v1
∅ = x
v10
y2 = ∅
v11
y2 = ∅
v12
y3 = ∅
v13
y3 = ∅
v14
y3 = ∅
v15
∅ = z1
v16
z1 = ∅
v17
∅ = z2
v18
z2 = ∅
v19
∅ = z3
v2
x = ∅
v20
z3 = ∅
v21
∅ = w
v22
∅ = w
v23
∅ = w
v24
w = ∅
v3
x = y1
v4
x = y2
v5
x = y3
v6
y1 = ∅
v7
y1 = ∅
v8
y1 = ∅
v9
y2 = ∅
Trigger: time>2499
Delay: 0
Assignments:
- y1 = 0.15
- z1 = 0.00992693
- w = 0.0215649
Note that constraints are not enforced in simulations. It remains the responsibility of the user to verify that simulation results satisfy these constraints.
Immunological transitions in response to antigenic mutation during viral infection.
Int. Immunol. 2000;
12
(10):
1371-1380
- PubMed: 11007754
- ISSN: 0953-8178
- URL: https://ncbi.nlm.nih.gov/pubmed/11007754
Abstract
Antigenic variation is an important factor in viral persistence and disease progression. We analyze immunological changes which occur in response to antigenic mutation during chronic viral infection. Using an established model of viral and immune system dynamics, we determine which qualitative shifts in the immune response can be elicited by the appearance of a new mutant. We find that antigenic mutation can cause dramatic shifts in the magnitude and type of anti-viral immune response. For example, the appearance of a mutant can elicit a new immune response which recognizes the original viral strain. We also find that novel strains of the virus which replicate more slowly than existing viral strains are able to invade and survive, even when the immune system is capable of mounting an immune response against the mutant.
The model reproduces Fig 6 of the paper.