#dutoit2 #reactions vPFvALD: {1.0}f16bpPF = {1.0}gapPF + {1.0}dhapPF VPFvALD * f16bpPF * (1 - dhapPF * gapPF / (KeqPFvALD * Vpf * f16bpPF)) / (Kf16bpPFvALD * (1 + dhapPF / (KdhapPFvALD * Vpf) + f16bpPF / (Kf16bpPFvALD * Vpf) + gapPF / (KgapPFvALD * Vpf) + dhapPF * gapPF / (KdhapPFvALD * KgapPFvALD * pow(Vpf, 2)))) vPFvATPASE: {1.0}atpPF = {1.0}adpPF VPFvATPASE * pow(atpPF, 5) / (pow(KmPFvATPASE, 5) * pow(Vpf, 4) * (1 + pow(atpPF, 5) / (pow(KmPFvATPASE, 5) * pow(Vpf, 5)))) vPFvENO: {1.0}p2gPF = {1.0}pepPF VPFvENO * p2gPF * (1 - pepPF / (KeqPFvENO * p2gPF)) / (Kp2gPFvENO * (1 + p2gPF / (Kp2gPFvENO * Vpf) + pepPF / (KpepPFvENO * Vpf))) vPFvG3PDH: {1.0}nadhPF + {1.0}dhapPF = {1.0}nadPF + {1.0}g3pPF VfPFvG3PDH * dhapPF * nadhPF * (1 - g3pPF * nadPF / (KeqPFvG3PDH * dhapPF * nadhPF)) / (KdhapPFvG3PDH * KnadhPFvG3PDH * Vpf * (1 + dhapPF / (KdhapPFvG3PDH * Vpf) + g3pPF / (Kg3pPFvG3PDH * Vpf)) * (1 + nadhPF / (KnadhPFvG3PDH * Vpf) + nadPF / (KnadPFvG3PDH * Vpf))) vPFvGAPDH: {1.0}nadPF + {1.0}gapPF = {1.0}nadhPF + {1.0}b13pgPF (-(VrPFvGAPDH * b13pgPF * nadhPF / (Kb13pgPFvGAPDH * KnadhPFvGAPDH * Vpf)) + VPFvGAPDH * gapPF * nadPF / (KgapPFvGAPDH * KnadPFvGAPDH * Vpf)) / ((1 + b13pgPF / (Kb13pgPFvGAPDH * Vpf) + gapPF / (KgapPFvGAPDH * Vpf)) * (1 + nadhPF / (KnadhPFvGAPDH * Vpf) + nadPF / (KnadPFvGAPDH * Vpf))) vPFvGLCtr: {1.0}glcRBCi = {1.0}glcPF (-(VPFvGLCtr * glcPF / ((1 + cyt / ki1) * KmPFvGLCtr)) + Vpf * VPFvGLCtr * glcRBCi / ((1 + cyt / ki1) * KmPFvGLCtr * Vrbci)) / (1 + (1 + cyt / ki2) * glcPF / ((1 + cyt / ki1) * KmPFvGLCtr * Vpf) + (1 + cyt / ki2) * glcRBCi / ((1 + cyt / ki1) * KmPFvGLCtr * Vrbci) + alphaPFvGLCtr * glcPF * glcRBCi / ((1 + cyt / ki1) * pow(KmPFvGLCtr, 2) * Vpf * Vrbci)) vPFvGLYtr: {1.0}g3pPF = {1.0}glyEXT kPFvGLYtr * Vpf * (-(glyEXT / vBld) + g3pPF / Vpf) vPFvHK: {1.0}glcPF + {1.0}atpPF = {1.0}g6pPF + {1.0}adpPF VPFvHK * atpPF * (1 - adpPF * g6pPF / (KeqPFvHK * atpPF * glcPF)) * glcPF / (KatpPFvHK * KglcPFvHK * Vpf * (1 + adpPF / (KadpPFvHK * Vpf) + atpPF / (KatpPFvHK * Vpf)) * (1 + atpPF / (KiatpPFvHK * Vpf)) * (1 + g6pPF / (Kg6pPFvHK * Vpf) + glcPF / (KglcPFvHK * Vpf))) vPFvLACtr: {1.0}lacPF = {1.0}lacRBCi KdPFvLACtr * lacPF * (1 - hRBC * Vpf * lacRBCi / (hPF * Vrbci * lacPF)) + VPFvLACtr * lacPF * (1 - hRBC * Vpf * lacRBCi / (hPF * Vrbci * lacPF)) / (KlacPFvLACtr * (1 + lacPF / (KlacPFvLACtr * Vpf) + lacRBCi / (KlacPFvLACtr * Vrbci) + pyrPF / (KipyrPFvLACtr * Vpf) + pyrRBCi / (KipyrPFvLACtr * Vrbci))) vPFvLDH: {1.0}pyrPF + {1.0}nadhPF = {1.0}nadPF + {1.0}lacPF (-(VrPFvLDH * lacPF * nadPF / (KlacPFvLDH * KnadPFvLDH * Vpf)) + VfPFvLDH * nadhPF * pyrPF / (KnadhPFvLDH * KpyrPFvLDH * Vpf)) / ((1 + nadhPF / (KnadhPFvLDH * Vpf) + nadPF / (KnadPFvLDH * Vpf)) * (1 + lacPF / (KlacPFvLDH * Vpf) + pyrPF / (KpyrPFvLDH * Vpf))) vPFvPFK: {1.0}f6pPF + {1.0}atpPF = {1.0}f16bpPF + {1.0}adpPF VPFvPFK * atpPF * f6pPF / (KatpPFvPFK * Kf6pPFvPFK * Vpf * (1 + atpPF / (KatpPFvPFK * Vpf)) * (1 + adpPF / (KadpPFvPFK * Vpf) + atpPF / (KatpPFvPFK * Vpf)) * (1 + f16bpPF / (Kf16bpPFvPFK * Vpf) + f6pPF / (Kf6pPFvPFK * Vpf))) vPFvPGI: {1.0}g6pPF = {1.0}f6pPF VPFvPGI * (1 - f6pPF / (KeqPFvPGI * g6pPF)) * g6pPF / (Kg6pPFvPGI * (1 + f6pPF / (Kf6pPFvPGI * Vpf) + g6pPF / (Kg6pPFvPGI * Vpf))) vPFvPGK: {1.0}b13pgPF + {1.0}adpPF = {1.0}p3gPF + {1.0}atpPF KadpPFvPGK * Kb13pgPFvPGK * KeqPFvPGK * VrPFvPGK * atpPF * (-1 + KeqPFvPGK * adpPF * b13pgPF / (atpPF * p3gPF)) * p3gPF / (pow(KatpPFvPGK, 2) * pow(Kp3gPFvPGK, 2) * Vpf * (1 + adpPF / (KadpPFvPGK * Vpf) + atpPF / (KatpPFvPGK * Vpf)) * (1 + b13pgPF / (Kb13pgPFvPGK * Vpf) + p3gPF / (Kp3gPFvPGK * Vpf))) vPFvPGM: {1.0}p3gPF = {1.0}p2gPF VPFvPGM * (1 - p2gPF / (KeqPFvPGM * p3gPF)) * p3gPF / (Kp3gPFvPGM * (1 + p2gPF / (Kp2gPFvPGM * Vpf) + p3gPF / (Kp3gPFvPGM * Vpf))) vPFvPK: {1.0}pepPF + {1.0}adpPF = {1.0}pyrPF + {1.0}atpPF VPFvPK * adpPF * pepPF / (KadpPFvPK * KpepPFvPK * Vpf * (1 + adpPF / (KadpPFvPK * Vpf)) * (1 + pepPF / (KpepPFvPK * Vpf)) * (1 + LPFvPK * (1 + pow(adpPF / (KiadpPFvPK * Vpf) + atpPF / (KiatpPFvPK * Vpf), h)) * (1 + pow(pepPF / (KipepPFvPK * Vpf) + pyrPF / (KipyrPFvPK * Vpf), h)))) vPFvPYRtr: {1.0}pyrPF = {1.0}pyrRBCi KdPFvPYRtr * pyrPF * (1 - hRBC * Vpf * pyrRBCi / (hPF * Vrbci * pyrPF)) + VPFvPYRtr * pyrPF * (1 - hRBC * Vpf * pyrRBCi / (hPF * Vrbci * pyrPF)) / (KpyrPFvPYRtr * (1 + lacPF / (KilacPFvPYRtr * Vpf) + lacRBCi / (KilacPFvPYRtr * Vrbci) + pyrPF / (KpyrPFvPYRtr * Vpf) + pyrRBCi / (KpyrPFvPYRtr * Vrbci))) vPFvTPI: {1.0}dhapPF = {1.0}gapPF VPFvTPI * dhapPF * (1 - gapPF / (KeqPFvTPI * dhapPF)) / (KdhapPFvTPI * (1 + dhapPF / (KdhapPFvTPI * Vpf) + gapPF / (KgapPFvTPI * Vpf) + pepPF / (KipepPFvTPI * Vpf))) vRBCivAK: {1.0}mgadpRBCi + {1.0}adpRBCi = {1.0}mgatpRBCi + {1.0}ampRBCi TsRBC * Vrbci * (K1appRBCvAK * adpRBCi * mgadpRBCi / pow(Vrbci, 2) - K2appRBCvAK * ampRBCi * mgatpRBCi / pow(Vrbci, 2)) vRBCivALD: {1.0}f16p2RBCi = {1.0}gapRBCi + {1.0}dhapRBCi TsRBC * Vrbci * VRBCvALD * (KcatfRBCvALD * f16p2RBCi / (Kmf16p2RBCvALD * Vrbci) - KcatrRBCvALD * dhapRBCi * gapRBCi / (KidhapRBCvALD * KmgapRBCvALD * pow(Vrbci, 2))) / (1 + dhapRBCi / (KidhapRBCvALD * Vrbci) + f16p2RBCi / (Kmf16p2RBCvALD * Vrbci) + dhapRBCi * gapRBCi / (KidhapRBCvALD * KmgapRBCvALD * pow(Vrbci, 2)) + KmdhapRBCvALD * f16p2RBCi * gapRBCi / (KidhapRBCvALD * Kif16p2RBCvALD * KmgapRBCvALD * pow(Vrbci, 2)) + (b23pgRBCi / Vrbci + mgb23pgRBCi / Vrbci) / Kib23pgRBCvALD + KmdhapRBCvALD * gapRBCi * (1 + (b23pgRBCi / Vrbci + mgb23pgRBCi / Vrbci) / Kib23pgRBCvALD) / (KidhapRBCvALD * KmgapRBCvALD * Vrbci)) vRBCivATPASE: {1.0}mgatpRBCi = {1.0}phosRBCi + {1.0}mgadpRBCi KRBCvATPASE * TsRBC * mgatpRBCi vRBCivBPGSP1: {1.0}bpgspRBCi + {1.0}b13pgRBCi = {1.0}bpgspb13pgRBCi TsRBC * Vrbci * (-(K2RBCvBPGSP1 * bpgspb13pgRBCi / Vrbci) + K1appRBCvBPGSP1 * b13pgRBCi * bpgspRBCi / pow(Vrbci, 2)) vRBCivBPGSP2: {1.0}bpgspb13pgRBCi = {1.0}p3gRBCi + {1.0}bpgsppRBCi K3appRBCvBPGSP2 * TsRBC * bpgspb13pgRBCi vRBCivBPGSP3: {1.0}p3gRBCi + {1.0}bpgsppRBCi = {1.0}bpgsppp3gRBCi TsRBC * Vrbci * (-(K5RBCvBPGSP3 * bpgsppp3gRBCi / Vrbci) + K4appRBCvBPGSP3 * bpgsppRBCi * p3gRBCi / pow(Vrbci, 2)) vRBCivBPGSP4: {1.0}p2gRBCi + {1.0}bpgsppRBCi = {1.0}bpgsppp2gRBCi TsRBC * Vrbci * (-(K7RBCvBPGSP4 * bpgsppp2gRBCi / Vrbci) + K6appRBCvBPGSP4 * bpgsppRBCi * p2gRBCi / pow(Vrbci, 2)) vRBCivBPGSP5: {1.0}bpgsppp3gRBCi = {1.0}bpgspb23pgRBCi TsRBC * Vrbci * (-(K9RBCvBPGSP5 * bpgspb23pgRBCi / Vrbci) + K8RBCvBPGSP5 * bpgsppp3gRBCi / Vrbci) vRBCivBPGSP6: {1.0}bpgsppp2gRBCi = {1.0}bpgspb23pgRBCi TsRBC * Vrbci * (-(K11RBCvBPGSP6 * bpgspb23pgRBCi / Vrbci) + K10RBCvBPGSP6 * bpgsppp2gRBCi / Vrbci) vRBCivBPGSP7: {1.0}bpgspb23pgRBCi = {1.0}bpgspRBCi + {1.0}b23pgRBCi TsRBC * Vrbci * (K12RBCvBPGSP7 * bpgspb23pgRBCi / Vrbci - K13appRBCvBPGSP7 * b23pgRBCi * bpgspRBCi / pow(Vrbci, 2)) vRBCivBPGSP8: {1.0}phosRBCi + {1.0}bpgsppRBCi = {1.0}bpgsppphosRBCi TsRBC * Vrbci * (-(K15RBCvBPGSP8 * bpgsppphosRBCi / Vrbci) + K14RBCvBPGSP8 * bpgsppRBCi * phosRBCi / pow(Vrbci, 2)) vRBCivBPGSP9: {1.0}bpgsppphosRBCi = {2.0}phosRBCi + {1.0}bpgspRBCi K16RBCvBPGSP9 * TsRBC * bpgsppphosRBCi vRBCivENO: {1.0}p2gRBCi = {1.0}pepRBCi TsRBC * Vrbci * VRBCvENO * (KcatfRBCvENO * mgRBCi * p2gRBCi / (KimgRBCvENO * Kmp2gRBCvENO * pow(Vrbci, 2)) - KcatrRBCvENO * mgRBCi * pepRBCi / (KipepRBCvENO * KmmgRBCvENO * pow(Vrbci, 2))) / (1 + mgRBCi / (KimgRBCvENO * Vrbci) + p2gRBCi / (Kip2gRBCvENO * Vrbci) + mgRBCi * p2gRBCi / (KimgRBCvENO * Kmp2gRBCvENO * pow(Vrbci, 2)) + pepRBCi / (KipepRBCvENO * Vrbci) + mgRBCi * pepRBCi / (KipepRBCvENO * KmmgRBCvENO * pow(Vrbci, 2))) vRBCivG6PDH: {1.0}nadpRBCi + {1.0}g6pRBCi = {1.0}p6glRBCi + {1.0}nadphRBCi TsRBC * Vrbci * VRBCvG6PDH * (K1RBCvG6PDH * K3RBCvG6PDH * K5RBCvG6PDH * K7RBCvG6PDH * K9RBCvG6PDH * g6pRBCi * nadpRBCi / pow(Vrbci, 2) - K10RBCvG6PDH * K2RBCvG6PDH * K4RBCvG6PDH * K6RBCvG6PDH * K8RBCvG6PDH * nadphRBCi * p6glRBCi / pow(Vrbci, 2)) / (K2RBCvG6PDH * (K4RBCvG6PDH * K6RBCvG6PDH + K4RBCvG6PDH * K7RBCvG6PDH + K5RBCvG6PDH * K7RBCvG6PDH) * K9RBCvG6PDH + K3RBCvG6PDH * K5RBCvG6PDH * K7RBCvG6PDH * K9RBCvG6PDH * g6pRBCi / Vrbci + K10RBCvG6PDH * K2RBCvG6PDH * (K4RBCvG6PDH * K6RBCvG6PDH + K5RBCvG6PDH * K6RBCvG6PDH + K5RBCvG6PDH * K7RBCvG6PDH) * nadphRBCi / Vrbci + K10RBCvG6PDH * K3RBCvG6PDH * K5RBCvG6PDH * K7RBCvG6PDH * g6pRBCi * nadphRBCi / pow(Vrbci, 2) + K1RBCvG6PDH * (K4RBCvG6PDH * K6RBCvG6PDH + K4RBCvG6PDH * K7RBCvG6PDH + K5RBCvG6PDH * K7RBCvG6PDH) * K9RBCvG6PDH * nadpRBCi / Vrbci + K1RBCvG6PDH * K3RBCvG6PDH * (K5RBCvG6PDH * K7RBCvG6PDH + K5RBCvG6PDH * K9RBCvG6PDH + K6RBCvG6PDH * K9RBCvG6PDH + K7RBCvG6PDH * K9RBCvG6PDH) * g6pRBCi * nadpRBCi / pow(Vrbci, 2) + K2RBCvG6PDH * K4RBCvG6PDH * K6RBCvG6PDH * K8RBCvG6PDH * p6glRBCi / Vrbci + K10RBCvG6PDH * (K2RBCvG6PDH * K4RBCvG6PDH + K2RBCvG6PDH * K5RBCvG6PDH + K2RBCvG6PDH * K6RBCvG6PDH + K4RBCvG6PDH * K6RBCvG6PDH) * K8RBCvG6PDH * nadphRBCi * p6glRBCi / pow(Vrbci, 2) + K10RBCvG6PDH * K3RBCvG6PDH * (K5RBCvG6PDH + K6RBCvG6PDH) * K8RBCvG6PDH * g6pRBCi * nadphRBCi * p6glRBCi / pow(Vrbci, 3) + K1RBCvG6PDH * K4RBCvG6PDH * K6RBCvG6PDH * K8RBCvG6PDH * nadpRBCi * p6glRBCi / pow(Vrbci, 2) + K1RBCvG6PDH * K3RBCvG6PDH * (K5RBCvG6PDH + K6RBCvG6PDH) * K8RBCvG6PDH * g6pRBCi * nadpRBCi * p6glRBCi / pow(Vrbci, 3)) vRBCivGAPDH: {1.0}phosRBCi + {1.0}nadRBCi + {1.0}gapRBCi = {1.0}nadhRBCi + {1.0}b13pgRBCi TsRBC * Vrbci * VRBCvGAPDH * (-(KcatrappRBCvGAPDH * b13pgRBCi * nadhRBCi / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH * pow(Vrbci, 2))) + KcatfappRBCvGAPDH * gapRBCi * nadRBCi * phosRBCi / (KiappgapRBCvGAPDH * KiphosRBCvGAPDH * KmnadRBCvGAPDH * pow(Vrbci, 3))) / (b13pgRBCi * (1 + gapRBCi / (KidgapRBCvGAPDH * Vrbci)) / (Kiappb13pgRBCvGAPDH * Vrbci) + gapRBCi * (1 + gapRBCi / (KidgapRBCvGAPDH * Vrbci)) / (KiappgapRBCvGAPDH * Vrbci) + Kmb13pgRBCvGAPDH * nadhRBCi / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH * Vrbci) + b13pgRBCi * nadhRBCi / (Kiappb13pgRBCvGAPDH * KmappnadhRBCvGAPDH * pow(Vrbci, 2)) + gapRBCi * nadhRBCi / (KiappgapRBCvGAPDH * KiappnadhRBCvGAPDH * pow(Vrbci, 2)) + b13pgRBCi * nadRBCi / (Kiappb13pgRBCvGAPDH * KinadRBCvGAPDH * pow(Vrbci, 2)) + gapRBCi * nadRBCi / (KiappgapRBCvGAPDH * KinadRBCvGAPDH * pow(Vrbci, 2)) + gapRBCi * (1 + gapRBCi / (KidgapRBCvGAPDH * Vrbci)) * phosRBCi / (KiappgapRBCvGAPDH * KiphosRBCvGAPDH * pow(Vrbci, 2)) + Kmb13pgRBCvGAPDH * nadhRBCi * phosRBCi / (Kiappb13pgRBCvGAPDH * KiphosRBCvGAPDH * KmappnadhRBCvGAPDH * pow(Vrbci, 2)) + Kmb13pgRBCvGAPDH * b13pgRBCi * nadhRBCi * phosRBCi / (Kiappb13pgRBCvGAPDH * Kidb13pgRBCvGAPDH * KiphosRBCvGAPDH * KmappnadhRBCvGAPDH * pow(Vrbci, 3)) + gapRBCi * nadhRBCi * phosRBCi / (KiappgapRBCvGAPDH * KiappnadhRBCvGAPDH * KiphosRBCvGAPDH * pow(Vrbci, 3)) + KmgapRBCvGAPDH * nadRBCi * phosRBCi / (KiappgapRBCvGAPDH * KiphosRBCvGAPDH * KmnadRBCvGAPDH * pow(Vrbci, 2)) + KmgapRBCvGAPDH * b13pgRBCi * nadRBCi * phosRBCi / (KiappgapRBCvGAPDH * Kidb13pgRBCvGAPDH * KiphosRBCvGAPDH * KmnadRBCvGAPDH * pow(Vrbci, 3)) + gapRBCi * nadRBCi * phosRBCi / (KiappgapRBCvGAPDH * KiphosRBCvGAPDH * KmnadRBCvGAPDH * pow(Vrbci, 3))) vRBCivGLCTRANSPORT: {1.0}glcEXT = {1.0}glcRBCi TsRBC * Vrbci * (VRBCvGLCTRANSPORT * glcEXT / vBld * glcAlpha / (kAlpha + kAlpha / kBeta * glcEXT / vBld * (1 - glcAlpha) + glcEXT / vBld * glcAlpha) - VRBCvGLCTRANSPORT * glcRBCi / Vrbci * glcAlpha / (kAlpha + kAlpha / kBeta * glcRBCi / Vrbci * (1 - glcAlpha) + glcRBCi / Vrbci * glcAlpha) + VRBCvGLCTRANSPORT * glcEXT / vBld * (1 - glcAlpha) / (kBeta + kBeta / kAlpha * glcEXT / vBld * glcAlpha + glcEXT / vBld * (1 - glcAlpha)) - VRBCvGLCTRANSPORT * glcRBCi / Vrbci * (1 - glcAlpha) / (kBeta + kBeta / kAlpha * glcRBCi / Vrbci * glcAlpha + glcRBCi / Vrbci * (1 - glcAlpha))) vRBCivGSSGR: {1.0}nadphRBCi + {1.0}gssgRBCi = {1.0}nadpRBCi + {2.0}gshRBCi TsRBC * Vrbci * VRBCvGSSGR * (K11RBCvGSSGR * K1RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR * gssgRBCi * nadphRBCi / pow(Vrbci, 2) - K10RBCvGSSGR * K12RBCvGSSGR * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * pow(gshRBCi, 2) * nadpRBCi / pow(Vrbci, 3)) / (K11RBCvGSSGR * K2RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K9RBCvGSSGR + K11RBCvGSSGR * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * gshRBCi / Vrbci + K10RBCvGSSGR * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * pow(gshRBCi, 2) / pow(Vrbci, 2) + K11RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR * gssgRBCi / Vrbci + K11RBCvGSSGR * K1RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K9RBCvGSSGR * nadphRBCi / Vrbci + K11RBCvGSSGR * K1RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * gshRBCi * nadphRBCi / pow(Vrbci, 2) + K10RBCvGSSGR * K1RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * pow(gshRBCi, 2) * nadphRBCi / pow(Vrbci, 3) + K1RBCvGSSGR * K3RBCvGSSGR * (K11RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR + K11RBCvGSSGR * K5RBCvGSSGR * K9RBCvGSSGR + K11RBCvGSSGR * K6RBCvGSSGR * K9RBCvGSSGR + K11RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR) * gssgRBCi * nadphRBCi / pow(Vrbci, 2) + K10RBCvGSSGR * K1RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * gshRBCi * gssgRBCi * nadphRBCi / pow(Vrbci, 3) + K11RBCvGSSGR * K1RBCvGSSGR * K3RBCvGSSGR * (K5RBCvGSSGR + K6RBCvGSSGR) * K8RBCvGSSGR * gshRBCi * gssgRBCi * nadphRBCi / pow(Vrbci, 3) + K10RBCvGSSGR * K1RBCvGSSGR * K3RBCvGSSGR * (K5RBCvGSSGR + K6RBCvGSSGR) * K8RBCvGSSGR * pow(gshRBCi, 2) * gssgRBCi * nadphRBCi / pow(Vrbci, 4) + K12RBCvGSSGR * K2RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * K9RBCvGSSGR * nadpRBCi / Vrbci + K10RBCvGSSGR * K12RBCvGSSGR * K2RBCvGSSGR * (K4RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K7RBCvGSSGR + K5RBCvGSSGR * K7RBCvGSSGR) * gshRBCi * nadpRBCi / pow(Vrbci, 2) + K12RBCvGSSGR * K2RBCvGSSGR * K4RBCvGSSGR * K6RBCvGSSGR * K8RBCvGSSGR * gshRBCi * nadpRBCi / pow(Vrbci, 2) + K10RBCvGSSGR * K12RBCvGSSGR * (K2RBCvGSSGR * K4RBCvGSSGR + K2RBCvGSSGR * K5RBCvGSSGR + K2RBCvGSSGR * K6RBCvGSSGR + K4RBCvGSSGR * K6RBCvGSSGR) * K8RBCvGSSGR * pow(gshRBCi, 2) * nadpRBCi / pow(Vrbci, 3) + K12RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * K9RBCvGSSGR * gssgRBCi * nadpRBCi / pow(Vrbci, 2) + K10RBCvGSSGR * K12RBCvGSSGR * K3RBCvGSSGR * K5RBCvGSSGR * K7RBCvGSSGR * gshRBCi * gssgRBCi * nadpRBCi / pow(Vrbci, 3) + K10RBCvGSSGR * K12RBCvGSSGR * K3RBCvGSSGR * (K5RBCvGSSGR + K6RBCvGSSGR) * K8RBCvGSSGR * pow(gshRBCi, 2) * gssgRBCi * nadpRBCi / pow(Vrbci, 4)) vRBCivHBADP: {1.0}hbRBCi + {1.0}adpRBCi = {1.0}hbadpRBCi TsRBC * Vrbci * (-(KdRBCvHBADP * hbadpRBCi / Vrbci) + KaappRBCvHBADP * adpRBCi * hbRBCi / pow(Vrbci, 2)) vRBCivHBATP: {1.0}hbRBCi + {1.0}atpRBCi = {1.0}hbatpRBCi TsRBC * Vrbci * (-(KdRBCvHBATP * hbatpRBCi / Vrbci) + KaappRBCvHBATP * atpRBCi * hbRBCi / pow(Vrbci, 2)) vRBCivHBB13PG: {1.0}hbRBCi + {1.0}b13pgRBCi = {1.0}hbb13pgRBCi TsRBC * Vrbci * (-(KdRBCvHBB13PG * hbb13pgRBCi / Vrbci) + KaappRBCvHBB13PG * b13pgRBCi * hbRBCi / pow(Vrbci, 2)) vRBCivHBB23PG: {1.0}hbRBCi + {1.0}b23pgRBCi = {1.0}hbb23pgRBCi TsRBC * Vrbci * (-(KdRBCvHBBPG * hbb23pgRBCi / Vrbci) + KaappRBCvHBBPG * b23pgRBCi * hbRBCi / pow(Vrbci, 2)) vRBCivHBMGATP: {1.0}mgatpRBCi + {1.0}hbRBCi = {1.0}hbmgatpRBCi TsRBC * Vrbci * (-(KdRBCvHBMGATP * hbmgatpRBCi / Vrbci) + KaappRBCvHBMGATP * hbRBCi * mgatpRBCi / pow(Vrbci, 2)) vRBCivHK: {1.0}mgatpRBCi + {1.0}glcRBCi = {1.0}mgadpRBCi + {1.0}g6pRBCi TsRBC * Vrbci * (-(ERBCvHK * KcatrappRBCvHK * g6pRBCi * mgadpRBCi / (Kig6pRBCvHK * KmmgadpRBCvHK * pow(Vrbci, 2))) + ERBCvHK * KcatfappRBCvHK * glcRBCi * mgatpRBCi / (KiglcRBCvHK * KmmgatpRBCvHK * pow(Vrbci, 2))) / (1 + g6pRBCi / (Kig6pRBCvHK * Vrbci) + glcRBCi / (KiglcRBCvHK * Vrbci) + b23pgRBCi * glcRBCi / (KdibpgRBCvHK * KiglcRBCvHK * pow(Vrbci, 2)) + g16p2RBCi * glcRBCi / (Kdig16p2RBCvHK * KiglcRBCvHK * pow(Vrbci, 2)) + g6pRBCi * glcRBCi / (Kdig6pRBCvHK * KiglcRBCvHK * pow(Vrbci, 2)) + glcRBCi * gshRBCi / (KdigshRBCvHK * KiglcRBCvHK * pow(Vrbci, 2)) + mgadpRBCi / (KimgadpRBCvHK * Vrbci) + g6pRBCi * mgadpRBCi / (Kig6pRBCvHK * KmmgadpRBCvHK * pow(Vrbci, 2)) + mgatpRBCi / (KimgatpRBCvHK * Vrbci) + glcRBCi * mgatpRBCi / (KiglcRBCvHK * KmmgatpRBCvHK * pow(Vrbci, 2))) vRBCivLACTRANSPORT: {1.0}lacRBCi = {1.0}lacEXT TsRBC * vBld * (-(KiRBCvLACTRANSPORT * lacEXT / vBld) + KoRBCvLACTRANSPORT * lacRBCi / Vrbci) vRBCivLDH: {1.0}pyrRBCi + {1.0}nadhRBCi = {1.0}nadRBCi + {1.0}lacRBCi TsRBC * Vrbci * VRBCvLDH * (-(KcatrRBCvLDH * lacRBCi * nadRBCi / (KinadRBCvLDH * KmapplacRBCvLDH * pow(Vrbci, 2))) + KcatfRBCvLDH * nadhRBCi * pyrRBCi / (KinadhRBCvLDH * KmapppyrRBCvLDH * pow(Vrbci, 2))) / (nadhRBCi / (KinadhRBCvLDH * Vrbci) + KmnadRBCvLDH * lacRBCi * nadhRBCi / (KinadhRBCvLDH * KinadRBCvLDH * KmapplacRBCvLDH * pow(Vrbci, 2)) + nadRBCi / (KinadRBCvLDH * Vrbci) + lacRBCi * nadRBCi / (KinadRBCvLDH * KmapplacRBCvLDH * pow(Vrbci, 2)) + nadhRBCi * pyrRBCi / (KinadhRBCvLDH * KmapppyrRBCvLDH * pow(Vrbci, 2)) + lacRBCi * nadhRBCi * pyrRBCi / (KiapplacRBCvLDH * KinadhRBCvLDH * KmapppyrRBCvLDH * pow(Vrbci, 3)) + KmnadhRBCvLDH * nadRBCi * pyrRBCi / (KinadhRBCvLDH * KinadRBCvLDH * KmapppyrRBCvLDH * pow(Vrbci, 2)) + lacRBCi * nadRBCi * pyrRBCi / (KiapppyrRBCvLDH * KinadRBCvLDH * KmapplacRBCvLDH * pow(Vrbci, 3)) + (1 + pyrRBCi / (KidpyrRBCvLDH * Vrbci)) * (1 + KmnadRBCvLDH * lacRBCi / (KinadRBCvLDH * KmapplacRBCvLDH * Vrbci) + KmnadhRBCvLDH * pyrRBCi / (KinadhRBCvLDH * KmapppyrRBCvLDH * Vrbci))) vRBCivLDHP: {1.0}pyrRBCi + {1.0}nadphRBCi = {1.0}nadpRBCi + {1.0}lacRBCi TsRBC * Vrbci * (-(KrRBCvLDHP * lacRBCi * nadpRBCi / (KmlacRBCvLDHP * pow(Vrbci, 2))) + KfRBCvLDHP * nadphRBCi * pyrRBCi / (KmpyrRBCvLDHP * pow(Vrbci, 2))) / (1 + lacRBCi / (KmlacRBCvLDHP * Vrbci) + pyrRBCi / (KmpyrRBCvLDHP * Vrbci)) vRBCivMGADP: {1.0}mgRBCi + {1.0}adpRBCi = {1.0}mgadpRBCi TsRBC * Vrbci * (-(KdRBCvMGADP * mgadpRBCi / Vrbci) + KaappRBCvMGADP * adpRBCi * mgRBCi / pow(Vrbci, 2)) vRBCivMGATP: {1.0}atpRBCi + {1.0}mgRBCi = {1.0}mgatpRBCi TsRBC * Vrbci * (-(KdRBCvMGATP * mgatpRBCi / Vrbci) + KaappRBCvMGATP * atpRBCi * mgRBCi / pow(Vrbci, 2)) vRBCivMGB13PG: {1.0}mgRBCi + {1.0}b13pgRBCi = {1.0}mgb13pgRBCi TsRBC * Vrbci * (-(KdRBCvMGB13PG * mgb13pgRBCi / Vrbci) + KaappRBCvMGB13PG * b13pgRBCi * mgRBCi / pow(Vrbci, 2)) vRBCivMGB23PG: {1.0}mgRBCi + {1.0}b23pgRBCi = {1.0}mgb23pgRBCi TsRBC * Vrbci * (-(KdRBCvMGB23PG * mgb23pgRBCi / Vrbci) + KaappRBCvMGB23PG * b23pgRBCi * mgRBCi / pow(Vrbci, 2)) vRBCivMGF16P2: {1.0}mgRBCi + {1.0}f16p2RBCi = {1.0}mgf16p2RBCi TsRBC * Vrbci * (-(KdRBCvMGF16P2 * mgf16p2RBCi / Vrbci) + KaappRBCvMGF16P2 * f16p2RBCi * mgRBCi / pow(Vrbci, 2)) vRBCivMGG16P2: {1.0}mgRBCi + {1.0}g16p2RBCi = {1.0}mgg16p2RBCi TsRBC * Vrbci * (-(KdRBCvMGG16P2 * mgg16p2RBCi / Vrbci) + KaappRBCvMGG16P2 * g16p2RBCi * mgRBCi / pow(Vrbci, 2)) vRBCivMGPHOS: {1.0}phosRBCi + {1.0}mgRBCi = {1.0}mgphosRBCi TsRBC * Vrbci * (-(KdRBCvMGPHOS * mgphosRBCi / Vrbci) + KaappRBCvMGPHOS * mgRBCi * phosRBCi / pow(Vrbci, 2)) vRBCivOX: {2.0}gshRBCi = {1.0}gssgRBCi KRBCvOX * TsRBC * gshRBCi vRBCivOXNADH: {1.0}nadhRBCi = {1.0}nadRBCi KRBCvOXNADH * TsRBC * nadhRBCi vRBCivP6GDH: {1.0}p6gRBCi + {1.0}nadpRBCi = {1.0}ru5pRBCi + {1.0}nadphRBCi TsRBC * Vrbci * VRBCvP6GDH * (K11RBCvP6GDH * K1RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH * nadpRBCi * p6gRBCi / pow(Vrbci, 2) - co2RBCi * K10RBCvP6GDH * K12RBCvP6GDH * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * nadphRBCi * ru5pRBCi / pow(Vrbci, 3)) / (K11RBCvP6GDH * K2RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K9RBCvP6GDH + co2RBCi * K11RBCvP6GDH * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH / Vrbci + co2RBCi * K12RBCvP6GDH * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * nadphRBCi / pow(Vrbci, 2) + K12RBCvP6GDH * K2RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K9RBCvP6GDH * nadphRBCi / Vrbci + co2RBCi * K11RBCvP6GDH * K1RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * nadpRBCi / pow(Vrbci, 2) + K11RBCvP6GDH * K1RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * K9RBCvP6GDH * nadpRBCi / Vrbci + K11RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH * p6gRBCi / Vrbci + K12RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH * nadphRBCi * p6gRBCi / pow(Vrbci, 2) + co2RBCi * K11RBCvP6GDH * K1RBCvP6GDH * K3RBCvP6GDH * (K5RBCvP6GDH + K6RBCvP6GDH) * K8RBCvP6GDH * nadpRBCi * p6gRBCi / pow(Vrbci, 3) + K1RBCvP6GDH * K3RBCvP6GDH * (K11RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH + K11RBCvP6GDH * K5RBCvP6GDH * K9RBCvP6GDH + K11RBCvP6GDH * K6RBCvP6GDH * K9RBCvP6GDH + K11RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH * K9RBCvP6GDH) * nadpRBCi * p6gRBCi / pow(Vrbci, 2) + co2RBCi * K10RBCvP6GDH * K2RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * ru5pRBCi / pow(Vrbci, 2) + co2RBCi * K10RBCvP6GDH * K12RBCvP6GDH * (K2RBCvP6GDH * K4RBCvP6GDH + K2RBCvP6GDH * K5RBCvP6GDH + K2RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K6RBCvP6GDH) * K8RBCvP6GDH * nadphRBCi * ru5pRBCi / pow(Vrbci, 3) + K10RBCvP6GDH * K12RBCvP6GDH * K2RBCvP6GDH * (K4RBCvP6GDH * K6RBCvP6GDH + K4RBCvP6GDH * K7RBCvP6GDH + K5RBCvP6GDH * K7RBCvP6GDH) * nadphRBCi * ru5pRBCi / pow(Vrbci, 2) + co2RBCi * K10RBCvP6GDH * K1RBCvP6GDH * K4RBCvP6GDH * K6RBCvP6GDH * K8RBCvP6GDH * nadpRBCi * ru5pRBCi / pow(Vrbci, 3) + co2RBCi * K10RBCvP6GDH * K12RBCvP6GDH * K3RBCvP6GDH * (K5RBCvP6GDH + K6RBCvP6GDH) * K8RBCvP6GDH * nadphRBCi * p6gRBCi * ru5pRBCi / pow(Vrbci, 4) + K10RBCvP6GDH * K12RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * nadphRBCi * p6gRBCi * ru5pRBCi / pow(Vrbci, 3) + co2RBCi * K10RBCvP6GDH * K1RBCvP6GDH * K3RBCvP6GDH * (K5RBCvP6GDH + K6RBCvP6GDH) * K8RBCvP6GDH * nadpRBCi * p6gRBCi * ru5pRBCi / pow(Vrbci, 4) + K10RBCvP6GDH * K1RBCvP6GDH * K3RBCvP6GDH * K5RBCvP6GDH * K7RBCvP6GDH * nadpRBCi * p6gRBCi * ru5pRBCi / pow(Vrbci, 3)) vRBCivPFK: {1.0}mgatpRBCi + {1.0}f6pRBCi = {1.0}mgadpRBCi + {1.0}f16p2RBCi TsRBC * Vrbci * VRBCvPFK * (-(KcatfRBCvPFK * f16p2RBCi * mgadpRBCi / (Kmf16p2RBCvPFK * KmmgadpRBCvPFK * pow(Vrbci, 2))) + KcatfRBCvPFK * f6pRBCi * mgatpRBCi / (Kmf6pRBCvPFK * KmmgatpRBCvPFK * pow(Vrbci, 2))) / ((1 + f16p2RBCi / (Kmf16p2RBCvPFK * Vrbci) + f6pRBCi / (Kmf6pRBCvPFK * Vrbci) + mgadpRBCi / (KmmgadpRBCvPFK * Vrbci) + f16p2RBCi * mgadpRBCi / (Kmf16p2RBCvPFK * KmmgadpRBCvPFK * pow(Vrbci, 2)) + mgatpRBCi / (KmmgatpRBCvPFK * Vrbci) + f6pRBCi * mgatpRBCi / (Kmf6pRBCvPFK * KmmgatpRBCvPFK * pow(Vrbci, 2))) * (1 + pow(hRBC / KaRBCvPFK, nRBCvPFK) * pow(1 + atpRBCi / (KtatpRBCvPFK * Vrbci), 4) * pow(1 + b23pgRBCi / (Ktb23pgRBCvPFK * Vrbci), 4) * pow(1 + mgRBCi / (KtmgRBCvPFK * Vrbci), 4) / (pow(1 + ampRBCi / (KrampRBCvPFK * Vrbci), 4) * pow(1 + f16p2RBCi / (Kmf16p2RBCvPFK * Vrbci) + f6pRBCi / (Kmf6pRBCvPFK * Vrbci), 4) * pow(1 + g16p2RBCi / (Krg16p2RBCvPFK * Vrbci), 4) * pow(1 + phosRBCi / (KrphosRBCvPFK * Vrbci), 4)))) vRBCivPGI: {1.0}g6pRBCi = {1.0}f6pRBCi ERBCvPGI * TsRBC * Vrbci * (-(KcatrRBCvPGI * f6pRBCi / (Kmf6pRBCvPGI * Vrbci)) + KcatfRBCvPGI * g6pRBCi / (Kmg6pRBCvPGI * Vrbci)) / (1 + f6pRBCi / (Kmf6pRBCvPGI * Vrbci) + g6pRBCi / (Kmg6pRBCvPGI * Vrbci)) vRBCivPGK: {1.0}mgadpRBCi + {1.0}b13pgRBCi = {1.0}p3gRBCi + {1.0}mgatpRBCi TsRBC * Vrbci * VRBCvPGK * (KcatfRBCvPGK * b13pgRBCi * mgadpRBCi / (KimgadpRBCvPGK * Kmb13pgRBCvPGK * pow(Vrbci, 2)) - KcatrRBCvPGK * mgatpRBCi * p3gRBCi / (KimgatpRBCvPGK * Kmp3gRBCvPGK * pow(Vrbci, 2))) / (1 + b13pgRBCi / (Kib13pgRBCvPGK * Vrbci) + mgadpRBCi / (KimgadpRBCvPGK * Vrbci) + b13pgRBCi * mgadpRBCi / (KimgadpRBCvPGK * Kmb13pgRBCvPGK * pow(Vrbci, 2)) + mgatpRBCi / (KimgatpRBCvPGK * Vrbci) + p3gRBCi / (Kip3gRBCvPGK * Vrbci) + mgatpRBCi * p3gRBCi / (KimgatpRBCvPGK * Kmp3gRBCvPGK * pow(Vrbci, 2))) vRBCivPGLHYDROLYSIS: {1.0}p6glRBCi = {1.0}p6gRBCi TsRBC * Vrbci * (KhydrolRBCvPGLHYDROLYSIS * p6glRBCi / Vrbci + Klactonase3RBCvPGLHYDROLYSIS * VRBCvPGLHYDROLYSIS * p6glRBCi / (Vrbci * ((Klactonase2RBCvPGLHYDROLYSIS + Klactonase3RBCvPGLHYDROLYSIS) / Klactonase1RBCvPGLHYDROLYSIS + p6glRBCi / Vrbci))) vRBCivPGM: {1.0}p3gRBCi = {1.0}p2gRBCi TsRBC * Vrbci * VRBCvPGM * (-(KcatrRBCvPGM * p2gRBCi / (Kmp2gRBCvPGM * Vrbci)) + KcatfRBCvPGM * p3gRBCi / (Kmp3gRBCvPGM * Vrbci)) / (1 + p2gRBCi / (Kmp2gRBCvPGM * Vrbci) + p3gRBCi / (Kmp3gRBCvPGM * Vrbci)) vRBCivPHOSTRANSPORT: {1.0}phosRBCi = {1.0}phosEXT TsRBC * vBld * (-(KiRBCvPHOSTRANSPORT * phosEXT / vBld) + KoRBCvPHOSTRANSPORT * phosRBCi / Vrbci) vRBCivPK: {1.0}pepRBCi + {1.0}mgadpRBCi = {1.0}pyrRBCi + {1.0}mgatpRBCi TsRBC * Vrbci * VRBCvPK * (KcatfRBCvPK * mgadpRBCi * pepRBCi / (KrmgadpRBCvPK * KrpepRBCvPK * pow(Vrbci, 2)) - KcatrRBCvPK * mgatpRBCi * pyrRBCi / (KrmgatpRBCvPK * KrpyrRBCvPK * pow(Vrbci, 2))) / ((1 + LRBCvPK) * (1 + mgadpRBCi / (KrmgadpRBCvPK * Vrbci) + mgatpRBCi / (KrmgatpRBCvPK * Vrbci) + pepRBCi / (KrpepRBCvPK * Vrbci) + mgadpRBCi * pepRBCi / (KrmgadpRBCvPK * KrpepRBCvPK * pow(Vrbci, 2)) + pyrRBCi / (KrpyrRBCvPK * Vrbci) + mgatpRBCi * pyrRBCi / (KrmgatpRBCvPK * KrpyrRBCvPK * pow(Vrbci, 2)))) vRBCivPYRTRANSPORT: {1.0}pyrRBCi = {1.0}pyrEXT TsRBC * vBld * (-(KiRBCvPYRTRANSPORT * pyrEXT / vBld) + KoRBCvPYRTRANSPORT * pyrRBCi / Vrbci) vRBCivR5PI: {1.0}ru5pRBCi = {1.0}rib5pRBCi TsRBC * Vrbci * VRBCvR5PI * (-(K2RBCvR5PI * K4RBCvR5PI * rib5pRBCi / ((K2RBCvR5PI + K3RBCvR5PI) * Vrbci)) + K1RBCvR5PI * K3RBCvR5PI * ru5pRBCi / ((K2RBCvR5PI + K3RBCvR5PI) * Vrbci)) / (1 + K1RBCvR5PI * ru5pRBCi / ((K2RBCvR5PI + K3RBCvR5PI) * Vrbci) + K4RBCvR5PI * xu5pRBCi / ((K2RBCvR5PI + K3RBCvR5PI) * Vrbci)) vRBCivRu5PE: {1.0}ru5pRBCi = {1.0}xu5pRBCi TsRBC * Vrbci * VRBCvRu5PE * (K1RBCvRu5PE * K3RBCvRu5PE * ru5pRBCi / ((K2RBCvRu5PE + K3RBCvRu5PE) * Vrbci) - K2RBCvRu5PE * K4RBCvRu5PE * xu5pRBCi / ((K2RBCvRu5PE + K3RBCvRu5PE) * Vrbci)) / (1 + K1RBCvRu5PE * ru5pRBCi / ((K2RBCvRu5PE + K3RBCvRu5PE) * Vrbci) + K4RBCvRu5PE * xu5pRBCi / ((K2RBCvRu5PE + K3RBCvRu5PE) * Vrbci)) vRBCivTA: {1.0}sed7pRBCi + {1.0}gapRBCi = {1.0}f6pRBCi + {1.0}ery4pRBCi TsRBC * Vrbci * VRBCvTA * (-(K2RBCvTA * K4RBCvTA * K6RBCvTA * K8RBCvTA * ery4pRBCi * f6pRBCi / pow(Vrbci, 2)) + K1RBCvTA * K3RBCvTA * K5RBCvTA * K7RBCvTA * gapRBCi * sed7pRBCi / pow(Vrbci, 2)) / (K2RBCvTA * K4RBCvTA * (K6RBCvTA + K7RBCvTA) * ery4pRBCi / Vrbci + (K2RBCvTA + K3RBCvTA) * K6RBCvTA * K8RBCvTA * f6pRBCi / Vrbci + K4RBCvTA * (K2RBCvTA + K6RBCvTA) * K8RBCvTA * ery4pRBCi * f6pRBCi / pow(Vrbci, 2) + (K2RBCvTA + K3RBCvTA) * K5RBCvTA * K7RBCvTA * gapRBCi / Vrbci + (K2RBCvTA + K3RBCvTA) * K5RBCvTA * K8RBCvTA * f6pRBCi * gapRBCi / pow(Vrbci, 2) + K1RBCvTA * K3RBCvTA * (K6RBCvTA + K7RBCvTA) * sed7pRBCi / Vrbci + K1RBCvTA * K4RBCvTA * (K6RBCvTA + K7RBCvTA) * ery4pRBCi * sed7pRBCi / pow(Vrbci, 2) + K1RBCvTA * K5RBCvTA * (K3RBCvTA + K7RBCvTA) * gapRBCi * sed7pRBCi / pow(Vrbci, 2)) vRBCivTIM: {1.0}gapRBCi = {1.0}dhapRBCi TsRBC * Vrbci * VRBCvTIM * (-(KcatrRBCvTIM * dhapRBCi / (KmdhapRBCvTIM * Vrbci)) + KcatfRBCvTIM * gapRBCi / (KmgapRBCvTIM * Vrbci)) / (1 + dhapRBCi / (KmdhapRBCvTIM * Vrbci) + gapRBCi / (KmgapRBCvTIM * Vrbci)) vRBCivTK1: {1.0}xu5pRBCi + {1.0}tkRBCi = {1.0}tkxu5pRBCi TsRBC * Vrbci * (-(K2RBCvTK1 * tkxu5pRBCi / Vrbci) + K1RBCvTK1 * tkRBCi * xu5pRBCi / pow(Vrbci, 2)) vRBCivTK2: {1.0}tkxu5pRBCi = {1.0}tkgRBCi + {1.0}gapRBCi TsRBC * Vrbci * (-(K4RBCvTK2 * gapRBCi * tkgRBCi / pow(Vrbci, 2)) + K3RBCvTK2 * tkxu5pRBCi / Vrbci) vRBCivTK3: {1.0}tkgRBCi + {1.0}rib5pRBCi = {1.0}tkgrib5pRBCi TsRBC * Vrbci * (K5RBCvTK3 * rib5pRBCi * tkgRBCi / pow(Vrbci, 2) - K6RBCvTK3 * tkgrib5pRBCi / Vrbci) vRBCivTK4: {1.0}tkgrib5pRBCi = {1.0}tkRBCi + {1.0}sed7pRBCi TsRBC * Vrbci * (K7RBCvTK4 * tkgrib5pRBCi / Vrbci - K8RBCvTK4 * sed7pRBCi * tkRBCi / pow(Vrbci, 2)) vRBCivTK5: {1.0}tkgRBCi + {1.0}ery4pRBCi = {1.0}tkgery4pRBCi TsRBC * Vrbci * (-(K10RBCvTK5 * tkgery4pRBCi / Vrbci) + K9RBCvTK5 * ery4pRBCi * tkgRBCi / pow(Vrbci, 2)) vRBCivTK6: {1.0}tkgery4pRBCi = {1.0}tkRBCi + {1.0}f6pRBCi TsRBC * Vrbci * (K11RBCvTK6 * tkgery4pRBCi / Vrbci - K12RBCvTK6 * f6pRBCi * tkRBCi / pow(Vrbci, 2)) #parameters CRBCvMGADP = 0.00062 CRBCvMGATP = 8.4e-05 CRBCvMGB13PG = 0.0032 CRBCvMGB23PG = 0.0032 CRBCvMGF16P2 = 0.0083 CRBCvMGG16P2 = 0.0083 CRBCvMGPHOS = 40800.0 ConcADPRBC = 8.2127e-05 ConcAMPRBC = 1.69612e-05 ConcATPRBC = 0.000152428 ConcAdpPF = 0.00050117 ConcAtpPF = 0.00249883 ConcB13PGRBC = 6.40805e-07 ConcB13pgPF = 7.85111e-07 ConcB23PGRBC = 0.00246965 ConcBPGSPB13PGRBC = 3.53412e-08 ConcBPGSPB23PGRBC = 1.25618e-06 ConcBPGSPPP2GRBC = 6.31235e-12 ConcBPGSPPP3GRBC = 6.90966e-11 ConcBPGSPPRBC = 3.84364e-07 ConcBPGSPRBC = 2.82581e-07 ConcBpgsppphosRBC = 1.84146e-06 ConcCo2RBC = 0.0012 ConcDhapPF = 0.00112155 ConcDhapRBC = 5.48566e-05 ConcEry4PRBC = 1.08815e-06 ConcF16P2RBC = 1.04074e-05 ConcF16bpPF = 0.00103544 ConcF6PRBC = 1.0225e-05 ConcF6pPF = 0.000242841 ConcG16P2RBC = 0.000105238 ConcG6PRBC = 3.16467e-05 ConcG6pPF = 0.000787 ConcGSHRBC = 0.00320001 ConcGapPF = 4.83651e-05 ConcGapRBC = 1.32213e-05 ConcGlcEXT = 0.005 ConcGlcPF = 0.000716005 ConcGlcRBC = 0.00497498 ConcGly3pPF = 0.000402813 ConcGlyEXT = 0.0 ConcGssgRBC = 8.64759e-08 ConcHbADPRBC = 8.19307e-05 ConcHbATPRBC = 0.000218972 ConcHbB13PGRBC = 8.09746e-07 ConcHbB23PGRBC = 0.00246374 ConcHbRBC = 0.00399044 ConcHbmgatpRBC = 0.000244108 ConcLacEXT = 0.0 ConcLacPF = 0.0152295 ConcLacRBC = 0.0139333 ConcMgADPRBC = 7.49323e-05 ConcMgB13PGRBC = 4.84129e-08 ConcMgB23PGRBC = 0.000657947 ConcMgF16P2RBC = 1.65763e-06 ConcMgRBC = 0.000396596 ConcMgatpRBC = 0.00156854 ConcMgg16p2RBC = 1.67617e-05 ConcMgphosRBC = 3.94073e-05 ConcNADPRBC = 1.17876e-07 ConcNADRBC = 5.90924e-05 ConcNadPF = 0.00294008 ConcNadhPF = 5.99179e-05 ConcNadhRBC = 1.04756e-06 ConcNadphRBC = 6.40071e-05 ConcP2GARBC = 1.62417e-05 ConcP2gPF = 4.91857e-05 ConcP3GARBC = 9.71722e-05 ConcP3gPF = 0.000500884 ConcP6GLRBC = 1.07976e-08 ConcP6GRBC = 2.90872e-05 ConcPEPRBC = 2.91125e-05 ConcPepPF = 5.40171e-05 ConcPhosEXT = 0.00564 ConcPhosRBC = 0.00292247 ConcPyrEXT = 0.0 ConcPyrPF = 0.00495586 ConcPyrRBC = 0.000128581 ConcRib5PRBC = 5.28348e-06 ConcRu5PRBC = 4.46661e-06 ConcSed7PRBC = 2.74128e-06 ConcTKGEry4PRBC = 1.55119e-09 ConcTKGRBC = 1.18944e-07 ConcTKGRib5PRBC = 1.07597e-09 ConcTKRBC = 2.00128e-07 ConcTkxu5pRBC = 8.30135e-09 ConcXu5PRBC = 8.1516e-06 ERBCvHK = 2.5e-08 ERBCvPGI = 2.18e-07 K10RBCvBPGSP6 = 1979.0 K10RBCvG6PDH = 1400000000.0 K10RBCvGSSGR = 50000000.0 K10RBCvP6GDH = 225000.0 K10RBCvTK5 = 175.0 K11RBCvBPGSP6 = 0.01 K11RBCvGSSGR = 7000.0 K11RBCvP6GDH = 300.0 K11RBCvTK6 = 40.0 K12RBCvBPGSP7 = 1000.0 K12RBCvGSSGR = 100000000.0 K12RBCvP6GDH = 4950000.0 K12RBCvTK6 = 21300.0 K13RBCvBPGSP7 = 1800000.0 K14RBCvBPGSP8 = 1000000000.0 K15RBCvBPGSP8 = 610000.0 K16RBCvBPGSP9 = 0.19 K1RBCvAK = 4300.0 K1RBCvBPGSP1 = 80000000.0 K1RBCvG6PDH = 110000000.0 K1RBCvGSSGR = 85000000.0 K1RBCvP6GDH = 2400000.0 K1RBCvR5PI = 60900.0 K1RBCvRu5PE = 3910000.0 K1RBCvTA = 580000.0 K1RBCvTK1 = 216000.0 K2RBCvAK = 1400.0 K2RBCvBPGSP1 = 400.0 K2RBCvG6PDH = 870.0 K2RBCvGSSGR = 510.0 K2RBCvP6GDH = 410.0 K2RBCvR5PI = 33.3 K2RBCvRu5PE = 438.0 K2RBCvTA = 45.3 K2RBCvTK1 = 38.0 K3RBCvBPGSP2 = 9.9 K3RBCvG6PDH = 26000000.0 K3RBCvGSSGR = 1000000000.0 K3RBCvP6GDH = 2000000000.0 K3RBCvR5PI = 14.2 K3RBCvRu5PE = 305.0 K3RBCvTA = 16.3 K3RBCvTK2 = 34.0 K4RBCvBPGSP3 = 185000000.0 K4RBCvG6PDH = 300.0 K4RBCvGSSGR = 72000.0 K4RBCvP6GDH = 26000.0 K4RBCvR5PI = 21600.0 K4RBCvRu5PE = 1490000.0 K4RBCvTA = 1010000.0 K4RBCvTK2 = 156000.0 K5RBCvBPGSP3 = 100000000.0 K5RBCvG6PDH = 750.0 K5RBCvGSSGR = 810.0 K5RBCvP6GDH = 48.0 K5RBCvTA = 490000.0 K5RBCvTK3 = 329000.0 K6RBCvBPGSP4 = 1000.0 K6RBCvG6PDH = 2000.0 K6RBCvGSSGR = 1000.0 K6RBCvP6GDH = 30.0 K6RBCvTA = 60.0 K6RBCvTK3 = 175.0 K7RBCvBPGSP4 = 1000.0 K7RBCvG6PDH = 220000.0 K7RBCvGSSGR = 1000000.0 K7RBCvP6GDH = 630.0 K7RBCvTA = 17.0 K7RBCvTK4 = 40.0 K8RBCvBPGSP5 = 10000.0 K8RBCvG6PDH = 1100000000.0 K8RBCvGSSGR = 50000000.0 K8RBCvP6GDH = 36000.0 K8RBCvTA = 79000.0 K8RBCvTK4 = 44800.0 K9RBCvBPGSP5 = 0.55 K9RBCvG6PDH = 10000.0 K9RBCvGSSGR = 1000000.0 K9RBCvP6GDH = 800.0 K9RBCvTK5 = 2240000.0 KRBCvATPASE = 0.000585 KRBCvMGADP = 3290.0 KRBCvMGATP = 43200.0 KRBCvMGB13PG = 7410.0 KRBCvMGB23PG = 7410.0 KRBCvMGF16P2 = 363.0 KRBCvMGG16P2 = 363.0 KRBCvOX = 3.4e-05 KRBCvOXNADH = 0.0163 KaRBCvHBADP = 300000.0 KaRBCvHBATP = 432000.0 KaRBCvHBB13PG = 380000.0 KaRBCvHBBPG = 300000.0 KaRBCvHBMGATP = 46800.0 KaRBCvMGADP = 2760000.0 KaRBCvMGATP = 31200000.0 KaRBCvMGB13PG = 228000.0 KaRBCvMGB23PG = 804000.0 KaRBCvMGF16P2 = 480000.0 KaRBCvMGG16P2 = 480000.0 KaRBCvMGPHOS = 40800.0 KaRBCvPFK = 8.91251e-08 KadpPFvHK = 0.000846735 KadpPFvPFK = 0.00074176 KadpPFvPGK = 0.00015 KadpPFvPK = 0.000317 KahbRBC = 2.51189e-07 KatpPFvHK = 0.00069647 KatpPFvPFK = 0.0007862 KatpPFvPGK = 0.00077 Kb13pgPFvGAPDH = 2.359e-05 Kb13pgPFvPGK = 1.34e-05 KcatfRBCvALD = 68.0 KcatfRBCvENO = 190.0 KcatfRBCvGAPDH = 695.304 KcatfRBCvHK = 299.16 KcatfRBCvLDH = 458.0 KcatfRBCvPFK = 822.0 KcatfRBCvPGI = 1470.0 KcatfRBCvPGK = 2290.0 KcatfRBCvPGM = 795.0 KcatfRBCvPK = 1386.0 KcatfRBCvTIM = 14560.0 KcatrRBCvALD = 234.0 KcatrRBCvENO = 50.0 KcatrRBCvGAPDH = 512.487 KcatrRBCvHK = 1.92792 KcatrRBCvLDH = 115.0 KcatrRBCvPFK = 36.0 KcatrRBCvPGI = 1760.0 KcatrRBCvPGK = 917.0 KcatrRBCvPGM = 714.0 KcatrRBCvPK = 3.26 KcatrRBCvTIM = 1280.0 KdPFvLACtr = 0.005 KdPFvPYRtr = 0.0007 KdRBCvHBADP = 1200.0 KdRBCvHBATP = 1200.0 KdRBCvHBB13PG = 1200.0 KdRBCvHBBPG = 1200.0 KdRBCvHBMGATP = 1200.0 KdRBCvMGADP = 1200.0 KdRBCvMGATP = 1200.0 KdRBCvMGB13PG = 1200.0 KdRBCvMGB23PG = 1200.0 KdRBCvMGF16P2 = 1200.0 KdRBCvMGG16P2 = 1200.0 KdRBCvMGPHOS = 1200.0 KdhapPFvALD = 0.00011 KdhapPFvG3PDH = 0.00034 KdhapPFvTPI = 0.001954 KdibpgRBCvHK = 0.004 Kdig16p2RBCvHK = 3e-05 Kdig6pRBCvHK = 1e-05 KdigshRBCvHK = 0.003 KeqPFvALD = 9e-05 KeqPFvENO = 4.6 KeqPFvG3PDH = 32600.0 KeqPFvHK = 1310.0 KeqPFvPGI = 0.33 KeqPFvPGK = 3200.0 KeqPFvPGM = 0.19 KeqPFvTPI = 0.04545 Kf16bpPFvALD = 6.84e-05 Kf16bpPFvPFK = 0.003626 Kf6pPFvPFK = 0.00109454 Kf6pPFvPGI = 9.6651e-05 KfRBCvLDHP = 0.00346 Kg3pPFvG3PDH = 0.00398 Kg6pPFvHK = 4.3e-05 Kg6pPFvPGI = 0.00100774 KgapPFvALD = 4.6e-05 KgapPFvGAPDH = 0.000917 KgapPFvTPI = 0.000337 KglcPFvHK = 0.000168613 Kh2bpgRBCvMGB13PG = 4270000.0 Kh2bpgRBCvMGB23PG = 4270000.0 Kh2fRBCvMGF16P2 = 1120000.0 Kh2fRBCvMGG16P2 = 1120000.0 KhadpRBCvAK = 5420000.0 KhadpRBCvMGADP = 5420000.0 KhampRBCvAK = 3090000.0 KhatpRBCvMGATP = 9070000.0 KhbpgRBCvMGB13PG = 162000000.0 KhbpgRBCvMGB23PG = 162000000.0 KhfRBCvMGF16P2 = 7560000.0 KhfRBCvMGG16P2 = 7560000.0 KhphosRBCvMGPHOS = 5680000.0 KhydrolRBCvPGLHYDROLYSIS = 0.00071 KiRBCvLACTRANSPORT = 0.0036 KiRBCvPHOSTRANSPORT = 0.00056 KiRBCvPYRTRANSPORT = 0.018 KiadpPFvPK = 0.002 KiatpPFvHK = 0.026 KiatpPFvPK = 0.00182 Kib13pgRBCvGAPDH = 4.55544e-21 Kib13pgRBCvPGK = 1.6e-06 Kib23pgRBCvALD = 0.0015 Kidb13pgRBCvGAPDH = 1e-06 KidgapRBCvGAPDH = 3.1e-05 KidhapRBCvALD = 1.1e-05 KidpyrRBCvLDH = 0.000101 Kif16p2RBCvALD = 1.98e-05 Kig6pRBCvHK = 4.7e-05 KigapRBCvGAPDH = 4.76523e-19 KiglcRBCvHK = 4.7e-05 KilacPFvPYRtr = 0.000358 KilacRBCvLDH = 0.00733 KimgRBCvENO = 4.6e-05 KimgadpRBCvHK = 0.001 KimgadpRBCvPGK = 8e-05 KimgatpRBCvHK = 0.001 KimgatpRBCvPGK = 0.000186 KinadRBCvGAPDH = 4.5e-05 KinadRBCvLDH = 0.000503 KinadhRBCvGAPDH = 1e-05 KinadhRBCvLDH = 2.45e-06 Kip2gRBCvENO = 0.00014 Kip3gRBCvPGK = 0.000205 KipepPFvPK = 0.00292 KipepPFvTPI = 1.59e-05 KipepRBCvENO = 0.0001105 KiphosRBCvGAPDH = 0.00316 KipyrPFvLACtr = 0.00163 KipyrPFvPK = 0.105 KipyrRBCvLDH = 0.000228 KkadpRBCvAK = 4.8 KkadpRBCvMGADP = 4.8 KkampRBCvAK = 1.8 KkatpRBCvMGATP = 14.0 KkbpgRBCvMGB13PG = 85.1 KkbpgRBCvMGB23PG = 85.1 KkfRBCvMGF16P2 = 10.7 KkfRBCvMGG16P2 = 10.7 KkhbpgRBCvMGB13PG = 8.9 KkhbpgRBCvMGB23PG = 8.9 KkhfRBCvMGF16P2 = 3.3 KkhfRBCvMGG16P2 = 3.3 KkphosRBCvMGPHOS = 3.0 KlacPFvLACtr = 0.0038 KlacPFvLDH = 0.003611 Klactonase1RBCvPGLHYDROLYSIS = 13000000.0 Klactonase2RBCvPGLHYDROLYSIS = 1000.0 Klactonase3RBCvPGLHYDROLYSIS = 29.0 KmPFvATPASE = 0.0045 KmPFvGLCtr = 0.000213 Kmb13pgRBCvGAPDH = 6.71e-07 Kmb13pgRBCvPGK = 2e-06 KmdhapRBCvALD = 3.5e-05 KmdhapRBCvTIM = 0.0001624 Kmf16p2RBCvALD = 7.1e-06 Kmf16p2RBCvPFK = 0.0005 Kmf6pRBCvPFK = 7.5e-05 Kmf6pRBCvPGI = 7.1e-05 Kmg6pRBCvPGI = 0.000181 KmgapRBCvALD = 0.000189 KmgapRBCvGAPDH = 9.5e-05 KmgapRBCvTIM = 0.000446 KmghadpRBCvMGADP = 107.0 KmghatpRBCvMGATP = 748.0 KmghbpgRBCvMGB13PG = 513.0 KmghbpgRBCvMGB23PG = 513.0 KmghfRBCvMGF16P2 = 89.0 KmghfRBCvMGG16P2 = 89.0 KmlacRBCvLDH = 0.00107 KmlacRBCvLDHP = 0.000414 KmmgRBCvENO = 4.6e-05 KmmgadpRBCvHK = 0.001 KmmgadpRBCvPFK = 0.00054 KmmgadpRBCvPGK = 0.0001 KmmgatpRBCvHK = 0.001 KmmgatpRBCvPFK = 6.8e-05 KmmgatpRBCvPGK = 0.001 KmnadRBCvGAPDH = 4.5e-05 KmnadRBCvLDH = 0.000107 KmnadhRBCvGAPDH = 3.3e-06 KmnadhRBCvLDH = 8.44e-06 Kmp2gRBCvENO = 0.00014 Kmp2gRBCvPGM = 2.56e-05 Kmp3gRBCvPGK = 0.0011 Kmp3gRBCvPGM = 0.000168 KmpepRBCvENO = 0.0001105 KmphosRBCvGAPDH = 0.00316 KmpyrRBCvLDH = 0.000137 KmpyrRBCvLDHP = 0.000414 KnadPFvG3PDH = 0.00051 KnadPFvGAPDH = 0.0005662 KnadPFvLDH = 0.000234 KnadhPFvG3PDH = 9e-05 KnadhPFvGAPDH = 2.87e-05 KnadhPFvLDH = 4.6e-05 Kp2gPFvENO = 0.000521 Kp2gPFvPGM = 0.000318 Kp3gPFvPGK = 0.000267 Kp3gPFvPGM = 0.00173 KpepPFvENO = 0.00129 KpepPFvPK = 0.000406 KpyrPFvLDH = 0.000133 KpyrPFvPYRtr = 0.0157 KrRBCvLDHP = 5.43e-07 KrampRBCvPFK = 0.0003 Krf16p2RBCvPK = 5e-06 Krg16p2RBCvPFK = 0.01 Krg16p2RBCvPK = 0.0001 KrmgadpRBCvPK = 0.000474 KrmgatpRBCvPK = 0.003 KrpepRBCvPK = 0.000225 KrphosRBCvPFK = 0.03 KrpyrRBCvPK = 0.002 KtatpRBCvPFK = 0.0001 KtatpRBCvPK = 0.00339 Ktb23pgRBCvPFK = 0.005 KtmgRBCvPFK = 0.004 LPFvPK = 0.255 RtvRBC = 0.69 TsRBC = 60.0 VPFvALD = 0.0569593 VPFvATPASE = 0.345 VPFvENO = 0.286296 VPFvGAPDH = 0.656263 VPFvGLCtr = 0.0469 VPFvHK = 0.083 VPFvLACtr = 0.598 VPFvPFK = 0.41 VPFvPGI = 0.800428 VPFvPGM = 0.186938 VPFvPK = 0.762 VPFvPYRtr = 0.216 VPFvTPI = 1.506 VRBCvALD = 3.7e-07 VRBCvENO = 2.2e-07 VRBCvG6PDH = 9.3e-08 VRBCvGAPDH = 7.66e-06 VRBCvGLCTRANSPORT = 0.047 VRBCvGSSGR = 1.25e-07 VRBCvLDH = 3.43e-06 VRBCvP6GDH = 2.1e-06 VRBCvPFK = 1.1e-07 VRBCvPGK = 2.74e-06 VRBCvPGLHYDROLYSIS = 1.4e-05 VRBCvPGM = 4.1e-07 VRBCvPK = 8.7e-08 VRBCvR5PI = 1.42e-05 VRBCvRu5PE = 4.22e-06 VRBCvTA = 6.9e-07 VRBCvTIM = 1.14e-06 VfPFvG3PDH = 0.012 VfPFvLDH = 0.542612 VrPFvGAPDH = 0.243199 VrPFvLDH = 0.290792 VrPFvPGK = 0.353533 alphaPFvGLCtr = 0.91 bpgxRBC = 3.8e-06 cyt = 0.0 glcAlpha = 0.36 gssgxRBC = 0.00160009 h = 4.0 hbxRBC = 0.007 kAlpha = 0.0083 kBeta = 0.007 kPFvGLYtr = 2.0 kRBC = 0.15 ki1 = 8.86746e-08 ki2 = 2.08e-05 nRBCvPFK = 5.0 nadpxRBC = 6.4125e-05 pHConversionFactor = 1.0 phPF = 7.2 phRBC = 7.2 pt = 0.07 tkxRBC = 3.3e-07 xatpRBC = -0.00456 xg16p2RBC = 0.000122 xphosRBC = 0.000438 Vpf = 32.0 Vrbci = 90.0 vBld = 4050.0 #initial values adpPF = 0.01603744 adpRBCi = 0.007391430000000001 ampRBCi = 0.0015265080000000002 atpPF = 0.07996256 atpRBCi = 0.01371852 b13pgPF = 0.000025123552 b13pgRBCi = 0.000057672450000000004 b23pgRBCi = 0.22226849999999998 bpgspRBCi = 0.00002543229 bpgspb13pgRBCi = 3.180708*^-6 bpgspb23pgRBCi = 0.0001130562 bpgsppRBCi = 0.00003459276 bpgsppp2gRBCi = 5.681115*^-10 bpgsppp3gRBCi = 6.2186939999999985*^-9 bpgsppphosRBCi = 0.0001657314 dhapPF = 0.0358896 dhapRBCi = 0.004937094 ery4pRBCi = 0.0000979335 f16bpPF = 0.03313408 f16p2RBCi = 0.0009366660000000001 f6pPF = 0.007770912 f6pRBCi = 0.00092025 g16p2RBCi = 0.00947142 g3pPF = 0.012890016 g6pPF = 0.025184 g6pRBCi = 0.0028482030000000005 gapPF = 0.0015476832 gapRBCi = 0.0011899170000000002 glcEXT = 20.25 glcPF = 0.02291216 glcRBCi = 0.44774820000000004 glyEXT = 0 gshRBCi = 0.2880009 gssgRBCi = 7.782831*^-6 hbRBCi = 0.35913959999999995 hbadpRBCi = 0.007373763000000001 hbatpRBCi = 0.01970748 hbb13pgRBCi = 0.00007287714 hbb23pgRBCi = 0.22173659999999998 hbmgatpRBCi = 0.021969719999999998 lacEXT = 0 lacPF = 0.487344 lacRBCi = 1.253997 mgRBCi = 0.03569364 mgadpRBCi = 0.0067439069999999995 mgatpRBCi = 0.1411686 mgb13pgRBCi = 4.3571609999999995*^-6 mgb23pgRBCi = 0.05921523 mgf16p2RBCi = 0.00014918669999999999 mgg16p2RBCi = 0.0015085530000000002 mgphosRBCi = 0.003546657 nadPF = 0.09408256 nadRBCi = 0.005318316 nadhPF = 0.0019173728000000001 nadhRBCi = 0.0000942804 nadpRBCi = 0.00001060884 nadphRBCi = 0.0057606390000000006 p2gPF = 0.0015739424000000002 p2gRBCi = 0.001461753 p3gPF = 0.016028288 p3gRBCi = 0.008745497999999999 p6gRBCi = 0.0026178480000000003 p6glRBCi = 9.717840000000001*^-7 pepPF = 0.0017285472 pepRBCi = 0.002620125 phosEXT = 22.842 phosRBCi = 0.2630223 pyrEXT = 0 pyrPF = 0.15858752 pyrRBCi = 0.01157229 rib5pRBCi = 0.00047551319999999996 ru5pRBCi = 0.0004019949 sed7pRBCi = 0.0002467152 tkRBCi = 0.000018011519999999997 tkgRBCi = 0.000010704959999999999 tkgery4pRBCi = 1.396071*^-7 tkgrib5pRBCi = 9.683730000000002*^-8 tkxu5pRBCi = 7.471215*^-7 xu5pRBCi = 0.000733644 #assignment rules !F HbpHRBC = (1.0 + 2.51188643150958 * pow(10.0, 14.0) * pow(KahbRBC, 2.0) / pow(pHConversionFactor, 2.0) + 3.16978638492223 * pow(10.0, 7.0) * KahbRBC / pHConversionFactor) / (1.0 + 2.0 * KahbRBC / hRBC + pow(KahbRBC, 2.0) / pow(hRBC, 2.0)) !F K1appRBCvAK = K1RBCvAK * (1.0 + KkadpRBCvAK * kRBC + KhadpRBCvAK * pHConversionFactor / pow(10.0, phRBC)) !F KcatrappRBCvGAPDH = KcatrRBCvGAPDH / (1.0 + pow(10.0, -10.0 + phRBC) + 3.16227766016838 * pow(10.0, 7.0) / pow(10.0, phRBC)) !F KcatfappRBCvHK = KcatfRBCvHK / (1.0 + 1.0471285480509 * pow(10.0, 7.0) / pow(10.0, phRBC) + 2.81838293126445 * pow(10.0, -10.0) * pow(10.0, phRBC)) !F K1appRBCvBPGSP1 = 3.51188643150958 * K1RBCvBPGSP1 / (1.0 + 1.58489319246111 * pow(10.0, -7.0) * pow(10.0, phRBC)) !F KaappRBCvHBATP = HbpHRBC * KaRBCvHBATP !F KcatrappRBCvHK = KcatrRBCvHK / (1.0 + 1.0471285480509 * pow(10.0, 7.0) / pow(10.0, phRBC) + 2.81838293126445 * pow(10.0, -10.0) * pow(10.0, phRBC)) !F KoRBCvPHOSTRANSPORT = KiRBCvPHOSTRANSPORT / KeqRBCvPHOSTRANSPORT !F co2RBCi = ConcCo2RBC * Vrbci !F KoRBCvPYRTRANSPORT = KiRBCvPYRTRANSPORT / RtvRBC !F KoRBCvLACTRANSPORT = KiRBCvLACTRANSPORT / KeqRBCvLACTRANSPORT !F KmapppyrRBCvLDH = 0.284747248950801 * (1.0 + 1.58489319246111 * pow(10.0, -7.0) * pow(10.0, phRBC)) * KmpyrRBCvLDH !F hRBC = pHConversionFactor / pow(10.0, phRBC) !F K4appRBCvBPGSP3 = 1.75857757502918 * K4RBCvBPGSP3 / (1.0 + 4.78630092322638 * pow(10.0, 28.0) / pow(10.0, 4.0 * phRBC)) !F K2appRBCvAK = K2RBCvAK * (1.0 + hRBC * KhampRBCvAK + KkampRBCvAK * kRBC) !F Kiappb13pgRBCvGAPDH = Kib13pgRBCvGAPDH / (1.0 + pow(10.0, -10.0 + phRBC) + 3.16227766016838 * pow(10.0, 7.0) / pow(10.0, phRBC)) !F KaappRBCvHBADP = HbpHRBC * KaRBCvHBADP !F trophToRBC = Vpf / Vrbci !F KeqRBCvLACTRANSPORT = (1.0 + pow(10.0, -3.73 + phRBC)) / (1.0 + pow(10.0, -3.73 + phRBC) / RtvRBC) !F KaappRBCvHBMGATP = HbpHRBC * KaRBCvHBMGATP !F hPF = pHConversionFactor / pow(10.0, phPF) !F KaappRBCvHBB13PG = HbpHRBC * KaRBCvHBB13PG !F KiappgapRBCvGAPDH = KigapRBCvGAPDH / (1.0 + pow(10.0, -10.0 + phRBC) + 3.16227766016838 * pow(10.0, 7.0) / pow(10.0, phRBC)) !F K6appRBCvBPGSP4 = 1.75857757502918 * K6RBCvBPGSP4 / (1.0 + 4.78630092322638 * pow(10.0, 28.0) / pow(10.0, 4.0 * phRBC)) !F KcatfappRBCvGAPDH = KcatfRBCvGAPDH / (1.0 + pow(10.0, -10.0 + phRBC) + 3.16227766016838 * pow(10.0, 7.0) / pow(10.0, phRBC)) !F KiapplacRBCvLDH = 0.715252751049199 * (1.0 + 6.30957344480193 * pow(10.0, 6.0) / pow(10.0, phRBC)) * KilacRBCvLDH !F KiapppyrRBCvLDH = 0.284747248950801 * (1.0 + 1.58489319246111 * pow(10.0, -7.0) * pow(10.0, phRBC)) * KipyrRBCvLDH !F KaappRBCvMGB13PG = CRBCvMGB13PG * KaRBCvMGB13PG * (hRBC * KhbpgRBCvMGB13PG * KmghbpgRBCvMGB13PG + KRBCvMGB13PG) / (1.0 + hRBC * KhbpgRBCvMGB13PG + pow(hRBC, 2.0) * Kh2bpgRBCvMGB13PG * KhbpgRBCvMGB13PG + KkbpgRBCvMGB13PG * kRBC + hRBC * KhbpgRBCvMGB13PG * KkhbpgRBCvMGB13PG * kRBC) !F KaappRBCvMGATP = CRBCvMGATP * KaRBCvMGATP * (hRBC * KhatpRBCvMGATP * KmghatpRBCvMGATP + KRBCvMGATP) / (1.0 + KkatpRBCvMGATP * kRBC + KhatpRBCvMGATP / (pow(10.0, phRBC) * pHConversionFactor)) !F K3appRBCvBPGSP2 = 1.75857757502918 * K3RBCvBPGSP2 / (1.0 + 4.78630092322638 * pow(10.0, 28.0) / pow(10.0, 4.0 * phRBC)) !F KaappRBCvMGPHOS = KaRBCvMGPHOS * (1.0 + KkphosRBCvMGPHOS * kRBC + 6.30957344480193 * pow(10.0, -8.0) * KhphosRBCvMGPHOS * pHConversionFactor) / (1.0 + hRBC * KhphosRBCvMGPHOS + KkphosRBCvMGPHOS * kRBC) !F KeqRBCvPHOSTRANSPORT = (1.0 + pow(10.0, -6.75 + phRBC)) / (pow(10.0, -6.75 + phRBC) / pow(RtvRBC, 2.0) + pow(RtvRBC, -1.0)) !F KiappnadhRBCvGAPDH = 6.30957344480193 * pow(10.0, -8.0) * pow(10.0, phRBC) * KinadhRBCvGAPDH !F KaappRBCvHBBPG = HbpHRBC * KaRBCvHBBPG !F KmappnadhRBCvGAPDH = 6.30957344480193 * pow(10.0, -8.0) * pow(10.0, phRBC) * KmnadhRBCvGAPDH !F KmapplacRBCvLDH = 0.715252751049199 * (1.0 + 6.30957344480193 * pow(10.0, 6.0) / pow(10.0, phRBC)) * KmlacRBCvLDH !F KaappRBCvMGADP = CRBCvMGADP * KaRBCvMGADP * (hRBC * KhadpRBCvMGADP * KmghadpRBCvMGADP + KRBCvMGADP) / (1.0 + hRBC * KhadpRBCvMGADP + KkadpRBCvMGADP * kRBC) !F K13appRBCvBPGSP7 = 1.75857757502918 * K13RBCvBPGSP7 / (1.0 + 4.78630092322638 * pow(10.0, 28.0) / pow(10.0, 4.0 * phRBC)) !F KaappRBCvMGB23PG = CRBCvMGB23PG * KaRBCvMGB23PG * (hRBC * KhbpgRBCvMGB23PG * KmghbpgRBCvMGB23PG + KRBCvMGB23PG) / (1.0 + hRBC * KhbpgRBCvMGB23PG + pow(hRBC, 2.0) * Kh2bpgRBCvMGB23PG * KhbpgRBCvMGB23PG + KkbpgRBCvMGB23PG * kRBC + hRBC * KhbpgRBCvMGB23PG * KkhbpgRBCvMGB23PG * kRBC) !F KaappRBCvMGG16P2 = CRBCvMGG16P2 * KaRBCvMGG16P2 * (hRBC * KhfRBCvMGG16P2 * KmghfRBCvMGG16P2 + KRBCvMGG16P2) / (1.0 + hRBC * KhfRBCvMGG16P2 + pow(hRBC, 2.0) * Kh2fRBCvMGG16P2 * KhfRBCvMGG16P2 + KkfRBCvMGG16P2 * kRBC + hRBC * KhfRBCvMGG16P2 * KkhfRBCvMGG16P2 * kRBC) !F KaappRBCvMGF16P2 = CRBCvMGF16P2 * KaRBCvMGF16P2 * (hRBC * KhfRBCvMGF16P2 * KmghfRBCvMGF16P2 + KRBCvMGF16P2) / (1.0 + hRBC * KhfRBCvMGF16P2 + pow(hRBC, 2.0) * Kh2fRBCvMGF16P2 * KhfRBCvMGF16P2 + KkfRBCvMGF16P2 * kRBC + hRBC * KhfRBCvMGF16P2 * KkhfRBCvMGF16P2 * kRBC) !F LRBCvPK = 1.58489319246111 * pow(10.0, -7.0) * pHConversionFactor * pow(1.0 + atpRBCi / (KtatpRBCvPK * Vrbci), 4.0) / (hRBC * pow(1.0 + f16p2RBCi / (Krf16p2RBCvPK * Vrbci) + g16p2RBCi / (Krg16p2RBCvPK * Vrbci), 4.0) * pow(1.0 + pepRBCi / (KrpepRBCvPK * Vrbci) + pyrRBCi / (KrpyrRBCvPK * Vrbci), 4.0)) !F glcExtConc = 1000.0*glcEXT/vBld !F lacExtConc = 1000.0*lacEXT/vBld !F glyExtConc = 1000.0*glyEXT/vBld