A1 A2 A3 A4 2 A4 A1 A2 A1 A3 A2 A4 A1 2 A2 A1 A3 A2 A4 A1 2 4 A2 A1 A4 A1 CycBt 2 CycBt CKIt CycBt CKIt 1 Keq CycBt CKIt 1 Keq 2 4 CycBt CKIt 1 2 1 GK k15p m k15pp SK k16p k16pp m CycB J15 J16 2 CycBt CKIt CycBt CKIt 1 Keq CycBt CKIt 1 Keq 2 4 CycBt CKIt 1 2 k12p CKIt k12pp SK CKIt k11 k7 IEP Cdc20t Cdc20a J7 Cdc20t Cdc20a k6 Cdc20a k8 Mad Cdc20a J8 Cdc20a k6 Cdc20t k5p k5pp CycB m J5 n 1 CycB m J5 n k4p SK Cdh1 k4 m CycB Cdh1 J4 Cdh1 k3p k3pp Cdc20a 1 Cdh1 J3 1 Cdh1 k2p CycBt k2pp Cdh1 CycBt k1 k2ppp Cdc20a CycBt k10 IEP k9 m CycB 1 IEP k14 SK k13 TF k12ppp m CycB CKIt mu m 1 m mmax CycB 0.1 0 m 2