begin name
albert1
end name

begin reactions
vAKc {1.0}species3 + {1.0}species6 = {2.0}species2
vAKg {1.0}species11 + {1.0}species13 = {2.0}species12
vALD {1.0}species16 = {1.0}species17 + {1.0}species18
vANTI {1.0}species22 + {1.0}species8 = {1.0}species9 + {1.0}species17
vAU {1.0}species3 = {1.0}species2
vENO {1.0}species5 = {1.0}species4
vGAPDH {1.0}species18 + {1.0}species19 = {1.0}species21 + {1.0}species20
vGK {1.0}species22 + {1.0}species12 = {1.0}species24 + {1.0}species11
vGPDH {1.0}species17 + {1.0}species20 = {1.0}species19 + {1.0}species22
vGPO {1.0}species9 = {1.0}species8
vGT {1.0}$species25 = {1.0}species10
vGlyT {1.0}species24 = {1.0}$species27
vHK {1.0}species10 + {1.0}species11 = {1.0}species14 + {1.0}species12
vPFK {1.0}species15 + {1.0}species11 = {1.0}species16 + {1.0}species12
vPGI {1.0}species14 = {1.0}species15
vPGK {1.0}species21 + {1.0}species12 = {1.0}species23 + {1.0}species11
vPGM {1.0}species7 = {1.0}species5
vPGT {1.0}species23 = {1.0}species7
vPK {1.0}species4 + {1.0}species2 = {1.0}species1 + {1.0}species3
vPT {1.0}species1 = {1.0}$species26
vTPI {1.0}species17 = {1.0}species18
end reactions

begin rate equations
vAKc = compartment1*function22[vAKck, species3[t], species6[t], vAKckeqak, species2[t]]
vAKg = compartment2*function22[vAKgk, species11[t], species13[t], vAKgkeqak, species12[t]]
vALD = compartment2*function14[vALDVmaxv5, species16[t], species18[t], species17[t], vALDKeqv5, species11[t], species12[t], species13[t], vALDrv5, vALDKGAPv5, vALDKGAPiv5]
vANTI = vANTIk1*species22[t]*species8[t] - vANTIk2*species17[t]*species9[t]
vAU = compartment1*function20[vAUk, species3[t], species2[t]]
vENO = compartment1*RaENO*function12[species5[t], species4[t], vENOKms, vENOKmp, vENOVf, vENOVr]
vGAPDH = compartment2*function15[vGAPDHVmaxv7, species18[t], vGAPDHKGAPv7, species19[t], vGAPDHKNADv7, vGAPDHrv7, species21[t], vGAPDHKBPGA13v7, species20[t], vGAPDHKNADHv7]
vGK = compartment2*function21[vGKVmaxv14, species22[t], vGKKGly3Pgv14, species12[t], vGKKADPgv14, vGKrv14, species24[t], vGKKGlycerolv14, species11[t], vGKKATPgv14]
vGPDH = compartment2*function16[vGPDHVmaxv8, species17[t], vGPDHKDHAPgv8, species20[t], vGPDHKNADHv8, vGPDHrv8, species19[t], vGPDHKNADv8, species22[t], vGPDHKGly3Pgv8]
vGPO = compartment1*function17[species9[t], vGPOKm, vGPOV]
vGT = function10[vGTVmaxv1, species25, species10[t], vGTKGlc, vGTAlphav1]
vGlyT = -(species27*vGlyTk2) + vGlyTk1*species24[t]
vHK = compartment2*RaHXK*function11[vHKVmaxv2, species10[t], vHKKGlcIntv2, species11[t], vHKKATPgv2, species12[t], vHKKADPgv2, species14[t], vHKKGlc6Pv2]
vPFK = compartment2*RaPFK*function13[vPFKVmaxv4, vPFKKi1Fru16BPv4, species16[t], species15[t], vPFKKFru6Pv4, species11[t], vPFKKATPgv4, vPFKKi2Fru16BPv4]
vPGI = compartment2*function12[species14[t], species15[t], vPGIKms, vPGIKmp, vPGIVf, vPGIVr]
vPGK = compartment2*function18[vPGKVmaxv11, species21[t], vPGKKBPGA13v11, species12[t], vPGKKADPgv11, vPGKrv11, species23[t], vPGKKPGA3v11, species11[t], vPGKKATPgv11]
vPGM = compartment1*RaPGAM*function12[species7[t], species5[t], vPGMKms, vPGMKmp, vPGMVf, vPGMVr]
vPGT = vPGTk1*species23[t] - vPGTk2*species7[t]
vPK = compartment1*RaPYK*function19[vPKVmaxv12, species4[t], vPKPKn, species2[t], vPKKADPv12, species3[t]]
vPT = function17[species1[t], vPTKm, vPTV]
vTPI = compartment2*function12[species17[t], species18[t], vTPIKms, vTPIKmp, vTPIVf, vTPIVr]
end rate equations

begin parameters
RaENO = 1.0
RaHXK = 1.0
RaPFK = 1.0
RaPGAM = 1.0
RaPYK = 1.0
species25 = 5.0
species26 = 0.0
species27 = 0.0
vHKKATPgv2 = 0.116
vGTVmaxv1 = 108.9
vGTKGlc = 1.0
vGTAlphav1 = 0.75
vHKVmaxv2 = 1929.0
vHKKGlcIntv2 = 0.1
vHKKADPgv2 = 0.126
vHKKGlc6Pv2 = 12.0
vPGIKms = 0.4
vPGIKmp = 0.12
vPGIVf = 1305.0
vPGIVr = 1305.0
vPFKVmaxv4 = 1708.0
vPFKKi1Fru16BPv4 = 15.8
vPFKKFru6Pv4 = 0.82
vPFKKATPgv4 = 0.026
vPFKKi2Fru16BPv4 = 10.7
vALDVmaxv5 = 560.0
vALDKeqv5 = 0.069
vALDrv5 = 1.19
vALDKGAPv5 = 0.067
vALDKGAPiv5 = 0.098
vTPIKms = 1.2
vTPIKmp = 0.25
vTPIVf = 999.3
vTPIVr = 5696.01
vGAPDHVmaxv7 = 720.9
vGAPDHKGAPv7 = 0.15
vGAPDHKNADv7 = 0.45
vGAPDHrv7 = 0.67
vGAPDHKBPGA13v7 = 0.1
vGAPDHKNADHv7 = 0.02
vGPDHVmaxv8 = 465.0
vGPDHKDHAPgv8 = 0.1
vGPDHKNADHv8 = 0.01
vGPDHrv8 = 0.28
vGPDHKNADv8 = 0.4
vGPDHKGly3Pgv8 = 2.0
vGPOKm = 1.7
vGPOV = 368.0
vPTKm = 1.96
vPTV = 200.0
vPGKVmaxv11 = 2862.0
vPGKKBPGA13v11 = 0.003
vPGKKADPgv11 = 0.1
vPGKrv11 = 0.47
vPGKKPGA3v11 = 1.62
vPGKKATPgv11 = 0.29
vPKVmaxv12 = 1020.0
vPKPKn = 2.5
vPKKADPv12 = 0.114
vAUk = 50.0
vGKVmaxv14 = 200.0
vGKKGly3Pgv14 = 3.83
vGKKADPgv14 = 0.56
vGKrv14 = 60.86
vGKKGlycerolv14 = 0.44
vGKKATPgv14 = 0.24
vPGMKms = 0.27
vPGMKmp = 0.11
vPGMVf = 225.0
vPGMVr = 495.0
vENOKms = 0.054
vENOKmp = 0.24
vENOVf = 598.0
vENOVr = 394.68
vAKck = 1000000.0
vAKckeqak = 0.442
vAKgk = 1000000.0
vAKgkeqak = 0.442
vPGTk1 = 1000000.0
vPGTk2 = 1000000.0
vANTIk1 = 1000000.0
vANTIk2 = 1000000.0
vGlyTk1 = 1000000.0
vGlyTk2 = 1000000.0
compartment1 = 1.0
compartment2 = 1.0
compartment3 = 1.0
end parameters

begin initial conditions
species1[0] = species1i
species10[0] = species10i
species11[0] = species11i
species12[0] = species12i
species13[0] = species13i
species14[0] = species14i
species15[0] = species15i
species16[0] = species16i
species17[0] = species17i
species18[0] = species18i
species19[0] = species19i
species2[0] = species2i
species20[0] = species20i
species21[0] = species21i
species22[0] = species22i
species23[0] = species23i
species24[0] = species24i
species3[0] = species3i
species4[0] = species4i
species5[0] = species5i
species6[0] = species6i
species7[0] = species7i
species8[0] = species8i
species9[0] = species9i
end initial conditions

begin initial values
species1i = 10.0
species10i = 0.0
species11i = 0.240501857508
species12i = 1.51899628498
species13i = 4.24050185751
species14i = 0.5
species15i = 0.5
species16i = 10.0
species17i = 8.47911460193
species18i = 2.5
species19i = 2.0
species2i = 1.31652277625
species20i = 2.0
species21i = 0.5
species22i = 10.5208853981
species23i = 0.0
species24i = 0.0
species3i = 0.341738611875
species4i = 0.0
species5i = 0.0
species6i = 2.24173861188
species7i = 0.0
species8i = 2.23134594788
species9i = 2.76865405212
end initial values

begin assignment rules
end assignment rules

begin function definitions
function17[substrate_,Km_,V_] := (substrate*V)/(Km + substrate)
function12[substrate_,product_,Kms_,Kmp_,Vf_,Vr_] := ((substrate*Vf)/Kms - (product*Vr)/Kmp)/(1 + product/Kmp + substrate/Kms)
function20[k_,atpc_,adpc_] := (atpc*k)/adpc
function18[Vmaxv11_,BPGA13_,KBPGA13v11_,ADPg_,KADPgv11_,rv11_,PGA3_,KPGA3v11_,ATPg_,KATPgv11_] := (((ADPg*BPGA13)/(KADPgv11*KBPGA13v11) - (ATPg*PGA3*rv11)/(KATPgv11*KPGA3v11))*Vmaxv11)/((1 + ADPg/KADPgv11 + ATPg/KATPgv11)*(1 + BPGA13/KBPGA13v11 + PGA3/KPGA3v11))
function11[Vmaxv2_,GlucoseInt_,KGlcIntv2_,ATPg_,KATPgv2_,ADPg_,KADPgv2_,Glc6P_,KGlc6Pv2_] := (ATPg*GlucoseInt*Vmaxv2)/((1 + ADPg/KADPgv2 + ATPg/KATPgv2)*KATPgv2*(1 + Glc6P/KGlc6Pv2 + GlucoseInt/KGlcIntv2)*KGlcIntv2)
function22[k_,atp_,amp_,keqak_,adp_] := k*(amp*atp - adp^2*keqak)
function10[Vmaxv1_,GlucoseExt_,GlucoseInt_,KGlc_,Alphav1_] := ((GlucoseExt - GlucoseInt)*Vmaxv1)/(GlucoseExt + GlucoseInt + (Alphav1*GlucoseExt*GlucoseInt)/KGlc + KGlc)
function14[Vmaxv5_,Fru16BP_,GAP_,DHAPg_,Keqv5_,ATPg_,ADPg_,AMPg_,rv5_,KGAPv5_,KGAPiv5_] := ((Fru16BP - (DHAPg*GAP)/Keqv5)*Vmaxv5)/(0.009*(1 + 0.6622516556291391*ADPg + 0.273972602739726*AMPg + 1.4705882352941175*ATPg) + Fru16BP + (Fru16BP*GAP)/KGAPiv5 + (0.015*(1 + 0.6622516556291391*ADPg + 0.273972602739726*AMPg + 1.4705882352941175*ATPg)*GAP)/(Keqv5*rv5) + (DHAPg*GAP)/(Keqv5*rv5) + (DHAPg*KGAPv5)/(Keqv5*rv5))
function21[Vmaxv14_,Gly3Pg_,KGly3Pgv14_,ADPg_,KADPgv14_,rv14_,Glycerol_,KGlycerolv14_,ATPg_,KATPgv14_] := (((ADPg*Gly3Pg)/(KADPgv14*KGly3Pgv14) - (ATPg*Glycerol*rv14)/(KATPgv14*KGlycerolv14))*Vmaxv14)/((1 + ADPg/KADPgv14 + ATPg/KATPgv14)*(1 + Gly3Pg/KGly3Pgv14 + Glycerol/KGlycerolv14))
function13[Vmaxv4_,Ki1Fru16BPv4_,Fru16BP_,Fru6P_,KFru6Pv4_,ATPg_,KATPgv4_,Ki2Fru16BPv4_] := (ATPg*Fru6P*Ki1Fru16BPv4*Vmaxv4)/((1 + ATPg/KATPgv4)*KATPgv4*KFru6Pv4*(Fru16BP + Ki1Fru16BPv4)*(1 + Fru6P/KFru6Pv4 + Fru16BP/Ki2Fru16BPv4))
function16[Vmaxv8_,DHAPg_,KDHAPgv8_,NADH_,KNADHv8_,rv8_,NAD_,KNADv8_,Gly3Pg_,KGly3Pgv8_] := (((DHAPg*NADH)/(KDHAPgv8*KNADHv8) - (Gly3Pg*NAD*rv8)/(KGly3Pgv8*KNADv8))*Vmaxv8)/((1 + DHAPg/KDHAPgv8 + Gly3Pg/KGly3Pgv8)*(1 + NAD/KNADv8 + NADH/KNADHv8))
function19[Vmaxv12_,PEP_,PKn_,ADPc_,KADPv12_,ATPc_] := (2.941176470588235^PKn*ADPc*(PEP/(1 + 1.5625*ADPc + 1.7543859649122808*ATPc))^PKn*Vmaxv12)/((1 + ADPc/KADPv12)*KADPv12*(1 + 2.941176470588235^PKn*(PEP/(1 + 1.5625*ADPc + 1.7543859649122808*ATPc))^PKn))
function15[Vmaxv7_,GAP_,KGAPv7_,NAD_,KNADv7_,rv7_,BPGA13_,KBPGA13v7_,NADH_,KNADHv7_] := (((GAP*NAD)/(KGAPv7*KNADv7) - (BPGA13*NADH*rv7)/(KBPGA13v7*KNADHv7))*Vmaxv7)/((1 + BPGA13/KBPGA13v7 + GAP/KGAPv7)*(1 + NAD/KNADv7 + NADH/KNADHv7))
end function definitions

begin events
end events

begin process annotations
vAKc http://identifiers.org/kegg.reaction/R00127
vAKc http://identifiers.org/ec-code/2.7.4.3
vAKc http://identifiers.org/go/GO:0004017
vAKc http://identifiers.org/reactome/REACT_643
vAKg http://identifiers.org/kegg.reaction/R00127
vAKg http://identifiers.org/ec-code/2.7.4.3
vAKg http://identifiers.org/go/GO:0004017
vAKg http://identifiers.org/reactome/REACT_643
vENO http://identifiers.org/kegg.reaction/R00658
vENO http://identifiers.org/ec-code/4.2.1.11
vENO http://identifiers.org/go/GO:0004634
vENO http://identifiers.org/reactome/REACT_1400
vPGM http://identifiers.org/kegg.reaction/R01518
vPGM http://identifiers.org/ec-code/5.4.2.1
vPGM http://identifiers.org/go/GO:0004619
vPGM http://identifiers.org/reactome/REACT_576
end process annotations

begin species annotations
species_10 http://identifiers.org/chebi/CHEBI:4167
species_10 http://identifiers.org/kegg.compound/C00031
species_10 http://identifiers.org/pubchem.substance/3587
species_11 http://identifiers.org/chebi/CHEBI:15422
species_11 http://identifiers.org/kegg.compound/C00002
species_11 http://identifiers.org/pubchem.substance/3304
species_11 http://identifiers.org/cas/56-65-5
species_12 http://identifiers.org/chebi/CHEBI:16761
species_12 http://identifiers.org/kegg.compound/C00008
species_12 http://identifiers.org/pubchem.substance/3310
species_12 http://identifiers.org/cas/20398-34-9
species_13 http://identifiers.org/chebi/CHEBI:16027
species_13 http://identifiers.org/kegg.compound/C00020
species_13 http://identifiers.org/pubchem.substance/3322
species_13 http://identifiers.org/cas/61-19-8
species_14 http://identifiers.org/chebi/CHEBI:4170
species_14 http://identifiers.org/kegg.compound/C00668
species_14 http://identifiers.org/pubchem.substance/3937
species_15 http://identifiers.org/chebi/CHEBI:16084
species_15 http://identifiers.org/kegg.compound/C05345
species_15 http://identifiers.org/pubchem.substance/7723
species_16 http://identifiers.org/chebi/CHEBI:28013
species_16 http://identifiers.org/kegg.compound/C05378
species_16 http://identifiers.org/pubchem.substance/7752
species_17 http://identifiers.org/chebi/CHEBI:16108
species_17 http://identifiers.org/kegg.compound/C00111
species_17 http://identifiers.org/pubchem.substance/3411
species_17 http://identifiers.org/3dmet/B00029
species_18 http://identifiers.org/chebi/CHEBI:29052
species_18 http://identifiers.org/kegg.compound/C00118
species_18 http://identifiers.org/pubchem.substance/3418
species_18 http://identifiers.org/cas/591-57-1
species_19 http://identifiers.org/chebi/CHEBI:15846
species_19 http://identifiers.org/kegg.compound/C00003
species_19 http://identifiers.org/pubchem.substance/3305
species_19 http://identifiers.org/cas/53-84-9
species_2 http://identifiers.org/chebi/CHEBI:16761
species_2 http://identifiers.org/kegg.compound/C00008
species_2 http://identifiers.org/pubchem.substance/3310
species_2 http://identifiers.org/cas/20398-34-9
species_20 http://identifiers.org/chebi/CHEBI:16908
species_20 http://identifiers.org/kegg.compound/C00004
species_20 http://identifiers.org/pubchem.substance/3306
species_21 http://identifiers.org/chebi/CHEBI:16001
species_21 http://identifiers.org/kegg.compound/C00236
species_21 http://identifiers.org/pubchem.substance/3535
species_21 http://identifiers.org/cas/38168-82-0
species_22 http://identifiers.org/chebi/CHEBI:15978
species_22 http://identifiers.org/kegg.compound/C00093
species_22 http://identifiers.org/pubchem.substance/3393
species_22 http://identifiers.org/cas/57-03-4
species_23 http://identifiers.org/chebi/CHEBI:17794
species_23 http://identifiers.org/kegg.compound/C00197
species_23 http://identifiers.org/pubchem.substance/3497
species_24 http://identifiers.org/chebi/CHEBI:17754
species_24 http://identifiers.org/kegg.compound/C00116
species_24 http://identifiers.org/pubchem.substance/3416
species_24 http://identifiers.org/3dmet/B00032
species_24 http://identifiers.org/cas/56-81-5
species_25 http://identifiers.org/chebi/CHEBI:4167
species_25 http://identifiers.org/kegg.compound/C00031
species_27 http://identifiers.org/chebi/CHEBI:17754
species_27 http://identifiers.org/kegg.compound/C00116
species_27 http://identifiers.org/pubchem.substance/3416
species_27 http://identifiers.org/3dmet/B00032
species_27 http://identifiers.org/cas/56-81-5
species_3 http://identifiers.org/chebi/CHEBI:15422
species_3 http://identifiers.org/kegg.compound/C00002
species_3 http://identifiers.org/pubchem.substance/3304
species_3 http://identifiers.org/cas/56-65-5
species_4 http://identifiers.org/kegg.compound/C00074
species_4 http://identifiers.org/pubchem.substance/3374
species_4 http://identifiers.org/3dmet/B00019
species_4 http://identifiers.org/cas/138-08-9
species_4 http://identifiers.org/chebi/CHEBI:18021
species_5 http://identifiers.org/chebi/CHEBI:17835
species_5 http://identifiers.org/kegg.compound/C00631
species_5 http://identifiers.org/pubchem.substance/3904
species_6 http://identifiers.org/chebi/CHEBI:16027
species_6 http://identifiers.org/kegg.compound/C00020
species_6 http://identifiers.org/pubchem.substance/3322
species_6 http://identifiers.org/cas/61-19-8
species_7 http://identifiers.org/chebi/CHEBI:16108
species_7 http://identifiers.org/chebi/CHEBI:17794
species_7 http://identifiers.org/kegg.compound/C00197
species_7 http://identifiers.org/pubchem.substance/3497
species_8 http://identifiers.org/chebi/CHEBI:16108
species_8 http://identifiers.org/kegg.compound/C00111
species_8 http://identifiers.org/pubchem.substance/3411
species_8 http://identifiers.org/3dmet/B00029
species_9 http://identifiers.org/chebi/CHEBI:15978
species_9 http://identifiers.org/kegg.compound/C00093
species_9 http://identifiers.org/pubchem.substance/3393
species_9 http://identifiers.org/cas/57-03-4
end species annotations

begin units
end units