#becker1



#reactions
reaction_1:
 $pool = {1.0}EpoR
  kt * Bmax * cell
reaction_2:
 {1.0}EpoR = $pool
  kt * EpoR * cell
reaction_3:
 {1.0}Epo + {1.0}EpoR = {1.0}Epo_EpoR
  kon * Epo * EpoR * cell
reaction_4:
 {1.0}Epo_EpoR = {1.0}Epo + {1.0}EpoR
  koff * Epo_EpoR * cell
reaction_5:
 {1.0}Epo_EpoR = {1.0}Epo_EpoRi
  ke * Epo_EpoR * cell
reaction_6:
 {1.0}Epo_EpoRi = {1.0}Epo + {1.0}EpoR
  kex * Epo_EpoRi * cell
reaction_7:
 {1.0}Epo_EpoRi = {1.0}dEpoi
  kdi * Epo_EpoRi * cell
reaction_8:
 {1.0}Epo_EpoRi = {1.0}dEpoe
  kde * Epo_EpoRi * cell


#parameters
Bmax = 516.0
kde = 0.0164042
kdi = 0.00317871
ke = 0.0748267
kex = 0.00993805
koff = 0.0172135
kon = 0.00010496
kt = 0.0329366
cell = 1.0
cellsurface = 1.0
medium = 1.0


#initial values
Epo = 2030.19
EpoR = 516.0
Epo_EpoR = 0.0
Epo_EpoRi = 0.0
dEpoe = 0.0
dEpoi = 0.0


#assignment rules
!F Epo_cells = Epo_EpoRi + dEpoi
!F Epo_medium = Epo + dEpoe