begin name
achcar1
end name

begin reactions
AKc {2.0}ADPc = {1.0}AMPc + {1.0}ATPc
AKg {44.5116}ADPg = {22.2558}AMPg + {22.2558}ATPg
ALDg {22.2558}Fru16BPg = {22.2558}DHAPg + {22.2558}GA3Pg
ATPuc {1.0}ATPc = {1.0}ADPc
ENOc {1.0}PGA2c = {1.0}PEPc
G3PDHg {22.2558}DHAPg + {22.2558}NADHg = {22.2558}Gly3Pg + {22.2558}NADg
GAPDHg {1.0}$Pig + {22.2558}GA3Pg + {22.2558}NADg = {22.2558}BPGA13g + {22.2558}NADHg
GDAg {1.0}DHAPc + {22.2558}Gly3Pg = {1.0}Gly3Pc + {22.2558}DHAPg
GKg {22.2558}ADPg + {22.2558}Gly3Pg = {22.2558}ATPg + {22.2558}Glyg
GPOc {1.0}Gly3Pc = {1.0}DHAPc
GlcTc {1.0}$Glce = {1.0}Glcc
GlcTg {1.0}Glcc = {22.2558}Glcg
GlyTc {1.0}Glyc = {1.0}$Glye
Glytg {22.2558}Glyg = {1.0}Glyc
HXKg {22.2558}ATPg + {22.2558}Glcg = {22.2558}ADPg + {22.2558}Glc6Pg
PFKg {22.2558}ATPg + {22.2558}Fru6Pg = {22.2558}ADPg + {22.2558}Fru16BPg
PGA3Tg {22.2558}PGA3g = {1.0}PGA3c
PGAMc {1.0}PGA3c = {1.0}PGA2c
PGIg {22.2558}Glc6Pg = {22.2558}Fru6Pg
PGKg {22.2558}BPGA13g + {22.2558}ADPg = {22.2558}PGA3g + {22.2558}ATPg
PYKc {1.0}ADPc + {1.0}PEPc = {1.0}ATPc + {1.0}Pyrc
PyrTc {1.0}Pyrc = {1.0}$Pyre
TPIg {22.2558}DHAPg = {22.2558}GA3Pg
end reactions

begin rate equations
AKc = (AKcAKck1*ADPc[t]^2 - AKcAKck2*AMPc[t]*ATPc[t])/cytosol
AKg = (AKgAKgk1*ADPg[t]^2 - AKgAKgk2*AMPg[t]*ATPg[t])/cytosol
ALDg = (ALDgALDgVmax*Fru16BPg[t]*(1 - (DHAPg[t]*GA3Pg[t])/(ALDgALDgKeq*Fru16BPg[t])))/(ALDgALDgKmFru16BP*cytosol*(1 + ADPg[t]/ALDgALDgKiADP + AMPg[t]/ALDgALDgKiAMP + ATPg[t]/ALDgALDgKiATP)*(1 + DHAPg[t]/ALDgALDgKmDHAP + Fru16BPg[t]/(ALDgALDgKmFru16BP*(1 + ADPg[t]/ALDgALDgKiADP + AMPg[t]/ALDgALDgKiAMP + ATPg[t]/ALDgALDgKiATP)) + GA3Pg[t]/ALDgALDgKmGA3P + (DHAPg[t]*GA3Pg[t])/(ALDgALDgKmDHAP*ALDgALDgKmGA3P) + (Fru16BPg[t]*GA3Pg[t])/(ALDgALDgKiGA3P*ALDgALDgKmFru16BP*(1 + ADPg[t]/ALDgALDgKiADP + AMPg[t]/ALDgALDgKiAMP + ATPg[t]/ALDgALDgKiATP))))
ATPuc = (ATPucATPuck*ATPc[t])/(cytosol*ADPc[t])
ENOc = (ENOcENOcVmax*(1 - PEPc[t]/(ENOcENOcKeq*PGA2c[t]))*PGA2c[t])/(cytosol*ENOcENOcKmPGA2*(1 + PEPc[t]/ENOcENOcKmPEP + PGA2c[t]/ENOcENOcKmPGA2))
G3PDHg = (G3PDHgG3PDHgVmax*DHAPg[t]*(1 - (Gly3Pg[t]*NADg[t])/(G3PDHgG3PDHgKeq*DHAPg[t]*NADHg[t]))*NADHg[t])/(cytosol*G3PDHgG3PDHgKmDHAP*G3PDHgG3PDHgKmNADH*(1 + DHAPg[t]/G3PDHgG3PDHgKmDHAP + Gly3Pg[t]/G3PDHgG3PDHgKmGly3P)*(1 + NADg[t]/G3PDHgG3PDHgKmNAD + NADHg[t]/G3PDHgG3PDHgKmNADH))
GAPDHg = (GAPDHgGAPDHgVmax*GA3Pg[t]*NADg[t]*(1 - (BPGA13g[t]*NADHg[t])/(GAPDHgGAPDHgKeq*GA3Pg[t]*NADg[t])))/(cytosol*GAPDHgGAPDHgKmGA3P*GAPDHgGAPDHgKmNAD*(1 + BPGA13g[t]/GAPDHgGAPDHgKmBPGA13 + GA3Pg[t]/GAPDHgGAPDHgKmGA3P)*(1 + NADg[t]/GAPDHgGAPDHgKmNAD + NADHg[t]/GAPDHgGAPDHgKmNADH))
GDAg = (-(GDAgGDAgk*DHAPg[t]*Gly3Pc[t]) + GDAgGDAgk*DHAPc[t]*Gly3Pg[t])/cytosol
GKg = (GKgGKgVmax*ADPg[t]*Gly3Pg[t]*(1 - (ATPg[t]*Glyg[t])/(GKgGKgKeq*ADPg[t]*Gly3Pg[t])))/(cytosol*GKgGKgKmADP*GKgGKgKmGly3P*(1 + ADPg[t]/GKgGKgKmADP + ATPg[t]/GKgGKgKmATP)*(1 + Gly3Pg[t]/GKgGKgKmGly3P + Glyg[t]/GKgGKgKmGly))
GPOc = (GPOcGPOcVmax*Gly3Pc[t])/(cytosol*GPOcGPOcKmGly3P*(1 + ((1 + SHAM/GPOcGPOcKiSHAM)*Gly3Pc[t])/GPOcGPOcKmGly3P))
GlcTc = (GlcTcGlcTcVmax*(Glce - Glcc[t]))/(cytosol*(Glce + GlcTcGlcTcKmGlc + Glcc[t] + (Glce*GlcTcGlcTcalpha*Glcc[t])/GlcTcGlcTcKmGlc))
GlcTg = (GlcTgGlcTgk*Glcc[t] - GlcTgGlcTgk*Glcg[t])/cytosol
GlyTc = (GlyTcGlyTck*(-Glye + Glyc[t]) + (GlyTcGlyTcVrmax*GlyTcGlyTcy*(-Glye + Glyc[t]))/(Glye*GlyTcGlyTcy + GlyTcGlyTcKmGlye*GlyTcGlyTcy + Glyc[t] + (Glye*GlyTcGlyTcx*(1 - GlyTcGlyTcx + GlyTcGlyTcy)*Glyc[t])/(GlyTcGlyTcKmGlye*GlyTcGlyTcy)))/cytosol
Glytg = (GlytgGlytgk*(-Glyc[t] + Glyg[t]))/cytosol
HXKg = (HXKgHXKgVmax*ATPg[t]*(1 - (ADPg[t]*Glc6Pg[t])/(HXKgHXKgKeq*ATPg[t]*Glcg[t]))*Glcg[t])/(cytosol*HXKgHXKgKmATP*HXKgHXKgKmGlc*(1 + ADPg[t]/HXKgHXKgKmADP + ATPg[t]/HXKgHXKgKmATP)*(1 + Glc6Pg[t]/HXKgHXKgKmGlc6P + Glcg[t]/HXKgHXKgKmGlc))
PFKg = (PFKgPFKgKi1*PFKgPFKgVmax*ATPg[t]*(1 - (ADPg[t]*Fru16BPg[t])/(PFKgPFKgKeq*ATPg[t]*Fru6Pg[t]))*Fru6Pg[t])/(cytosol*PFKgPFKgKmATP*PFKgPFKgKmFru6P*(PFKgPFKgKi1 + Fru16BPg[t])*(PFKgPFKgKsATP/PFKgPFKgKmATP + ADPg[t]/PFKgPFKgKmADP + ATPg[t]/PFKgPFKgKmATP + (ADPg[t]*Fru16BPg[t])/(PFKgPFKgKi2*PFKgPFKgKmADP) + Fru6Pg[t]/PFKgPFKgKmFru6P + (ATPg[t]*Fru6Pg[t])/(PFKgPFKgKmATP*PFKgPFKgKmFru6P)))
PGA3Tg = (-(PGA3TgPGA3Tgk*PGA3c[t]) + PGA3TgPGA3Tgk*PGA3g[t])/cytosol
PGAMc = (PGAMcPGAMcVmax*(1 - PGA2c[t]/(PGAMcPGAMcKeq*PGA3c[t]))*PGA3c[t])/(cytosol*PGAMcPGAMcKmPGA3*(1 + PGA2c[t]/PGAMcPGAMcKmPGA2 + PGA3c[t]/PGAMcPGAMcKmPGA3))
PGIg = (PGIgPGIgVmax*(1 - Fru6Pg[t]/(PGIgPGIgKeq*Glc6Pg[t]))*Glc6Pg[t])/(cytosol*PGIgPGIgKmGlc6P*(1 + Fru6Pg[t]/PGIgPGIgKmFru6P + Glc6Pg[t]/PGIgPGIgKmGlc6P))
PGKg = (PGKgPGKgVmax*ADPg[t]*BPGA13g[t]*(1 - (ATPg[t]*PGA3g[t])/(PGKgPGKgKeq*ADPg[t]*BPGA13g[t])))/(cytosol*PGKgPGKgKmADP*PGKgPGKgKmBPGA13*(1 + ADPg[t]/PGKgPGKgKmADP + ATPg[t]/PGKgPGKgKmATP)*(1 + BPGA13g[t]/PGKgPGKgKmBPGA13 + PGA3g[t]/PGKgPGKgKmPGA3))
PYKc = (PYKcPYKcVmax*ADPc[t]*(PEPc[t]/(PYKcPYKcKmPEP*(1 + ADPc[t]/PYKcPYKcKiADP + ATPc[t]/PYKcPYKcKiATP)))^PYKcPYKcn*(1 - (ATPc[t]*Pyrc[t])/(PYKcPYKcKeq*ADPc[t]*PEPc[t])))/(cytosol*PYKcPYKcKmADP*(1 + ADPc[t]/PYKcPYKcKmADP + ATPc[t]/PYKcPYKcKmATP)*(1 + (PEPc[t]/(PYKcPYKcKmPEP*(1 + ADPc[t]/PYKcPYKcKiADP + ATPc[t]/PYKcPYKcKiATP)))^PYKcPYKcn + Pyrc[t]/PYKcPYKcKmPyr))
PyrTc = (PyrTcPyrTcVmax*Pyrc[t])/(cytosol*PyrTcPyrTcKmPyr*(1 + Pyrc[t]/PyrTcPyrTcKmPyr))
TPIg = (TPIgTPIgVmax*DHAPg[t]*(1 - GA3Pg[t]/(TPIgTPIgKeq*DHAPg[t])))/(cytosol*TPIgTPIgKmDHAP*(1 + DHAPg[t]/TPIgTPIgKmDHAP + GA3Pg[t]/TPIgTPIgKmGA3P))
end rate equations

begin parameters
AKcAKck1 = 442.0
AKcAKck2 = 1000.0
AKgAKgk1 = 442.0
AKgAKgk2 = 1000.0
ALDgALDgKeq = 0.084
ALDgALDgKiADP = 1.51
ALDgALDgKiAMP = 3.65
ALDgALDgKiATP = 0.68
ALDgALDgKiGA3P = 0.098
ALDgALDgKmDHAP = 0.015
ALDgALDgKmFru16BP = 0.009
ALDgALDgKmGA3P = 0.067
ALDgALDgVmax = 560.0
ATPucATPuck = 50.0
ENOcENOcKeq = 4.12
ENOcENOcKmPEP = 0.24
ENOcENOcKmPGA2 = 0.054
ENOcENOcVmax = 598.0
EXTERNAL = 0.0
G3PDHgG3PDHgKeq = 17085.0
G3PDHgG3PDHgKmDHAP = 0.1
G3PDHgG3PDHgKmGly3P = 2.0
G3PDHgG3PDHgKmNAD = 0.4
G3PDHgG3PDHgKmNADH = 0.01
G3PDHgG3PDHgVmax = 465.0
GAPDHgGAPDHgKeq = 0.066
GAPDHgGAPDHgKmBPGA13 = 0.1
GAPDHgGAPDHgKmGA3P = 0.15
GAPDHgGAPDHgKmNAD = 0.45
GAPDHgGAPDHgKmNADH = 0.02
GAPDHgGAPDHgVmax = 720.9
GDAgGDAgk = 600.0
GKgGKgKeq = 0.000837
GKgGKgKmADP = 0.56
GKgGKgKmATP = 0.24
GKgGKgKmGly = 0.44
GKgGKgKmGly3P = 3.83
GKgGKgVmax = 200.0
GPOcGPOcKiSHAM = 0.021
GPOcGPOcKmGly3P = 1.7
GPOcGPOcVmax = 368.0
GlcTcGlcTcKmGlc = 1.1
GlcTcGlcTcVmax = 111.7
GlcTcGlcTcalpha = 0.75
GlcTgGlcTgk = 250000.0
GlyTcGlyTcKmGlye = 0.17
GlyTcGlyTcVrmax = 85.0
GlyTcGlyTck = 8.5
GlyTcGlyTcx = 1.0
GlyTcGlyTcy = 1.0
GlytgGlytgk = 1000.0
HXKgHXKgKeq = 759.0
HXKgHXKgKmADP = 0.126
HXKgHXKgKmATP = 0.116
HXKgHXKgKmGlc = 0.1
HXKgHXKgKmGlc6P = 12.0
HXKgHXKgVmax = 1929.0
O2c = 1.0
PFKgPFKgKeq = 1035.0
PFKgPFKgKi1 = 15.8
PFKgPFKgKi2 = 10.7
PFKgPFKgKmADP = 1.0
PFKgPFKgKmATP = 0.0648
PFKgPFKgKmFru6P = 0.999
PFKgPFKgKsATP = 0.0393
PFKgPFKgVmax = 1708.0
PGA3TgPGA3Tgk = 250.0
PGAMcPGAMcKeq = 0.17
PGAMcPGAMcKmPGA2 = 0.16
PGAMcPGAMcKmPGA3 = 0.15
PGAMcPGAMcVmax = 225.0
PGIgPGIgKeq = 0.46
PGIgPGIgKmFru6P = 0.12
PGIgPGIgKmGlc6P = 0.4
PGIgPGIgVmax = 1305.0
PGKgPGKgKeq = 3376.0
PGKgPGKgKmADP = 0.1
PGKgPGKgKmATP = 0.29
PGKgPGKgKmBPGA13 = 0.003
PGKgPGKgKmPGA3 = 1.62
PGKgPGKgVmax = 2862.0
PYKcPYKcKeq = 10800.0
PYKcPYKcKiADP = 0.64
PYKcPYKcKiATP = 0.57
PYKcPYKcKmADP = 0.114
PYKcPYKcKmATP = 15.0
PYKcPYKcKmPEP = 0.34
PYKcPYKcKmPyr = 50.0
PYKcPYKcVmax = 1020.0
PYKcPYKcn = 2.5
PyrTcPyrTcKmPyr = 1.96
PyrTcPyrTcVmax = 230.0
SHAM = 0.0
TPIgTPIgKeq = 0.046
TPIgTPIgKmDHAP = 1.2
TPIgTPIgKmGA3P = 0.25
TPIgTPIgVmax = 999.3
cytosol = 5.4549
default = 1.0
glycosome = 0.2451
Glce = 5.0
Glye = "1e-06"
Pig = 0.0
Pyre = 0.0
defaultcompartment = 1.0
end parameters

begin initial conditions
ADPc[0] = ADPci
ADPg[0] = ADPgi
AMPc[0] = AMPci
AMPg[0] = AMPgi
ATPc[0] = ATPci
ATPg[0] = ATPgi
BPGA13g[0] = BPGA13gi
DHAPc[0] = DHAPci
DHAPg[0] = DHAPgi
Fru16BPg[0] = Fru16BPgi
Fru6Pg[0] = Fru6Pgi
GA3Pg[0] = GA3Pgi
Glc6Pg[0] = Glc6Pgi
Glcc[0] = Glcci
Glcg[0] = Glcgi
Gly3Pc[0] = Gly3Pci
Gly3Pg[0] = Gly3Pgi
Glyc[0] = Glyci
Glyg[0] = Glygi
NADHg[0] = NADHgi
NADg[0] = NADgi
PEPc[0] = PEPci
PGA2c[0] = PGA2ci
PGA3c[0] = PGA3ci
PGA3g[0] = PGA3gi
Pyrc[0] = Pyrci
end initial conditions

begin initial values
ADPci = 1.0
ADPgi = 1.0
AMPci = 0.1
AMPgi = 0.1
ATPci = 4.9
ATPgi = 4.9
BPGA13gi = 0.4
DHAPci = 4.6
DHAPgi = 4.6
Fru16BPgi = 13.0
Fru6Pgi = 0.2
GA3Pgi = 0.14
Glc6Pgi = 0.8
Glcci = 0.01
Glcgi = 0.01
Gly3Pci = 1.5
Gly3Pgi = 1.5
Glyci = 1e-06
Glygi = 1e-06
NADHgi = 0.1
NADgi = 3.9
PEPci = 1.4
PGA2ci = 0.5
PGA3ci = 17.0
PGA3gi = 17.0
Pyrci = 14.0
end initial values

begin assignment rules
end assignment rules

begin function definitions
end function definitions

begin events
end events

begin process annotations
AKc http://identifiers.org/interpro/IPR000850
end process annotations

begin species annotations
ADPc http://identifiers.org/kegg.compound/C00008
ADPg http://identifiers.org/kegg.compound/C00008
AMPc http://identifiers.org/kegg.compound/C00020
AMPg http://identifiers.org/kegg.compound/C00020
ATPc http://identifiers.org/kegg.compound/C00002
ATPg http://identifiers.org/kegg.compound/C00002
BPGA13g http://identifiers.org/kegg.compound/C00236
DHAPc http://identifiers.org/kegg.compound/C00111
DHAPg http://identifiers.org/kegg.compound/C00111
Fru16BPg http://identifiers.org/kegg.compound/C00354
Fru6Pg http://identifiers.org/kegg.compound/C00085
GA3Pg http://identifiers.org/cas/142-10-9
Glc6Pg http://identifiers.org/kegg.compound/C00092
Glcc http://identifiers.org/kegg.compound/C00293
Glce http://identifiers.org/kegg.compound/C00293
Glcg http://identifiers.org/kegg.compound/C00293
Gly3Pc http://identifiers.org/kegg.compound/C00093
Gly3Pg http://identifiers.org/kegg.compound/C00093
Glyc http://identifiers.org/kegg.compound/C00116
Glye http://identifiers.org/kegg.compound/C00116
Glyg http://identifiers.org/kegg.compound/C00116
NADHg http://identifiers.org/kegg.compound/C00004
NADg http://identifiers.org/kegg.compound/C00003
PEPc http://identifiers.org/kegg.compound/C00074
PGA2c http://identifiers.org/obo.chebi/CHEBI%3A24344
PGA3c http://identifiers.org/kegg.compound/C00197
PGA3g http://identifiers.org/kegg.compound/C00197
Pig http://identifiers.org/obo.chebi/CHEBI%3A24838
Pyrc http://identifiers.org/kegg.compound/C00022
Pyre http://identifiers.org/kegg.compound/C00022
end species annotations

begin units
end units