(* Generated by JWS Online *) (* This is an experimental feature of JWS Online. Please report any mistakes.*) (* Note that the following notable SBML entities or features are not supported in notebook outputyet: *) (* Events *) (* Constraints *) (* Units and UnitDefinitions *) (* AlgebraicRules *) (* conversionFactors *) variables = { species\[LetterSpace]1[t], species\[LetterSpace]2[t], species\[LetterSpace]3[t], species\[LetterSpace]4[t] }; initialValues = { species\[LetterSpace]1[0] == 0.0, species\[LetterSpace]2[0] == 0.0, species\[LetterSpace]3[0] == 0.0, species\[LetterSpace]4[0] == 0.0 }; rates = { reaction\[LetterSpace]1, reaction\[LetterSpace]2, reaction\[LetterSpace]3, reaction\[LetterSpace]4, reaction\[LetterSpace]5, reaction\[LetterSpace]6, reaction\[LetterSpace]7, reaction\[LetterSpace]8 }; rateEquations = { reaction\[LetterSpace]1 -> compartment\[LetterSpace]1*function\[LetterSpace]1[reaction\[LetterSpace]1\[LetterSpace]theta, reaction\[LetterSpace]1\[LetterSpace]a, species\[LetterSpace]3[t], reaction\[LetterSpace]1\[LetterSpace]n], reaction\[LetterSpace]2 -> compartment\[LetterSpace]1*reaction\[LetterSpace]2\[LetterSpace]k1*species\[LetterSpace]1[t], reaction\[LetterSpace]3 -> compartment\[LetterSpace]1*function\[LetterSpace]2[reaction\[LetterSpace]3\[LetterSpace]theta, reaction\[LetterSpace]3\[LetterSpace]b, species\[LetterSpace]2[t], species\[LetterSpace]4[t], reaction\[LetterSpace]3\[LetterSpace]n, reaction\[LetterSpace]3\[LetterSpace]c, species\[LetterSpace]1[t]], reaction\[LetterSpace]4 -> compartment\[LetterSpace]1*reaction\[LetterSpace]4\[LetterSpace]k1*species\[LetterSpace]2[t], reaction\[LetterSpace]5 -> compartment\[LetterSpace]1*function\[LetterSpace]1[reaction\[LetterSpace]5\[LetterSpace]theta, reaction\[LetterSpace]5\[LetterSpace]a, species\[LetterSpace]1[t], reaction\[LetterSpace]5\[LetterSpace]n], reaction\[LetterSpace]6 -> compartment\[LetterSpace]1*reaction\[LetterSpace]6\[LetterSpace]k1*species\[LetterSpace]3[t], reaction\[LetterSpace]7 -> compartment\[LetterSpace]1*function\[LetterSpace]2[reaction\[LetterSpace]7\[LetterSpace]theta, reaction\[LetterSpace]7\[LetterSpace]b, species\[LetterSpace]2[t], species\[LetterSpace]4[t], reaction\[LetterSpace]7\[LetterSpace]n, reaction\[LetterSpace]7\[LetterSpace]c, species\[LetterSpace]3[t]], reaction\[LetterSpace]8 -> compartment\[LetterSpace]1*reaction\[LetterSpace]8\[LetterSpace]k1*species\[LetterSpace]4[t] }; parameters = { reaction\[LetterSpace]1\[LetterSpace]theta -> 0.0001, reaction\[LetterSpace]1\[LetterSpace]a -> 1.0, reaction\[LetterSpace]1\[LetterSpace]n -> 4.0, reaction\[LetterSpace]2\[LetterSpace]k1 -> 1.0, reaction\[LetterSpace]3\[LetterSpace]theta -> 0.0001, reaction\[LetterSpace]3\[LetterSpace]b -> 21.0, reaction\[LetterSpace]3\[LetterSpace]n -> 4.0, reaction\[LetterSpace]3\[LetterSpace]c -> 1.0, reaction\[LetterSpace]4\[LetterSpace]k1 -> 1.0, reaction\[LetterSpace]5\[LetterSpace]theta -> 0.0001, reaction\[LetterSpace]5\[LetterSpace]a -> 1.0, reaction\[LetterSpace]5\[LetterSpace]n -> 4.0, reaction\[LetterSpace]6\[LetterSpace]k1 -> 1.0, reaction\[LetterSpace]7\[LetterSpace]theta -> 0.0001, reaction\[LetterSpace]7\[LetterSpace]b -> 21.0, reaction\[LetterSpace]7\[LetterSpace]n -> 4.0, reaction\[LetterSpace]7\[LetterSpace]c -> 1.0, reaction\[LetterSpace]8\[LetterSpace]k1 -> 1.0, compartment\[LetterSpace]1 -> 1.0 }; assignments = { function\[LetterSpace]1[theta_,a_,Xj_,n_] -> theta/(theta + a*Xj^n), function\[LetterSpace]2[theta_,b_,Yi_,Yj_,n_,c_,Xi_] -> (theta + b*(Yi*Yj)^n)/(theta + c*Xi^n + b*(Yi*Yj)^n) }; events = { }; speciesAnnotations = { }; reactionAnnotations = { }; units = { {"time" -> "", "metabolite" -> "", "extent" -> ""} }; (* Time evolution *) odes = { species\[LetterSpace]1'[t] == 1.0*reaction\[LetterSpace]1 -1.0*reaction\[LetterSpace]2, species\[LetterSpace]2'[t] == 1.0*reaction\[LetterSpace]3 -1.0*reaction\[LetterSpace]4, species\[LetterSpace]3'[t] == 1.0*reaction\[LetterSpace]5 -1.0*reaction\[LetterSpace]6, species\[LetterSpace]4'[t] == 1.0*reaction\[LetterSpace]7 -1.0*reaction\[LetterSpace]8 }; timeCourse = NDSolve[Join[odes, initialValues]//.rateEquations//.assignments//.parameters, variables, {t, 0, 100}]; (* Steady-state solution initialized with result of time evolution *) findRootEquations = odes /.D[_[t],t]->0; findRootVariables = Partition[Flatten[{#, #/.timeCourse/.t->100} &/@variables],2]; steadyStateVariables = FindRoot[findRootEquations//.rateEquations//.assignments//.parameters, findRootVariables, MaxIterations->100] fluxes = #//.assignments//.parameters/.steadyStateVariables&/@rateEquations (* Plot the time evolution of the variables *) plotTable=Table[Plot[variables[[i]]/.parameters/.timeCourse,{t,0,100},PlotLegends->variables[[i]],PlotRange->Full],{i,Length[variables]}]