#bungay3



#reactions
LB1:
 {1.0}II_f + {100.0}LIPID = {1.0}II_l
  compartment * (konII * II_f * LIPID / nva - koffII * II_l)
LB10:
 {1.0}IXa_f + {100.0}LIPID = {1.0}IXa_l
  compartment * (konIXa * IXa_f * LIPID / nva - koffIXa * IXa_l)
LB11:
 {1.0}X_f + {100.0}LIPID = {1.0}X_l
  compartment * (konX * X_f * LIPID / nva - koffX * X_l)
LB12:
 {1.0}Xa_f + {100.0}LIPID = {1.0}Xa_l
  konXa * Xa_f * LIPID / nva - koffXa * Xa_l
LB13:
 {1.0}APC_f + {100.0}LIPID = {1.0}APC_l
  compartment * (konAPC * APC_f * LIPID / nva - koffAPC * APC_l)
LB14:
 {1.0}PS_f + {100.0}LIPID = {1.0}PS_l
  compartment * (konPS * PS_f * LIPID / nva - koffPS * PS_l)
LB15:
 {1.0}VIIIai_f + {100.0}LIPID = {1.0}VIIIai_l
  compartment * (konVIIIai * VIIIai_f * LIPID / nva - koffVIIIai * VIIIai_l)
LB16:
 {1.0}Vai_f + {100.0}LIPID = {1.0}Vai_l
  compartment * (konVai * Vai_f * LIPID / nva - koffVai * Vai_l)
LB17:
 {1.0}PC_f + {100.0}LIPID = {1.0}PC_l
  compartment * (konPC * PC_f * LIPID / nva - koffPC * PC_l)
LB2:
 {1.0}mIIa_f + {100.0}LIPID = {1.0}mIIa_l
  compartment * (konmIIa * mIIa_f * LIPID / nva - koffmIIa * mIIa_l)
LB3:
 {1.0}V_f + {100.0}LIPID = {1.0}V_l
  compartment * (konV * V_f * LIPID / nva - koffV * V_l)
LB4:
 {1.0}Va_f + {100.0}LIPID = {1.0}Va_l
  compartment * (konVa * Va_f * LIPID / nva - koffVa * Va_l)
LB5:
 {1.0}VII_f + {100.0}LIPID = {1.0}VII_l
  compartment * (konVII * VII_f * LIPID / nva - koffVII * VII_l)
LB6:
 {1.0}VIIa_f + {100.0}LIPID = {1.0}VIIa_l
  compartment * (konVIIa * VIIa_f * LIPID / nva - koffVIIa * VIIa_l)
LB7:
 {1.0}VIII_f + {100.0}LIPID = {1.0}VIII_l
  compartment * (konVIII * VIII_f * LIPID / nva - koffVIII * VIII_l)
LB8:
 {1.0}VIIIa_f + {100.0}LIPID = {1.0}VIIIa_l
  compartment * (konVIIIa * VIIIa_f * LIPID / nva - koffVIIIa * VIIIa_l)
LB9:
 {1.0}IX_f + {100.0}LIPID = {1.0}IX_l
  compartment * (konIX * IX_f * LIPID / nva - koffIX * IX_l)
R1:
 {1.0}VIIa_l + {1.0}TF_l = {1.0}TF_VIIa_l
  compartment * (k1 * TF_l * VIIa_l - k2 * TF_VIIa_l)
R10:
 {1.0}Xa_l + {1.0}VIII_l = {1.0}VIII_Xa_l
  k24 * VIII_l * Xa_l - k25 * VIII_Xa_l
R10b:
 {1.0}VIII_Xa_l = {1.0}Xa_l + {1.0}VIIIa_l
  compartment * k26 * VIII_Xa_l
R11:
 {1.0}IIa_f + {1.0}V_l = {1.0}V_IIa_l
  compartment * (k27 * V_l * IIa_f - k28 * V_IIa_l)
R11b:
 {1.0}V_IIa_l = {1.0}IIa_f + {1.0}Va_l
  compartment * k29 * V_IIa_l
R12:
 {1.0}IIa_f + {1.0}VIII_l = {1.0}VIII_IIa_l
  compartment * (k30 * VIII_l * IIa_f - k31 * VIII_IIa_l)
R12b:
 {1.0}VIII_IIa_l = {1.0}IIa_f + {1.0}VIIIa_l
  compartment * k32 * VIII_IIa_l
R13:
 {1.0}II_l + {1.0}Xa_Va_l = {1.0}Xa_Va_II_l
  compartment * (k33 * Xa_Va_l * II_l - k34 * Xa_Va_II_l)
R14:
 {1.0}mIIa_l + {1.0}Xa_Va_l = {1.0}Xa_Va_mIIa_l
  compartment * (k35 * Xa_Va_l * mIIa_l - k36 * Xa_Va_mIIa_l)
R15:
 {1.0}Xa_Va_II_l = {1.0}Xa_Va_mIIa_l
  compartment * k37 * Xa_Va_II_l
R15b:
 {1.0}Xa_Va_mIIa_l = {1.0}IIa_f + {1.0}Xa_Va_l
  compartment * k38 * Xa_Va_mIIa_l
R16:
 {1.0}Xa_l + {1.0}VII_l = {1.0}VII_Xa_l
  compartment * (k39 * VII_l * Xa_l - k40 * VII_Xa_l)
R16b:
 {1.0}VII_Xa_l = {1.0}Xa_l + {1.0}VIIa_l
  compartment * k41 * VII_Xa_l
R17:
 {1.0}IIa_f + {1.0}XI_f = {1.0}XI_IIa_l
  compartment * (k42 * XI_f * IIa_f - k43 * XI_IIa_l)
R17b:
 {1.0}XI_IIa_l = {1.0}IIa_f + {1.0}XIa_l
  compartment * k44 * XI_IIa_l
R18:
 {1.0}VIIIa_l + {1.0}APC_PS_l = {1.0}APC_PS_VIIIa_l
  compartment * (k45 * APC_PS_l * VIIIa_l - k46 * APC_PS_VIIIa_l)
R18b:
 {1.0}APC_PS_VIIIa_l = {1.0}VIIIai_l + {1.0}APC_PS_l
  compartment * k47 * APC_PS_VIIIa_l
R19:
 {1.0}Va_l + {1.0}APC_PS_l = {1.0}APC_PS_Va_l
  compartment * (k48 * APC_PS_l * Va_l - k49 * APC_PS_Va_l)
R19b:
 {1.0}APC_PS_Va_l = {1.0}Vai_l + {1.0}APC_PS_l
  compartment * k50 * APC_PS_Va_l
R2:
 {1.0}VII_l + {1.0}TF_l = {1.0}TF_VII_l
  compartment * (k3 * TF_l * VII_l - k4 * TF_VII_l)
R20:
 {1.0}Xa_f + {1.0}TFPI_f = {1.0}TFPI_Xa_l
  compartment * (k51 * TFPI_f * Xa_f - k52 * TFPI_Xa_l)
R21:
 {1.0}TF_VIIa_l + {1.0}TFPI_Xa_l = {1.0}TFPI_Xa_TF_VIIa_l
  compartment * (k53 * TFPI_Xa_l * TF_VIIa_l - k54 * TFPI_Xa_TF_VIIa_l)
R22:
 {1.0}AT_f + {1.0}IXa_f = {1.0}IXa_AT_f
  compartment * k55 * IXa_f * AT_f
R23:
 {1.0}AT_f + {1.0}Xa_f = {1.0}Xa_AT_f
  compartment * k56 * Xa_f * AT_f
R24:
 {1.0}AT_f + {1.0}IIa_f = {1.0}IIa_AT_f
  compartment * k57 * IIa_f * AT_f
R25:
 {1.0}mIIa_l + {1.0}V_l = {1.0}V_mIIa_l
  compartment * (k58 * V_l * mIIa_l - k59 * V_mIIa_l)
R25b:
 {1.0}V_mIIa_l = {1.0}mIIa_l + {1.0}Va_l
  compartment * k60 * V_mIIa_l
R26:
 {1.0}mIIa_l + {1.0}VIII_l = {1.0}VIII_mIIa_l
  compartment * (k61 * VIII_l * mIIa_l - k62 * VIII_mIIa_l)
R26b:
 {1.0}VIII_mIIa_l = {1.0}mIIa_l + {1.0}VIIIa_l
  compartment * k63 * VIII_mIIa_l
R27:
 {1.0}TM_l + {1.0}IIa_f = {1.0}IIa_TM_l
  compartment * (k64 * IIa_f * TM_l - k65 * IIa_TM_l)
R28:
 {1.0}PC_l + {1.0}IIa_TM_l = {1.0}IIa_TM_PC_l
  compartment * (k66 * IIa_TM_l * PC_l - k67 * IIa_TM_PC_l)
R28b:
 {1.0}IIa_TM_PC_l = {1.0}APC_l + {1.0}IIa_TM_l
  compartment * k68 * IIa_TM_PC_l
R29:
 {1.0}AT_f + {1.0}mIIa_f = {1.0}mIIa_AT_l
  compartment * k69 * mIIa_f * AT_f
R3:
 {1.0}IX_l + {1.0}TF_VIIa_l = {1.0}TF_VIIa_IX_l
  compartment * (k5 * TF_VIIa_l * IX_l - k6 * TF_VIIa_IX_l)
R30:
 {1.0}PS_l + {1.0}APC_l = {1.0}APC_PS_l
  compartment * (k70 * APC_l * PS_l - k71 * APC_PS_l)
R31:
 {1.0}IX_l + {1.0}XIa_l = {1.0}XIa_IX_l
  compartment * (k72 * XIa_l * IX_l - k73 * XIa_IX_l)
R31b:
 {1.0}XIa_IX_l = {1.0}IXa_l + {1.0}XIa_l
  compartment * k74 * XIa_IX_l
R3b:
 {1.0}TF_VIIa_IX_l = {1.0}TF_VIIa_l + {1.0}IXa_l
  compartment * k7 * TF_VIIa_IX_l
R4:
 {1.0}X_l + {1.0}TF_VIIa_l = {1.0}TF_VIIa_X_l
  compartment * (k8 * TF_VIIa_l * X_l - k9 * TF_VIIa_X_l)
R4b:
 {1.0}TF_VIIa_X_l = {1.0}TF_VIIa_Xa_l
  compartment * k10 * TF_VIIa_X_l
R4c:
 {1.0}TF_VIIa_Xa_l = {1.0}Xa_l + {1.0}TF_VIIa_l
  compartment * k75 * TF_VIIa_Xa_l
R5:
 {1.0}Xa_l + {1.0}TF_VII_l = {1.0}TF_VII_Xa_l
  compartment * (k11 * TF_VII_l * Xa_l - k12 * TF_VII_Xa_l)
R5b:
 {1.0}TF_VII_Xa_l = {1.0}Xa_l + {1.0}TF_VIIa_l
  compartment * k13 * TF_VII_Xa_l
R6:
 {1.0}VIIIa_l + {1.0}IXa_l = {1.0}IXa_VIIIa_l
  compartment * (k14 * IXa_l * VIIIa_l - k15 * IXa_VIIIa_l)
R7:
 {1.0}Va_l + {1.0}Xa_l = {1.0}Xa_Va_l
  compartment * (k16 * Xa_l * Va_l - k17 * Xa_Va_l)
R8:
 {1.0}X_l + {1.0}IXa_VIIIa_l = {1.0}IXa_VIIIa_X_l
  compartment * (k18 * IXa_VIIIa_l * X_l - k19 * IXa_VIIIa_X_l)
R8b:
 {1.0}IXa_VIIIa_X_l = {1.0}Xa_l + {1.0}IXa_VIIIa_l
  compartment * k20 * IXa_VIIIa_X_l
R9:
 {1.0}Xa_l + {1.0}V_l = {1.0}V_Xa_l
  compartment * (k21 * V_l * Xa_l - k22 * V_Xa_l)
R9b:
 {1.0}V_Xa_l = {1.0}Xa_l + {1.0}Va_l
  compartment * k23 * V_Xa_l


#parameters
k1 = 0.5
k10 = 1.5
k11 = 0.05
k12 = 44.8
k13 = 15.2
k14 = 0.1
k15 = 0.2
k16 = 1.0
k17 = 1.0
k18 = 0.1
k19 = 10.7
k2 = 0.005
k20 = 8.3
k21 = 0.1
k22 = 1.0
k23 = 0.043
k24 = 0.1
k25 = 2.1
k26 = 0.023
k27 = 0.1
k28 = 6.94
k29 = 0.23
k3 = 0.005
k30 = 0.1
k31 = 13.8
k32 = 0.9
k33 = 0.1
k34 = 100.0
k35 = 0.1
k36 = 66.0
k37 = 13.0
k38 = 15.0
k39 = 0.05
k4 = 0.005
k40 = 44.8
k41 = 15.2
k42 = 0.1
k43 = 10.0
k44 = 1.43
k45 = 0.1
k46 = 1.6
k47 = 0.4
k48 = 0.1
k49 = 1.6
k5 = 0.01
k50 = 0.4
k51 = 0.016
k52 = 0.00033
k53 = 0.01
k54 = 0.0011
k55 = 4.9e-07
k56 = 2.3e-06
k57 = 6.83e-05
k58 = 0.1
k59 = 6.94
k6 = 2.09
k60 = 1.035
k61 = 0.1
k62 = 13.8
k63 = 0.9
k64 = 1.0
k65 = 0.5
k66 = 0.1
k67 = 6.4
k68 = 3.6
k69 = 6.83e-06
k7 = 0.34
k70 = 0.1
k71 = 0.5
k72 = 0.01
k73 = 1.417
k74 = 0.183
k75 = 1.0
k8 = 0.1
k9 = 32.5
koffAPC = 3.5
koffII = 1.0
koffIX = 0.115
koffIXa = 0.115
koffPC = 11.5
koffPS = 0.2
koffV = 0.145
koffVII = 0.66
koffVIII = 0.1
koffVIIIa = 0.335
koffVIIIai = 0.335
koffVIIa = 0.227
koffVa = 0.17
koffVai = 0.17
koffX = 1.9
koffXa = 3.3
koffmIIa = 0.475
konAPC = 0.05
konII = 0.0043
konIX = 0.05
konIXa = 0.05
konPC = 0.05
konPS = 0.05
konV = 0.05
konVII = 0.05
konVIII = 0.05
konVIIIa = 0.05
konVIIIai = 0.05
konVIIa = 0.05
konVa = 0.057
konVai = 0.057
konX = 0.01
konXa = 0.029
konmIIa = 0.05
nva = 100.0
compartment = 1.0


#initial values
APC_PS_VIIIa_l = 0.0
APC_PS_Va_l = 0.0
APC_PS_l = 0.0
APC_f = 0.0
APC_l = 0.0
AT_f = 3400.0
II_f = 1400.0
II_l = 0.0
IIa_AT_f = 0.0
IIa_TM_PC_l = 0.0
IIa_TM_l = 0.0
IIa_f = 0.0
IX_f = 90.0
IX_l = 0.0
IXa_AT_f = 0.0
IXa_VIIIa_X_l = 0.0
IXa_VIIIa_l = 0.0
IXa_f = 0.0
IXa_l = 0.0
LIPID = 849079.0
PC_f = 60.0
PC_l = 0.0
PS_f = 300.0
PS_l = 0.0
TFPI_Xa_TF_VIIa_l = 0.0
TFPI_Xa_l = 0.0
TFPI_f = 2.5
TF_VII_Xa_l = 0.0
TF_VII_l = 0.0
TF_VIIa_IX_l = 0.0
TF_VIIa_IXa_l = 0.0
TF_VIIa_X_l = 0.0
TF_VIIa_Xa_l = 0.0
TF_VIIa_l = 0.0
TF_l = 0.005
TM_l = 1.0
VIII_IIa_l = 0.0
VIII_Xa_l = 0.0
VIII_f = 0.7
VIII_l = 0.0
VIII_mIIa_l = 0.0
VIIIa_f = 0.0
VIIIa_l = 0.0
VIIIai_f = 0.0
VIIIai_l = 0.0
VII_Xa_l = 0.0
VII_f = 10.0
VII_l = 0.0
VIIa_f = 0.1
VIIa_l = 0.0
V_IIa_l = 0.0
V_Xa_l = 0.0
V_f = 20.0
V_l = 0.0
V_mIIa_l = 0.0
Va_f = 0.0
Va_l = 0.0
Vai_f = 0.0
Vai_l = 0.0
XI_IIa_l = 0.0
XI_f = 30.0
XIa_IX_l = 0.0
XIa_l = 0.0
X_f = 170.0
X_l = 0.0
Xa_AT_f = 0.0
Xa_Va_II_l = 0.0
Xa_Va_l = 0.0
Xa_Va_mIIa_l = 0.0
Xa_f = 0.0
Xa_l = 0.0
mIIa_AT_l = 0.0
mIIa_f = 0.0
mIIa_l = 0.0


#assignment rules