nadRBCi nadRBCi[0] = nadRBCii nadhPF[0] = nadhPFi nadhRBC[0] = nadhRBCi nadhRBCi[0] = nadhRBCii nadpRBC[0] = nadpRBCi nadpRBCi[0] = nadpRBCii nadphRBC[0] = nadphRBCi nadphRBCi[0] = nadphRBCii p2gPF[0] = p2gPFi p2gRBC[0] = p2gRBCi p2gRBCi[0] = p2gRBCii p3gPF[0] = p3gPFi p3gRBC[0] = p3gRBCi p3gRBCi[0] = p3gRBCii p6gRBC[0] = p6gRBCi p6gRBCi[0] = p6gRBCii p6glRBC[0] = p6glRBCi p6glRBCi[0] = p6glRBCii pepPF[0] = pepPFi pepRBC[0] = pepRBCi pepRBCi[0] = pepRBCii phosRBC[0] = phosRBCi phosRBCi[0] = phosRBCii pyrPF[0] = pyrPFi pyrRBC[0] = pyrRBCi pyrRBCi[0] = pyrRBCii rib5pRBC[0] = rib5pRBCi rib5pRBCi[0] = rib5pRBCii ru5pRBC[0] = ru5pRBCi ru5pRBCi[0] = ru5pRBCii sed7pRBC[0] = sed7pRBCi sed7pRBCi[0] = sed7pRBCii tkRBC[0] = tkRBCi tkRBCi[0] = tkRBCii tkgRBC[0] = tkgRBCi tkgRBCi[0] = tkgRBCii tkgery4pRBC[0] = tkgery4pRBCi tkgery4pRBCi[0] = tkgery4pRBCii tkgrib5pRBC[0] = tkgrib5pRBCi tkgrib5pRBCi[0] = tkgrib5pRBCii tkxu5pRBC[0] = tkxu5pRBCi tkxu5pRBCi[0] = tkxu5pRBCii xu5pRBC[0] = xu5pRBCi xu5pRBCi[0] = xu5pRBCii end initial conditions begin initial values adpPFi = 0.032000000000039996 adpRBCi = 0.00031 adpRBCii = 0.0279 ampRBCi = 3/100000 ampRBCii = 27/10000 atpPFi = 0.06400000000007999 atpRBCi = 0.0021 atpRBCii = 0.189 b13pgPFi = 0.003200000000004 b13pgRBCi = 7/10000000 b13pgRBCii = 63/1000000 b23pgRBCi = 0.0067 b23pgRBCii = 0.603 bpgspRBCi = 3.7999999999999996*^-6 bpgspRBCii = 0.00034199999999999996 bpgspb13pgRBCi = 0 bpgspb13pgRBCii = 0 bpgspb23pgRBCi = 0 bpgspb23pgRBCii = 0 bpgsppRBCi = 0 bpgsppRBCii = 0 bpgsppp2gRBCi = 0 bpgsppp2gRBCii = 0 bpgsppp3gRBCi = 0 bpgsppp3gRBCii = 0 bpgsppphosRBCi = 0 bpgsppphosRBCii = 0 dhapPFi = 0.003200000000004 dhapRBCi = 0.000019 dhapRBCii = 0.0017100000000000001 ery4pRBCi = 1/100000 ery4pRBCii = 9/10000 f16bpPFi = 0.003200000000004 f16p2RBCi = 2.7*^-6 f16p2RBCii = 0.00024300000000000002 f6pPFi = 0.003200000000004 f6pRBCi = 0.000013000000000000001 f6pRBCii = 0.00117 g16p2RBCi = 0.000122 g16p2RBCii = 0.01098 g3pPFi = 0.003200000000004 g6pPFi = 0.003200000000004 g6pRBCi = 1/25000 g6pRBCii = 9/2500 gapPFi = 0.003200000000004 gapRBCi = 5.7*^-6 gapRBCii = 0.000513 glcPFi = 0.003200000000004 glcRBCi = 0.001 glcRBCii = 0.09 gshRBCi = 0.0032 gshRBCii = 0.28800000000000003 gssgRBCi = 9/100000000 gssgRBCii = 81/10000000 hbRBCi = 0.007 hbRBCii = 0.63 hbadpRBCi = 0 hbadpRBCii = 0 hbatpRBCi = 0 hbatpRBCii = 0 hbb13pgRBCi = 0 hbb13pgRBCii = 0 hbb23pgRBCi = 0 hbb23pgRBCii = 0 hbmgatpRBCi = 0 hbmgatpRBCii = 0 lacPFi = 0.003200000000004 lacRBCi = 0.0014 lacRBCii = 0.126 mgRBCi = 0.003 mgRBCii = 0.27 mgadpRBCi = 0 mgadpRBCii = 0 mgatpRBCi = 0 mgatpRBCii = 0 mgb13pgRBCi = 0 mgb13pgRBCii = 0 mgb23pgRBCi = 0 mgb23pgRBCii = 0 mgf16p2RBCi = 0 mgf16p2RBCii = 0 mgg16p2RBCi = 0 mgg16p2RBCii = 0 mgphosRBCi = 0 mgphosRBCii = 0 nadPFi = 0.08000000000009999 nadRBCi = 3/50000 nadRBCii = 27/5000 nadhPFi = 0.016000000000019998 nadhRBCi = 1.3999999999999998*^-7 nadhRBCii = 0.000012599999999999998 nadpRBCi = 1.25*^-7 nadpRBCii = 0.000011249999999999999 nadphRBCi = 0.00006400000000000001 nadphRBCii = 0.00576 p2gPFi = 0.003200000000004 p2gRBCi = 1/100000 p2gRBCii = 9/10000 p3gPFi = 0.003200000000004 p3gRBCi = 0.00006400000000000001 p3gRBCii = 0.00576 p6gRBCi = 1.3999999999999998*^-7 p6gRBCii = 0.000012599999999999998 p6glRBCi = 1.4*^-10 p6glRBCii = 1.2599999999999999*^-8 pepPFi = 0.003200000000004 pepRBCi = 0.000023 pepRBCii = 0.00207 phosRBCi = 0.001 phosRBCii = 0.09 pyrPFi = 0.003200000000004 pyrRBCi = 3/50000 pyrRBCii = 27/5000 rib5pRBCi = 1/100000 rib5pRBCii = 9/10000 ru5pRBCi = 1/100000 ru5pRBCii = 9/10000 sed7pRBCi = 1/100000 sed7pRBCii = 9/10000 tkRBCi = 3.2999999999999996*^-7 tkRBCii = 0.0000297 tkgRBCi = 0 tkgRBCii = 0 tkgery4pRBCi = 0 tkgery4pRBCii = 0 tkgrib5pRBCi = 0 tkgrib5pRBCii = 0 tkxu5pRBCi = 0 tkxu5pRBCii = 0 xu5pRBCi = 1/1000000 xu5pRBCii = 9/100000 end initial values begin assignment rules KiapplacRBCvLDH := 0.715252751049199*(1 + 6.309573444801929*^6/10^phRBC)*KilacRBCvLDH K1appRBCvBPGSP1 := (3.51188643150958*K1RBCvBPGSP1)/(1 + 1.5848931924611098*^-7*10^phRBC) KiapppyrRBCvLDH := 0.284747248950801*(1 + 1.5848931924611098*^-7*10^phRBC)*KipyrRBCvLDH KcatfappRBCvGAPDH := KcatfRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.16227766016838*^7/10^phRBC) KaappRBCvMGG16P2 := (CRBCvMGG16P2*KaRBCvMGG16P2*(hRBC*KhfRBCvMGG16P2*KmghfRBCvMGG16P2 + KRBCvMGG16P2))/(1 + hRBC*KhfRBCvMGG16P2 + hRBC^2*Kh2fRBCvMGG16P2*KhfRBCvMGG16P2 + KkfRBCvMGG16P2*kRBC + hRBC*KhfRBCvMGG16P2*KkhfRBCvMGG16P2*kRBC) K2appRBCvAK := K2RBCvAK*(1 + hRBC*KhampRBCvAK + KkampRBCvAK*kRBC) K1appRBCvAK := K1RBCvAK*(1 + KkadpRBCvAK*kRBC + (KhadpRBCvAK*pHConversionFactor)/10^phRBC) Vpf := Piecewise[{{trophToRBC*Vrbci, par > 0}}, 1] KcatrappRBCvGAPDH := KcatrRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.16227766016838*^7/10^phRBC) parMultiUninf := Piecewise[{{1, par < 1}}, 0] parMulti := Piecewise[{{1, par > 0}}, 0] hRBC := pHConversionFactor/10^phRBC glcEXT := ConcGlcEXT*vBld glyEXT := ConcGlyEXT*vBld phosEXT := ConcPhosEXT*vBld pyrEXT := ConcPyrEXT*vBld lacEXT := ConcLacEXT*vBld KmapppyrRBCvLDH := 0.284747248950801*(1 + 1.5848931924611098*^-7*10^phRBC)*KmpyrRBCvLDH KaappRBCvMGADP := (CRBCvMGADP*KaRBCvMGADP*(hRBC*KhadpRBCvMGADP*KmghadpRBCvMGADP + KRBCvMGADP))/(1 + hRBC*KhadpRBCvMGADP + KkadpRBCvMGADP*kRBC) KcatfappRBCvHK := KcatfRBCvHK/(1 + 1.0471285480509*^7/10^phRBC + 2.8183829312644505*^-10*10^phRBC) K13appRBCvBPGSP7 := (1.75857757502918*K13RBCvBPGSP7)/(1 + 4.78630092322638*^28/10^(4*phRBC)) K6appRBCvBPGSP4 := (1.75857757502918*K6RBCvBPGSP4)/(1 + 4.78630092322638*^28/10^(4*phRBC)) K3appRBCvBPGSP2 := (1.75857757502918*K3RBCvBPGSP2)/(1 + 4.78630092322638*^28/10^(4*phRBC)) K4appRBCvBPGSP3 := (1.75857757502918*K4RBCvBPGSP3)/(1 + 4.78630092322638*^28/10^(4*phRBC)) co2RBCi := ConcCo2RBC*Vrbci KaappRBCvHBATP := HbpHRBC*KaRBCvHBATP KoRBCvPHOSTRANSPORT := KiRBCvPHOSTRANSPORT/KeqRBCvPHOSTRANSPORT KoRBCvLACTRANSPORT := KiRBCvLACTRANSPORT/KeqRBCvLACTRANSPORT KaappRBCvHBMGATP := HbpHRBC*KaRBCvHBMGATP co2RBC := ConcCo2RBC*Vrbcu KaappRBCvHBB13PG := HbpHRBC*KaRBCvHBB13PG hPF := pHConversionFactor/10^phPF KiappnadhRBCvGAPDH := 6.30957344480193*^-8*10^phRBC*KinadhRBCvGAPDH Vrbci := Piecewise[{{par*Vrbc, par > 0}}, 1] KmapplacRBCvLDH := 0.715252751049199*(1 + 6.309573444801929*^6/10^phRBC)*KmlacRBCvLDH KmappnadhRBCvGAPDH := 6.30957344480193*^-8*10^phRBC*KmnadhRBCvGAPDH KaappRBCvHBADP := HbpHRBC*KaRBCvHBADP Vrbcu := Piecewise[{{Vrbc - parMulti*Vrbci, par < 1}}, 1] Kiappb13pgRBCvGAPDH := Kib13pgRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.16227766016838*^7/10^phRBC) KaappRBCvHBBPG := HbpHRBC*KaRBCvHBBPG KoRBCvPYRTRANSPORT := KiRBCvPYRTRANSPORT/RtvRBC KeqRBCvPHOSTRANSPORT := (1 + 10^(-6.75 + phRBC))/(10^(-6.75 + phRBC)/RtvRBC^2 + RtvRBC^(-1)) KcatrappRBCvHK := KcatrRBCvHK/(1 + 1.0471285480509*^7/10^phRBC + 2.8183829312644505*^-10*10^phRBC) KiappgapRBCvGAPDH := KigapRBCvGAPDH/(1 + 10^(-10 + phRBC) + 3.16227766016838*^7/10^phRBC) KaappRBCvMGATP := (CRBCvMGATP*KaRBCvMGATP*(hRBC*KhatpRBCvMGATP*KmghatpRBCvMGATP + KRBCvMGATP))/(1 + KkatpRBCvMGATP*kRBC + KhatpRBCvMGATP/(10^phRBC*pHConversionFactor)) KaappRBCvMGB23PG := (CRBCvMGB23PG*KaRBCvMGB23PG*(hRBC*KhbpgRBCvMGB23PG*KmghbpgRBCvMGB23PG + KRBCvMGB23PG))/(1 + hRBC*KhbpgRBCvMGB23PG + hRBC^2*Kh2bpgRBCvMGB23PG*KhbpgRBCvMGB23PG + KkbpgRBCvMGB23PG*kRBC + hRBC*KhbpgRBCvMGB23PG*KkhbpgRBCvMGB23PG*kRBC) KaappRBCvMGPHOS := (KaRBCvMGPHOS*(1 + KkphosRBCvMGPHOS*kRBC + 6.30957344480193*^-8*KhphosRBCvMGPHOS*pHConversionFactor))/(1 + hRBC*KhphosRBCvMGPHOS + KkphosRBCvMGPHOS*kRBC) LRBCvPK := (1.5848931924611098*^-7*pHConversionFactor*(1 + atpRBC[t]/(KtatpRBCvPK*Vrbcu))^4)/(hRBC*(1 + f16p2RBC[t]/(Krf16p2RBCvPK*Vrbcu) + g16p2RBC[t]/(Krg16p2RBCvPK*Vrbcu))^4*(1 + pepRBC[t]/(KrpepRBCvPK*Vrbcu) + pyrRBC[t]/(KrpyrRBCvPK*Vrbcu))^4) HbpHRBC := (1 + (2.51188643150958*^14*KahbRBC^2)/pHConversionFactor^2 + (3.16978638492223*^7*KahbRBC)/pHConversionFactor)/(1 + (2*KahbRBC)/hRBC + KahbRBC^2/hRBC^2) KeqRBCvLACTRANSPORT := (1 + 10^(-3.73 + phRBC))/(1 + 10^(-3.73 + phRBC)/RtvRBC) KaappRBCvMGF16P2 := (CRBCvMGF16P2*KaRBCvMGF16P2*(hRBC*KhfRBCvMGF16P2*KmghfRBCvMGF16P2 + KRBCvMGF16P2))/(1 + hRBC*KhfRBCvMGF16P2 + hRBC^2*Kh2fRBCvMGF16P2*KhfRBCvMGF16P2 + KkfRBCvMGF16P2*kRBC + hRBC*KhfRBCvMGF16P2*KkhfRBCvMGF16P2*kRBC) LRBCivPK := (1.5848931924611098*^-7*pHConversionFactor*(1 + atpRBCi[t]/(KtatpRBCvPK*Vrbci))^4)/(hRBC*(1 + f16p2RBCi[t]/(Krf16p2RBCvPK*Vrbci) + g16p2RBCi[t]/(Krg16p2RBCvPK*Vrbci))^4*(1 + pepRBCi[t]/(KrpepRBCvPK*Vrbci) + pyrRBCi[t]/(KrpyrRBCvPK*Vrbci))^4) KaappRBCvMGB13PG := (CRBCvMGB13PG*KaRBCvMGB13PG*(hRBC*KhbpgRBCvMGB13PG*KmghbpgRBCvMGB13PG + KRBCvMGB13PG))/(1 + hRBC*KhbpgRBCvMGB13PG + hRBC^2*Kh2bpgRBCvMGB13PG*KhbpgRBCvMGB13PG + KkbpgRBCvMGB13PG*kRBC + hRBC*KhbpgRBCvMGB13PG*KkhbpgRBCvMGB13PG*kRBC) end assignment rules begin function definitions end function definitions begin events end events begin process annotations end process annotations begin species annotations end species annotations begin units end units