#delcontezerail1



#reactions
reaction_0:
 $pool = {1.0}r5
  endosome * K1
reaction_1:
 {1.0}r5 = {1.0}R5
  endosome * sig_act_t(r5, ke, time, kg, R5, kf)
reaction_2:
 {1.0}r5 = $pool
  endosome * extraction(kminus1, r5)
reaction_3:
 $pool = {1.0}r7
  endosome * K1
reaction_4:
 {1.0}r7 = {1.0}R7
  endosome * hill_act(r7, ke, R7, h, kg)
reaction_5:
 {1.0}r7 = {1.0}R7
  endosome * sig_act(ke, r7, kg, R5, kf)
reaction_6:
 {1.0}R5 = {1.0}r5
  endosome * sig_act(ke, R5, kg, R7, kf)
reaction_7:
 {1.0}r7 = $pool
  endosome * extraction(kminus1, r7)
reaction_8:
 {1.0}R5 = {1.0}r5
  endosome * hydrolysis(kh, R5)
reaction_9:
 {1.0}R7 = {1.0}r7
  endosome * hydrolysis(kh, R7)


#parameters
reaction_0_K1 = 1.0
reaction_1_ke = 0.3
reaction_1_kg = 0.1
reaction_1_kf = 2.5
reaction_2_kminus1 = 1.0
reaction_3_K1 = 0.483
reaction_4_ke = 0.21
reaction_4_h = 3.0
reaction_4_kg = 0.1
reaction_5_ke = 0.021
reaction_5_kg = 1.0
reaction_5_kf = 3.0
reaction_6_ke = 0.31
reaction_6_kg = 0.3
reaction_6_kf = 3.0
reaction_7_kminus1 = 0.483
reaction_8_kh = 0.06
reaction_9_kh = 0.15
endosome = 1.0


#initial values
R5 = 0.001
R7 = 0.001
r5 = 1.0
r7 = 1.0


#assignment rules