two enzyme pathway with inhibitor, host-parasite

two enzyme pathway with inhibitor, host-parasite

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Abstract

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Unit definitions have no effect on the numerical analysis of the model. It remains the responsibility of the modeler to ensure the internal numerical consistency of the model. If units are provided, however, the consistency of the model units will be checked.

Name Definition
Id Name Spatial dimensions Size
default 0.0 1.0
Id Name Initial quantity Compartment Fixed
i1 inhibitor 0.0 default
p product 0.0 default
s substrate 5.0 default
xH intermediate host 0.0 default
xP intermediate parasite 0.0 default

Initial assignments are expressions that are evaluated at time=0. It is not recommended to create initial assignments for all model entities. Restrict the use of initial assignments to cases where a value is expressed in terms of values or sizes of other model entities. Note that it is not permitted to have both an initial assignment and an assignment rule for a single model entity.

Definition
Id Name Objective coefficient Reaction Equation and Kinetic Law Flux bounds
v1H v1H s = xH

Vmax1H * s / Km1S1 * (1 - xH / (s * Keq1)) / (1 + s / Km1S1 + xH / Km1X + i1 / K1I1)
v1P v1P s = xP

Vmax1P * s / Km1S1 * (1 - xP / (s * Keq1)) / (1 + s / Km1S1 + xP / Km1X + i1 / K1I1)
v2H xH = p

Vmax2 * xH / Km2X / (1 + xH / Km2X)
v2P xP = p

Vmax2 * xP / Km2X / (1 + xP / Km2X)

Global parameters

Id Value
K1I1 1.0
Keq1 10.0
Km1S1 1.0
Km1X 2.0
Km2X 1.0
Vmax1H 10.0
Vmax1P 10.0
Vmax2 10.0

Local parameters

Id Value Reaction

Assignment rules

Definition

Rate rules

Definition

Algebraic rules

Definition
Trigger Assignments