begin name
aguda1
end name

begin reactions
v1 {1.0}pRBE2F = {1.0}aCYCEcdk21 + {1.0}E2F
v10 {1.0}CYCDcdk4 = {1.0}$xvar
v11 {1.0}$xvar = {1.0}p27
v12 {1.0}p27 = {1.0}$xvar
v13 {1.0}aCYCEcdk2 + {1.0}p27 = {1.0}CYCEcdk2p27
v14 {1.0}CYCEcdk2p27 = {1.0}aCYCEcdk2 + {1.0}p27
v15 {1.0}aCYCEcdk20 + {1.0}CYCDcdk4 = {1.0}$xvar
v16 {1.0}$xvar = {1.0}E2F
v17 {1.0}CYCDcdk4 + {1.0}p27 = {1.0}CYCDcdk4p27
v18 {1.0}CYCDcdk4p27 = {1.0}CYCDcdk4 + {1.0}p27
v19 {1.0}aCYCEcdk2 = {1.0}$xvar
v2 {1.0}E2F + {1.0}pRB = {1.0}pRBE2F
v20 {1.0}p27 = {1.0}$xvar
v21 {1.0}$xvar = {1.0}aCYCEcdk20
v22 {1.0}aCYCEcdk20 = {1.0}$xvar
v23 {1.0}$xvar = {1.0}aCYCEcdk20
v24 {1.0}$xvar = {1.0}pRB
v25 {1.0}$xvar = {1.0}pRB
v26 {1.0}pRB = {1.0}$xvar
v27 {1.0}aCYCEcdk21 = {1.0}pRB
v3 {1.0}iCYCEcdk2 = {1.0}aCYCEcdk2
v4 {1.0}aCYCEcdk2 = {1.0}iCYCEcdk2
v5 {1.0}$xvar = {1.0}iCYCEcdk2
v6 {1.0}$xvar = {1.0}E2F
v7 {1.0}E2F = {1.0}$xvar
v8 {1.0}iCYCEcdk2 = {1.0}$xvar
v9 {1.0}$xvar = {1.0}CYCDcdk4
end reactions

begin rate equations
v1 = k1*aCYCEcdk2[t]*pRBE2F[t] + k1a*CYCDcdk4[t]*pRBE2F[t] + k1aa*CYCDcdk4p27[t]*pRBE2F[t]
v10 = kmin6*CYCDcdk4[t]
v11 = k7
v12 = k8*aCYCEcdk2[t]*p27[t]
v13 = k9*aCYCEcdk2[t]*p27[t]
v14 = k10*CYCEcdk2p27[t]
v15 = k17*aCYCEcdk20[t]*CYCDcdk4[t]
v16 = k18*E2F[t]
v17 = k19*CYCDcdk4[t]*p27[t]
v18 = k20*CYCDcdk4p27[t]
v19 = k21*aCYCEcdk2[t]^2
v2 = kmin1*E2F[t]*pRB[t]
v20 = k22*p27[t]
v21 = k23
v22 = k24*aCYCEcdk20[t]
v23 = k25/(1 + k25a*pRB[t])
v24 = k26/(1 + k26a*aCYCEcdk20[t])
v25 = k27
v26 = k28*pRB[t]
v27 = k29*aCYCEcdk21[t]
v3 = k2*aCYCEcdk2[t]*iCYCEcdk2[t]
v4 = kmin2*aCYCEcdk2[t]
v5 = k3a + k3*E2F[t]
v6 = k4
v7 = kmin4*E2F[t]
v8 = k5*iCYCEcdk2[t]
v9 = k6
end rate equations

begin parameters
k1 = 0.1
k10 = 0.035
k17 = 3.5
k18 = "1e-05"
k19 = 0.05
k1a = 0.5
k1aa = 0.5
k2 = 0.1
k20 = 0.01
k21 = 0.1
k22 = 0.001
k23 = 0.2
k24 = 0.1
k25 = 0.01
k25a = 0.02
k26 = 0.01
k26a = 0.1
k27 = 0.01
k28 = 0.01
k29 = 0.001
k3 = 1.42
k3a = 0.0
k4 = "1e-06"
k5 = 0.02
k6 = 0.018
k7 = "1e-05"
k8 = 2.0
k9 = 2.0
kmin1 = 0.001
kmin2 = 1.0
kmin4 = 0.016
kmin6 = 5.0
xvar = 0.0
defaultcompartment = 1.0
end parameters

begin initial conditions
CYCDcdk4[0] = CYCDcdk4i
CYCDcdk4p27[0] = CYCDcdk4p27i
CYCEcdk2p27[0] = CYCEcdk2p27i
E2F[0] = E2Fi
aCYCEcdk2[0] = aCYCEcdk2i
aCYCEcdk20[0] = aCYCEcdk20i
aCYCEcdk21[0] = aCYCEcdk21i
iCYCEcdk2[0] = iCYCEcdk2i
p27[0] = p27i
pRB[0] = pRBi
pRBE2F[0] = pRBE2Fi
end initial conditions

begin initial values
CYCDcdk4i = 0.0
CYCDcdk4p27i = 0.0
CYCEcdk2p27i = 1.0
E2Fi = 0.0
aCYCEcdk2i = 0.0
aCYCEcdk20i = 5.0
aCYCEcdk21i = 0.01
iCYCEcdk2i = 0.01
p27i = 2.0
pRBi = 0.05
pRBE2Fi = 1.95
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
end process annotations

begin species annotations
end species annotations

begin units
end units