$\mathrm{Smad7mRNA}\mathrm{k\_S7\_protein\_C5}\mapsto \mathrm{Smad7mRNA}\mathrm{k\_S7\_protein\_C5}$ $\mathrm{S2\_c}\mathrm{S2\_import\_to\_nuc\_C5}\mathrm{cyt}\mapsto \mathrm{cyt}\mathrm{S2\_c}\mathrm{S2\_import\_to\_nuc\_C5}$ $\mathrm{TGFb\_R2\_endo}\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5}\mapsto \mathrm{TGFb\_R2\_endo}\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5}$ $\mathrm{TGFb}\mathrm{TGFb\_R2\_surface}\mathrm{k\_medium}\mathrm{kf\_R2\_activation}\mapsto \frac{\mathrm{TGFb}\mathrm{TGFb\_R2\_surface}\mathrm{kf\_R2\_activation}}{\mathrm{k\_medium}}$ $\mathrm{Inactive\_Rec}\mathrm{index\_induced\_R2\_deg}\mathrm{kdeg\_R2}\mapsto \mathrm{Inactive\_Rec}\mathrm{index\_induced\_R2\_deg}\mathrm{kdeg\_R2}$ $\mathrm{Active\_R2}\mathrm{index\_kb\_R2}\mathrm{k\_medium}\mathrm{kf\_R2\_activation}\mapsto \frac{\mathrm{Active\_R2}\mathrm{index\_kb\_R2}\mathrm{kf\_R2\_activation}}{\mathrm{k\_medium}}$ $\mathrm{TGFb}\mathrm{TGFb\_R2\_surface}\mathrm{kf\_R2\_activation}\mapsto \mathrm{TGFb}\mathrm{TGFb\_R2\_surface}\mathrm{kf\_R2\_activation}$ $\mathrm{Inactive\_Rec}\mathrm{index\_seq\_kb}\mathrm{kf\_Seq\_S7\_Rec}\mapsto \mathrm{Inactive\_Rec}\mathrm{index\_seq\_kb}\mathrm{kf\_Seq\_S7\_Rec}$ $\mathrm{Active\_R2}\mathrm{index\_kb\_R2}\mathrm{kf\_R2\_activation}\mapsto \mathrm{Active\_R2}\mathrm{index\_kb\_R2}\mathrm{kf\_R2\_activation}$ $\mathrm{Active\_R2}\mathrm{index\_kb\_R2}\mathrm{kf\_R2\_activation}\mapsto \mathrm{Active\_R2}\mathrm{index\_kb\_R2}\mathrm{kf\_R2\_activation}$ $\mathrm{index\_kf\_homotrimer}\mathrm{kf\_trimmer}\mathrm{pS2\_c}\mapsto \mathrm{index\_kf\_homotrimer}\mathrm{kf\_trimmer}\mathrm{pS2\_c}^3$ $\mathrm{Active\_Rec\_endo}\mathrm{S2\_c}\mathrm{k\_phosphorylation}\mapsto \mathrm{Active\_Rec\_endo}\mathrm{S2\_c}\mathrm{k\_phosphorylation}$ $\mathrm{Smad7mRNA1}\mathrm{export\_cytoplasm}\mathrm{nuc}\mapsto \mathrm{nuc}\mathrm{Smad7mRNA1}\mathrm{export\_cytoplasm}$ $\mathrm{index\_kb\_homotrimer}\mathrm{kb\_trimmer}\mathrm{pS2\_pS2\_pS2\_c}\mapsto \mathrm{index\_kb\_homotrimer}\mathrm{kb\_trimmer}\mathrm{pS2\_pS2\_pS2\_c}$ $\mathrm{S4\_c}\mathrm{S4\_import\_to\_nuc\_C5}\mathrm{cyt}\mapsto \mathrm{cyt}\mathrm{S4\_c}\mathrm{S4\_import\_to\_nuc\_C5}$ $\mathrm{R2\_total\_C5}\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}\mapsto \frac{\mathrm{R2\_total\_C5}\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}^2}{\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}+\mathrm{kdeg\_R2}^2+\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}}$ $\mathrm{S4\_export\_from\_nuc\_C5}\mathrm{S4\_n}\mathrm{nuc}\mapsto \mathrm{nuc}\mathrm{S4\_n}\mathrm{S4\_export\_from\_nuc\_C5}$ $\mathrm{index\_trimer\_dephos}\mathrm{k\_Dephos\_C5}\mathrm{pS2\_pS2\_S4\_n}\mapsto \mathrm{index\_trimer\_dephos}\mathrm{k\_Dephos\_C5}\mathrm{pS2\_pS2\_S4\_n}$ $\mathrm{Active\_Rec}\mathrm{index\_active\_Rec\_internalize\_C5}\mathrm{k\_in\_R1\_C5}\mapsto \mathrm{Active\_Rec}\mathrm{index\_active\_Rec\_internalize\_C5}\mathrm{k\_in\_R1\_C5}$ $\mathrm{S2\_export\_from\_nuc\_C5}\mathrm{S2\_n}\mathrm{nuc}\mapsto \mathrm{nuc}\mathrm{S2\_n}\mathrm{S2\_export\_from\_nuc\_C5}$ $\mathrm{S2\_export\_from\_nuc\_C5}\mathrm{nuc}\mathrm{pS2\_n}\mapsto \mathrm{nuc}\mathrm{S2\_export\_from\_nuc\_C5}\mathrm{pS2\_n}$ $\mathrm{Trimer\_import\_to\_nuc}\mathrm{cyt}\mathrm{pS2\_pS2\_pS2\_c}\mapsto \mathrm{cyt}\mathrm{Trimer\_import\_to\_nuc}\mathrm{pS2\_pS2\_pS2\_c}$ $\mathrm{index\_kf\_homotrimer}\mathrm{kf\_trimmer}\mathrm{pS2\_n}\mapsto \mathrm{index\_kf\_homotrimer}\mathrm{kf\_trimmer}\mathrm{pS2\_n}^3$ $\mathrm{Trimer\_import\_to\_nuc}\mathrm{cyt}\mathrm{pS2\_pS2\_S4\_c}\mapsto \mathrm{cyt}\mathrm{Trimer\_import\_to\_nuc}\mathrm{pS2\_pS2\_S4\_c}$ $\mathrm{K\_mran}\mathrm{S7KD}\mathrm{hill\_fact1}\mathrm{k\_induced\_S7\_production\_C5}\mathrm{mRNA\_prod\_C5}\mathrm{pS2\_pS2\_S4\_n}\mapsto \mathrm{S7KD}(\mathrm{mRNA\_prod\_C5}+\frac{\mathrm{k\_induced\_S7\_production\_C5}\mathrm{pS2\_pS2\_S4\_n}^{\mathrm{hill\_fact1}}}{\mathrm{K\_mran}^{\mathrm{hill\_fact1}}+\mathrm{pS2\_pS2\_S4\_n}^{\mathrm{hill\_fact1}}})$ $\mathrm{S2\_export\_from\_nuc\_C5}\mathrm{S2\_import\_to\_nuc\_C5}\mathrm{S2\_total\_C5}\mathrm{kdeg\_S2}\mapsto \frac{\mathrm{S2\_total\_C5}(\mathrm{S2\_import\_to\_nuc\_C5}\mathrm{kdeg\_S2}+\mathrm{S2\_export\_from\_nuc\_C5}\mathrm{kdeg\_S2}+\mathrm{kdeg\_S2}^2)}{2\mathrm{S2\_import\_to\_nuc\_C5}+\mathrm{S2\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S2}}$ $\mathrm{R1\_total\_C5}\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}\mapsto \frac{\mathrm{R1\_total\_C5}\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}^2}{\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}+\mathrm{kdeg\_R1}^2+\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}}$ $\mathrm{S4\_export\_from\_nuc\_C5}\mathrm{S4\_import\_to\_nuc\_C5}\mathrm{S4\_total\_C5}\mathrm{kdeg\_S4}\mapsto \frac{\mathrm{S4\_total\_C5}(\mathrm{S4\_import\_to\_nuc\_C5}\mathrm{kdeg\_S4}+\mathrm{S4\_export\_from\_nuc\_C5}\mathrm{kdeg\_S4}+\mathrm{kdeg\_S4}^2)}{2\mathrm{S4\_import\_to\_nuc\_C5}+\mathrm{S4\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S4}}$ $\mathrm{index\_kb\_homotrimer}\mathrm{kb\_trimmer}\mathrm{pS2\_pS2\_pS2\_n}\mapsto \mathrm{index\_kb\_homotrimer}\mathrm{kb\_trimmer}\mathrm{pS2\_pS2\_pS2\_n}$ $\mathrm{S2\_import\_to\_nuc\_C5}\mathrm{cyt}\mathrm{pS2\_c}\mapsto \mathrm{cyt}\mathrm{S2\_import\_to\_nuc\_C5}\mathrm{pS2\_c}$ $\mathrm{TGFb\_R1\_endo}\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5}\mapsto \mathrm{TGFb\_R1\_endo}\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5}$ $\mathrm{Active\_Rec}\mathrm{index\_kb\_R1}\mathrm{kf\_R1\_activation}\mapsto \mathrm{Active\_Rec}\mathrm{index\_kb\_R1}\mathrm{kf\_R1\_activation}$ $\mathrm{Inactive\_Rec}\mathrm{index\_induced\_ligand\_deg}\mathrm{kin\_deg\_Ligand}\mapsto \mathrm{Inactive\_Rec}\mathrm{index\_induced\_ligand\_deg}\mathrm{kin\_deg\_Ligand}$ $\mathrm{TGFb}\mathrm{TGFb\_R2\_surface}\mathrm{kf\_R2\_activation}\mapsto \mathrm{TGFb}\mathrm{TGFb\_R2\_surface}\mathrm{kf\_R2\_activation}$ $\frac{\mathrm{R1\_total\_C5}\mathrm{kdeg\_R1}(\mathrm{kdeg\_R1}+\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5})}{\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}+\mathrm{kdeg\_R1}^2+\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}}$ $\frac{\mathrm{R2\_total\_C5}\mathrm{kdeg\_R2}(\mathrm{kdeg\_R2}+\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5})}{\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}+\mathrm{kdeg\_R2}^2+\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}}$ $\frac{\mathrm{R1\_total\_C5}\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}}{\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}+\mathrm{kdeg\_R1}^2+\mathrm{index\_k\_out\_1\_relative\_speed\_C5}\mathrm{k\_in\_R1\_C5}\mathrm{kdeg\_R1}}$ $\frac{\mathrm{R2\_total\_C5}\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}}{\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}+\mathrm{kdeg\_R2}^2+\mathrm{index\_k\_out\_2\_relative\_speed\_C5}\mathrm{k\_in\_R2\_C5}\mathrm{kdeg\_R2}}$ $\frac{\mathrm{S2\_total\_C5}(\mathrm{S2\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S2})}{2\mathrm{S2\_import\_to\_nuc\_C5}+\mathrm{S2\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S2}}$ $\frac{\mathrm{S4\_total\_C5}(\mathrm{S4\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S4})}{2\mathrm{S4\_import\_to\_nuc\_C5}+\mathrm{S4\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S4}}$ $\frac{\mathrm{export\_cytoplasm}\mathrm{mRNA\_prod\_C5}}{2\mathrm{kmRNAdeg\_S7}(\mathrm{export\_cytoplasm}+\mathrm{kmRNA1deg\_S7})}$ $\frac{\mathrm{mRNA\_prod\_C5}}{\mathrm{export\_cytoplasm}+\mathrm{kmRNA1deg\_S7}}$ $\frac{\mathrm{export\_cytoplasm}\mathrm{k\_S7\_protein\_C5}\mathrm{mRNA\_prod\_C5}}{2\mathrm{kdeg\_S7}\mathrm{kmRNAdeg\_S7}(\mathrm{export\_cytoplasm}+\mathrm{kmRNA1deg\_S7})}$ $\frac{2\mathrm{S2\_total\_C5}\mathrm{S2\_import\_to\_nuc\_C5}}{2\mathrm{S2\_import\_to\_nuc\_C5}+\mathrm{S2\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S2}}$ $\frac{2\mathrm{S4\_total\_C5}\mathrm{S4\_import\_to\_nuc\_C5}}{2\mathrm{S4\_import\_to\_nuc\_C5}+\mathrm{S4\_export\_from\_nuc\_C5}+\mathrm{kdeg\_S4}}$ $\frac{2\mathrm{pS2\_pS2\_S4\_n}+\mathrm{pS2\_n}+\mathrm{S2\_n}+3\mathrm{pS2\_pS2\_pS2\_n}}{2\mathrm{pS2\_pS2\_S4\_c}+\mathrm{pS2\_c}+\mathrm{S2\_c}+3\mathrm{pS2\_pS2\_pS2\_c}}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction1\_0}(\mathrm{TGFb}, \mathrm{TGFb\_R2\_surface}, \mathrm{k\_medium}, \mathrm{kf\_R2\_activation})$ $\mathrm{cyt}\mathrm{kdeg\_R1}\mathrm{Active\_Rec\_endo}$ $\mathrm{cyt}\mathrm{kin\_deg\_Ligand}\mathrm{Active\_Rec\_endo}$ $\mathrm{cyt}\mathrm{kdeg\_R1}\mathrm{TGFb\_R1\_endo}$ $\mathrm{cyt}\mathrm{kdeg\_R2}\mathrm{TGFb\_R2\_endo}$ $\mathrm{cyt}\mathrm{kf\_Seq\_S7\_Rec}\mathrm{Active\_Rec}\mathrm{S7}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction15\_0}(\mathrm{Inactive\_Rec}, \mathrm{index\_seq\_kb}, \mathrm{kf\_Seq\_S7\_Rec})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction16\_0}(\mathrm{Inactive\_Rec}, \mathrm{index\_induced\_ligand\_deg}, \mathrm{kin\_deg\_Ligand})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction17\_0}(\mathrm{Inactive\_Rec}, \mathrm{index\_induced\_R2\_deg}, \mathrm{kdeg\_R2})$ $\mathrm{cyt}\mathrm{k\_in\_R1\_C5}\mathrm{TGFb\_R1\_surface}$ $\mathrm{cyt}\mathrm{k\_in\_R2\_C5}\mathrm{TGFb\_R2\_surface}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction2\_0}(\mathrm{TGFb}, \mathrm{TGFb\_R2\_surface}, \mathrm{kf\_R2\_activation})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction20}(\mathrm{TGFb\_R1\_endo}, \mathrm{index\_k\_out\_1\_relative\_speed\_C5}, \mathrm{k\_in\_R1\_C5})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction21}(\mathrm{TGFb\_R2\_endo}, \mathrm{index\_k\_out\_2\_relative\_speed\_C5}, \mathrm{k\_in\_R2\_C5})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction22}(\mathrm{Active\_Rec}, \mathrm{index\_active\_Rec\_internalize\_C5}, \mathrm{k\_in\_R1\_C5})$ $\mathrm{cyt}\mathrm{k\_disso\_Active\_Rec}\mathrm{Active\_Rec\_endo}$ $\mathrm{cyt}\mathrm{kin\_deg\_Ligand}\mathrm{TGFb\_In}$ $\mathrm{cyt}\mathrm{kout\_deg\_Ligand\_100pM}\mathrm{TGFb}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction26\_0}(\mathrm{Active\_Rec\_endo}, \mathrm{S2\_c}, \mathrm{k\_phosphorylation})$ $\mathrm{cyt}\mathrm{kf\_trimmer}\mathrm{pS2\_c}^2\mathrm{S4\_c}$ $\mathrm{cyt}\mathrm{kb\_trimmer}\mathrm{pS2\_pS2\_S4\_c}$ $\mathrm{nuc}\mathrm{kf\_trimmer}\mathrm{pS2\_n}^2\mathrm{S4\_n}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction3\_0}(\mathrm{TGFb}, \mathrm{TGFb\_R2\_surface}, \mathrm{kf\_R2\_activation})$ $\mathrm{nuc}\mathrm{kb\_trimmer}\mathrm{pS2\_pS2\_S4\_n}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction31\_2}(\mathrm{index\_kf\_homotrimer}, \mathrm{kf\_trimmer}, \mathrm{pS2\_c})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction32\_3}(\mathrm{index\_kb\_homotrimer}, \mathrm{kb\_trimmer}, \mathrm{pS2\_pS2\_pS2\_c})$ $\mathrm{nuc}\mathrm{Function\_for\_reaction33\_2}(\mathrm{index\_kf\_homotrimer}, \mathrm{kf\_trimmer}, \mathrm{pS2\_n})$ $\mathrm{nuc}\mathrm{Function\_for\_reaction34\_2}(\mathrm{index\_kb\_homotrimer}, \mathrm{kb\_trimmer}, \mathrm{pS2\_pS2\_pS2\_n})$ $\mathrm{Function\_for\_reaction35}(\mathrm{S2\_c}, \mathrm{S2\_import\_to\_nuc\_C5}, \mathrm{cyt})$ $\mathrm{Function\_for\_reaction36}(\mathrm{S2\_export\_from\_nuc\_C5}, \mathrm{S2\_n}, \mathrm{nuc})$ $\mathrm{Function\_for\_reaction37}(\mathrm{S4\_c}, \mathrm{S4\_import\_to\_nuc\_C5}, \mathrm{cyt})$ $\mathrm{Function\_for\_reaction38}(\mathrm{S4\_export\_from\_nuc\_C5}, \mathrm{S4\_n}, \mathrm{nuc})$ $\mathrm{Function\_for\_reaction39}(\mathrm{S2\_import\_to\_nuc\_C5}, \mathrm{cyt}, \mathrm{pS2\_c})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction4\_0}(\mathrm{Active\_R2}, \mathrm{index\_kb\_R2}, \mathrm{kf\_R2\_activation})$ $\mathrm{Function\_for\_reaction40}(\mathrm{S2\_export\_from\_nuc\_C5}, \mathrm{nuc}, \mathrm{pS2\_n})$ $\mathrm{Function\_for\_reaction41\_2}(\mathrm{Trimer\_import\_to\_nuc}, \mathrm{cyt}, \mathrm{pS2\_pS2\_S4\_c})$ $\mathrm{Function\_for\_reaction42\_0}(\mathrm{Trimer\_import\_to\_nuc}, \mathrm{cyt}, \mathrm{pS2\_pS2\_pS2\_c})$ $\mathrm{nuc}\mathrm{k\_Dephos\_C5}\mathrm{pS2\_n}$ $\mathrm{nuc}\mathrm{Function\_for\_reaction44}(\mathrm{index\_trimer\_dephos}, \mathrm{k\_Dephos\_C5}, \mathrm{pS2\_pS2\_S4\_n})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction45}(\mathrm{S2\_export\_from\_nuc\_C5}, \mathrm{S2\_import\_to\_nuc\_C5}, \mathrm{S2\_total\_C5}, \mathrm{kdeg\_S2})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction46}(\mathrm{S4\_export\_from\_nuc\_C5}, \mathrm{S4\_import\_to\_nuc\_C5}, \mathrm{S4\_total\_C5}, \mathrm{kdeg\_S4})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction47}(\mathrm{R1\_total\_C5}, \mathrm{index\_k\_out\_1\_relative\_speed\_C5}, \mathrm{k\_in\_R1\_C5}, \mathrm{kdeg\_R1})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction48}(\mathrm{R2\_total\_C5}, \mathrm{index\_k\_out\_2\_relative\_speed\_C5}, \mathrm{k\_in\_R2\_C5}, \mathrm{kdeg\_R2})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction5\_0}(\mathrm{Active\_R2}, \mathrm{index\_kb\_R2}, \mathrm{kf\_R2\_activation})$ $\mathrm{nuc}\mathrm{Function\_for\_reaction51}(\mathrm{K\_mran}, \mathrm{S7KD}, \mathrm{hill\_fact1}, \mathrm{k\_induced\_S7\_production\_C5}, \mathrm{mRNA\_prod\_C5}, \mathrm{pS2\_pS2\_S4\_n})$ $\mathrm{Function\_for\_reaction52\_3}(\mathrm{Smad7mRNA1}, \mathrm{export\_cytoplasm}, \mathrm{nuc})$ $\mathrm{cyt}\mathrm{Function\_for\_reaction53}(\mathrm{Smad7mRNA}, \mathrm{k\_S7\_protein\_C5})$ $\mathrm{cyt}\mathrm{kdeg\_S2}\mathrm{S2\_c}$ $\mathrm{nuc}\mathrm{kdeg\_S2}\mathrm{S2\_n}$ $\mathrm{nuc}\mathrm{kdeg\_S2}\mathrm{pS2\_n}$ $\mathrm{cyt}\mathrm{kdeg\_S2}\mathrm{pS2\_c}$ $\mathrm{cyt}\mathrm{kdeg\_S4}\mathrm{S4\_c}$ $\mathrm{nuc}\mathrm{kdeg\_S4}\mathrm{S4\_n}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction6\_0}(\mathrm{Active\_R2}, \mathrm{index\_kb\_R2}, \mathrm{k\_medium}, \mathrm{kf\_R2\_activation})$ $\mathrm{cyt}\mathrm{kdeg\_S2}\mathrm{pS2\_pS2\_S4\_c}$ $\mathrm{cyt}\mathrm{kdeg\_S4}\mathrm{pS2\_pS2\_S4\_c}$ $\mathrm{cyt}\mathrm{kdeg\_S2}\mathrm{pS2\_pS2\_pS2\_c}$ $\mathrm{nuc}\mathrm{kdeg\_S2}\mathrm{pS2\_pS2\_S4\_n}$ $\mathrm{nuc}\mathrm{kdeg\_S4}\mathrm{pS2\_pS2\_S4\_n}$ $\mathrm{nuc}\mathrm{kdeg\_S2}\mathrm{pS2\_pS2\_pS2\_n}$ $\mathrm{nuc}\mathrm{kmRNA1deg\_S7}\mathrm{Smad7mRNA1}$ $\mathrm{cyt}\mathrm{kmRNAdeg\_S7}\mathrm{Smad7mRNA}$ $\mathrm{cyt}\mathrm{kdeg\_S7}\mathrm{S7}$ $\mathrm{cyt}\mathrm{kf\_R1\_activation}\mathrm{TGFb\_R1\_surface}\mathrm{Active\_R2}$ $\mathrm{cyt}\mathrm{Function\_for\_reaction8\_0}(\mathrm{Active\_Rec}, \mathrm{index\_kb\_R1}, \mathrm{kf\_R1\_activation})$ $\mathrm{cyt}\mathrm{kdeg\_R2}\mathrm{Active\_Rec\_endo}$