begin name
bertram1
end name

begin reactions
reaction0000001 {1.0}$EXTERNAL = {1.0}c
reaction0000002 {1.0}$EXTERNAL = {1.0}cer
reaction000003 {1.0}$EXTERNAL = {1.0}cAMP
end reactions

begin rate equations
reaction0000001 = cell*f*(jertot + jmemtot)
reaction0000002 = -(cell*fer*jertot*sigmav)
reaction000003 = (cell*ETswitch*(cAMPlow - cAMP[t]))/taudir
end rate equations

begin parameters
ETswitch = 0.0
IP3 = 0.0
alpha = "4.5e-06"
cAMPlow = 0.2
cm = 5300.0
dact = 0.35
dinh = 0.4
dip3 = 0.5
f = 0.01
fer = 0.01
gca = 2000.0
girk = 1000.0
gk = 3500.0
kc = 0.15
ki = 0.5
kserca = 0.4
lambda = 1.25
perl = 0.0005
sh = 70.0
sigmav = 10.0
sm = 12.0
sn = 5.0
taudir = 20000.0
tauh = 20.0
taun = 20.0
vca = 25.0
vh = -20.0
vk = -75.0
vm = -20.0
vn = -16.0
cell = 1.0
end parameters

begin initial conditions
c[0] = ci
cAMP[0] = cAMPi
cer[0] = ceri
h[0] = hi
inh[0] = inhi
V[0] = Vi
n[0] = ni
end initial conditions

begin initial values
ci = 0.3
cAMPi = 1.0
ceri = 260.0
hi = 0.0
inhi = 1.0
Vi = -60.0
ni = 0.0
end initial values

begin assignment rules
igirk := girk*h[t]*(-vk + V[t])
ica := gca*minf*(-vca + V[t])
jerp := kserca*c[t]
jerip3 := o*(-c[t] + cer[t])
hinfer := (1 + c[t]/dinh)^(-1)
ainf := (1 + dact/c[t])^(-1)
ik := gk*n[t]*(-vk + V[t])
perlinf := (c[t]^4*cAMP[t]*inh[t])/(ki^4 + c[t]^4)
jertot := jerip3 + jerleak - kserca*c[t]
jerleak := perl*(-c[t] + cer[t])
jmemtot := -(kc*c[t]) - (alpha*gca*(-vca + V[t]))/(1 + E^((vm - V[t])/sm))
o := ainf^3*binf^3*hinfer^3
binf := IP3/(dip3 + IP3)
hinf := (1 + E^((vh - V[t])/sh))^(-1)
ninf := (1 + E^((vn - V[t])/sn))^(-1)
minf := (1 + E^((vm - V[t])/sm))^(-1)
end assignment rules

begin function definitions
end function definitions

begin events
event_0000001 = (t > 60000, {ETswitch -> 1, girk -> 3000, IP3 -> 0.3}, 0)
end events

begin process annotations
end process annotations

begin species annotations
c http://identifiers.org/obo.chebi/CHEBI:29108
c http://identifiers.org/kegg.compound/C00076
cAMP http://identifiers.org/obo.chebi/CHEBI:17489
cAMP http://identifiers.org/kegg.compound/C00575
cer http://identifiers.org/obo.chebi/CHEBI:29108
cer http://identifiers.org/kegg.compound/C00076
end species annotations

begin units
end units