#aguda1

FIX: xvar

#reactions
v_1:
 {1.0}pRBE2F = {1.0}aCYCEcdk21 + {1.0}E2F
  k1*aCYCEcdk2*pRBE2F + k1a*CYCDcdk4*pRBE2F + k1aa*CYCDcdk4p27*pRBE2F
v_10:
 {1.0}CYCDcdk4 = {1.0}xvar
  kmin6*CYCDcdk4
v_11:
 {1.0}xvar = {1.0}p27
  k7
v_12:
 {1.0}p27 = {1.0}xvar
  k8*aCYCEcdk2*p27
v_13:
 {1.0}aCYCEcdk2 + {1.0}p27 = {1.0}CYCEcdk2p27
  k9*aCYCEcdk2*p27
v_14:
 {1.0}CYCEcdk2p27 = {1.0}aCYCEcdk2 + {1.0}p27
  k10*CYCEcdk2p27
v_15:
 {1.0}aCYCEcdk20 + {1.0}CYCDcdk4 = {1.0}xvar
  k17*aCYCEcdk20*CYCDcdk4
v_16:
 {1.0}xvar = {1.0}E2F
  k18*E2F
v_17:
 {1.0}CYCDcdk4 + {1.0}p27 = {1.0}CYCDcdk4p27
  k19*CYCDcdk4*p27
v_18:
 {1.0}CYCDcdk4p27 = {1.0}CYCDcdk4 + {1.0}p27
  k20*CYCDcdk4p27
v_19:
 {1.0}aCYCEcdk2 = {1.0}xvar
  k21*aCYCEcdk2**2
v_2:
 {1.0}E2F + {1.0}pRB = {1.0}pRBE2F
  kmin1*E2F*pRB
v_20:
 {1.0}p27 = {1.0}xvar
  k22*p27
v_21:
 {1.0}xvar = {1.0}aCYCEcdk20
  k23
v_22:
 {1.0}aCYCEcdk20 = {1.0}xvar
  k24*aCYCEcdk20
v_23:
 {1.0}xvar = {1.0}aCYCEcdk20
  k25/(1 + k25a*pRB)
v_24:
 {1.0}xvar = {1.0}pRB
  k26/(1 + k26a*aCYCEcdk20)
v_25:
 {1.0}xvar = {1.0}pRB
  k27
v_26:
 {1.0}pRB = {1.0}xvar
  k28*pRB
v_27:
 {1.0}aCYCEcdk21 = {1.0}pRB
  k29*aCYCEcdk21
v_3:
 {1.0}iCYCEcdk2 = {1.0}aCYCEcdk2
  k2*aCYCEcdk2*iCYCEcdk2
v_4:
 {1.0}aCYCEcdk2 = {1.0}iCYCEcdk2
  kmin2*aCYCEcdk2
v_5:
 {1.0}xvar = {1.0}iCYCEcdk2
  k3a + k3*E2F
v_6:
 {1.0}xvar = {1.0}E2F
  k4
v_7:
 {1.0}E2F = {1.0}xvar
  kmin4*E2F
v_8:
 {1.0}iCYCEcdk2 = {1.0}xvar
  k5*iCYCEcdk2
v_9:
 {1.0}xvar = {1.0}CYCDcdk4
  k6


#parameters
k1 = 0.1
k10 = 0.035
k17 = 3.5
k18 = 1e-05
k19 = 0.05
k1a = 0.5
k1aa = 0.5
k2 = 0.1
k20 = 0.01
k21 = 0.1
k22 = 0.001
k23 = 0.2
k24 = 0.1
k25 = 0.01
k25a = 0.02
k26 = 0.01
k26a = 0.1
k27 = 0.01
k28 = 0.01
k29 = 0.001
k3 = 1.42
k3a = 0.0
k4 = 1e-06
k5 = 0.02
k6 = 0.018
k7 = 1e-05
k8 = 2.0
k9 = 2.0
kmin1 = 0.001
kmin2 = 1.0
kmin4 = 0.016
kmin6 = 5.0
xvar = 0.0
default_compartment = 1.0


#initial values
CYCDcdk4 = 0.0
CYCDcdk4p27 = 0.0
CYCEcdk2p27 = 1.0
E2F = 0.0
aCYCEcdk2 = 0.0
aCYCEcdk20 = 5.0
aCYCEcdk21 = 0.01
iCYCEcdk2 = 0.01
p27 = 2.0
pRB = 0.05
pRBE2F = 1.95


#assignment rules