R1
p53 production
∅ > x
R2
Mdm2 independent p53 degradation
x > ∅
R3
Mdm2 dependent p53 degradation
x > ∅
R4
p53 dependent Mdm2 precursor production
∅ > y0
R5
Mdm2 synthesis from precursor
y0 > y
R6
Mdm2 degradation
y = ∅
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
No manuscript information is available for this model.
The model reproduces time profile of p53 and Mdm2 as depicted in Fig 6B of the paper for Model 4.